Nature Biotechnology
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Moving beyond monogenic disorders in clinical healthcare - @ki.se @scilifelab.se go.nature.com/4spqsof
Moving beyond monogenic disorders in clinical healthcare - Nature Biotechnology
Our understanding of the genetic mechanisms underlying rare diseases has rapidly advanced over the past decade, largely because of technological innovations. Yet clinical practice still has a strong m...
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January 6, 2026 at 5:41 PM
Moving beyond monogenic disorders in clinical healthcare - @ki.se @scilifelab.se go.nature.com/4spqsof
Integrated experimental and AI innovations for RNA structure determination go.nature.com/3NcBzk8
Integrated experimental and AI innovations for RNA structure determination - Nature Biotechnology
RNA’s dynamic nature and complex physiochemical properties make it difficult to structurally resolve. This Perspectives examines how integrating experimental and computational approaches to structure ...
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January 6, 2026 at 2:57 PM
Integrated experimental and AI innovations for RNA structure determination go.nature.com/3NcBzk8
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - @zevgartner.bsky.social @ucsanfrancisco.bsky.social go.nature.com/4jsNxSL
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - Nature Biotechnology
CONCORD generates denoised cell encodings that preserve key biological structures in single-cell datasets.
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January 5, 2026 at 4:44 PM
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - @zevgartner.bsky.social @ucsanfrancisco.bsky.social go.nature.com/4jsNxSL
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - @columbiasysbio.bsky.social @davidaknowles.bsky.social go.nature.com/3NaXw31
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - Nature Biotechnology
Differential isoform usage is identified with high statistical power from spatial transcriptomics data.
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January 5, 2026 at 4:33 PM
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - @columbiasysbio.bsky.social @davidaknowles.bsky.social go.nature.com/3NaXw31
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis - @utokyoofficial.bsky.social go.nature.com/4bkfOcb
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis - Nature Biotechnology
Cas3 nuclease is used for therapeutic deletion of a gene in mice.
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January 5, 2026 at 4:21 PM
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis - @utokyoofficial.bsky.social go.nature.com/4bkfOcb
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma - @columbiacancer.bsky.social go.nature.com/496Ins7
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma - Nature Biotechnology
Engineered inhalable exosomes deliver a bispecific T cell activator to pembrolizumab-resistant metastatic melanoma.
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January 5, 2026 at 4:09 PM
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma - @columbiacancer.bsky.social go.nature.com/496Ins7
Reposted by Nature Biotechnology
One of our top-rated posts on @altmetric.com in 2025 was published in @natbiotech.nature.com. You can read 'Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning' open access here: spklr.io/63322BQufI
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
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December 31, 2025 at 5:30 PM
One of our top-rated posts on @altmetric.com in 2025 was published in @natbiotech.nature.com. You can read 'Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning' open access here: spklr.io/63322BQufI
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - @stjuderesearch.bsky.social go.nature.com/4qB6qp8
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - Nature Biotechnology
Base editor off-target effects are profiled with high precision in a tailored approach.
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January 2, 2026 at 7:12 PM
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - @stjuderesearch.bsky.social go.nature.com/4qB6qp8
Single-strand deaminase-assisted editing for functional RNA manipulation go.nature.com/3MZrB5K
Single-strand deaminase-assisted editing for functional RNA manipulation - Nature Biotechnology
A single-strand deaminase-assisted platform simultaneously rewrites multiple bases within a single RNA transcript.
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January 2, 2026 at 7:05 PM
Single-strand deaminase-assisted editing for functional RNA manipulation go.nature.com/3MZrB5K
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles go.nature.com/45r0M0t
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles - Nature Biotechnology
Codelivery of an antifungal drug within antifungal micelles achieves effective combinatorial therapy.
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January 2, 2026 at 6:48 PM
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles go.nature.com/45r0M0t
Predicting small molecule–RNA interactions without RNA tertiary structures - @tsinghuauniversity.bsky.social go.nature.com/494J2ug
Predicting small molecule–RNA interactions without RNA tertiary structures - Nature Biotechnology
SMRTnet predicts compounds that bind to disease-associated RNA targets.
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January 2, 2026 at 6:39 PM
Predicting small molecule–RNA interactions without RNA tertiary structures - @tsinghuauniversity.bsky.social go.nature.com/494J2ug
Troubleshooting common errors in assemblies of long-read metagenomes - @merenbey.bsky.social @banfieldlab.bsky.social go.nature.com/44P7nSm
Troubleshooting common errors in assemblies of long-read metagenomes - Nature Biotechnology
Long-read sequence assemblies from metagenomes contain frequent errors.
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January 2, 2026 at 4:39 PM
Troubleshooting common errors in assemblies of long-read metagenomes - @merenbey.bsky.social @banfieldlab.bsky.social go.nature.com/44P7nSm
Recent patents relating to methods, devices and use of liquid biopsy go.nature.com/3MWRuTG
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Liquid biopsy - Nature Biotechnology
Recent patents relating to methods, devices and use of liquid biopsy.
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January 2, 2026 at 4:27 PM
Recent patents relating to methods, devices and use of liquid biopsy go.nature.com/3MWRuTG
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A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo go.nature.com/4gYcS4Z
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Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy - Nature Biotechnology
A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo.
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January 1, 2026 at 9:54 PM
A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo go.nature.com/4gYcS4Z
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Recent moves of note in and around the biotech and pharma industries go.nature.com/3N9ypO5
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People - Nature Biotechnology
Recent moves of note in and around the biotech and pharma industries.
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December 31, 2025 at 5:31 PM
Recent moves of note in and around the biotech and pharma industries go.nature.com/3N9ypO5
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This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems facing our world go.nature.com/4pzXi3P
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Five questions with Pranam Chatterjee - Nature Biotechnology
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems fac...
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December 31, 2025 at 5:10 PM
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems facing our world go.nature.com/4pzXi3P
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Primary T cells with multiple genetic modifications are rapidly isolated by negative selection go.nature.com/4gBnaqY
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SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci - Nature Biotechnology
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.
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December 31, 2025 at 3:37 AM
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection go.nature.com/4gBnaqY
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The right AI workflow can help you to read more widely and think more deeply — without sacrificing rigor go.nature.com/49pa7YY
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FOCUS: an AI-assisted reading workflow for information overload - Nature Biotechnology
The right AI workflow can help you to read more widely and think more deeply — without sacrificing rigor.
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December 30, 2025 at 6:23 PM
The right AI workflow can help you to read more widely and think more deeply — without sacrificing rigor go.nature.com/49pa7YY
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Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence go.nature.com/4r9HhTw
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Heart matters: new treatments, tools and access channels - Nature Biotechnology
Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence.
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December 30, 2025 at 5:09 PM
Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence go.nature.com/4r9HhTw
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The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. In 2025 the final synthetic chromosome was completed, marking the culmination of over a decade of iterative design and international collaboration go.nature.com/48Fqxwi
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Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - Nature Biotechnology
The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed duri...
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December 30, 2025 at 3:43 PM
The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. In 2025 the final synthetic chromosome was completed, marking the culmination of over a decade of iterative design and international collaboration go.nature.com/48Fqxwi
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Biotech news from around the world: Kuwait, China, United Kingdom, Pakistan nature.com/articles/s41...
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Biotech news from around the world - Nature Biotechnology
Nature Biotechnology - Biotech news from around the world
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December 30, 2025 at 2:23 PM
Biotech news from around the world: Kuwait, China, United Kingdom, Pakistan nature.com/articles/s41...
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An ultra-rapid 3D immunostaining protocol can uniformly label organ-scale tissues go.nature.com/40wig8l
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Uniform volumetric single-cell processing for organ-scale molecular phenotyping - Nature Biotechnology
An ultra-rapid 3D immunostaining protocol can uniformly label organ-scale tissues.
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December 30, 2025 at 4:36 AM
An ultra-rapid 3D immunostaining protocol can uniformly label organ-scale tissues go.nature.com/40wig8l
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This year’s most popular stories are a testament to biotech ingenuity and a cause for celebration: the gene editing triumph that cured ‘baby KJ’ of a rare genetic disorder in record time; the bispecific molecules that trick HIV out of cells to destroy them... nature.com/articles/s41...
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December 29, 2025 at 10:02 PM
This year’s most popular stories are a testament to biotech ingenuity and a cause for celebration: the gene editing triumph that cured ‘baby KJ’ of a rare genetic disorder in record time; the bispecific molecules that trick HIV out of cells to destroy them... nature.com/articles/s41...
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In Brief: The first malaria drug in over 20 years to have a new mechanism of action, GanLum, which combines the novel ingredient ganaplacide with the approved antimalarial lumefatrine, cured 97.4% of phase 3 trial participants www.nature.com/articles/s41...
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Novel anti-malarial aces phase 3 - Nature Biotechnology
Nature Biotechnology - Novel anti-malarial aces phase 3
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December 29, 2025 at 7:46 PM
In Brief: The first malaria drug in over 20 years to have a new mechanism of action, GanLum, which combines the novel ingredient ganaplacide with the approved antimalarial lumefatrine, cured 97.4% of phase 3 trial participants www.nature.com/articles/s41...
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This year, biotechnology was characterized by accelerated convergence between gene editing, cell and gene therapy, immunotherapy, and AI. CRISPR-based editing tools are more precise and clinically relevant, and biotech continues to push the boundaries of immunotherapy go.nature.com/4oCK84L
December 29, 2025 at 7:21 PM
This year, biotechnology was characterized by accelerated convergence between gene editing, cell and gene therapy, immunotherapy, and AI. CRISPR-based editing tools are more precise and clinically relevant, and biotech continues to push the boundaries of immunotherapy go.nature.com/4oCK84L