Journal of Cell Biology
@jcb.org
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
🌐 https://rupress.org/jcb
🌐 https://rupress.org/jcb
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Our annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
@ascbiology.bsky.social
#CellBio2025
@ascbiology.bsky.social
Keeping a stiff upper lip: p120ctn and tissue fusion. Jeff Hardin @uwmadison.bsky.social discusses recent work by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#Adhesion #Development
#Adhesion #Development
December 26, 2025 at 2:45 PM
Keeping a stiff upper lip: p120ctn and tissue fusion. Jeff Hardin @uwmadison.bsky.social discusses recent work by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#Adhesion #Development
#Adhesion #Development
SynSeg: A synthetic data-driven approach for robust subcellular structure segmentation, developed by Zhengyang Guo, Guangshuo Ou and colleagues @tsinghuauniversity.bsky.social: rupress.org/jcb/article/...
#Technology #Cytoskeleton
#Technology #Cytoskeleton
December 25, 2025 at 2:45 PM
SynSeg: A synthetic data-driven approach for robust subcellular structure segmentation, developed by Zhengyang Guo, Guangshuo Ou and colleagues @tsinghuauniversity.bsky.social: rupress.org/jcb/article/...
#Technology #Cytoskeleton
#Technology #Cytoskeleton
A crucial step towards understanding tip growth in plants. Ivan Radin @radinbio.bsky.social (University of Minnesota) highlights work from Ryken et al. of the Bezanilla lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling #PlantBiology #PlantCellBiology
#CellSignaling #PlantBiology #PlantCellBiology
December 24, 2025 at 4:15 PM
A crucial step towards understanding tip growth in plants. Ivan Radin @radinbio.bsky.social (University of Minnesota) highlights work from Ryken et al. of the Bezanilla lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling #PlantBiology #PlantCellBiology
#CellSignaling #PlantBiology #PlantCellBiology
Reposted by Journal of Cell Biology
Very nice highlight on Camilla’s new paper! @xsciteng.bsky.social
Spotlight @jcb.org: Jeff Hardin highlights recent work from @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...), studying the function of p120-catenin and #cadherin-mediated #adhesion in upper lip fusion in mammalian embryos. rupress.org/jcb/article/...
December 23, 2025 at 4:35 AM
Very nice highlight on Camilla’s new paper! @xsciteng.bsky.social
Reposted by Journal of Cell Biology
It's such an honor to be featured in @jcb.org The Year in Cell Biology 2025 Collection!! 🤩
Huge thanks to my amazing PI @nanigrotjahn.bsky.social and my wonderful lab mate @nitishdua.bsky.social for bringing the hard copy of the magazine back from #cellbio1025 for me. It truly made my day! 🥰
Huge thanks to my amazing PI @nanigrotjahn.bsky.social and my wonderful lab mate @nitishdua.bsky.social for bringing the hard copy of the magazine back from #cellbio1025 for me. It truly made my day! 🥰
December 23, 2025 at 4:52 PM
It's such an honor to be featured in @jcb.org The Year in Cell Biology 2025 Collection!! 🤩
Huge thanks to my amazing PI @nanigrotjahn.bsky.social and my wonderful lab mate @nitishdua.bsky.social for bringing the hard copy of the magazine back from #cellbio1025 for me. It truly made my day! 🥰
Huge thanks to my amazing PI @nanigrotjahn.bsky.social and my wonderful lab mate @nitishdua.bsky.social for bringing the hard copy of the magazine back from #cellbio1025 for me. It truly made my day! 🥰
Steady and escort cyst cells regulate #Drosophila germline stem cell differentiation and death, say Aya Ben-Hamo-Arad, Hila Toledano and colleagues (University of Haifa): rupress.org/jcb/article/...
#CellDeath #StemCells
#CellDeath #StemCells
December 23, 2025 at 4:15 PM
Steady and escort cyst cells regulate #Drosophila germline stem cell differentiation and death, say Aya Ben-Hamo-Arad, Hila Toledano and colleagues (University of Haifa): rupress.org/jcb/article/...
#CellDeath #StemCells
#CellDeath #StemCells
Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/...
#Trafficking #Organelles #Disease
#Trafficking #Organelles #Disease
December 23, 2025 at 2:45 PM
Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/...
#Trafficking #Organelles #Disease
#Trafficking #Organelles #Disease
Reposted by Journal of Cell Biology
Check this out! Camilla is awesome! @xsciteng.bsky.social
🎥 New video summary of a recent paper by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social (rupress.org/jcb/article/...), revealing cellular mechanisms of tissue fusion in the developing face.
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion
Original paper: https://rupress.org/jcb/article/225/1/e202503070/278464/Actomyosin-contractility-and-a-threshold-of
Video summary by Camilla S. Teng (Jeffrey Bush Lab, University of California San…
youtu.be
December 23, 2025 at 4:28 AM
Check this out! Camilla is awesome! @xsciteng.bsky.social
Reposted by Journal of Cell Biology
On the first day of the Christmas holidays, I got... a new preprint out! Challenging the reproducibility of our manual presynaptic actin nanostructure identification: www.biorxiv.org/content/10.6...
(data from Bingham et al. @jcb.org 2023 doi.org/10.1083/jcb....) with @flevet.bsky.social
(data from Bingham et al. @jcb.org 2023 doi.org/10.1083/jcb....) with @flevet.bsky.social
December 22, 2025 at 6:49 PM
On the first day of the Christmas holidays, I got... a new preprint out! Challenging the reproducibility of our manual presynaptic actin nanostructure identification: www.biorxiv.org/content/10.6...
(data from Bingham et al. @jcb.org 2023 doi.org/10.1083/jcb....) with @flevet.bsky.social
(data from Bingham et al. @jcb.org 2023 doi.org/10.1083/jcb....) with @flevet.bsky.social
Reposted by Journal of Cell Biology
JCB’s Cover of the Year voting is open!
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 22, 2025 at 8:03 PM
JCB’s Cover of the Year voting is open!
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬
#teamtomo @attychang.bsky.social
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 22, 2025 at 7:30 PM
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
🎥 New video summary of a recent paper by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social (rupress.org/jcb/article/...), revealing cellular mechanisms of tissue fusion in the developing face.
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion
Original paper: https://rupress.org/jcb/article/225/1/e202503070/278464/Actomyosin-contractility-and-a-threshold-of
Video summary by Camilla S. Teng (Jeffrey Bush Lab, University of California San…
youtu.be
December 19, 2025 at 6:30 PM
🎥 New video summary of a recent paper by @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social (rupress.org/jcb/article/...), revealing cellular mechanisms of tissue fusion in the developing face.
Spotlight: Jeff Hardin highlights recent work from @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...), studying the function of p120-catenin and #cadherin-mediated #adhesion in upper lip fusion in mammalian embryos. rupress.org/jcb/article/...
#Development
#Development
December 19, 2025 at 5:01 PM
Spotlight: Jeff Hardin highlights recent work from @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...), studying the function of p120-catenin and #cadherin-mediated #adhesion in upper lip fusion in mammalian embryos. rupress.org/jcb/article/...
#Development
#Development
Zhengyang Guo, Guangshuo Ou et al. @tsinghuauniversity.bsky.social introduce SynSeg, a method that eliminates manual annotation by training #DeepLearning models on synthetic data from abstracted “primitives” to robustly segment diverse subcellular structures rupress.org/jcb/article/...
#Technology
#Technology
December 18, 2025 at 5:33 PM
Zhengyang Guo, Guangshuo Ou et al. @tsinghuauniversity.bsky.social introduce SynSeg, a method that eliminates manual annotation by training #DeepLearning models on synthetic data from abstracted “primitives” to robustly segment diverse subcellular structures rupress.org/jcb/article/...
#Technology
#Technology
Perinuclear non-centrosomal #microtubules direct nuclei dispersion during epithelial #morphogenesis, say Rashmi Budhathoki et al. @blankenshiplab.bsky.social rupress.org/jcb/article/...
#Drosophila #Cytoskeleton #Development #Organelles
#Drosophila #Cytoskeleton #Development #Organelles
December 18, 2025 at 3:44 PM
Perinuclear non-centrosomal #microtubules direct nuclei dispersion during epithelial #morphogenesis, say Rashmi Budhathoki et al. @blankenshiplab.bsky.social rupress.org/jcb/article/...
#Drosophila #Cytoskeleton #Development #Organelles
#Drosophila #Cytoskeleton #Development #Organelles
Independent nuclear and organellar mechanisms determine #apicoplast fate in #malaria #parasites, say Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social
rupress.org/jcb/article/...
rupress.org/jcb/article/...
December 17, 2025 at 7:32 PM
Independent nuclear and organellar mechanisms determine #apicoplast fate in #malaria #parasites, say Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Spotlight: Ivan Radin discusses new work from Ryken and colleagues (rupress.org/jcb/article/...) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. rupress.org/jcb/article/...
#PlantBiology
#PlantBiology
December 17, 2025 at 5:15 PM
Spotlight: Ivan Radin discusses new work from Ryken and colleagues (rupress.org/jcb/article/...) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. rupress.org/jcb/article/...
#PlantBiology
#PlantBiology
Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...
December 16, 2025 at 6:15 PM
Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...
Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...
December 16, 2025 at 5:30 PM
Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...
TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion, say Jianfei Zheng, Haodong Wang, Min Zhang, Liang Ge and colleagues @tsinghuauniversity.bsky.social: rupress.org/jcb/article/...
#Biochemistry #Membrane #lipid
#Biochemistry #Membrane #lipid
December 16, 2025 at 2:45 PM
TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion, say Jianfei Zheng, Haodong Wang, Min Zhang, Liang Ge and colleagues @tsinghuauniversity.bsky.social: rupress.org/jcb/article/...
#Biochemistry #Membrane #lipid
#Biochemistry #Membrane #lipid
JCB's The Year of Cell Biology: 2025 features new advances in plasma membrane repair, autophagy, protein homeostasis, and organelle-dependent cell signaling. Find the original research articles that have garnered exceptional interest from our readership this year 👉 rupress.org/jcb/collecti...
December 15, 2025 at 3:04 PM
JCB's The Year of Cell Biology: 2025 features new advances in plasma membrane repair, autophagy, protein homeostasis, and organelle-dependent cell signaling. Find the original research articles that have garnered exceptional interest from our readership this year 👉 rupress.org/jcb/collecti...
Macrophage fireworks 🎆 from Miller et al. of the @mmorrissey.bsky.social lab (doi.org/10.1083/jcb....) showing a #macrophage expressing Vav1-mCherry (magenta) interacting with IgG (yellow) on a supported lipid bilayer containing ICAM-1. More in JCB's December issue: rupress.org/jcb/issue/22...
December 15, 2025 at 3:02 PM
Macrophage fireworks 🎆 from Miller et al. of the @mmorrissey.bsky.social lab (doi.org/10.1083/jcb....) showing a #macrophage expressing Vav1-mCherry (magenta) interacting with IgG (yellow) on a supported lipid bilayer containing ICAM-1. More in JCB's December issue: rupress.org/jcb/issue/22...
Reposted by Journal of Cell Biology
Congratulations to Amanda Bentley-DeSousa of the Ferguson lab for her paper being selected as one of JCB’s most impactful papers of 2025! @shawnferguson.bsky.social
Our annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
@ascbiology.bsky.social
#CellBio2025
@ascbiology.bsky.social
December 12, 2025 at 6:43 PM
Congratulations to Amanda Bentley-DeSousa of the Ferguson lab for her paper being selected as one of JCB’s most impactful papers of 2025! @shawnferguson.bsky.social
Reposted by Journal of Cell Biology
This might be my favorite piece of conference swag ever. My 5yo is obsessed with it. #cellbio2025 @jcb.org
December 13, 2025 at 1:05 AM
This might be my favorite piece of conference swag ever. My 5yo is obsessed with it. #cellbio2025 @jcb.org