Michael Way
@drmichaelway.bsky.social
Cell Biologist working at Crick Institute @crick.ac.uk - Cytoskeleton, Arp2/3 iso-complexes, Signalling and Vaccinia Virus. Editor-in chief Journal Cell Science - @jcellsci.bsky.social - comments are my own opinion
Pinned
Michael Way
@drmichaelway.bsky.social
· Dec 3
SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.
When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...
www.biorxiv.org
SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Michael Way
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
Researchers at the Crick have uncovered how certain proteins that become exposed on dying tumour cells can be detected by the immune system, alerting it to the cancer’s presence and prompting an immune response.
www.crick.ac.uk/news/2025-12...
www.crick.ac.uk/news/2025-12...
Lifting cancer’s invisibility cloak
Dying tumour cells alert the immune system to fight cancer.
www.crick.ac.uk
January 2, 2026 at 5:26 PM
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
Reposted by Michael Way
Happy New Year from Heidelberg and looking forward to SingMalNet in Singapore in February, BioMalPar in sunny Heidelberg in May and other adventures.
January 1, 2026 at 11:22 AM
Happy New Year from Heidelberg and looking forward to SingMalNet in Singapore in February, BioMalPar in sunny Heidelberg in May and other adventures.
Reposted by Michael Way
Pssst! I have a PhD position available. Please pass it on
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge) on FindAPhD.com
PhD Project - Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge), listed on FindAPhD.com
www.findaphd.com
December 28, 2025 at 6:18 PM
Pssst! I have a PhD position available. Please pass it on
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Michael Way
Should funders mandate where grantees can publish?
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
December 24, 2025 at 12:12 AM
Should funders mandate where grantees can publish?
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Reposted by Michael Way
Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Modeling human embryo implantation in vitro
Building an in vitro model of receptive endometrium allows investigation of human
embryo implantation and early post-implantation development and recapitulates the
earliest stages in establishing the ...
www.cell.com
December 23, 2025 at 3:55 PM
Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Michael Way
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
At the helm of JCS – Editors-in-Chief past, present… and future
The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...
doi.org
December 22, 2025 at 10:33 AM
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
Reposted by Michael Way
This crazy world got you feeling down? Just listen to a little perspective from Monty Python’s Meaning of Life:
#MontyPython #meaningoflife
#MontyPython #meaningoflife
December 20, 2025 at 3:04 AM
This crazy world got you feeling down? Just listen to a little perspective from Monty Python’s Meaning of Life:
#MontyPython #meaningoflife
#MontyPython #meaningoflife
Reposted by Michael Way
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
December 19, 2025 at 4:13 PM
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
Reposted by Michael Way
Great job Andrew!
Andrew Neumann, Rytis Prekeris @prekerislab.bsky.social and colleagues discover a leading role for Rap2 in cell migration.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 19, 2025 at 2:30 PM
Great job Andrew!
Reposted by Michael Way
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
December 18, 2025 at 2:42 PM
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Seen on way back to London from ASCB. As Jez Carlton said “if rudder falls off will it regenerate”. Have a good flight home everyone after another great meeting…… long may ASCB continue
December 10, 2025 at 7:24 PM
Seen on way back to London from ASCB. As Jez Carlton said “if rudder falls off will it regenerate”. Have a good flight home everyone after another great meeting…… long may ASCB continue
Reposted by Michael Way
Graffiti spotted on artwork at #cellbio2025
December 10, 2025 at 1:11 PM
Graffiti spotted on artwork at #cellbio2025
Reposted by Michael Way
It's free to publish in JCS - there are no page charges, colour charges or hidden fees.
We also offer various #OA options and routes to help you comply with funder mandates.
Visit booth 1232 at #CellBio2025 or journals.biologists.com/jcs/pages/re... to find out more.
#ForScientistsByScientists
We also offer various #OA options and routes to help you comply with funder mandates.
Visit booth 1232 at #CellBio2025 or journals.biologists.com/jcs/pages/re... to find out more.
#ForScientistsByScientists
December 9, 2025 at 2:21 PM
It's free to publish in JCS - there are no page charges, colour charges or hidden fees.
We also offer various #OA options and routes to help you comply with funder mandates.
Visit booth 1232 at #CellBio2025 or journals.biologists.com/jcs/pages/re... to find out more.
#ForScientistsByScientists
We also offer various #OA options and routes to help you comply with funder mandates.
Visit booth 1232 at #CellBio2025 or journals.biologists.com/jcs/pages/re... to find out more.
#ForScientistsByScientists
Reposted by Michael Way
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover th...
www.biorxiv.org
December 6, 2025 at 6:48 AM
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
Reposted by Michael Way
Also in Issue 22:
- Research Highlights on spindle assembly & cell migration
- Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy @roylab-ucsd.bsky.social
- Clathrin-mediated endocytosis at a glance
- Adherens junction Review
journals.biologists.com/jcs/issue/13...
- Research Highlights on spindle assembly & cell migration
- Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy @roylab-ucsd.bsky.social
- Clathrin-mediated endocytosis at a glance
- Adherens junction Review
journals.biologists.com/jcs/issue/13...
December 4, 2025 at 11:44 AM
Also in Issue 22:
- Research Highlights on spindle assembly & cell migration
- Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy @roylab-ucsd.bsky.social
- Clathrin-mediated endocytosis at a glance
- Adherens junction Review
journals.biologists.com/jcs/issue/13...
- Research Highlights on spindle assembly & cell migration
- Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy @roylab-ucsd.bsky.social
- Clathrin-mediated endocytosis at a glance
- Adherens junction Review
journals.biologists.com/jcs/issue/13...
Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB @ascbiology.bsky.social in Philadelphia. Just drop me a line.
December 4, 2025 at 8:42 AM
Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB @ascbiology.bsky.social in Philadelphia. Just drop me a line.
Reposted by Michael Way
New #cryo-EM #preprint- 'Structural mechanisms of drebrin-mediated F-actin network modulation'. Weilong impressively classified out two small #actin binding domains competing for the same surface on #F-actin, one of which also exists in two conformations! #drebrin
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 3, 2025 at 11:20 AM
Reposted by Michael Way
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 9:02 PM
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.
When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...
www.biorxiv.org
December 3, 2025 at 8:30 AM
SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Michael Way
We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...
November 28, 2025 at 2:04 PM
We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...
Reposted by Michael Way
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Postdoctoral Fellow - H Yardimci Lab
www.crick.ac.uk
November 25, 2025 at 11:55 AM
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
how do they do if you lower the temp?
So i'm usually interested about how cells divide in the cold, but couldnt resist helping out a tiny bit for a Euk dividing at 63°C.
Congrats to the whole team @hbrappap.bsky.social & Kudos to @fmikus.bsky.social for yet again the almighty #UExM !
Congrats to the whole team @hbrappap.bsky.social & Kudos to @fmikus.bsky.social for yet again the almighty #UExM !
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:59 PM
how do they do if you lower the temp?
wow....just wondering if they might also have Mimiviruses.......as wouldn't want to meet one of them!
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:57 PM
wow....just wondering if they might also have Mimiviruses.......as wouldn't want to meet one of them!