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jcellsci.bsky.social
Journal of Cell Science
@jcellsci.bsky.social
5.2K followers 1.7K following 570 posts
Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio
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jcellsci.bsky.social
Dagmar Wachten @wachtenlab.bsky.social & Søren Tvorup Christensen @sorentc.bsky.social explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways in development & homeostasis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
JCS poster - Primary cilia signalling at a glance
November 11, 2025 at 3:04 PM
jcellsci.bsky.social
Melis Dalbay, Stephen Hart @ucl.ac.uk and colleagues develop and characterise a robust human PCD airway cell model via BMI1 transduction, which will enable therapeutic and mechanistic studies.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 11, 2025 at 10:27 AM
jcellsci.bsky.social
In this Opinion piece, Rachel Turn, Mohammad Ovais Aziz-Zanjani, Anushweta Asthana & Peter Jackson highlight strategies for multiplexing diverse approaches to map transient phosphorylations driving ciliary function & G0 in health versus disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Graphical summary representing strategies for deciphering temporal–spatial phosphoproteomic outcomes of primary cilia signaling in different biological contexts.
November 10, 2025 at 3:03 PM
jcellsci.bsky.social
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that EP4 localizes to primary cilia of ASCs.
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Conserved MIPs. (A) 16 common MIPs that are conserved across almost all examined species. (B) Cross-section view of the location of the conserved MIPs within a DMT. (C) Longitudinal view of the eight conserved MIPs at the outer junction and seam region. (D) Longitudinal view of the six conserved MIPs at the inner junction. The figures are generated based on structure of DMTs from human respiratory epithelium cilia (PDB: 8J07). Black arrow indicates the position of the seam.
November 7, 2025 at 3:02 PM
jcellsci.bsky.social
Alyssa Long, Tamara Caspary and colleagues discover that ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and uncover a role for ARL13B in spermatogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Micrographs showing that pancreatic islets appear normal in Arl13bhnn/hnn;Arl13b-Cerulean mice.
November 7, 2025 at 1:02 PM
Reposted by Journal of Cell Science
mick-lab.bsky.social
It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.
November 4, 2025 at 12:46 PM
jcellsci.bsky.social
Stepan Vodopyanov, George Karagiannis & colleagues examine intrathymic cystic structures uncovering a continuous & structured epithelial network embedded within the thymic parenchyma, with possible roles in thymocyte selection, maturation & egress.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing the microanatomical organisation of intrathymic epithelial networks.
November 7, 2025 at 9:00 AM
jcellsci.bsky.social
In their Review, Bernhard Schermer, Ronald Roepman and David Mick explore proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labelling techniques.
#JCSciliaSI #OpenAccess
journals.biologists.com/jcs/article/...
Timeline showing cilia research from a proteomics perspective. Selected key publications significantly shaping our current understanding of cilia. We apologize for not including numerous other relevant studies due to space constraints. Created in BioRender by Schermer, B., 2025. https://BioRender.com/jf2fayw. This figure was sublicensed under CC-BY 4.0 terms.
November 6, 2025 at 3:00 PM
jcellsci.bsky.social
Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that both overexpression of and loss of PPK-1 impacts shedding of CLHM-1-containing EVs.
November 6, 2025 at 1:17 PM
Reposted by Journal of Cell Science
theracilproject.bsky.social
💥 Check the Cilia special issue #JCSciliaSI from @jcellsci.bsky.social co-edited by @lottepedersen.bsky.social and with several exciting papers by other @theracilproject.bsky.social members - congrats Bernhard Schermer @cilib.bsky.social Ronald Roepman Soren Christensen John Sayer and co-authors 💥
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 7d
Our #JCSciliaSI is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
JCS Cover: Human tracheal epithelial cells (hTECs) from an air–liquid interface culture imaged using ultrastructural expansion microscopy (U-ExM). Cells are labelled for tubulin (magenta), mCLING (cyan) and DNA (blue, DAPI). Image from Olivier Mercey and Marine Brunet in the Guichard-Hamel lab. See article by O. Mercey et al. (jcs264260).
November 6, 2025 at 10:32 AM
jcellsci.bsky.social
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 6, 2025 at 9:05 AM
Reposted by Journal of Cell Science
jbwallingford.bsky.social
Stoked to have this perspective about my favorite organelle out in JCS! Give it a read, then let's argue!
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 13d
In their Perspective, John Wallingford @jbwallingford.bsky.social and colleagues present their view on the assembly and potential function of DynAPs, as well as their place within the broader context of motile ciliated cells.
#JCSciliaSI
journals.biologists.com/jcs/article/...
DynAPs and multiciliated cells. (A) Cross-sectional view of the very large Xenopus MCCs (∼30 μm across) labeled for the ODA subunit Dnai2, revealing the localization of the protein in apical axonemes and in DynAPs. Image by Chanjae Lee. (B) Schematic of a MCC showing the position of the axonemes and DynAPs, as well as the positions of ODAs and IDAs in the axoneme. The fluorescence microscopy images shown from the expansion at the bottom show colocalization of a DNAAF (Dnaaf5) and a chaperone (Hsp90ab1) throughout DynAPs and the partitioning of an ODA subunit (Dnai2) and IDA subunit (Wdr78) into sub-domains within DynAPs (sub-DynAPs). Images by Chanjae Lee. (C) The DNAAF Lrrc6/Dnaaf11 labels DynAPs in a human airway MCC. Image reproduced from Huizar et al. (2018) where it was published under a CC-BY 4.0 license.
November 5, 2025 at 11:19 PM
Reposted by Journal of Cell Science
focalplane.bsky.social
Incoming deadline - 7 November 2025

Apply for a @jcellsci.bsky.social @focalplane.bsky.social Training Grant to support your attendance at a #microscopy or #bioimageanalysis training course.

Open to ECRs in #cellbio. For more info: www.biologists.com/grants/jcs-f...
Microscopy Training Grants Supporting microscopy training for early-career researchers in cell biology Apply for a grant of up to £1,000 Cartoon of a person looking down a microscope, which is next to a computer Journal of Cell Science logo and FocalPlane logo
November 5, 2025 at 11:54 AM
jcellsci.bsky.social
In their Review, Olivier Mercey, @marinebrunet.bsky.social, Paul Guichard & Virginie Hamel @centriolelab.bsky.social highlight advances in microscopy that have significantly deepened our understanding of centriolar & ciliary structure & function.
journals.biologists.com/jcs/article/...
#OpenAccess
Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
journals.biologists.com
November 5, 2025 at 3:37 PM
jcellsci.bsky.social
Praveen Dhondurao Sudhindar, John Sayer, Juliana Arcila-Galvis and colleagues find that urinary renal epithelial cells can be used for NPHP1 phenotyping and a personalized therapeutic strategy.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Heatmap illustrating UP-DOWN and DOWN-UP genes (Padj<0.05, lfSE<1, and |log₂FC|>0.58) for the comparisons between NPHP1 untreated versus NPHP1 plus ALP or (C) NPHP1 untreated versus NPHP1 plus AG556.
November 5, 2025 at 11:43 AM
jcellsci.bsky.social
Amanda Smith, Lawrence Ostrowski and colleagues find that lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 5, 2025 at 10:23 AM
Reposted by Journal of Cell Science
natmosqueda.bsky.social
So excited that our paper is now out with @jcellsci.bsky.social and a special thank you to the editors for featuring our work! Check out below! 🐸🔬
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 7d
@natmosqueda.bsky.social, @psutton54.bsky.social and @brownlee.bsky.social @stonybrooku.bsky.social discover that importin α plays a regulatory role in ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that palmitoylated importin α has a conserved role in regulating multiciliogenesis in X. laevis epidermal MCCs
November 4, 2025 at 5:06 PM
jcellsci.bsky.social
Our #JCSciliaSI is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
JCS Cover: Human tracheal epithelial cells (hTECs) from an air–liquid interface culture imaged using ultrastructural expansion microscopy (U-ExM). Cells are labelled for tubulin (magenta), mCLING (cyan) and DNA (blue, DAPI). Image from Olivier Mercey and Marine Brunet in the Guichard-Hamel lab. See article by O. Mercey et al. (jcs264260).
November 4, 2025 at 1:36 PM
Reposted by Journal of Cell Science
marinebrunet.bsky.social
Exciting news: the new review from @centriolelab.bsky.social is out in the amazing #JCSciliaSI! 🎉
I had the pleasure of working alongside Olivier Mercey, Paul Guichard and Virginie Hamel on this one.
Cherry on top: our #UExM image was selected for the cover of the issue! 🤩
Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
journals.biologists.com
November 3, 2025 at 2:47 PM
Reposted by Journal of Cell Science
cilib.bsky.social
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!

#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social

tinyurl.com/yc8ztn5v
Advances in ciliary proteomics – towards cracking the hidden proteome code of cilia
Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.
journals.biologists.com
November 1, 2025 at 4:34 PM
jcellsci.bsky.social
@natmosqueda.bsky.social, @psutton54.bsky.social and @brownlee.bsky.social @stonybrooku.bsky.social discover that importin α plays a regulatory role in ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that palmitoylated importin α has a conserved role in regulating multiciliogenesis in X. laevis epidermal MCCs
November 4, 2025 at 10:07 AM
Reposted by Journal of Cell Science
lottepedersen.bsky.social
It was a great pleasure working with @cilialab.bsky.social and @seemagrewal.bsky.social plus others at @jcellsci.bsky.social on this special issue on ‘Cilia and flagella’. Lots of cool stuff on #cilia #flagella in there, enjoy!
November 4, 2025 at 9:17 AM
Reposted by Journal of Cell Science
rburdine1.bsky.social
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · 8d
Marvin Cortez, Cullen Young, Rebecca Burdine @rburdine1.bsky.social and colleagues identify a conserved domain in Cfap298 that governs left–right symmetry breaking in vertebrates.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 3, 2025 at 6:33 PM
jcellsci.bsky.social
Priyanka Verma, John Varga, Dibyendu Bhattacharyya @dibcell.bsky.social and colleagues find that morphological reprogramming of primary cilia length mitigates the fibrotic phenotype in fibroblasts across diverse fibrotic conditions
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing the opposing responses elicited by TGF-β1 and LiCl in SSc skin fibroblasts.
November 3, 2025 at 11:31 AM