(GIRISH)MALI LAB
@dyneinassembly.bsky.social
Group Leader/MRC CDA Fellow (Dunn School of Pathology, University of Oxford)
https://www.path.ox.ac.uk/research-group/girish-ram-mali/
https://www.path.ox.ac.uk/research-group/girish-ram-mali/
Pinned
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Reposted by (GIRISH)MALI LAB
Reposted by (GIRISH)MALI LAB
Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:
November 10, 2025 at 7:58 PM
Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:
Reposted by (GIRISH)MALI LAB
The construction industry, where more than a quarter of workers are foreign-born, has long struggled to find enough workers. Now, industry officials say Trump's immigration crackdown is making it worse.
ICE is sending a chill through the construction industry
The construction industry, where more than a quarter of workers are foreign-born, has long struggled to find enough workers. Now, industry officials say Trump's immigration crackdown is making it worse.
n.pr
November 11, 2025 at 3:52 AM
The construction industry, where more than a quarter of workers are foreign-born, has long struggled to find enough workers. Now, industry officials say Trump's immigration crackdown is making it worse.
Reposted by (GIRISH)MALI LAB
Also in Issue 20:
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI
November 4, 2025 at 1:36 PM
Also in Issue 20:
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI
- Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
- 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social
journals.biologists.com/jcs/issue/13...
#JCSciliaSI
Reposted by (GIRISH)MALI LAB
It was a great pleasure working with @cilialab.bsky.social and @seemagrewal.bsky.social plus others at @jcellsci.bsky.social on this special issue on ‘Cilia and flagella’. Lots of cool stuff on #cilia #flagella in there, enjoy!
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 4, 2025 at 9:17 AM
It was a great pleasure working with @cilialab.bsky.social and @seemagrewal.bsky.social plus others at @jcellsci.bsky.social on this special issue on ‘Cilia and flagella’. Lots of cool stuff on #cilia #flagella in there, enjoy!
Reposted by (GIRISH)MALI LAB
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Marvin Cortez, Cullen Young, Rebecca Burdine @rburdine1.bsky.social and colleagues identify a conserved domain in Cfap298 that governs left–right symmetry breaking in vertebrates.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 3, 2025 at 6:33 PM
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Reposted by (GIRISH)MALI LAB
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
October 31, 2025 at 8:44 AM
This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
Reposted by (GIRISH)MALI LAB
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Reposted by (GIRISH)MALI LAB
Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones | Science www.science.org/doi/10.1126/...
Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones
Microtubule assembly requires a set of chaperones known as tubulin-binding cofactors (TBCs). We used cryo–electron microscopy to visualize how human TBCD, TBCE, TBCC, and guanosine triphosphatase (GTP...
www.science.org
October 30, 2025 at 8:38 PM
Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones | Science www.science.org/doi/10.1126/...
Reposted by (GIRISH)MALI LAB
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI.
journals.biologists.com/jcs/issue/13...
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
journals.biologists.com
October 27, 2025 at 10:30 AM
Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI.
journals.biologists.com/jcs/issue/13...
journals.biologists.com/jcs/issue/13...
Reposted by (GIRISH)MALI LAB
An enormous thanks to @wellcometrust and everyone who’s helped along the way
📢 PhD position open now 🎓– apply here 👉
www.bioch.ox.ac.uk/supervisors-...
🧪 Postdoc adverts coming 2026!
📢 PhD position open now 🎓– apply here 👉
www.bioch.ox.ac.uk/supervisors-...
🧪 Postdoc adverts coming 2026!
Supervisors and Projects
www.bioch.ox.ac.uk
October 14, 2025 at 11:09 AM
An enormous thanks to @wellcometrust and everyone who’s helped along the way
📢 PhD position open now 🎓– apply here 👉
www.bioch.ox.ac.uk/supervisors-...
🧪 Postdoc adverts coming 2026!
📢 PhD position open now 🎓– apply here 👉
www.bioch.ox.ac.uk/supervisors-...
🧪 Postdoc adverts coming 2026!
Reposted by (GIRISH)MALI LAB
I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉
October 14, 2025 at 11:09 AM
I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉
Reposted by (GIRISH)MALI LAB
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 6, 2025 at 11:31 AM
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 29, 2025 at 7:09 PM
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Lovely tribute to David's legacy.
Lovely to see David Stephens highlighted in 100 years of cell biologists at J. Cell Sci., alongside Linda Amos, Peter Medawar, Juan Bonifacino, and others
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
journals.biologists.com
September 19, 2025 at 9:36 AM
Lovely tribute to David's legacy.
Reposted by (GIRISH)MALI LAB
Our PhD studentship programme is officially open; pass it on
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
Applications now open for our PhD studentship programme - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
www.path.ox.ac.uk
September 8, 2025 at 11:15 AM
Our PhD studentship programme is officially open; pass it on
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
Reposted by (GIRISH)MALI LAB
Another exciting opportunity @dunnschool.bsky.social !
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
We're hiring (again)!
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
September 10, 2025 at 1:34 PM
Another exciting opportunity @dunnschool.bsky.social !
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Reposted by (GIRISH)MALI LAB
We've had a very active summer of Cilia and Centrosome science!
We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.
www.cilianetwork.org.uk/events/annua...
We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.
www.cilianetwork.org.uk/events/annua...
Annual Meeting 2025 - Highlights: UK Cilia and Centrosome Network
UK Cilia and Centrosome Network
www.cilianetwork.org.uk
September 16, 2025 at 3:38 PM
We've had a very active summer of Cilia and Centrosome science!
We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.
www.cilianetwork.org.uk/events/annua...
We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.
www.cilianetwork.org.uk/events/annua...
Reposted by (GIRISH)MALI LAB
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers
Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...
rdcu.be
September 16, 2025 at 6:09 AM
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team.
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is a genetic disorder caused by defective cilia motility, powered by axonemal dynein motors. Assembly of these motors is facilitated by the molecular chaperone HSP90, ...
www.biorxiv.org
September 15, 2025 at 8:00 PM
Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team.
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
Reposted by (GIRISH)MALI LAB
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia
Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting
endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins
while suppressing their relea...
www.cell.com
September 10, 2025 at 7:26 AM
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...
Reposted by (GIRISH)MALI LAB
The annual Dunn School DPhil studentship competition for 2026 is open for applications.
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School
Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.
www.path.ox.ac.uk
September 9, 2025 at 9:22 AM
The annual Dunn School DPhil studentship competition for 2026 is open for applications.
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
Reposted by (GIRISH)MALI LAB
The Dunn School PhD programme is live! 🎉
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
How to Apply - Dunn School
Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.
www.path.ox.ac.uk
September 8, 2025 at 6:40 PM
The Dunn School PhD programme is live! 🎉
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
The annual Dunn School DPhil studentship competition for 2026 is open for applications.
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School
Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.
www.path.ox.ac.uk
September 9, 2025 at 9:22 AM
The annual Dunn School DPhil studentship competition for 2026 is open for applications.
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...
We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.
www.path.ox.ac.uk/project/mech...