Lotte B. Pedersen
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lottepedersen.bsky.social
Lotte B. Pedersen
@lottepedersen.bsky.social
190 followers 170 following 30 posts
Cell biologist interested in cilia research
Posts Replies Media Videos
Reposted by Lotte B. Pedersen
cilialab.bsky.social
We are back April 21 2026- volunteer or nominate yourself or someone with hot cilia and centrosome science to speak by dropping me an email or use the google doc forms.gle/9QoSvkmQ3gZL...! /FIN
BSCB GenSoc UK Cilia Network e-symposium series talk
Sign-up to be on the rota of future speakers for the 2025 series!
forms.gle
January 13, 2026 at 11:05 PM
Reposted by Lotte B. Pedersen
cilialab.bsky.social
From limitless primary basal cells for #PCD therapies, to the TOGORAM1 complex, cytoskeleton & ciliopathies, to #PrimaryCilia diversity in brain #microvasculature, to #ExtrasynapticSignaling at neuronal cilia by in situ proteomics, to an epigenetic 'eraser' controlling #cilia stability... 🔥 /fin
January 5, 2026 at 5:40 PM
Reposted by Lotte B. Pedersen
guillaumeniel.bsky.social
What a great start for 2026 for the EVICAT team!!!
Everything you need to know about extracellular vesicles' recipient cells and how to harness these pathways for therapeutic purposes
Thanks to all co-authors!
bit.ly/3N9InyW
Biology and therapeutic potential of extracellular vesicle targeting and uptake - Nature Reviews Molecular Cell Biology
Extracellular vesicles are released from almost all cell types and mediate intercellular communication by delivering proteins, nucleic acids and lipids. This Review examines extracellular vesicle upta...
bit.ly
January 4, 2026 at 7:20 PM
Reposted by Lotte B. Pedersen
eurocilia.bsky.social
🌍 Cilia2027 | Mar 8–12, 2027 | 📍 Stresa, Lake Maggiore, Italy

Join the global cilia community for science, collaboration & discovery (+ fun!!).

#Cilia2027 #CiliaBiology
Cilia2027, the 7th European Cilia Conference to be held in Italy from March 8th- 12th, 2027.
December 16, 2025 at 3:29 PM
Reposted by Lotte B. Pedersen
plosbiology.org
CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP
Top: lf5 mutant cells untransformed, or expressing CDKL5-GFP, CDKL5K33R-GFP, CDKL5S162A,T164A,Y166A-GFP, or CDKL5Y166F-GFP, and lf2 mutant cells expressing CDKL5-GFP were stained for flagella (acetylated tubulin, red) and CDKL5 (GFP, green top panels, gray in bottom panels). The cell bodies of all strains are green (or gray) due to autofluorescence. Wild-type CDKL5-GFP concentrates at the basal end of the flagellar shaft (arrows). Note that all of the mutant CDKL5 proteins lack the major enrichment at the basal end of the flagellum but continue to show punctate stain along the flagellar shaft. Scale bar, 5 µm. Z projection of slices taken at 0.5-µm intervals. Bottom: Larger version of the first image in the top row.
December 15, 2025 at 5:28 PM
lottepedersen.bsky.social
Very grateful to @carlsbergfondet.dk for supporting our Research Infrastructure application to purchase a new NTA for studying #cilia and #extracellular #vesicles 🙏😀

bsky.app/profile/carl...
carlsbergfondet.dk Carlsbergfondet @carlsbergfondet.dk · Dec 10
Fra politologi til arkæologi. Fra astrofysik til marinbiologi og glaciologi. 159 forskere modtager i dag en bevilling fra Carlsbergfondet til vidt forskellige grundvidenskabelige initiativer. Se hvilke projekter, der har fået støtte 👉 bit.ly/4iK2fV2 #dkforsk
December 11, 2025 at 3:42 PM
Reposted by Lotte B. Pedersen
centriolelab.bsky.social
🥳 Our new paper on C2CD3 is out in @plosbiology.org
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
plosbiology.org PLOS Biology @plosbiology.org · Dec 10
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom: Model of the architecture of the distal region of the human centriole.
December 10, 2025 at 12:36 PM
Reposted by Lotte B. Pedersen
alexbnmrh.bsky.social
Nice work indeed… among all the interesting findings, quite amazed to see that you can induce the formation of ciliary pockets just by the removal of Arp3! #cilia #ciliopathies #kidney
December 2, 2025 at 1:11 PM
Reposted by Lotte B. Pedersen
embojournal.org
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 28, 2025 at 4:10 PM
Reposted by Lotte B. Pedersen
focalplane.bsky.social
We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!

To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
JCS snapshots: the cilia and flagella edition - FocalPlane
JCS snapshots: the cilia and flagella edition - News
focalplane.biologists.com
November 25, 2025 at 12:29 PM
Reposted by Lotte B. Pedersen
cilialab.bsky.social
And we’ll be back for four sessions in 2026- first 14/01/2026! Register: www.eventbrite.co.uk/e/bscb-genso...
#UKCilia2025 /9
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
www.eventbrite.co.uk
November 25, 2025 at 7:27 PM
Reposted by Lotte B. Pedersen
cilialab.bsky.social
In the meantime, try a deep dive into our JCS Special Issue on Cilia and Flagella to fully immerse yourself into some great research, fantastic insight and provocative opinions: journals.biologists.com/jcs/issue/13... /fin
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 25, 2025 at 7:27 PM
Reposted by Lotte B. Pedersen
dyneinassembly.bsky.social
Thanks for the shoutout! @jcellsci.bsky.social :)
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · Nov 17
In their Perspective article, Muyang Ren, Siham Jaleel, Stephen King & Girish Mali @dyneinassembly.bsky.social highlight the structural diversity of the axonemal dynein assembly factors & their emerging roles in the biology of motile cilia.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Schematic of the dynein assembly pathway and putative roles of DNAAFs that work within it. Axonemal dynein arm motor subunits (heavy chains, intermediate chains and light chains) are assembled in a multi-step dynein assembly pathway involving steps of folding, assembly and transport. DNAAFs are thought to operate at distinct steps. HSP70 proteins likely engage nascent dynein heavy chain, intermediate chain and light chain subunits as they emerge from the ribosome exit tunnel. Specific DNAAFs then likely hand over semi-folded subunits to the HSP90 chaperone and its co-chaperone R2TP complex for further folding and assembly. Many DNAAFs are proposed to function at this step with RUVBL1/2. Pre-assembled ODA motors are finally packaged into an inhibited closed conformation by DNAAF9 (Shulin) for stable attachment to IFT trains for ciliary import. IDAs might undergo similar packaging for IFT transport via currently unknown factors. Genetic variants that block any step of assembly can cause severe motile ciliopathies such as PCD. PTM, post-translational modification.
November 17, 2025 at 7:04 PM
Reposted by Lotte B. Pedersen
mick-lab.bsky.social
It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.
November 4, 2025 at 12:46 PM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that tissue-resident macrophages promote cytogenesis in an in vitro 3D model system.
November 14, 2025 at 2:14 PM
Reposted by Lotte B. Pedersen
mick-lab.bsky.social
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
November 14, 2025 at 8:07 PM
Reposted by Lotte B. Pedersen
focalplane.bsky.social
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.

And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News
focalplane.biologists.com
November 13, 2025 at 11:26 AM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Akisato Marumo, Hiroto Ishii, Shin Yamaguchi, Junichiro Yajima and colleagues characterise the 3D beating pattern of the ciliary tip in the live ciliate Tetrahymena.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
November 12, 2025 at 9:44 AM
Reposted by Lotte B. Pedersen
biologists.bsky.social
Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti.

Find out more: biologists.com/meetings/jcs...

#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience
Imaging Cell Dynamics 11-14 May 2026 Montanyà Hotel, Catalonia, Spain Register now - early-bird deadline: 16 January 2026 Journal of Cell Science Meeting
October 9, 2025 at 11:15 AM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that EP4 localizes to primary cilia of ASCs.
November 10, 2025 at 9:01 AM
Reposted by Lotte B. Pedersen
theracilproject.bsky.social
🥳TheRaCil Publications Alert🚨Visit theracil.eu/news-and-pub... - cilia biology & perspectives for AI in nephrology👉KIF13B controls ciliary protein content, Rezi et al @lottepedersen.bsky.social 👉AI for diagnosis and care in rare kidney disease review, Chen et al @knebel.bsky.social #cilia #kidney
News and Publications - TheRaCil
theracil.eu
November 10, 2025 at 2:03 PM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Malek Elsayyid, Alexis Semmel, Jessica Tanis and colleagues find that phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that both overexpression of and loss of PPK-1 impacts shedding of CLHM-1-containing EVs.
November 6, 2025 at 1:17 PM
Reposted by Lotte B. Pedersen
jcellsci.bsky.social
Also in Issue 20:
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI
Keren Hilgendorf Girish Ram Mali
November 4, 2025 at 1:36 PM
Reposted by Lotte B. Pedersen
marinebrunet.bsky.social
Exciting news: the new review from @centriolelab.bsky.social is out in the amazing #JCSciliaSI! 🎉
I had the pleasure of working alongside Olivier Mercey, Paul Guichard and Virginie Hamel on this one.
Cherry on top: our #UExM image was selected for the cover of the issue! 🤩
Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
journals.biologists.com
November 3, 2025 at 2:47 PM
Reposted by Lotte B. Pedersen
kuba-sedzinski.bsky.social
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
November 3, 2025 at 7:05 PM