Journal of Cell Biology
@jcb.org
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
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Journal of Cell Biology
@jcb.org
Β· 12d
Explore recent advances in #autophagy research, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy π rupress.org/jcb/collecti...
@keystonesymposia.bsky.social
#KSAutophagy26
@keystonesymposia.bsky.social
#KSAutophagy26
RCC1 depletion drives protein transport defects and rupture in #micronuclei. New study from Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch @fredhutch.org: rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
February 10, 2026 at 4:15 PM
RCC1 depletion drives protein transport defects and rupture in #micronuclei. New study from Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch @fredhutch.org: rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
Reposted by Journal of Cell Biology
So proud to share my paper on collective chemotaxis and force coordination in epithelial and mesenchymal cells, developed in the Mayor Lab and now published in JCB. Deeply grateful for everything I learned from Xenopus NC and the amphibian world, where adaptation is everythingπΈ
A new paper published in @jcb.org by postdoc Jorge Diaz from the Mayor lab at UCL shows that during collective migration, epithelial-like clusters generate traction force mainly through cryptic protrusions at the centre, while mesenchymal clusters do so at their periphery:
doi.org/10.1083/jcb....
doi.org/10.1083/jcb....
January 28, 2026 at 7:36 PM
So proud to share my paper on collective chemotaxis and force coordination in epithelial and mesenchymal cells, developed in the Mayor Lab and now published in JCB. Deeply grateful for everything I learned from Xenopus NC and the amphibian world, where adaptation is everythingπΈ
GRIPAP1 is an endosomal tethering factor mediating platelet Ξ±-granule biogenesis. New study from Andrea L. Ambrosio, Hallie P. Febvre, Gabrielle H. Schusler, & Santiago M. Di Pietro (Colorado State University): rupress.org/jcb/article/...
#Biochemistry #Disease #Organelles #Trafficking #Platelets
#Biochemistry #Disease #Organelles #Trafficking #Platelets
February 10, 2026 at 3:15 PM
GRIPAP1 is an endosomal tethering factor mediating platelet Ξ±-granule biogenesis. New study from Andrea L. Ambrosio, Hallie P. Febvre, Gabrielle H. Schusler, & Santiago M. Di Pietro (Colorado State University): rupress.org/jcb/article/...
#Biochemistry #Disease #Organelles #Trafficking #Platelets
#Biochemistry #Disease #Organelles #Trafficking #Platelets
NRZ complex facilitates virus infection via enhancing ER-LDs contacts, say Zhifang Li, Yifan Xing, Xinyi Huang, Buyun Tian, Jie Mei, Xinyue Fu, Xiaobao Cao, Yanhong Xue, Zonghong Li, Tao Xu, Yaming Jiu (Shanghai Institute of Materia Medica) and colleagues: rupress.org/jcb/article/...
#Virology
#Virology
February 10, 2026 at 2:15 PM
NRZ complex facilitates virus infection via enhancing ER-LDs contacts, say Zhifang Li, Yifan Xing, Xinyi Huang, Buyun Tian, Jie Mei, Xinyue Fu, Xiaobao Cao, Yanhong Xue, Zonghong Li, Tao Xu, Yaming Jiu (Shanghai Institute of Materia Medica) and colleagues: rupress.org/jcb/article/...
#Virology
#Virology
Join the #EMBL conference "Cellular mechanisms driven by phase separation" ποΈ May 19-22! Register now for in-person at @embl.org Heidelberg or Virtual π www.embl.org/about/info/c...
#EESPhaseSeparation
@events.embl.org
#EESPhaseSeparation
@events.embl.org
February 9, 2026 at 9:29 PM
Join the #EMBL conference "Cellular mechanisms driven by phase separation" ποΈ May 19-22! Register now for in-person at @embl.org Heidelberg or Virtual π www.embl.org/about/info/c...
#EESPhaseSeparation
@events.embl.org
#EESPhaseSeparation
@events.embl.org
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. π rupress.org/jcb/collecti...
February 9, 2026 at 2:30 PM
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. π rupress.org/jcb/collecti...
Reposted by Journal of Cell Biology
New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social
Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
February 6, 2026 at 7:53 PM
New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social
Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
February 6, 2026 at 5:00 PM
Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
Energy stress activates AMPK to arrest #mitochondria via phosphorylation of TRAK1. New study from Jill E. Falk, Thomas L. Schwarz and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...
#Metabolism #Neuroscience #Organelles #CellMetabolism #Cytoskeleton
#Metabolism #Neuroscience #Organelles #CellMetabolism #Cytoskeleton
February 6, 2026 at 3:30 PM
Energy stress activates AMPK to arrest #mitochondria via phosphorylation of TRAK1. New study from Jill E. Falk, Thomas L. Schwarz and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...
#Metabolism #Neuroscience #Organelles #CellMetabolism #Cytoskeleton
#Metabolism #Neuroscience #Organelles #CellMetabolism #Cytoskeleton
Actomyosin cortex integration with complex plasma membrane topography in the early #Drosophila embryo. New study from Rowan K. Naidoo, Rebecca Tam, and Tony J.C. Harris @uoftcellsysbiol.bsky.social: rupress.org/jcb/article/...
#Development #Cytoskeleton
#Development #Cytoskeleton
February 6, 2026 at 3:30 PM
Actomyosin cortex integration with complex plasma membrane topography in the early #Drosophila embryo. New study from Rowan K. Naidoo, Rebecca Tam, and Tony J.C. Harris @uoftcellsysbiol.bsky.social: rupress.org/jcb/article/...
#Development #Cytoskeleton
#Development #Cytoskeleton
ATG9A facilitates closure of mammalian autophagosomes. From Ruheena Javed, Vojo Deretic and colleagues: rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
February 5, 2026 at 6:15 PM
ATG9A facilitates closure of mammalian autophagosomes. From Ruheena Javed, Vojo Deretic and colleagues: rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/...
π In #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π In #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
February 5, 2026 at 4:15 PM
The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/...
π In #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π In #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Download JCB's CELLULAR DIVERSITY poster! π© Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab π info.rupress.org/jcb-collecti...
February 4, 2026 at 9:30 PM
π Download JCB's CELLULAR DIVERSITY poster! π© Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab π info.rupress.org/jcb-collecti...
Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
February 4, 2026 at 6:15 PM
Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
In this Perspective, North, @doroteaartscience.bsky.social, Shoemaker et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
February 4, 2026 at 4:15 PM
In this Perspective, North, @doroteaartscience.bsky.social, Shoemaker et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
Real time imaging reveals new mechanisms for pancreatic ductal establishment and remodeling. New study from Abigail Laura Jackson, Silja Heilmann @ucph.bsky.social, Pia Nyeng @roskildeuni.bsky.social and colleagues: rupress.org/jcb/article/...
#Polarity #Development
#Polarity #Development
February 4, 2026 at 2:30 PM
Real time imaging reveals new mechanisms for pancreatic ductal establishment and remodeling. New study from Abigail Laura Jackson, Silja Heilmann @ucph.bsky.social, Pia Nyeng @roskildeuni.bsky.social and colleagues: rupress.org/jcb/article/...
#Polarity #Development
#Polarity #Development
Reposted by Journal of Cell Biology
A key finding of our last study is that soluble and immobilized CCL21 gradients cooperate to fine-tune different steps of lymphatic migration, revealing a new layer in leukocyte guidance.
This work was only possible thanks to an amazing team effort!
This work was only possible thanks to an amazing team effort!
uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. New study from Victor Collado-Diaz, Maria-Nefeli Christakopoulou, Philipp Schineis, Cornelia Halin @halinlab.bsky.social @ethz.ch and colleagues: rupress.org/jcb/article/...
#Immunology #Migration #motility
#Immunology #Migration #motility
February 4, 2026 at 8:29 AM
A key finding of our last study is that soluble and immobilized CCL21 gradients cooperate to fine-tune different steps of lymphatic migration, revealing a new layer in leukocyte guidance.
This work was only possible thanks to an amazing team effort!
This work was only possible thanks to an amazing team effort!
MIM triggers formin to Arp2/3-based actin assembly in membrane remodeling in #Drosophila embryos, say Debasmita Mitra, Georgina K. Goddard, Sanjana S, Aparna K, Richa Rikhy (Indian Institute of Science Education and Research Pune) & colleagues: rupress.org/jcb/article/...
#Cytoskeleton #Development
#Cytoskeleton #Development
February 3, 2026 at 8:15 PM
MIM triggers formin to Arp2/3-based actin assembly in membrane remodeling in #Drosophila embryos, say Debasmita Mitra, Georgina K. Goddard, Sanjana S, Aparna K, Richa Rikhy (Indian Institute of Science Education and Research Pune) & colleagues: rupress.org/jcb/article/...
#Cytoskeleton #Development
#Cytoskeleton #Development
Andrea L. Ambrosio, Santiago M. Di Pietro et al. discover GRIPAP1 is a component of the cellular machinery that produces the #platelet Ξ±-granule, a member of the #lysosome-related organelle family. rupress.org/jcb/article/...
#Biochemistry #Disease #Organelles #Trafficking
#Biochemistry #Disease #Organelles #Trafficking
February 3, 2026 at 8:00 PM
Andrea L. Ambrosio, Santiago M. Di Pietro et al. discover GRIPAP1 is a component of the cellular machinery that produces the #platelet Ξ±-granule, a member of the #lysosome-related organelle family. rupress.org/jcb/article/...
#Biochemistry #Disease #Organelles #Trafficking
#Biochemistry #Disease #Organelles #Trafficking
Molly Zych, Emily Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
February 3, 2026 at 7:30 PM
Molly Zych, Emily Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
February 3, 2026 at 6:15 PM
Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
February 3, 2026 at 5:45 PM
Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ERβLD interactions by enhancing ERβLD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets
February 3, 2026 at 5:00 PM
Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ERβLD interactions by enhancing ERβLD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
February 3, 2026 at 4:15 PM
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
π Part of #Autophagy 2026 π rupress.org/jcb/collecti...
#KSAutophagy26
uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. New study from Victor Collado-Diaz, Maria-Nefeli Christakopoulou, Philipp Schineis, Cornelia Halin @halinlab.bsky.social @ethz.ch and colleagues: rupress.org/jcb/article/...
#Immunology #Migration #motility
#Immunology #Migration #motility
February 3, 2026 at 3:30 PM
uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. New study from Victor Collado-Diaz, Maria-Nefeli Christakopoulou, Philipp Schineis, Cornelia Halin @halinlab.bsky.social @ethz.ch and colleagues: rupress.org/jcb/article/...
#Immunology #Migration #motility
#Immunology #Migration #motility