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isdb.bsky.social
International Society of Developmental Biology
@isdb.bsky.social
1.9K followers 650 following 64 posts
ISDB is a non-profit scientific association that promotes the study of developmental biology
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International Society of Developmental Biology @isdb.bsky.social · Nov 15
Hello my lovely developmental biologists, The International Society for Developmental Biology is here with y'all in this #BlueSky. If you follow us on Twitter (we refuse to call it X), please drop us a follow here! Let's connect! #DevelopmentalBiology #cellbiology
Reposted by International Society of Developmental Biology
dev-journal.bsky.social
Our first issue of Vol 153 (2026) is complete!

On the cover: 3D image of the apical Drosophila pupal eye with depth-coding applied, showing a dome-like ommatidia.

See the Research Article by Bhattarai ( @abhibhattarai.bsky.social) et al. from @ruthjohnsonlab.bsky.social

doi.org/10.1242/dev....
3D image of the apical Drosophila pupal eye with depth-coding applied and a pronounced dome-like appearance of ommatidia, owing to the highly organized network of apical rib-like actin filaments (ARAFs)
January 16, 2026 at 2:46 PM
isdb.bsky.social
2-head frogs? 😲
cellsdev.bsky.social Cells & Development @cellsdev.bsky.social · 20h
A very curious paper from the De Robertis lab shows how Cerberus - a growth factor that inhibits Wnt signalling, and IGF - a growth factor that activates MAPK signalling, can synergistically induce a new head (aka ectopic archencephalic differentiation) in Xenopus embryos.
doi.org/10.1016/j.cd...
Fig. 1. IGF2 and Cerberus mRNAs cooperate in ectopic head induction in Xenopus embryos. Embryos were microinjected into the ventral marginal zone of a single blastomere at the 4- to 8-cell stage. (A) Uninjected control sibling at early tailbud stage (n = 81). (B) A single ventral injection of IGF2 mRNA caused a small ectopic head protrusion with a pigmented cement gland on the belly (n = 86, 68 % with ectopic structures). (C) Cerberus mRNA induced a secondary head-like structure (n = 78, 94 % with ectopic heads). (D) Co-injection of IGF2 and Cerberus mRNAs induced a large ectopic head with an expanded cement gland (n = 90, 98 % with ectopic heads). (E–H) Panoramic views of control and injected embryos. Injected mRNA doses per embryo were: Cerberus, 100 pg; IGF2, 2 ng. Results from two experiments. Scale bars are 500 μm (A-D) and 2 mm (E-H). Fig. 6. Dominant-negative IGF receptor 1 blocked ectopic head formation by Cerberus mRNA in single ventral injections. (A) Control embryo at stage 24 injected with LacZ (100 pg) mRNA but not stained for β-galactosidase (n = 50). (B) DN-IGFR (600 pg) and LacZ injected embryos (n = 20, all normal). (C) Cerberus (100 pg) injected embryos with ectopic heads (n = 56, 96 % ectopic heads). (D) DN-IGFR blocked Cerberus ectopic heads (n = 33, 88 % with no ectopic structures, 12 % with small cement glands). (E–F) LacZ staining for (A–D). Scale bar, 500 μm.
January 17, 2026 at 1:04 AM
Reposted by International Society of Developmental Biology
cellsdev.bsky.social
A very curious paper from the De Robertis lab shows how Cerberus - a growth factor that inhibits Wnt signalling, and IGF - a growth factor that activates MAPK signalling, can synergistically induce a new head (aka ectopic archencephalic differentiation) in Xenopus embryos.
doi.org/10.1016/j.cd...
Fig. 1. IGF2 and Cerberus mRNAs cooperate in ectopic head induction in Xenopus embryos. Embryos were microinjected into the ventral marginal zone of a single blastomere at the 4- to 8-cell stage. (A) Uninjected control sibling at early tailbud stage (n = 81). (B) A single ventral injection of IGF2 mRNA caused a small ectopic head protrusion with a pigmented cement gland on the belly (n = 86, 68 % with ectopic structures). (C) Cerberus mRNA induced a secondary head-like structure (n = 78, 94 % with ectopic heads). (D) Co-injection of IGF2 and Cerberus mRNAs induced a large ectopic head with an expanded cement gland (n = 90, 98 % with ectopic heads). (E–H) Panoramic views of control and injected embryos. Injected mRNA doses per embryo were: Cerberus, 100 pg; IGF2, 2 ng. Results from two experiments. Scale bars are 500 μm (A-D) and 2 mm (E-H). Fig. 6. Dominant-negative IGF receptor 1 blocked ectopic head formation by Cerberus mRNA in single ventral injections. (A) Control embryo at stage 24 injected with LacZ (100 pg) mRNA but not stained for β-galactosidase (n = 50). (B) DN-IGFR (600 pg) and LacZ injected embryos (n = 20, all normal). (C) Cerberus (100 pg) injected embryos with ectopic heads (n = 56, 96 % ectopic heads). (D) DN-IGFR blocked Cerberus ectopic heads (n = 33, 88 % with no ectopic structures, 12 % with small cement glands). (E–F) LacZ staining for (A–D). Scale bar, 500 μm.
January 17, 2026 at 1:03 AM
Reposted by International Society of Developmental Biology
cabd-upo-csic.bsky.social
#JobOffer

Join an exciting project in a growing team!

@sebioldev.bsky.social @izfs.bsky.social @segenetica.bsky.social @sebbm.bsky.social @isdb.bsky.social @the-node.bsky.social @pablodeolavide.upo.es @csicandalextrem.bsky.social
January 13, 2026 at 8:57 AM
Reposted by International Society of Developmental Biology
jcb.org
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
January 7, 2026 at 5:31 PM
Reposted by International Society of Developmental Biology
vmetzis.bsky.social
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!

Registration and abstract submission is now open - join us!

bsdb.org/meetings/

March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
isdb.bsky.social
Looks like a fantastic meeting. Register now.
bsdb.bsky.social British Society for Developmental Biology @bsdb.bsky.social · 8d
Don't forget to register for our upcoming Spring Meeting: 'Molecules to Morphogenesis'

Get your abstracts submitted by the 16th of January!

bsdb.org/meetings
January 12, 2026 at 1:12 PM
Reposted by International Society of Developmental Biology
bsdb.bsky.social
Don't forget to register for our upcoming Spring Meeting: 'Molecules to Morphogenesis'

Get your abstracts submitted by the 16th of January!

bsdb.org/meetings
January 9, 2026 at 2:20 PM
Reposted by International Society of Developmental Biology
bscb-official.bsky.social
Don't forget to register for our Spring Meeting: Dynamic Cell VI
A joint meeting with the @biochemsoc.bsky.social

Super early bird registration ends 21st Jan
December 18, 2025 at 6:07 PM
Reposted by International Society of Developmental Biology
jrmarmor.bsky.social
We are looking for a Bioinformatician (both graduate and postdoctoral levels) to join our lab. Please help us spread the word about this opportunity!

Applicants should submit their motivation letter, full CV and academic record to Juan R. Martínez-Morales: jrmarmor@upo.es
January 12, 2026 at 10:35 AM
Reposted by International Society of Developmental Biology
mikepiacentino.bsky.social
I’m thrilled to share the first preprint from the Piacentino Lab @hopkinsmedicine.bsky.social! We show that developing inner ear requires a secreted lipid chaperone, APOD, working in a positive feedback loop to amplify FGF/MAPK signaling. 👂 #DevBio Check it out! www.biorxiv.org/content/10.6...
Lipid-mediated reinforcement of FGF/MAPK signaling enables robust otic placode specification
The formation of cranial placodes requires groups of ectodermal cells to interpret inductive signals in a robust and organized manner, yet how signaling responses are coordinated across a developing f...
www.biorxiv.org
January 8, 2026 at 10:56 PM
Reposted by International Society of Developmental Biology
wiringthebrain.bsky.social
Rare microbial relict sheds light on an ancient eukaryotic supergroup www.nature.com/articles/s41... - so cool!
January 9, 2026 at 8:28 AM
Reposted by International Society of Developmental Biology
jcellsci.bsky.social
Julie Nielsen, Richard Treisman and colleagues @crick.ac.uk find that MRTFs link cytoskeletal dynamics to cell cycle progression.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that inhibition of contractility in WT cells induces a phenotype similar to MRTF inactivation.
January 9, 2026 at 9:25 AM
isdb.bsky.social
This is really cool work!
January 10, 2026 at 5:38 PM
Reposted by International Society of Developmental Biology
mpi-cbg.de
With Byung Ho Lee and Kana Fuji as first/lead authors, @anne-grapin.bsky.social group, @utokyoofficial.bsky.social, Inst. of Physics of Academia Sinica, & @igbmc.bsky.social found the shape of lumens in the developing pancreas is controlled by pressure & proliferation. www.mpi-cbg.de/news-outreac...
Engineering the development of the pancreas
Researchers found that the shape of the fluid-filled cavities in the developing pancreas is controlled by pressure and the rate cells divide.
www.mpi-cbg.de
January 9, 2026 at 12:17 PM
Reposted by International Society of Developmental Biology
arcinstitute.org
Predicting cell state in previously unseen conditions has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly at inference time, no fine-tuning required.
January 9, 2026 at 6:44 PM
Reposted by International Society of Developmental Biology
fishcscells.bsky.social
Microscopy Bat signal!

I want to compile a list of biological samples that demonstrate microscope capabilities, including the reagents to generate them. Please send me anything you know of!! Beads are great for QC, but there's a different teaching benefit with biology. 1/n
December 8, 2025 at 2:27 PM
Reposted by International Society of Developmental Biology
haoyin.bsky.social
Meningeal lymphatic drainage: novel insights into central nervous system disease

Drain immune cell, neurotoxic protein, senescent astrocyte

Lymphangiogenesis & Valvulogenesis
👉CCBE1▶️VEGFC processing
👉Piezo1
👉CGRP-CLR/RAMP
👉SOX18
👉GATA2

#STTT 2025
www.nature.com/articles/s41...
January 10, 2026 at 12:14 PM
Reposted by International Society of Developmental Biology
cellsdev.bsky.social
Organoid technology is one of the most significant advancements deriving from developmental biology. Yet, many aspects of the biology of organoid itself remain elusive, one of which is the role of mesenchymal stem cells.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
Fig. 1. Timeline of organoids development. The history of organoids was initiated by Ross Harrison's origin of nerve fiber experiments and continues to evolve to the present day. Fig. 2. Timeline of MSCs development. In 1970, Friedenstein first divided “fibroblast colonies” from guinea-pig bone marrow and spleen. In 1976, “clonogenic fibroblast precursor cells” were discovered in mouse bone marrow. In 1995, the first-in-human trial of MSCs was conducted. In 1999, it was first discovered that MSCs can differentiate in vitro into osteoblasts, adipocytes, and chondrocytes. During the period from 2000 to 2010, key functions of MSCs, including homing and migration, were discovered. In 2018, MSCs entered clinical trials for heart failure and Crohn's disease. From 2021 to 2025, clinical trials for MSCs expanded to include cirrhosis, osteoarthritis, and diabetic foot. Fig. 3. Schematic illustration of MSC-mediated optimization of organoids: from challenges to future perspectives. Current organoid systems face limitations such as lack of vasculature, central necrosis, and absence of functional immune components. MSCs address these challenges through two main strategies: acting as structural components in co-culture systems (direct relations) and serving as microenvironmental regulators via paracrine signaling and EVs (indirect relations). The integration of MSCs leads to improved organoid outcomes, including promoted angiogenesis, enhanced maturation, and immunomodulation. Future directions involve combining MSC-organoid systems with 3D bioprinting and organ-on-a-chip technologies to facilitate disease modeling, drug screening, and clinical translation.
January 10, 2026 at 5:33 PM
Reposted by International Society of Developmental Biology
dev-journal.bsky.social
Join us next week for #DevPres to hear 3 of our PI fellows talk about the environment & evolution

14 January 15:00 GMT/UTC

With talks from @ethanewe.bsky.social, @maxfarnworth.bsky.social & @sonyawiden.bsky.social, chaired by @pritiagarwal.bsky.social.

us02web.zoom.us/webinar/regi...

#DevPres
Development presents… Wednesday 14 January 15:00 GMT/UTC Chair: Priti Agarwal Chee Kiang (Ethan) Ewe Tel Aviv University ‘Neuronal oversight of germline small RNAs prevents heat-induced sterility in Caenorhabditis elegans’ Max Farnworth University of Bristol ‘How the evolution of spatial foraging shaped centres of cognition in Heliconiini butterflies’ Sonya Widen IMBA, Vienna BioCenter ‘“Unpacking” eukaryotic horizontal gene transfer: Mavericks transfer novel “cargo” genes across the globe’ #DevPres | @dev-journal.bsky.social thenode.biologists.com/devpres
January 5, 2026 at 12:38 PM
Reposted by International Society of Developmental Biology
aemonten.bsky.social
And if you can't make it, we at CSH Protocols have put together a collection of reviews and protocols for work on Xenopus! Guest edited by Hazel L. Sive.

Link below.
January 4, 2026 at 10:38 PM
Reposted by International Society of Developmental Biology
isdb.bsky.social
Modern Xenopus research uses this system to study #devbio, genetic diseases, biomechanics, and cell biology. If you want hands-on experience, register now to the CSHL Cell & Developmental Biology of Xenopus:
Gene Discovery & Disease
meetings.cshl.edu/courses.aspx...
Deadline: January 16, 2026
Cell & Developmental Biology of Xenopus: Gene Discovery & Disease
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 4, 2026 at 10:28 PM
Reposted by International Society of Developmental Biology
aemonten.bsky.social
Link to collection:

cshprotocols.cshlp.org/site/misc/ma...
cshprotocols.cshlp.org
January 4, 2026 at 10:38 PM
isdb.bsky.social
Modern Xenopus research uses this system to study #devbio, genetic diseases, biomechanics, and cell biology. If you want hands-on experience, register now to the CSHL Cell & Developmental Biology of Xenopus:
Gene Discovery & Disease
meetings.cshl.edu/courses.aspx...
Deadline: January 16, 2026
Cell & Developmental Biology of Xenopus: Gene Discovery & Disease
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 4, 2026 at 10:28 PM
Reposted by International Society of Developmental Biology
isdb.bsky.social
This is our last post of the year. Hope you have a wonderful holidays. Remember, good science only comes from a well-rested mind. We will see you again next year! #MicroscopyMonday #Christmas
Image: 3D Christmas spheroids
Staining: Phalloidin
Photo credit: Postdoc Hoang Anh Le, @ucl-cdb.bsky.social
December 22, 2025 at 11:39 AM