An experimental gene-editing therapy developed by Crispr Therapeutics is showing promise for treating heart disease.
A Gene Editing Therapy Cut Cholesterol Levels by Half
An experimental gene-editing therapy developed by Crispr Therapeutics is showing promise for treating heart disease.
wrd.cm
November 8, 2025 at 3:02 PM
An experimental gene-editing therapy developed by Crispr Therapeutics is showing promise for treating heart disease.
Using CRISPR gene-editing to permanently reduce cholesterol and triglycerides holds tremendous promise. It almost sounds like science fiction. Go science!
www.npr.org/2025/11/08/n...
www.npr.org/2025/11/08/n...
CRISPR gene-editing works to reduce high cholesterol in a new study
An experimental gene-editing treatment shows promise for permanently lowering levels of cholesterol and triglycerides, possibly helping cut the risk for heart disease.
www.npr.org
November 9, 2025 at 2:45 AM
Using CRISPR gene-editing to permanently reduce cholesterol and triglycerides holds tremendous promise. It almost sounds like science fiction. Go science!
www.npr.org/2025/11/08/n...
www.npr.org/2025/11/08/n...
CRISPR gene therapy slashes 'bad' cholesterol, triglycerides by half in small study reut.rs/47wFsIA
CRISPR gene therapy slashes 'bad' cholesterol, triglycerides by half in small study
A single infusion of CRISPR Therapeutics' experimental gene therapy was safe and reduced levels of harmful LDL cholesterol and triglycerides by half in four people taking the highest dose, raising hope for a one-time treatment.
reut.rs
November 8, 2025 at 3:10 PM
CRISPR gene therapy slashes 'bad' cholesterol, triglycerides by half in small study reut.rs/47wFsIA
After 5 years of waiting, the new #CRISPR classification by Makarova et al. is out @natmicrobiol.nature.com www.nature.com/articles/s41...
An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology
An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.
www.nature.com
November 6, 2025 at 1:49 PM
After 5 years of waiting, the new #CRISPR classification by Makarova et al. is out @natmicrobiol.nature.com www.nature.com/articles/s41...
I'm back doing zoo things in Let's Build a Zoo!
In this episode, watch me:
🩷 Expand my zoo a bit more
🩷 Start CRISPR experiments
🩷 Build a farm!
🩷 Not have enough storage for all my animal food so I keep having to buy more before they starve (man maybe I'm a bad zoo manager)
youtu.be/8ewbGaOaAYk
In this episode, watch me:
🩷 Expand my zoo a bit more
🩷 Start CRISPR experiments
🩷 Build a farm!
🩷 Not have enough storage for all my animal food so I keep having to buy more before they starve (man maybe I'm a bad zoo manager)
youtu.be/8ewbGaOaAYk
Let's Play: Let's Build a Zoo (Episode 2: Hyenas and Porcupines Join the Party)
YouTube video by Nesstalgic
youtu.be
November 10, 2025 at 6:16 PM
I'm back doing zoo things in Let's Build a Zoo!
In this episode, watch me:
🩷 Expand my zoo a bit more
🩷 Start CRISPR experiments
🩷 Build a farm!
🩷 Not have enough storage for all my animal food so I keep having to buy more before they starve (man maybe I'm a bad zoo manager)
youtu.be/8ewbGaOaAYk
In this episode, watch me:
🩷 Expand my zoo a bit more
🩷 Start CRISPR experiments
🩷 Build a farm!
🩷 Not have enough storage for all my animal food so I keep having to buy more before they starve (man maybe I'm a bad zoo manager)
youtu.be/8ewbGaOaAYk
This type of shit paired with CRISPR it’s like oh hey maybe we won’t all die from infections that haven’t killed anyone since 1919
November 10, 2025 at 7:07 AM
This type of shit paired with CRISPR it’s like oh hey maybe we won’t all die from infections that haven’t killed anyone since 1919
November 6, 2025 at 11:19 PM
CRISPR 유전자 가위로 간의 ANGPTL3를 비활성화해 LDL(나쁜 콜레스테롤)과 중성지방을 크게 낮춘 초기 임상 결과가 나와. edition.cnn.com/2025/11/08/h...
Scientists have edited a gene that may reduce high cholesterol permanently | CNN
Dangerously high levels of “bad” cholesterol and triglycerides may be reduced by gene editing, in what study researchers hope will be a “one and done” treatment.
edition.cnn.com
November 9, 2025 at 7:21 AM
CRISPR 유전자 가위로 간의 ANGPTL3를 비활성화해 LDL(나쁜 콜레스테롤)과 중성지방을 크게 낮춘 초기 임상 결과가 나와. edition.cnn.com/2025/11/08/h...
My former UC Davis colleagues Ermias Kebreab and Paulo de Meo Filho went on Marketplace to talk about using seaweed and CRISPR to mitigate cattle enteric methane emissions!
www.marketplace.org/story/2025/1...
www.marketplace.org/story/2025/1...
Could an early diet of seaweed produce climate-friendlier beef?
A UC Davis study shows promising results.
www.marketplace.org
November 7, 2025 at 8:48 PM
My former UC Davis colleagues Ermias Kebreab and Paulo de Meo Filho went on Marketplace to talk about using seaweed and CRISPR to mitigate cattle enteric methane emissions!
www.marketplace.org/story/2025/1...
www.marketplace.org/story/2025/1...
Oh dear. More worries about the consequences of CRISPR. The basic step - cutting both strands of DNA, which are then repaired, is not anodyne and has lasting effects.
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
www.science.org
November 6, 2025 at 9:44 PM
Oh dear. More worries about the consequences of CRISPR. The basic step - cutting both strands of DNA, which are then repaired, is not anodyne and has lasting effects.
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci - @tsinghuauniversity.bsky.social go.nature.com/49EhzA4
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci - Nature Biotechnology
Multiplexed DNA imaging uncovers promoter−enhancer interaction dynamics and effects of epigenetic modifications.
go.nature.com
November 6, 2025 at 5:26 PM
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci - @tsinghuauniversity.bsky.social go.nature.com/49EhzA4
cell-like T-cells, the patients lived longer and responded better to treatment. Researchers believe that by measuring the number of these cells, doctors can forecast which patients will benefit most from immunotherapy. Researchers, employing CRISPR technology, produced T-cells that overexpressed the
November 5, 2025 at 5:09 PM
cell-like T-cells, the patients lived longer and responded better to treatment. Researchers believe that by measuring the number of these cells, doctors can forecast which patients will benefit most from immunotherapy. Researchers, employing CRISPR technology, produced T-cells that overexpressed the
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci - Nature Biotechnology
Multiplexed DNA imaging uncovers promoter−enhancer interaction dynamics and effects of epigenetic modifications.
www.nature.com
November 7, 2025 at 12:56 PM
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPR is going to revolutionize medicine
November 11, 2025 at 1:07 AM
CRISPR is going to revolutionize medicine
LeDNA is a low-cost, open access tool ready to be deployed around the globe to democratize education in genetics and CRISPR gene editing technology go.nature.com/3Wybiyb
rdcu.be/eNF06
rdcu.be/eNF06
LeDNA: a cut-and-build toolkit to democratize CRISPR gene editing technology education - Nature Biotechnology
LeDNA is a low-cost, open access tool ready to be deployed around the globe to democratize education in genetics and CRISPR gene editing technology.
go.nature.com
November 7, 2025 at 4:13 PM
LeDNA is a low-cost, open access tool ready to be deployed around the globe to democratize education in genetics and CRISPR gene editing technology go.nature.com/3Wybiyb
rdcu.be/eNF06
rdcu.be/eNF06
CRISPR-Cas9 regelt.
a computer generated image of a dna structure
Alt: a computer generated image of a dna structure
media.tenor.com
November 5, 2025 at 8:15 AM
CRISPR-Cas9 regelt.
CRISPR-CAS9 y las terapias génicas.
https://culturacientifica.com/2025/11/08/crispr-cas9-y-las-terapias-genicas/
https://culturacientifica.com/2025/11/08/crispr-cas9-y-las-terapias-genicas/
November 8, 2025 at 11:02 AM
CRISPR-CAS9 y las terapias génicas.
https://culturacientifica.com/2025/11/08/crispr-cas9-y-las-terapias-genicas/
https://culturacientifica.com/2025/11/08/crispr-cas9-y-las-terapias-genicas/
November 10, 2025 at 1:57 PM
A highlight of my summer was this collab w/
@twangmdphd.bsky.social ! CRISPR base editors are driving several clinical trials, but it's hard to quantify off-target edits and their effects. Tong developed a sequencing assay to identify off-targets *in primary cells* 🧬🖥️🧪 #genomics #chromatin #CRISPR
@twangmdphd.bsky.social ! CRISPR base editors are driving several clinical trials, but it's hard to quantify off-target edits and their effects. Tong developed a sequencing assay to identify off-targets *in primary cells* 🧬🖥️🧪 #genomics #chromatin #CRISPR
1/ Happy to share our preprint from the Greenleaf Lab: beCasKAS, our method to directly detect CRISPR base editor off-targets in primary cells. We additionally show how non-coding edits can be triaged for epigenetic dysregulation using deep learning.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 7, 2025 at 6:38 PM
A highlight of my summer was this collab w/
@twangmdphd.bsky.social ! CRISPR base editors are driving several clinical trials, but it's hard to quantify off-target edits and their effects. Tong developed a sequencing assay to identify off-targets *in primary cells* 🧬🖥️🧪 #genomics #chromatin #CRISPR
@twangmdphd.bsky.social ! CRISPR base editors are driving several clinical trials, but it's hard to quantify off-target edits and their effects. Tong developed a sequencing assay to identify off-targets *in primary cells* 🧬🖥️🧪 #genomics #chromatin #CRISPR
That's what the validation would be for. Being a tool from scientists for scientists it's a bit weird that we have to rely on anecdotal experience on our own manuscripts. Out of curiosity, I have also run the CRISPR 2012 paper (the one that won the Nobel) and it found 6 unsupported claims
November 7, 2025 at 3:51 PM
That's what the validation would be for. Being a tool from scientists for scientists it's a bit weird that we have to rely on anecdotal experience on our own manuscripts. Out of curiosity, I have also run the CRISPR 2012 paper (the one that won the Nobel) and it found 6 unsupported claims
CRISPR gene-editing works to reduce high cholesterol in a new study : NPR www.npr.org/2025/11/08/n...
CRISPR gene-editing works to reduce high cholesterol in a new study
An experimental gene-editing treatment shows promise for permanently lowering levels of cholesterol and triglycerides, possibly helping cut the risk for heart disease.
www.npr.org
November 10, 2025 at 9:32 PM
CRISPR gene-editing works to reduce high cholesterol in a new study : NPR www.npr.org/2025/11/08/n...
'Het is daarmee de eerste behandeling die een hoog cholesterolgehalte en een hoog triglyceridegehalte tegelijk verlaagt.’ Niki Korteweg
@nikikorteweg.bsky.social @nrcwetenschap.bsky.social #geneeskunde #crispr-cas9
www.nrc.nl/nieuws/2025/...
@nikikorteweg.bsky.social @nrcwetenschap.bsky.social #geneeskunde #crispr-cas9
www.nrc.nl/nieuws/2025/...
Medicijn dat genen knipt kan hoog cholesterol te lijf
Hartziekten: Tegen erfelijk verhoogd cholesterol laat een behandeling met genknipper crispr-cas9 goede resultaten zien.
www.nrc.nl
November 11, 2025 at 6:19 AM
'Het is daarmee de eerste behandeling die een hoog cholesterolgehalte en een hoog triglyceridegehalte tegelijk verlaagt.’ Niki Korteweg
@nikikorteweg.bsky.social @nrcwetenschap.bsky.social #geneeskunde #crispr-cas9
www.nrc.nl/nieuws/2025/...
@nikikorteweg.bsky.social @nrcwetenschap.bsky.social #geneeskunde #crispr-cas9
www.nrc.nl/nieuws/2025/...
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Marvin Cortez, Cullen Young, Rebecca Burdine @rburdine1.bsky.social and colleagues identify a conserved domain in Cfap298 that governs left–right symmetry breaking in vertebrates.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 3, 2025 at 6:33 PM
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.