(GIRISH)MALI LAB
@dyneinassembly.bsky.social
Group Leader/MRC CDA Fellow (Dunn School of Pathology, University of Oxford)
https://www.path.ox.ac.uk/research-group/girish-ram-mali/
https://www.path.ox.ac.uk/research-group/girish-ram-mali/
Pinned
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Reposted by (GIRISH)MALI LAB
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:03 PM
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by (GIRISH)MALI LAB
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
www.biorxiv.org
February 6, 2026 at 11:20 AM
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
Incredible new work on ciliary axoneme assembly spearheaded by @helenfoster.bsky.social (#NewPI) from the @gaiapigino.bsky.social. Like all good science, answers many questions & opens up many new ones!
Kudos to the entire team for this important advance in cilia biology. Lovely animation!
Kudos to the entire team for this important advance in cilia biology. Lovely animation!
There was so much to unpack with this data, we teamed up with the marvellous @margotriggi.bsky.social to help explain what we think is going on. (Please also check out our model of central apparatus assembly here: www.biorxiv.org/content/10.6...)
February 7, 2026 at 3:12 PM
Incredible new work on ciliary axoneme assembly spearheaded by @helenfoster.bsky.social (#NewPI) from the @gaiapigino.bsky.social. Like all good science, answers many questions & opens up many new ones!
Kudos to the entire team for this important advance in cilia biology. Lovely animation!
Kudos to the entire team for this important advance in cilia biology. Lovely animation!
Reposted by (GIRISH)MALI LAB
Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome. http://dlvr.it/TQnW4n
February 5, 2026 at 11:58 PM
Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome. http://dlvr.it/TQnW4n
Reposted by (GIRISH)MALI LAB
Last couple spots remaining for the Craniofacial GRC in sunny CA! Looks to be a full house, with a great set of up-and-coming #craniofacial biologists spanning evo/devo, genetics, multiomics all the way to stem cells, engineering and repair. @brugmannlab.bsky.social www.grc.org/craniofacial...
2026 Craniofacial Morphogenesis and Tissue Regeneration Conference GRC
The 2026 Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
February 6, 2026 at 7:40 AM
Last couple spots remaining for the Craniofacial GRC in sunny CA! Looks to be a full house, with a great set of up-and-coming #craniofacial biologists spanning evo/devo, genetics, multiomics all the way to stem cells, engineering and repair. @brugmannlab.bsky.social www.grc.org/craniofacial...
Reposted by (GIRISH)MALI LAB
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
crick.ac.uk/WayPostdoc2026
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:22 AM
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
crick.ac.uk/WayPostdoc2026
Reposted by (GIRISH)MALI LAB
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:29 AM
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Reposted by (GIRISH)MALI LAB
'We have become familiar with videos of people we do not know getting detained & ripped from families and beaten by agents whose salaries we pay. As social media does its work putting pieces together about each unfolding tragedy, more of us will realize that those pieces belong to someone we know' 🥹
I wrote about my childhood friend Alexi Pretti. Please read it and share it and remember him as a human being. @theverge.com
I grew up with Alex Pretti
The kind-hearted ICU nurse shot by ICE agents was my childhood best friend.
www.theverge.com
January 27, 2026 at 11:07 PM
'We have become familiar with videos of people we do not know getting detained & ripped from families and beaten by agents whose salaries we pay. As social media does its work putting pieces together about each unfolding tragedy, more of us will realize that those pieces belong to someone we know' 🥹
Reposted by (GIRISH)MALI LAB
Laryssa de Liz, Jack Sunter and colleagues find that trypanosome bloodstream-specific flagellum attachment proteins can mediate attachment in an insect surface coat environment.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
January 20, 2026 at 10:28 AM
Laryssa de Liz, Jack Sunter and colleagues find that trypanosome bloodstream-specific flagellum attachment proteins can mediate attachment in an insect surface coat environment.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Reposted by (GIRISH)MALI LAB
Transport motor loss and hyperactivation cause axonal microtubule bundle damage mediated by inferred ROS dyshomeostasis upon motor loss, and through ROS-independent mechanisms, likely through increased mechanical load, upon motor hyperactivation
www.manchester.ac.uk/about/news/r...
www.manchester.ac.uk/about/news/r...
Research with fruit flies could unlock riddle of neurodegenerative disorders
A study by University of Manchester scientists using fruit flies as model has identified a mechanism which can explain aspects of neurodegeneration which have baffled scientists for decades.Scientists...
www.manchester.ac.uk
January 20, 2026 at 8:37 AM
Transport motor loss and hyperactivation cause axonal microtubule bundle damage mediated by inferred ROS dyshomeostasis upon motor loss, and through ROS-independent mechanisms, likely through increased mechanical load, upon motor hyperactivation
www.manchester.ac.uk/about/news/r...
www.manchester.ac.uk/about/news/r...
Reposted by (GIRISH)MALI LAB
Reposted by (GIRISH)MALI LAB
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
December 19, 2025 at 4:45 PM
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Reposted by (GIRISH)MALI LAB
A cilium of a fixed RPE-1 cell, expanded and imaged with #3DSTED and #FLEXPOSURE adaptive illumination. CEP164 🟥 (STAR RED), acetylated tubulin+CCDC41 🟦 (STAR ORANGE).
Samples courtesy: Dong Kong & Jadranka Loncarek. Cancer Innovation Laboratory, NCI/CCR.
#ExM #superresolution #fluorescencefriday
Samples courtesy: Dong Kong & Jadranka Loncarek. Cancer Innovation Laboratory, NCI/CCR.
#ExM #superresolution #fluorescencefriday
July 11, 2025 at 8:16 AM
A cilium of a fixed RPE-1 cell, expanded and imaged with #3DSTED and #FLEXPOSURE adaptive illumination. CEP164 🟥 (STAR RED), acetylated tubulin+CCDC41 🟦 (STAR ORANGE).
Samples courtesy: Dong Kong & Jadranka Loncarek. Cancer Innovation Laboratory, NCI/CCR.
#ExM #superresolution #fluorescencefriday
Samples courtesy: Dong Kong & Jadranka Loncarek. Cancer Innovation Laboratory, NCI/CCR.
#ExM #superresolution #fluorescencefriday
Reposted by (GIRISH)MALI LAB
New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection
YouTube video by International Union of Crystallography
www.youtube.com
December 11, 2025 at 1:07 PM
New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...
Reposted by (GIRISH)MALI LAB
Bummed to miss #ASCB this year (one of my fav meetings), but the lab is well represented!
Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025
Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025
December 7, 2025 at 3:43 PM
Bummed to miss #ASCB this year (one of my fav meetings), but the lab is well represented!
Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025
Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025
Reposted by (GIRISH)MALI LAB
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 9:02 PM
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Reposted by (GIRISH)MALI LAB
Add our first pre-print to your reading list?
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
November 25, 2025 at 9:57 AM
Add our first pre-print to your reading list?
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!
Please share: tinyurl.com/3h8r7f5y
Reposted by (GIRISH)MALI LAB
This has now been published in print! Check it out:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
November 28, 2025 at 10:53 AM
This has now been published in print! Check it out:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by (GIRISH)MALI LAB
Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal.
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
November 27, 2025 at 9:24 AM
Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal.
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
Reposted by (GIRISH)MALI LAB
We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!
To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
JCS snapshots: the cilia and flagella edition - FocalPlane
JCS snapshots: the cilia and flagella edition - News
focalplane.biologists.com
November 25, 2025 at 12:29 PM
We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!
To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
Reposted by (GIRISH)MALI LAB
So proud of the lab for its achievements - Thank you to the Pettenkofer foundation for recognising our contributions - here’s to some more bacterial effector related fun in the future! @dunnschool.bsky.social
Many congratulations Teresa!
Teresa Thurston was awarded the 2025 Pettenkofer Prize, recognising her contributions to identifying how different bacterial effectors impact the outcome of infection.
www.path.ox.ac.uk/news-article...
Teresa Thurston was awarded the 2025 Pettenkofer Prize, recognising her contributions to identifying how different bacterial effectors impact the outcome of infection.
www.path.ox.ac.uk/news-article...
2025 Pettenkofer Prize awarded to Teresa Thurston - Dunn School
The award by the Pettenkofer Foundation recognised Teresa’s contributions to identifying how different bacterial effectors impact the outcome of infection.
www.path.ox.ac.uk
November 23, 2025 at 9:43 PM
So proud of the lab for its achievements - Thank you to the Pettenkofer foundation for recognising our contributions - here’s to some more bacterial effector related fun in the future! @dunnschool.bsky.social
Reposted by (GIRISH)MALI LAB
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 5:12 PM
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
Reposted by (GIRISH)MALI LAB
Key transcripts encoded centrin-like proteins, a frequent component of sensory/contractile structures in protists. We visualized tentacle ultrastructure by U-ExM with @dudinlab.bsky.social lab, discovering stunning tip and collar structures 🤯that add structural complexity to new tentacle formation.
November 18, 2025 at 4:15 PM
Key transcripts encoded centrin-like proteins, a frequent component of sensory/contractile structures in protists. We visualized tentacle ultrastructure by U-ExM with @dudinlab.bsky.social lab, discovering stunning tip and collar structures 🤯that add structural complexity to new tentacle formation.
I saw her at the poster session at ASCB 2024! very very impressive work and such a cool model system to study.
This work shines because of @zjmaggiexu.bsky.social passion for these cells. She built it all—the cultures, transcriptomes, analyses, modeling and collaborations—from scratch. I can’t begin to express how brilliant and hard-working a scientist she is (and she's 👀 for postdocs!). So proud of her 🥲
November 19, 2025 at 9:14 AM
I saw her at the poster session at ASCB 2024! very very impressive work and such a cool model system to study.
Reposted by (GIRISH)MALI LAB
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2025 at 10:43 PM
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...