Cell Biology J-Club
@cellclub.bsky.social
SHORT DISORDERED PEPTIDES ARE SUFFICIENT TO CONVERT PROTEINS INTO MECHANOSENSORS THAT RESPOND TO PHYSIOLOGICAL CELLULAR FORCES www.biorxiv.org/content/10.1...
www.biorxiv.org
November 14, 2025 at 4:42 PM
SHORT DISORDERED PEPTIDES ARE SUFFICIENT TO CONVERT PROTEINS INTO MECHANOSENSORS THAT RESPOND TO PHYSIOLOGICAL CELLULAR FORCES www.biorxiv.org/content/10.1...
High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation url: rupress.org/jcb/article/...
High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation | Journal of Cell Biology | Rockefeller University Press
Cao, Peng, and Yang et al. present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. The interpretable fea
rupress.org
November 14, 2025 at 4:37 PM
High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation url: rupress.org/jcb/article/...
A dynamic feedback loop between retrograde sterol transport and TORC2 controls adaptation of the plasma membrane to stress | The EMBO Journal www.embopress.org/doi/full/10....
A dynamic feedback loop between retrograde sterol transport and TORC2 controls adaptation of the plasma membrane to stress | The EMBO Journal
imageimageSterols are essential components of eukaryotic membranes and play a key role in defining
membrane properties. This study shows that, in yeast, a TORC2 feedback loop allows
the plasma membran...
www.embopress.org
November 14, 2025 at 4:34 PM
A dynamic feedback loop between retrograde sterol transport and TORC2 controls adaptation of the plasma membrane to stress | The EMBO Journal www.embopress.org/doi/full/10....
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:47 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome: Cell www.cell.com/cell/fulltex...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Grammars inferred using NARDINI+ (GIN) is a resource that uncovers molecular grammars
of intrinsically disordered regions (IDRs) across the human proteome, revealing how
distinct grammars underlie pro...
www.cell.com
November 13, 2025 at 6:03 PM
Molecular grammars of predicted intrinsically disordered regions that span the human proteome: Cell www.cell.com/cell/fulltex...
Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion url: rupress.org/jcb/article/...
Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion | Journal of Cell Biology | Rockefeller University Press
Teng et al. investigate the cellular basis for tissue fusion during mammalian lip formation. They demonstrate that actomyosin contractility drives fusion,
rupress.org
November 13, 2025 at 5:22 PM
Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion url: rupress.org/jcb/article/...
The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy | Science Advances www.science.org/doi/10.1126/...
The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy
Revealing mechanisms of mtDNA transmission is critical for combating human disease.
www.science.org
November 13, 2025 at 5:18 PM
The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy | Science Advances www.science.org/doi/10.1126/...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...
www.nature.com
November 12, 2025 at 7:07 PM
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C www.biorxiv.org/content/10.1...
Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C
Bridge-like lipid transfer proteins (BLTPs) play central roles in redistributing lipids from their primary site of synthesis in the endoplasmic reticulum to other organelles. They comprise bridge-doma...
www.biorxiv.org
November 12, 2025 at 4:43 PM
Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C www.biorxiv.org/content/10.1...
Intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction www.biorxiv.org/content/10.1...
www.biorxiv.org
November 11, 2025 at 3:16 PM
Intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction www.biorxiv.org/content/10.1...
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology
Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...
www.nature.com
November 11, 2025 at 3:08 PM
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy www.biorxiv.org/content/10.1...
www.biorxiv.org
November 10, 2025 at 3:20 PM
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy www.biorxiv.org/content/10.1...
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb url: rupress.org/jcb/article-...
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb
Li et al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting myosin I–dependent me
rupress.org
November 10, 2025 at 3:17 PM
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb url: rupress.org/jcb/article-...
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans - Nature Communications
This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...
www.nature.com
November 10, 2025 at 3:16 PM
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites www.biorxiv.org/content/10.1...
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites
Phosphatidic acid (PA) is a central metabolic intermediate that can fuel triacylglycerol (TAG) synthesis in lipid droplets (LDs) or cardiolipin production in mitochondria, but how cells partition PA b...
www.biorxiv.org
November 8, 2025 at 9:59 PM
ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites www.biorxiv.org/content/10.1...
An Asgard archaeon with internal membrane compartments www.biorxiv.org/content/10.1...
An Asgard archaeon with internal membrane compartments
The emergence of eukaryotes from a merger between an archaeon and a bacterial cell ~two billion years ago involved a profound change in cellular organisation. While the order in which different featur...
www.biorxiv.org
November 7, 2025 at 4:12 PM
An Asgard archaeon with internal membrane compartments www.biorxiv.org/content/10.1...
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors url: rupress.org/jcb/article-...
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors
Calvo et al. describe a new bioluminescent sensor for measuring luminal Ca2+ in a mildly acidic subcompartment of the endo-lysosomal system. This Ca2+ stor
rupress.org
November 7, 2025 at 4:08 PM
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors url: rupress.org/jcb/article-...
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80 - Nature Communications
Familial spastic paraplegia (SPG) is a rare heritable neurodegenerative disorders. Here, the authors show SPG80-associated protein UBAP1 deficiency disrupts lysosomal and mTORC1 signal, indicating rap...
www.nature.com
November 7, 2025 at 4:06 PM
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
www.science.org
November 6, 2025 at 9:36 PM
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...
Contact-dependent incorporation of endoplasmic reticulum into retraction fibers and migrasomes url: rupress.org/jcb/article-...
Contact-dependent incorporation of endoplasmic reticulum into retraction fibers and migrasomes
Tubular ER extends into retraction fibers and migrasomes through microtubule-dependent ER extension and ER-plasma MCSs in migrating cells. MCSs facilitate
rupress.org
November 6, 2025 at 2:39 PM
Contact-dependent incorporation of endoplasmic reticulum into retraction fibers and migrasomes url: rupress.org/jcb/article-...
Mechanism of Arp2/3 complex branch disassembly by human Coro7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanism of Arp2/3 complex branch disassembly by human Coro7 - Nature Communications
Arp2/3 complex forms branched actin networks that drive cell and organelle motility. Here, authors show that Coro7 targets branch junctions by binding Arp2/3 complex and actin filaments, promoting deb...
www.nature.com
November 6, 2025 at 2:37 PM
Mechanism of Arp2/3 complex branch disassembly by human Coro7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Exciting seminars coming up tomorrow on Zoom! felixcampelo.wixsite.com/membranetraf...
1. Agata Witkowka (V. Haucke's Group)
Mechanical control of neurotransmission via a disordered domain of an endocytic protein
2. Abdou Rachid Thiam –
Lipid storage mechanisms in health and disease
1. Agata Witkowka (V. Haucke's Group)
Mechanical control of neurotransmission via a disordered domain of an endocytic protein
2. Abdou Rachid Thiam –
Lipid storage mechanisms in health and disease
MEMBRANE TRAFFICKING | Membrane Trafficking
felixcampelo.wixsite.com
November 5, 2025 at 9:11 PM
Exciting seminars coming up tomorrow on Zoom! felixcampelo.wixsite.com/membranetraf...
1. Agata Witkowka (V. Haucke's Group)
Mechanical control of neurotransmission via a disordered domain of an endocytic protein
2. Abdou Rachid Thiam –
Lipid storage mechanisms in health and disease
1. Agata Witkowka (V. Haucke's Group)
Mechanical control of neurotransmission via a disordered domain of an endocytic protein
2. Abdou Rachid Thiam –
Lipid storage mechanisms in health and disease
Reposted by Cell Biology J-Club
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 5, 2025 at 6:27 PM
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity www.biorxiv.org/content/10.1...
Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity
The endolysosomal phospholipid, bis(monoacylglycerol)phosphate (BMP), is aberrantly elevated in the urine of Parkinson's patients with mutations in genes encoding leucine-rich repeat kinase 2 (LRRK2) ...
www.biorxiv.org
November 5, 2025 at 2:50 PM
Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity www.biorxiv.org/content/10.1...