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jcellsci.bsky.social
Journal of Cell Science
@jcellsci.bsky.social
5.4K followers 1.7K following 670 posts
Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio
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jcellsci.bsky.social
Journal of Cell Science @jcellsci.bsky.social · Nov 13
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
jcellsci.bsky.social
Xiaofei Li, Adam Kwiatkowski @kwiatkowskilab.bsky.social, Glenn Radice and colleagues discover that vinculin Y822 phosphorylation regulates adhesion remodelling during cardiomyocyte maturation.
journals.biologists.com/jcs/article/...
Figure showing that Y822 phosphorylation regulates VCL recruitment to cell-cell contacts in cultured CMs.
December 24, 2025 at 12:31 PM
jcellsci.bsky.social
In their Tools and Resources article, Ryosuke Nishimura, Pakorn Kanchanawong and colleagues @mbisg.bsky.social use light-inducible dimerisation to illuminate the role of talin in cell adhesion.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
December 23, 2025 at 2:30 PM
Reposted by Journal of Cell Science
yalembb.bsky.social
Read Lily Kabeche's interview in the Journal of Cell Science about her career path and mentoring philosophy: journals.biologists.com/jcs/article/...
December 22, 2025 at 4:35 PM
Reposted by Journal of Cell Science
terjejohansen.bsky.social
A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2 url: journals.biologists.com/jcs/article/...
BIG Congratulations to all authors and particularly to the first author Birendra Kumar Shrestha who did a fantastic job !
A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2
Highlighted Article: The transcriptional coactivator TP53INP2 is degraded by nuclear proteasomes under basal conditions. Upon starvation and exposure to various chemical stressors, a conserved cytopla...
journals.biologists.com
December 19, 2025 at 11:38 AM
jcellsci.bsky.social
In their Editorial, Claire Moulton, Amelia Glazier and Katie Ward look back on an extraordinary year, as @biologists.bsky.social celebrated their 100-year anniversary.

journals.biologists.com/jcs/article/...
The winning microscopy images from the Node–FocalPlane image competition, held at the Biologists @ 100 conference in March 2025. Left, ‘Cell-estial bloom’, the first-place winner, from Özge Özgüç, showing a live human induced pluripotent stem cell (hiPSC) colony labelled for lamin B, marking the nuclear lamina. Centre, ‘Dancing actinotroch’, the second-place image, from Allan Carrillo-Baltodano, showing an actinotroch larva of a phoronid worm, stained for actin (phalloidin, yellow) and acetylated tubulin (magenta). Right, ‘Who's active?’, the third-place image, from Julia Peloggia de Castro, depicting a lateral view of a zebrafish embryo at 9 h post fertilisation. MitoTracker was used to stain active mitochondria (magenta to yellow intensity scale), and an EGFP transgenic tag marks cell membranes (cyan).
December 22, 2025 at 3:00 PM
Reposted by Journal of Cell Science
drmichaelway.bsky.social
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
At the helm of JCS – Editors-in-Chief past, present… and future
The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...
doi.org
December 22, 2025 at 10:33 AM
Reposted by Journal of Cell Science
peiferlabunc.bsky.social
I'm on the Board of @biologists.bsky.social. Many know them as publishers of @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social , DMM, and @biologyopen.bsky.social --but they also are a major funder of small grants that empower young biologists and enable scientific meetings 🧪
biologists.bsky.social The Company of Biologists @biologists.bsky.social · 7d
We believe that, as our future leaders in biology, it is vital to provide #ECRs with the right support during the early stages of your academic career. We offer a number of practical ways to help you meet the unique needs and challenges you may encounter: www.biologists.com/about-us/ear...
Supporting early-career researchers
On these pages we highlight the range of resources that we offer to early-career researchers.
www.biologists.com
December 22, 2025 at 12:26 PM
Reposted by Journal of Cell Science
gautamdey.bsky.social
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍

W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social

journals.biologists.com/jcs/article/...
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
December 19, 2025 at 4:13 PM
jcellsci.bsky.social
Paola Molina, Ian Macara and colleagues discover that non-canonical EGFR signalling promotes MAPK-dependent extrusion of epithelial cells.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 19, 2025 at 3:07 PM
jcellsci.bsky.social
Andrew Neumann, Rytis Prekeris @prekerislab.bsky.social and colleagues discover a leading role for Rap2 in cell migration.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 19, 2025 at 9:47 AM
Reposted by Journal of Cell Science
guijacquemet.bsky.social
If you're wondering if your manuscript could be suitable for our special issue but are unsure, don't hesitate to reach out 👍
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 8d
In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...

Submission deadline: 1 April 2026

#imaging #microscopy #cellbiology
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 8d
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.

Find out more: www.biologists.com/meetings/jcs...

Early-bird deadline: 16 January

#imaging #microscopy
December 18, 2025 at 8:26 PM
jcellsci.bsky.social
In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...

Submission deadline: 1 April 2026

#imaging #microscopy #cellbiology
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 8d
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.

Find out more: www.biologists.com/meetings/jcs...

Early-bird deadline: 16 January

#imaging #microscopy
December 18, 2025 at 2:47 PM
jcellsci.bsky.social
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.

Find out more: www.biologists.com/meetings/jcs...

Early-bird deadline: 16 January

#imaging #microscopy
December 18, 2025 at 2:42 PM
jcellsci.bsky.social
Issue 23 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows adeno-associated virus (white) distributed along detyrosinated (magenta) & tyrosinated (green) microtubules, 4 h post entry. See article by Tripathi et al.

journals.biologists.com/jcs/article/...
JCS cover: Structured illumination microscopy reveals the spatial distribution of adeno-associated virus (AAV; white) along detyrosinated (magenta) and tyrosinated (green) microtubules in Huh7 cells, 4 h after entry. The image shows AAV accumulation on detyrosinated microtubules and illustrates how this tubulin modification impedes AAV movement towards the nucleus, ultimately impairing its gene delivery efficacy.
December 18, 2025 at 12:28 PM
jcellsci.bsky.social
Neda Glisovic, Aleksandra Chikina, Danijela Matic Vignjevic and colleagues @institutcurie.bsky.social interrogate intestinal fibroblast heterogeneity and propose a standardized nomenclature for intestinal fibroblasts.
journals.biologists.com/jcs/article/...
December 18, 2025 at 9:51 AM
Reposted by Journal of Cell Science
jcellsci.bsky.social
Submit your latest research to our upcoming special issue: Cell Biology of the Nucleus. This issue is being coordinated by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
Deadline: 5 January 2026
journals.biologists.com/jcs/pages/nu...
Call for papers for JCS Special Issue Text: Special Issue Cell Biology of the Nucleus Guest Editor: Abby Buchwalter Deadline: 5 January 2026 Image of a cell with a heart-shaped nucleus (Image credit: Hoang Anh Le) Journal of Cell Science logo Call for papers Image credit: Hoang Anh Le At the heart of a cancer cell – An Ewing’s sarcoma cancer cell with a curious heart-shaped nucleus. Imaged using Zeiss880 with Airyscan.
December 10, 2025 at 3:02 PM
jcellsci.bsky.social
Ajay Pradhan, Santosh Kumar and colleagues find that maturation stage-specific V-ATPase disassembly explains the neutral pH of mature mucocyst lysosome-related organelles in Tetrahymena thermophila.
journals.biologists.com/jcs/article/...
#OpenAccess
Docked mucocysts visualized in fixed wild-type cells by anti-Grl3p mAb 5E9 (panel i) and anti-Grt1p mAb 4D11 (panel iii). Δv-atpase-a1 cells contain less mucocyst signal, and the Grl3p puncta are often irregularly shaped (panels ii and iv). Insets show the single docked mucocysts marked by boxes in the main images. The 5E9 antibody recognized both immature and mature mucocysts.
December 17, 2025 at 3:22 PM
jcellsci.bsky.social
Pragya Parashara, Teresa Gunn, Jennifer Kong @jennkong.bsky.social and colleagues discover that the E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.
journals.biologists.com/jcs/article/...
Figure showing that ATRN interacts with the RING domain of MGRN1. AlphaFold-predicted ATRN–MGRN1 and ATRNL1–MGRN1 interactions. Both ATRN (residues 1157–1429, dark pink) and ATRNL1 (residues 1107–1379, light pink) contain four distinct domains, which we refer to as the extracellular stem (Stem), transmembrane (TM), cytoplasmic helix (Helix) and cytoplasmic tail (Tail). In interaction models, MGRN1 (orange) interacts with the cytoplasmic helix and tail of ATRN and ATRNL1. AlphaFold prediction of ATRN and ATRNL1 interacting with the MGRN1 pre-engager (yellow), engager (light orange) and RING (dark orange) domains. (B) Schematic of the domain organization of MGRN1 (533 aa) and the large deletions generated for the interaction assays. (C) Co-IP analysis of the ATRN–MGRN1 interactions in wild-type and Mgrn1−/−; Rnf157−/− NIH/3T3 cells stably expressing FLAG-tagged wild-type Mgrn1 or one of several Mgrn1 truncation mutants. The mutants include deletions of the Pre-engager (ΔPreEngShort and ΔPreEngLong, residues 35–48 and 35–82, respectively), Engager (ΔEng, residues 79–260), RING (ΔRING, residues 260–335) and disordered tail (ΔTail, residues 335-460). The asterisks (*) indicate the endogenous monomeric band of ATRN observed in the Flag IPs that was used for quantification. (D) Quantification of endogenous ATRN western blot signal intensities relative to wild-type and truncated MGRN1 in immunoprecipitated samples. The graph represents data from three independent experiments, with each dot representing one experimental replicate and with horizontal lines denoting the mean±s.d. Statistical significance was determined using one-way ANOVA with multiple comparisons. *P<0.05; **P<0.01; ****P<0.0001; ns, not significant.
December 17, 2025 at 9:41 AM
jcellsci.bsky.social
We were delighted to support the UK Membrane Trafficking Meeting organised by @jezcarlton.bsky.social and Chris Stefan. It sounds like the meeting was a huge success once again. Congratulations to Nikita Zubkoc (Munro lab) and Jack Stanley @edenlab.bsky.social, winners of the JCS short talk prizes.
Photo of Nikita Zubkoc, Jack Stanley and Chris Stefan sitting on a stage. Behind them, the text on the slide is: Congratulations! Membrane Trafficking Meeting Picture of a tube map with UKMT in small circles Short Talk Prizes Journal of Cell Science logo
December 16, 2025 at 4:21 PM
jcellsci.bsky.social
Learn about @biologists.bsky.social Travelling Fellowships in this Essay from Saanjbati Adhikari, part of our anniversary collection.
journals.biologists.com/jcs/article/...
The deadline for the next round of Travelling Fellowships from JCS is 6 February 2026: www.biologists.com/grants/trave...
Sofía Masuelli, a student at the Institute of Histology and Embryology of Mendoza, Argentina, used a Travelling Fellowship from JCS to visit the Michael Levin lab and the Madeleine Oudin lab at Tufts University, USA.
December 16, 2025 at 3:02 PM
jcellsci.bsky.social
Yu-Kai Huang, Mary Zhuang & Michelle Digman @digmanlab.bsky.social develop FLIM intensity-based image segmentation to capture changes in mitochondria metabolic activity & morphological, & use FIBIS to interrogate metabolism & drug sensitivity in cancer cells.
journals.biologists.com/jcs/article/...
Flow chart of FIBIS (A) Experimental images are line scanned by two-photon laser excitation for 15 frames in total to collect sufficient photon arrival time resulting in (B) the accumulated intensity image. (C) Highlights pixels from images as in B that are z-score normalized, which amplifies artificial laser scanning noise. FIBIS detects artificial noise through assessing abnormal histogram peaks and determines optimal frequency smoothing from a Fourier transform shift to set up a threshold level. (D) Objects that are larger than a predefined size go through size iteration following intensity gradient, which results in (E) the final masked image.
December 16, 2025 at 9:32 AM
jcellsci.bsky.social
In their Review, Rosanna Wilkins and Eva Petermann @petermannlab.bsky.social @unibirmingham.bsky.social explore the emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer.
journals.biologists.com/jcs/article/...
RNase H2 localisation and potential functions at replication forks. (A) Mechanisms of RNase H2 localisation to TRCs. Direct substrate interaction through the active site of RNASEH2A can recruit RNase H2 (1). Alternatively, RNase H2 can be recruited to transcription machinery through interactions with BRCA2 (2) or RNAPII (3), or to the replisome through direct interactions with PCNA via PIP-boxes in RNASEH2A or RNASEH2B (4), or through recruitment by RTF2 (5). (B) RNase H2 can resolve an R-loop prior to (i) or upon (ii) interference with DNA replication. RNase H2 can initiate RER to remove genomic rNMPs, either as they are being incorporated, or upon their interference with DNA replication (iii). RNase H2 is implicated in removing the RNA primer required for lagging strand DNA synthesis during Okazaki fragment maturation (iv). (C) RNase H2 has been implicated in removing post-replicative RNA:DNA hybrid species that can interfere with replication fork restart. These species can arise from CMG bypass of a naked R-loop or de novo RNA synthesis behind the fork (i). Upon fork reversal, the last unprocessed Okazaki fragment primer can form post-replicative RNA:DNA hybrids that interfere with fork restart (ii). Unrestrained RNase H2 has also been implicated in degrading RNA primers required for fork restart (iii). Created in BioRender by Wilkins, R. (2025). https://BioRender.com/55rko5g. This figure was sublicensed under CC-BY 4.0 terms.
December 15, 2025 at 4:35 PM
Reposted by Journal of Cell Science
jezcarlton.bsky.social
Thanks, Chris! And yep, all going brilliantly - 270 delegates and fantastic talks and posters. Great to see so much support for fundamental discovery science and membrane biology here! Thanks @jcellsci.bsky.social, @embojournal.org and @bscb-official.bsky.social for support!
yorkyeast.bsky.social Chris MacDonald @yorkyeast.bsky.social · 11d
Haven’t posted for a while but @jezcarlton.bsky.social opening up the annual UK membrane trafficking meeting #UKMT seems like an appropriate reason to post!

Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
December 15, 2025 at 12:39 PM
Reposted by Journal of Cell Science
jcellsci.bsky.social
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
November 13, 2025 at 5:13 PM
jcellsci.bsky.social
David Cohen, Francisco Lázaro-Diéguez and Anne Müsch discover that bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organisation.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 15, 2025 at 9:56 AM