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jcellsci.bsky.social
Journal of Cell Science
@jcellsci.bsky.social
5.2K followers 1.7K following 570 posts
Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio
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jcellsci.bsky.social
Dagmar Wachten @wachtenlab.bsky.social & Søren Tvorup Christensen @sorentc.bsky.social explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways in development & homeostasis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
JCS poster - Primary cilia signalling at a glance
November 11, 2025 at 3:04 PM
jcellsci.bsky.social
Melis Dalbay, Stephen Hart @ucl.ac.uk and colleagues develop and characterise a robust human PCD airway cell model via BMI1 transduction, which will enable therapeutic and mechanistic studies.
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November 11, 2025 at 10:27 AM
jcellsci.bsky.social
In this Opinion piece, Rachel Turn, Mohammad Ovais Aziz-Zanjani, Anushweta Asthana & Peter Jackson highlight strategies for multiplexing diverse approaches to map transient phosphorylations driving ciliary function & G0 in health versus disease.
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journals.biologists.com/jcs/article/...
Graphical summary representing strategies for deciphering temporal–spatial phosphoproteomic outcomes of primary cilia signaling in different biological contexts.
November 10, 2025 at 3:03 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Mark Lee: journals.biologists.com/jcs/article/...
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Mark Lee
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
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Figure showing that EP4 localizes to primary cilia of ASCs.
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
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Conserved MIPs. (A) 16 common MIPs that are conserved across almost all examined species. (B) Cross-section view of the location of the conserved MIPs within a DMT. (C) Longitudinal view of the eight conserved MIPs at the outer junction and seam region. (D) Longitudinal view of the six conserved MIPs at the inner junction. The figures are generated based on structure of DMTs from human respiratory epithelium cilia (PDB: 8J07). Black arrow indicates the position of the seam.
November 7, 2025 at 3:02 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Alyssa Long: journals.biologists.com/jcs/article/...
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Alyssa Long
November 7, 2025 at 1:02 PM
jcellsci.bsky.social
Alyssa Long, Tamara Caspary and colleagues discover that ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and uncover a role for ARL13B in spermatogenesis.
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Micrographs showing that pancreatic islets appear normal in Arl13bhnn/hnn;Arl13b-Cerulean mice.
November 7, 2025 at 1:02 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Stepan Vodopyanov: journals.biologists.com/jcs/article/...
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Stepan Vodopyanov
November 7, 2025 at 9:00 AM
jcellsci.bsky.social
Stepan Vodopyanov, George Karagiannis & colleagues examine intrathymic cystic structures uncovering a continuous & structured epithelial network embedded within the thymic parenchyma, with possible roles in thymocyte selection, maturation & egress.
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Figure showing the microanatomical organisation of intrathymic epithelial networks.
November 7, 2025 at 9:00 AM
jcellsci.bsky.social
In their Review, Bernhard Schermer, Ronald Roepman and David Mick explore proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labelling techniques.
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Timeline showing cilia research from a proteomics perspective. Selected key publications significantly shaping our current understanding of cilia. We apologize for not including numerous other relevant studies due to space constraints. Created in BioRender by Schermer, B., 2025. https://BioRender.com/jf2fayw. This figure was sublicensed under CC-BY 4.0 terms.
November 6, 2025 at 3:00 PM
jcellsci.bsky.social
This article is associated with a wild cherry tree, planted in The Forest of Biologists.
forest.biologists.com/landscape/
Tree no. 14093 Wild cherry (Prunus avium) Wild cherry Medium-sized, fast-growing deciduous tree, native to the UK and Europe. It has a deep-reddish brown bark and cream-coloured lenticels. The oval, toothed leaves have pointed tips and two red glands on the stalk. A hermaphrodite species, it blossoms early in spring and produces white, cup-shaped flowers, pollinated by insects to develop deep-red cherries. The fruit is eaten by several birds and mammals that then disperse the seed in their droppings. A pioneer light-demanding species, wild cherry quickly colonizes glades and clearings. However, it is often outcompeted by other hardwoods later, and is thus extensively used for afforestation of agricultural land. The trees favour full sunlight and moist to well-drained fertile soil, including slightly acidic or calcareous conditions. Wild cherry is susceptible to bacterial cankers, and pruning wounds can allow fungal infection leading to silver leaf disease.
November 6, 2025 at 1:17 PM
jcellsci.bsky.social
Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
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Figure showing that both overexpression of and loss of PPK-1 impacts shedding of CLHM-1-containing EVs.
November 6, 2025 at 1:17 PM
jcellsci.bsky.social
This article is associated with a hazel tree, planted in The Forest of Biologists.
forest.biologists.com/landscape/
Tree no. 13995 Hazel (Corylus avellana) Hazel tree with catkins Large, usually multi-stemmed, deciduous shrub, found throughout Europe and cultivated worldwide for its nuts. Its soft, rounded leaves have a double-serrate margin and downy hairs. Clusters of yellow male catkins appear before the leaves in spring and release pollen for wind dispersal. The tiny, bud-like female flowers with red stigmas are found on branches above male catkins to avoid self-pollination. The fruits mature into nuts held in a short, leafy husk. Hazel often grows in the understorey of mixed deciduous forests. A highly adaptable pioneer species, it grows both in sun and shade. It grows best on fertile and nutrient-rich soils in a moderate climate but is also highly cold and frost resistant. Hazel shrubs support many insects and provide shelter for ground-nesting birds. The nuts are eaten by deer, dormice, squirrels and birds and are an important food source during winter.
November 6, 2025 at 9:05 AM
jcellsci.bsky.social
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
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journals.biologists.com/jcs/article/...
November 6, 2025 at 9:05 AM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Praveen Dhondurao Sudhindar: journals.biologists.com/jcs/article/...
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Praveen Dhondurao Sudhindar
November 5, 2025 at 11:43 AM
jcellsci.bsky.social
Praveen Dhondurao Sudhindar, John Sayer, Juliana Arcila-Galvis and colleagues find that urinary renal epithelial cells can be used for NPHP1 phenotyping and a personalized therapeutic strategy.
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journals.biologists.com/jcs/article/...
Heatmap illustrating UP-DOWN and DOWN-UP genes (Padj<0.05, lfSE<1, and |log₂FC|>0.58) for the comparisons between NPHP1 untreated versus NPHP1 plus ALP or (C) NPHP1 untreated versus NPHP1 plus AG556.
November 5, 2025 at 11:43 AM
jcellsci.bsky.social
Amanda Smith, Lawrence Ostrowski and colleagues find that lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models.
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November 5, 2025 at 10:23 AM
jcellsci.bsky.social
- Perspectives on DNAAFs, patient engagement, ciliopathies & DynAPs
- Cilia signalling at a glance
- Strategies for multimodal profiling of phosphorylation in cilia
- Reviews on MIPs, ciliary proteomics, high resolution imaging & ciliary signalling
journals.biologists.com/jcs/issue/13...
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JCS poster on 'Primary cilia signalling at a glance' from Dagmar Wachten and Søren Tvorup Christensen.
November 4, 2025 at 1:36 PM
jcellsci.bsky.social
Also in Issue 20:
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
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Keren Hilgendorf Girish Ram Mali
November 4, 2025 at 1:36 PM
jcellsci.bsky.social
Our #JCSciliaSI is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
JCS Cover: Human tracheal epithelial cells (hTECs) from an air–liquid interface culture imaged using ultrastructural expansion microscopy (U-ExM). Cells are labelled for tubulin (magenta), mCLING (cyan) and DNA (blue, DAPI). Image from Olivier Mercey and Marine Brunet in the Guichard-Hamel lab. See article by O. Mercey et al. (jcs264260).
November 4, 2025 at 1:36 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Natalie Mosqueda @natmosqueda.bsky.social: journals.biologists.com/jcs/article/...
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Natalie Mosqueda
November 4, 2025 at 10:07 AM
jcellsci.bsky.social
@natmosqueda.bsky.social, @psutton54.bsky.social and @brownlee.bsky.social @stonybrooku.bsky.social discover that importin α plays a regulatory role in ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
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Figure showing that palmitoylated importin α has a conserved role in regulating multiciliogenesis in X. laevis epidermal MCCs
November 4, 2025 at 10:07 AM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Priyanka Verma: journals.biologists.com/jcs/article/...
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Priyanka Verma
November 3, 2025 at 11:31 AM
jcellsci.bsky.social
Priyanka Verma, John Varga, Dibyendu Bhattacharyya @dibcell.bsky.social and colleagues find that morphological reprogramming of primary cilia length mitigates the fibrotic phenotype in fibroblasts across diverse fibrotic conditions
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Figure showing the opposing responses elicited by TGF-β1 and LiCl in SSc skin fibroblasts.
November 3, 2025 at 11:31 AM