Arc Institute
@arcinstitute.org
A new scientific institution for curiosity-driven biomedical science and technology.
Arc’s Science Fellows program gives a springboard to recent PhD and/or MD students to become a PI right out of grad school.
Interested? Apply by Jan 12 or hear from our team and current Fellows Jingtian Zhou, Uche Medoh, and @mayaarce.bsky.social in this video: youtu.be/3Qs5cmXxsWQ
Interested? Apply by Jan 12 or hear from our team and current Fellows Jingtian Zhou, Uche Medoh, and @mayaarce.bsky.social in this video: youtu.be/3Qs5cmXxsWQ
Arc Science Fellows Program for Early PIs - 2026 Application Cycle Information
YouTube video by Arc Institute
youtu.be
December 12, 2025 at 10:35 PM
Arc’s Science Fellows program gives a springboard to recent PhD and/or MD students to become a PI right out of grad school.
Interested? Apply by Jan 12 or hear from our team and current Fellows Jingtian Zhou, Uche Medoh, and @mayaarce.bsky.social in this video: youtu.be/3Qs5cmXxsWQ
Interested? Apply by Jan 12 or hear from our team and current Fellows Jingtian Zhou, Uche Medoh, and @mayaarce.bsky.social in this video: youtu.be/3Qs5cmXxsWQ
Reposted by Arc Institute
Altos Labs has taken home the Generalist Prize for the most "well-rounded" model across metrics at @arcinstitute.org's Virtual Cell Challenge!
The competition highlights the challenge of defining robust benchmarks for biology.
#NeurIPS2025
Read at GEN:
www.genengnews.com/topics/artif...
The competition highlights the challenge of defining robust benchmarks for biology.
#NeurIPS2025
Read at GEN:
www.genengnews.com/topics/artif...
NeurIPS 2025: Altos Labs Wins Generalist Prize at Arc's Virtual Cell Challenge
The inaugural competition surprisingly awarded two $100,000 grand prizes to address challenges in defining robust benchmarks for complex biology.
www.genengnews.com
December 8, 2025 at 6:59 PM
Altos Labs has taken home the Generalist Prize for the most "well-rounded" model across metrics at @arcinstitute.org's Virtual Cell Challenge!
The competition highlights the challenge of defining robust benchmarks for biology.
#NeurIPS2025
Read at GEN:
www.genengnews.com/topics/artif...
The competition highlights the challenge of defining robust benchmarks for biology.
#NeurIPS2025
Read at GEN:
www.genengnews.com/topics/artif...
Reposted by Arc Institute
Congratulations to the winners of the @arcinstitute.org Virtual Cell Challenge using 10x Genomics GEM-X Flex technology. Ready to build your own? http://virtualcellchallenge.org/
#VirtualCellChallenge #AI
#VirtualCellChallenge #AI
December 8, 2025 at 5:00 PM
Congratulations to the winners of the @arcinstitute.org Virtual Cell Challenge using 10x Genomics GEM-X Flex technology. Ready to build your own? http://virtualcellchallenge.org/
#VirtualCellChallenge #AI
#VirtualCellChallenge #AI
Thank you to everyone who made the inaugural Virtual Cell Challenge a success.
Over 5,000 participants from 114 countries competed to build AI models that predict cellular responses to genetic perturbations. Today we're announcing the winners and reflecting on what we learned.
Over 5,000 participants from 114 countries competed to build AI models that predict cellular responses to genetic perturbations. Today we're announcing the winners and reflecting on what we learned.
December 7, 2025 at 4:03 AM
Thank you to everyone who made the inaugural Virtual Cell Challenge a success.
Over 5,000 participants from 114 countries competed to build AI models that predict cellular responses to genetic perturbations. Today we're announcing the winners and reflecting on what we learned.
Over 5,000 participants from 114 countries competed to build AI models that predict cellular responses to genetic perturbations. Today we're announcing the winners and reflecting on what we learned.
A preprint out today from Arc Innovation Investigator Theo Roth, Austin Hartman, Oliver Takacsi-Nagy, and colleagues introduces CRISPR All–a unified programming language for editing human cells across all major genetic perturbation types at once.
November 20, 2025 at 6:35 PM
A preprint out today from Arc Innovation Investigator Theo Roth, Austin Hartman, Oliver Takacsi-Nagy, and colleagues introduces CRISPR All–a unified programming language for editing human cells across all major genetic perturbation types at once.
Published today in @nature.com, @adititm.bsky.social & researchers from the @brianhie.bsky.social lab report that the large-scale genomic model, Evo, is capable of using surrounding genomic context to produce novel, functional genes, enabling an an emergent approach they've termed 'semantic design'.
November 19, 2025 at 6:17 PM
Published today in @nature.com, @adititm.bsky.social & researchers from the @brianhie.bsky.social lab report that the large-scale genomic model, Evo, is capable of using surrounding genomic context to produce novel, functional genes, enabling an an emergent approach they've termed 'semantic design'.
Congratulations to Arc Science Fellow, @uchemedoh.bsky.social, on being named a winner of the 2025 @science.org & @scilifelab.se Prize for Young Scientists!
His work solves a decades-old mystery in cell biology, revealing the enzyme responsible for BMP synthesis: www.aaas.org/news/researc...
His work solves a decades-old mystery in cell biology, revealing the enzyme responsible for BMP synthesis: www.aaas.org/news/researc...
November 13, 2025 at 8:19 PM
Congratulations to Arc Science Fellow, @uchemedoh.bsky.social, on being named a winner of the 2025 @science.org & @scilifelab.se Prize for Young Scientists!
His work solves a decades-old mystery in cell biology, revealing the enzyme responsible for BMP synthesis: www.aaas.org/news/researc...
His work solves a decades-old mystery in cell biology, revealing the enzyme responsible for BMP synthesis: www.aaas.org/news/researc...
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
November 6, 2025 at 5:46 PM
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
November 5, 2025 at 4:21 PM
A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
Welcome to our 9th Core Investigator and first physician-scientist, John Pluvinage. His team investigates the hidden overlap between autoimmunity and neurodegeneration, developing targeted treatments for mysterious neurological cases and common dementias.
October 29, 2025 at 3:25 PM
Welcome to our 9th Core Investigator and first physician-scientist, John Pluvinage. His team investigates the hidden overlap between autoimmunity and neurodegeneration, developing targeted treatments for mysterious neurological cases and common dementias.
The genetic code is full of synonymous codons that, for decades, were assumed to be interchangeable.
Today, with NVIDIA, co-led by @genophoria.bsky.social, we announce CodonFM, a family of open-source AI models that reveal the grammar underlying codon choice: developer.nvidia.com/blog/introdu...
Today, with NVIDIA, co-led by @genophoria.bsky.social, we announce CodonFM, a family of open-source AI models that reveal the grammar underlying codon choice: developer.nvidia.com/blog/introdu...
Introducing the CodonFM Open Model for RNA Design and Analysis | NVIDIA Technical Blog
Open research is critical for driving innovation, and many breakthroughs in AI and science are achieved through open collaboration. In the field of digital biology research, NVIDIA Clara supports this...
developer.nvidia.com
October 28, 2025 at 8:55 PM
The genetic code is full of synonymous codons that, for decades, were assumed to be interchangeable.
Today, with NVIDIA, co-led by @genophoria.bsky.social, we announce CodonFM, a family of open-source AI models that reveal the grammar underlying codon choice: developer.nvidia.com/blog/introdu...
Today, with NVIDIA, co-led by @genophoria.bsky.social, we announce CodonFM, a family of open-source AI models that reveal the grammar underlying codon choice: developer.nvidia.com/blog/introdu...
Arc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...
October 24, 2025 at 5:32 PM
Arc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...
Published today in @natureportfolio.nature.com Biotechnology, Laine Goudy, Luke Gilbert, Alex Marson, & colleagues report an epigenetic editing platform that safely reprograms multiple genes in human T cells without many of the challenges & risks associated with traditional gene editing approaches.
October 21, 2025 at 4:43 PM
Published today in @natureportfolio.nature.com Biotechnology, Laine Goudy, Luke Gilbert, Alex Marson, & colleagues report an epigenetic editing platform that safely reprograms multiple genes in human T cells without many of the challenges & risks associated with traditional gene editing approaches.
Arc is looking for an outstanding early-career scientist to be our next Science Fellow. This program provides resources and freedom for those looking to transition into a principal investigator role immediately after doctoral training. Apply here: arcinstitute.org/programs/sea...
October 13, 2025 at 7:36 PM
Arc is looking for an outstanding early-career scientist to be our next Science Fellow. This program provides resources and freedom for those looking to transition into a principal investigator role immediately after doctoral training. Apply here: arcinstitute.org/programs/sea...
Hear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and
Serge Saxonov: thebioreport.podbean.com/e/transformi...
Serge Saxonov: thebioreport.podbean.com/e/transformi...
October 9, 2025 at 4:51 PM
Hear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and
Serge Saxonov: thebioreport.podbean.com/e/transformi...
Serge Saxonov: thebioreport.podbean.com/e/transformi...
Arc's community continues to grow this fall with our 9th Core Investigator John Pluvinage and 3rd Science Fellow @mayaarce.bsky.social joining us in Palo Alto, along with 7 Innovation Investigators and 15 Ignite Awardees at our partner universities.
Learn more:
arcinstitute.org/news/faculty...
Learn more:
arcinstitute.org/news/faculty...
Arc Institute Adds Two New Labs; Announces 2025 Cohort of Innovation Investigators and Ignite Awardees | Arc Institute
We are excited to launch three parallel searches for our curiosity-driven Laboratories.
arcinstitute.org
October 7, 2025 at 7:29 PM
Arc's community continues to grow this fall with our 9th Core Investigator John Pluvinage and 3rd Science Fellow @mayaarce.bsky.social joining us in Palo Alto, along with 7 Innovation Investigators and 15 Ignite Awardees at our partner universities.
Learn more:
arcinstitute.org/news/faculty...
Learn more:
arcinstitute.org/news/faculty...
For decades, human genome editing has been limited to small, localized modifications.
Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
September 25, 2025 at 6:27 PM
For decades, human genome editing has been limited to small, localized modifications.
Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
New work from Arc's @pauldatlinger.bsky.social of our Genome Engineering Technology Center. Congrats!
CAR T cells showcase the enormous potential of cell therapies, but often fail due to lack of evolutionary optimization. Today in @nature.com , we use #CELLFIE to engineer cell therapies at scale and share the largest resource of CRISPR screens in CAR T cells. www.nature.com/articles/s41...
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
www.nature.com
September 24, 2025 at 11:53 PM
New work from Arc's @pauldatlinger.bsky.social of our Genome Engineering Technology Center. Congrats!
Reposted by Arc Institute
Having often dealt with the frustration of binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.
September 24, 2025 at 4:32 PM
Having often dealt with the frustration of binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
September 24, 2025 at 3:07 PM
In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
Arc Innovation Investigator research highlight:
Stanford Professor Zhenan Bao and colleagues have developed NeuroString, a hair-thin multichannel biosensor and stimulator with promising potential applications in drug delivery, nerve stimulation, smart fabrics, and more.
Stanford Professor Zhenan Bao and colleagues have developed NeuroString, a hair-thin multichannel biosensor and stimulator with promising potential applications in drug delivery, nerve stimulation, smart fabrics, and more.
September 18, 2025 at 5:14 PM
Arc Innovation Investigator research highlight:
Stanford Professor Zhenan Bao and colleagues have developed NeuroString, a hair-thin multichannel biosensor and stimulator with promising potential applications in drug delivery, nerve stimulation, smart fabrics, and more.
Stanford Professor Zhenan Bao and colleagues have developed NeuroString, a hair-thin multichannel biosensor and stimulator with promising potential applications in drug delivery, nerve stimulation, smart fabrics, and more.
Reposted by Arc Institute
Genome foundation models, Evo 1 and Evo 2, have now generated viable bacteriophage genomes, demonstrating experimental validation of whole genomes designed by AI!
@arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social
Read more at GEN:
www.genengnews.com/topics/artif...
@arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social
Read more at GEN:
www.genengnews.com/topics/artif...
AI Designs Viable Bacteriophage Genomes, Combats Antibiotic Resistance
AI-guided design of 16 functional bacteriophage genomes offers a path for phage-based therapies against antibiotic-resistant infections.
www.genengnews.com
September 17, 2025 at 3:21 PM
Genome foundation models, Evo 1 and Evo 2, have now generated viable bacteriophage genomes, demonstrating experimental validation of whole genomes designed by AI!
@arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social
Read more at GEN:
www.genengnews.com/topics/artif...
@arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social
Read more at GEN:
www.genengnews.com/topics/artif...
In a new preprint from @brianhie.bsky.social's lab, the team reports the first generative design of viable bacteriophage genomes.
Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.
Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.
September 17, 2025 at 3:12 PM
In a new preprint from @brianhie.bsky.social's lab, the team reports the first generative design of viable bacteriophage genomes.
Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.
Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.
Reposted by Arc Institute
🧠 Arc Workshop at the upcoming scverse conference 2025 🧠
Processing and Modeling Large-Scale Single-Cell Perturbation Data with Machine Learning
🧵
@arcinstitute.org
#scverse2025 #PerturbSeq #MachineLearning #SingleCell #CRISPR #GenomicScreening #VirtualCells
Processing and Modeling Large-Scale Single-Cell Perturbation Data with Machine Learning
🧵
@arcinstitute.org
#scverse2025 #PerturbSeq #MachineLearning #SingleCell #CRISPR #GenomicScreening #VirtualCells
September 9, 2025 at 4:27 PM
🧠 Arc Workshop at the upcoming scverse conference 2025 🧠
Processing and Modeling Large-Scale Single-Cell Perturbation Data with Machine Learning
🧵
@arcinstitute.org
#scverse2025 #PerturbSeq #MachineLearning #SingleCell #CRISPR #GenomicScreening #VirtualCells
Processing and Modeling Large-Scale Single-Cell Perturbation Data with Machine Learning
🧵
@arcinstitute.org
#scverse2025 #PerturbSeq #MachineLearning #SingleCell #CRISPR #GenomicScreening #VirtualCells
Welcome to our third Science Fellow, Maya Arce (@mayaarce.bsky.social). Her team uses large-scale genomic screening and CRISPR editing to decode how genetic regulators control immune cell behavior.
September 3, 2025 at 4:12 PM
Welcome to our third Science Fellow, Maya Arce (@mayaarce.bsky.social). Her team uses large-scale genomic screening and CRISPR editing to decode how genetic regulators control immune cell behavior.