Arc Institute
@arcinstitute.org
A new scientific institution for curiosity-driven biomedical science and technology.
Arc is currently hiring for multiple postdoctoral roles.
Check out our open positions here: job-boards.greenhouse.io/arcinstitute...
Check out our open positions here: job-boards.greenhouse.io/arcinstitute...
Arc Institute
job-boards.greenhouse.io
February 6, 2026 at 4:51 PM
Arc is currently hiring for multiple postdoctoral roles.
Check out our open positions here: job-boards.greenhouse.io/arcinstitute...
Check out our open positions here: job-boards.greenhouse.io/arcinstitute...
By enabling programmable, reversible, and large-scale transcript editing, RESPLICE represents a powerful new tool in our RNA editing toolbox.
See the full paper: www.cell.com/cell-systems...
See the full paper: www.cell.com/cell-systems...
Rewriting endogenous human transcripts with dual CRISPR-guided 3′ trans-splicing
Programmable trans-splicing has the potential to transiently alter specific transcripts
for both research and therapeutic applications. Here, Chandrasekaran, Tau et al. introduce
RESPLICE, which uses ...
www.cell.com
February 6, 2026 at 4:51 PM
By enabling programmable, reversible, and large-scale transcript editing, RESPLICE represents a powerful new tool in our RNA editing toolbox.
See the full paper: www.cell.com/cell-systems...
See the full paper: www.cell.com/cell-systems...
As a proof-of-concept, the team used RESPLICE to tag the native LAMP1 and correct a disease-causing mutation in HFE, showing the system’s potential for both basic research and therapeutic applications, including repeat expansion disorders.
February 6, 2026 at 4:51 PM
As a proof-of-concept, the team used RESPLICE to tag the native LAMP1 and correct a disease-causing mutation in HFE, showing the system’s potential for both basic research and therapeutic applications, including repeat expansion disorders.
Across 11 naturally expressed transcripts and 3 cell types, the team achieved up to 45% trans-splicing efficiency in bulk and 90% when sorting for cells with the highest levels of the CRISPR components, with cargo sizes up to 2.1 kb.
February 6, 2026 at 4:51 PM
Across 11 naturally expressed transcripts and 3 cell types, the team achieved up to 45% trans-splicing efficiency in bulk and 90% when sorting for cells with the highest levels of the CRISPR components, with cargo sizes up to 2.1 kb.
RESPLICE solves this problem by pairing two RNA-targeting CRISPR proteins. One guides a new exon to the right location on the target transcript. The other blocks the cell’s normal splicing and tips the balance toward the desired edit.
February 6, 2026 at 4:51 PM
RESPLICE solves this problem by pairing two RNA-targeting CRISPR proteins. One guides a new exon to the right location on the target transcript. The other blocks the cell’s normal splicing and tips the balance toward the desired edit.
RNA editing can make temporary, reversible changes to transcripts without permanently altering DNA. While some tools exist for knocking down RNA or skipping exons, the ability to efficiently replace or add new exons has remained a major challenge.
February 6, 2026 at 4:51 PM
RNA editing can make temporary, reversible changes to transcripts without permanently altering DNA. While some tools exist for knocking down RNA or skipping exons, the ability to efficiently replace or add new exons has remained a major challenge.
A new paper from the Patrick Hsu and Silvana Konermann labs introduces RESPLICE, a dual CRISPR system that rewrites cellular transcripts by splicing new exons directly onto target mRNAs.
February 6, 2026 at 4:51 PM
A new paper from the Patrick Hsu and Silvana Konermann labs introduces RESPLICE, a dual CRISPR system that rewrites cellular transcripts by splicing new exons directly onto target mRNAs.
"Instead of designing experiments by hand, we're going to have AI models design the experiments for us and help us troubleshoot and decide what to do next."
Patrick Hsu talks about integrating AI models and biological research with Jacob Goldstein: www.pushkin.fm/podcasts/wha...
Patrick Hsu talks about integrating AI models and biological research with Jacob Goldstein: www.pushkin.fm/podcasts/wha...
Can AI Help Solve Alzheimer’s? | What’s Your Problem?
Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and u...
www.pushkin.fm
February 6, 2026 at 12:35 AM
"Instead of designing experiments by hand, we're going to have AI models design the experiments for us and help us troubleshoot and decide what to do next."
Patrick Hsu talks about integrating AI models and biological research with Jacob Goldstein: www.pushkin.fm/podcasts/wha...
Patrick Hsu talks about integrating AI models and biological research with Jacob Goldstein: www.pushkin.fm/podcasts/wha...
An amazing day for science at the 2nd Annual Arc Symposium!
Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.
Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.
February 5, 2026 at 1:16 AM
An amazing day for science at the 2nd Annual Arc Symposium!
Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.
Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.
Students can apply as a team or individually to be matched with others. Applications are due Feb 27, Fellows will be announced April 15, and the program starts May 18. The program is open to undergrads in North America.
FAQs and application: arcinstitute.org/programs/aix...
FAQs and application: arcinstitute.org/programs/aix...
Arc AIxBio Fellows Program for Undergrads | Arc Institute
Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.
arcinstitute.org
February 2, 2026 at 4:27 PM
Students can apply as a team or individually to be matched with others. Applications are due Feb 27, Fellows will be announced April 15, and the program starts May 18. The program is open to undergrads in North America.
FAQs and application: arcinstitute.org/programs/aix...
FAQs and application: arcinstitute.org/programs/aix...
We're launching the Arc AIxBio Fellows Program to support the next generation of researchers working at the interface of AI and biology. Teams of 2-3 undergrads propose and execute their own research projects over 6-12 months with Arc mentors.
arcinstitute.org/news/aixbio-...
arcinstitute.org/news/aixbio-...
Announcing the Arc AIxBio Fellows Program for Undergrads | Arc Institute
Advances in AI are only beginning to impact how biologists answer research questions, creating new training needs for the next generation of scientists. In our role operating at the interface of AI an...
arcinstitute.org
February 2, 2026 at 4:27 PM
We're launching the Arc AIxBio Fellows Program to support the next generation of researchers working at the interface of AI and biology. Teams of 2-3 undergrads propose and execute their own research projects over 6-12 months with Arc mentors.
arcinstitute.org/news/aixbio-...
arcinstitute.org/news/aixbio-...
Looking ahead, the authors propose that restoring body-brain signaling could open new therapeutic avenues, introducing the concept of “interoceptomimetics” to mimic or enhance healthy interoceptive communication.
Read more: www.cell.com/neuron/fullt...
Read more: www.cell.com/neuron/fullt...
Intestinal interoception: A nexus of environment-body-brain interactions
Salvador, Golynker, et al. discuss anatomical and functional principles of intestinal
interoception. They explore how environmental factors impact interoceptive signaling,
how interoceptive dysfunctio...
www.cell.com
January 28, 2026 at 7:24 PM
Looking ahead, the authors propose that restoring body-brain signaling could open new therapeutic avenues, introducing the concept of “interoceptomimetics” to mimic or enhance healthy interoceptive communication.
Read more: www.cell.com/neuron/fullt...
Read more: www.cell.com/neuron/fullt...
The team also shows how altered interoception can drive disease, linking disrupted internal sensing to conditions including inflammatory bowel disease, irritable bowel syndrome, and post-viral syndromes, where distorted internal signaling may contribute to symptoms beyond the gut.
January 28, 2026 at 7:24 PM
The team also shows how altered interoception can drive disease, linking disrupted internal sensing to conditions including inflammatory bowel disease, irritable bowel syndrome, and post-viral syndromes, where distorted internal signaling may contribute to symptoms beyond the gut.
Gut-brain interoception influences far more than digestion.
The authors highlight its role in shaping feeding decisions, food preferences, motivation, physical activity, sleep, and metabolic control, revealing how internal sensing helps align behavior with physiological needs.
The authors highlight its role in shaping feeding decisions, food preferences, motivation, physical activity, sleep, and metabolic control, revealing how internal sensing helps align behavior with physiological needs.
January 28, 2026 at 7:24 PM
Gut-brain interoception influences far more than digestion.
The authors highlight its role in shaping feeding decisions, food preferences, motivation, physical activity, sleep, and metabolic control, revealing how internal sensing helps align behavior with physiological needs.
The authors highlight its role in shaping feeding decisions, food preferences, motivation, physical activity, sleep, and metabolic control, revealing how internal sensing helps align behavior with physiological needs.
The team highlights that these signals are not diffuse or random. Gut-derived information travels through organized neural circuits, particularly via vagal and spinal pathways, allowing the brain to distinguish where signals originate and how they shape perception and action.
January 28, 2026 at 7:24 PM
The team highlights that these signals are not diffuse or random. Gut-derived information travels through organized neural circuits, particularly via vagal and spinal pathways, allowing the brain to distinguish where signals originate and how they shape perception and action.
The review reframes the gut as a sophisticated sensory organ.
Nutrients, microbes, mechanical forces, and immune signals are constantly detected by specialized gut cells and translated into messages that inform the brain about the body’s internal state.
Nutrients, microbes, mechanical forces, and immune signals are constantly detected by specialized gut cells and translated into messages that inform the brain about the body’s internal state.
January 28, 2026 at 7:24 PM
The review reframes the gut as a sophisticated sensory organ.
Nutrients, microbes, mechanical forces, and immune signals are constantly detected by specialized gut cells and translated into messages that inform the brain about the body’s internal state.
Nutrients, microbes, mechanical forces, and immune signals are constantly detected by specialized gut cells and translated into messages that inform the brain about the body’s internal state.
In a new review published in @cp-neuron.bsky.social, @christophthaiss.bsky.social and team synthesize emerging research on intestinal interoception, highlighting how signals from the gut shape communication between the environment, the body, and the brain to maintain human health.
January 28, 2026 at 7:24 PM
In a new review published in @cp-neuron.bsky.social, @christophthaiss.bsky.social and team synthesize emerging research on intestinal interoception, highlighting how signals from the gut shape communication between the environment, the body, and the brain to maintain human health.
Please see our jobs page for new roles we are hiring for (including postdoctoral researchers, scientists interested in functional genomics and machine learning, and a bioinformatics engineer): arcinstitute.org/jobs
Arc Institute
Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.
arcinstitute.org
January 27, 2026 at 12:15 AM
Please see our jobs page for new roles we are hiring for (including postdoctoral researchers, scientists interested in functional genomics and machine learning, and a bioinformatics engineer): arcinstitute.org/jobs
It's an exciting time to be at Arc. We recently welcomed a new CSO, announced a major partnership with Tahoe Therapeutics and Biohub, and are continuing to open source models and techniques to push forward progress on virtual cells.
January 27, 2026 at 12:15 AM
It's an exciting time to be at Arc. We recently welcomed a new CSO, announced a major partnership with Tahoe Therapeutics and Biohub, and are continuing to open source models and techniques to push forward progress on virtual cells.
Together, these findings establish oncRNAs as a new class of molecules that act as both drivers and biomarkers of cancer.
This work is also open source, with the goal of enabling new directions for cancer detection and classification
Learn more: arcinstitute.org/news/uncover...
This work is also open source, with the goal of enabling new directions for cancer detection and classification
Learn more: arcinstitute.org/news/uncover...
Uncovering Cancer's Hidden oncRNA Signatures: From Discovery to Liquid Biopsy | Arc Institute
We knew we had something interesting with T3p, a single small RNA found in breast cancer but absent from normal tissue. After being described in 2018, this molecule took our team on a six-year journey...
arcinstitute.org
January 23, 2026 at 5:38 PM
Together, these findings establish oncRNAs as a new class of molecules that act as both drivers and biomarkers of cancer.
This work is also open source, with the goal of enabling new directions for cancer detection and classification
Learn more: arcinstitute.org/news/uncover...
This work is also open source, with the goal of enabling new directions for cancer detection and classification
Learn more: arcinstitute.org/news/uncover...
Further analysis in breast cancer patients from the I-SPY 2 trial showed that changes in circulating oncRNA levels after treatment predicted clinical outcomes, supporting oncRNAs as blood-based cancer biomarkers.
January 23, 2026 at 5:38 PM
Further analysis in breast cancer patients from the I-SPY 2 trial showed that changes in circulating oncRNA levels after treatment predicted clinical outcomes, supporting oncRNAs as blood-based cancer biomarkers.
They then asked whether any oncRNAs actually drive disease.
Large-scale functional screens in mice showed ~5% have clear oncogenic activity, with two breast cancer oncRNAs found to promote increased tumor growth and metastasis.
Large-scale functional screens in mice showed ~5% have clear oncogenic activity, with two breast cancer oncRNAs found to promote increased tumor growth and metastasis.
January 23, 2026 at 5:38 PM
They then asked whether any oncRNAs actually drive disease.
Large-scale functional screens in mice showed ~5% have clear oncogenic activity, with two breast cancer oncRNAs found to promote increased tumor growth and metastasis.
Large-scale functional screens in mice showed ~5% have clear oncogenic activity, with two breast cancer oncRNAs found to promote increased tumor growth and metastasis.
Building on their earlier discovery of oncRNAs in breast cancer, the research team analyzed small RNA sequencing data from 32 cancers.
The team identified ~260,000 oncRNAs absent from normal tissue, forming digital barcodes of cancer type and subtype.
The team identified ~260,000 oncRNAs absent from normal tissue, forming digital barcodes of cancer type and subtype.
January 23, 2026 at 5:38 PM
Building on their earlier discovery of oncRNAs in breast cancer, the research team analyzed small RNA sequencing data from 32 cancers.
The team identified ~260,000 oncRNAs absent from normal tissue, forming digital barcodes of cancer type and subtype.
The team identified ~260,000 oncRNAs absent from normal tissue, forming digital barcodes of cancer type and subtype.
A new paper from Jeffrey Wang, @genophoria.bsky.social, and team describes orphan non-coding RNAs, known as "oncRNAs," as cancer-emergent molecules with important roles in tumor identity and progression, and clinical monitoring across human cancers: www.cell.com/cell-reports...
January 23, 2026 at 5:38 PM
A new paper from Jeffrey Wang, @genophoria.bsky.social, and team describes orphan non-coding RNAs, known as "oncRNAs," as cancer-emergent molecules with important roles in tumor identity and progression, and clinical monitoring across human cancers: www.cell.com/cell-reports...
Reposted by Arc Institute
Today I’m happy to release cyto, a tool I’ve developed at @arcinstitute.org to dramatically increase our computational throughput with 10x-flex single-cell processing by more than 16X!
cyto: ultra high-throughput processing of 10x-flex single cell sequencing https://www.biorxiv.org/content/10.64898/2026.01.21.700936v1
January 22, 2026 at 5:23 PM
Today I’m happy to release cyto, a tool I’ve developed at @arcinstitute.org to dramatically increase our computational throughput with 10x-flex single-cell processing by more than 16X!