Caetano Reis e Sousa
@reisesousalab.bsky.social
We are the Immunobiology Lab at the Francis Crick Institute (@crick.ac.uk). We study how the body detects and responds to infection, cancer and tissue damage.
Reposted by Caetano Reis e Sousa
Don't miss the 2026 Global Immunotalks!
February 4, 2026 at 6:19 AM
Don't miss the 2026 Global Immunotalks!
Here is a blurb with excerpts from an interview I gave about serendipity in science and the importance of supporting discovery research.
www.the-scientist.com/can-science-...
www.the-scientist.com/can-science-...
Can Science Still Afford Serendipity?
Serendipitous observations have shaped science for centuries. What happens to such discoveries when the academic atmosphere leaves no room for detours?
www.the-scientist.com
January 30, 2026 at 8:43 AM
Here is a blurb with excerpts from an interview I gave about serendipity in science and the importance of supporting discovery research.
www.the-scientist.com/can-science-...
www.the-scientist.com/can-science-...
Wonderful appointment! Look forward to hearing all about Mariana’s adventures in the Belkaid lab.
We're excited to welcome @marianapdc.bsky.social to the lab as our newest postdoctoral fellow! We're thrilled to have her expertise in the study of dendritic cells and her energy join the team. 😊 Welcome aboard!
January 15, 2026 at 11:04 AM
Wonderful appointment! Look forward to hearing all about Mariana’s adventures in the Belkaid lab.
Many congratulations to @belkaidlab.bsky.social and @doetschlab.bsky.social on being named the Jeantet Laureates for 2026!
📢 The Louis-Jeantet Foundation is happy to announce the 2026 #LouisJeantetPrizes, awarded to YASMINE BELKAID @pasteur.fr and to FIONA DOETSCH @doetschlab.bsky.social hlab.bsky.social @biozentrum.unibas.ch @unibas.ch
CONGRATULATIONS!!!
👉 jeantet.ch/en
👇 follow thread
CONGRATULATIONS!!!
👉 jeantet.ch/en
👇 follow thread
January 15, 2026 at 11:02 AM
Many congratulations to @belkaidlab.bsky.social and @doetschlab.bsky.social on being named the Jeantet Laureates for 2026!
Thanks to @acir-org.bsky.social for highlighting our article!
January 14, 2026 at 5:43 PM
Thanks to @acir-org.bsky.social for highlighting our article!
As is tradition we hold our lab Xmas lunch in January with cheese fondue! Thank you to my wonderful team and looking forward to a new year of continued great science.
January 9, 2026 at 8:15 PM
As is tradition we hold our lab Xmas lunch in January with cheese fondue! Thank you to my wonderful team and looking forward to a new year of continued great science.
Reposted by Caetano Reis e Sousa
Very grateful to Prof. Blander & Dr. Jha for a thoughtful @natimmunol.nature.com 𝘕𝘦𝘸𝘴 & 𝘝𝘪𝘦𝘸𝘴 piece on our work 🙏
📄 A clear & critical perspective that places our findings in the broader context of dendritic cell biology, cross-presentation, and tumour immunoediting.
@reisesousalab.bsky.social
📄 A clear & critical perspective that places our findings in the broader context of dendritic cell biology, cross-presentation, and tumour immunoediting.
@reisesousalab.bsky.social
Tethered neoantigens from the dead sculpt tumor fate - Nature Immunology
New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-e...
www.nature.com
January 2, 2026 at 5:22 PM
Very grateful to Prof. Blander & Dr. Jha for a thoughtful @natimmunol.nature.com 𝘕𝘦𝘸𝘴 & 𝘝𝘪𝘦𝘸𝘴 piece on our work 🙏
📄 A clear & critical perspective that places our findings in the broader context of dendritic cell biology, cross-presentation, and tumour immunoediting.
@reisesousalab.bsky.social
📄 A clear & critical perspective that places our findings in the broader context of dendritic cell biology, cross-presentation, and tumour immunoediting.
@reisesousalab.bsky.social
A great summary by @drjonlim.bsky.social!
My main PhD paper is finally out! 🎉
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
January 2, 2026 at 5:27 PM
A great summary by @drjonlim.bsky.social!
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
Researchers at the Crick have uncovered how certain proteins that become exposed on dying tumour cells can be detected by the immune system, alerting it to the cancer’s presence and prompting an immune response.
www.crick.ac.uk/news/2025-12...
www.crick.ac.uk/news/2025-12...
Lifting cancer’s invisibility cloak
Dying tumour cells alert the immune system to fight cancer.
www.crick.ac.uk
January 2, 2026 at 5:26 PM
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
The effect of shingles vaccination at different stages of the dementia disease course
A natural experiment found that herpes zoster vaccination reduced the occurrence of
mild cognitive impairment and deaths due to dementia, indicating that the vaccine
may slow the progression of dement...
www.cell.com
December 12, 2025 at 11:12 AM
Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Spot on!
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
www.bbc.com/news/article...
Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.
www.bbc.com
December 5, 2025 at 8:11 AM
Spot on!
Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...
Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
www.theguardian.com
December 1, 2025 at 10:15 PM
Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...
Reposted by Caetano Reis e Sousa
Last night we held our annual Crick Awards ceremony, presented by our Director Edith Heard, COO Claire Hook and guest host @bobbyseagull.bsky.social to celebrate the amazing people behind everything we do here.
Follow the posts below to see this year's winners.
Follow the posts below to see this year's winners.
November 28, 2025 at 11:29 AM
Last night we held our annual Crick Awards ceremony, presented by our Director Edith Heard, COO Claire Hook and guest host @bobbyseagull.bsky.social to celebrate the amazing people behind everything we do here.
Follow the posts below to see this year's winners.
Follow the posts below to see this year's winners.
Reposted by Caetano Reis e Sousa
We had another full house at our Annual Science Meeting this week, which featured over 100 posters and 30 talks by our Crick colleagues.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
November 7, 2025 at 10:28 AM
We had another full house at our Annual Science Meeting this week, which featured over 100 posters and 30 talks by our Crick colleagues.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
Cool new paper from @drmichaelway.bsky.social. Check it out!
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
How weakness in cell structure affects the host-microbiome relationship
Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk
November 13, 2025 at 9:22 PM
Cool new paper from @drmichaelway.bsky.social. Check it out!
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
November 13, 2025 at 9:18 PM
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
Reposted by Caetano Reis e Sousa
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
November 6, 2025 at 9:02 AM
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
End of our Annual Science Meeting @crick.ac.uk with a quiz. - happy winners and quiz organisers below. Thanks to everyone who made these two days of science so inspiring and enjoyable!
November 6, 2025 at 8:50 PM
End of our Annual Science Meeting @crick.ac.uk with a quiz. - happy winners and quiz organisers below. Thanks to everyone who made these two days of science so inspiring and enjoyable!
Great day today @crick.ac.uk Annual Science Meeting. Lots of exciting science and a convivial atmosphere. Looking forward to Day 2 tomorrow!
November 5, 2025 at 11:28 PM
Great day today @crick.ac.uk Annual Science Meeting. Lots of exciting science and a convivial atmosphere. Looking forward to Day 2 tomorrow!
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 5:23 PM
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Wonderful day celebrating Paul Nurse after he steps down from being the Director @crick.ac.uk. We are all very grateful to him for having created an amazing institute.
October 23, 2025 at 8:35 PM
Wonderful day celebrating Paul Nurse after he steps down from being the Director @crick.ac.uk. We are all very grateful to him for having created an amazing institute.
Reposted by Caetano Reis e Sousa
Researchers at the Crick found that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
Hunger influences the behaviour of female mice towards pups
Researchers find that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.
www.crick.ac.uk
October 22, 2025 at 3:14 PM
Researchers at the Crick found that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
Amazing opportunity.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:57 PM
Amazing opportunity.
Applications for the Crick PhD programme now open. One studentship available in our lab, starting Autumn 2026. Apply!
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 2, 2025 at 7:48 PM
Applications for the Crick PhD programme now open. One studentship available in our lab, starting Autumn 2026. Apply!
Reposted by Caetano Reis e Sousa
NEW PODCAST: ‘A Question of Science’ with Professor Brian Cox.
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
September 17, 2025 at 5:25 AM
NEW PODCAST: ‘A Question of Science’ with Professor Brian Cox.
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB