Fran Bottanelli
@franbottanelli.bsky.social
Solver of GTPases molecular puzzles | Membranes | CRISPR | STED super-res |Accidental immunologist | Academic mother of 2 cheeky monkeys | Assistant prof at FU Berlin. | Head of the Nanoscale Membrane Dynamics Lab
Pinned
After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...
To register your interest: www.biologists.com/meetings/jcs...
Save the date for what promises to be an amazing imaging/cell biology meeting!
Reposted by Fran Bottanelli
The latest version of our collaboration with Katalin Torok and her lab is up. We report some new glutamate sensors. Great work from Sara Bertelli in Berlin and the whole team in London (Holly & Oanh particularly).
www.biorxiv.org/content/10.1...
1/6
1/6
iGlu3Fast and iGlu3Slow, improved fluorescent reporters for detection of spontaneous glutamate activity in the brain
The genetically-encoded fluorescent glutamate sensor, iGluSnFR3, characterised by a high dynamic range and rapid on-kinetics, is an attractive sensor for glutamate imaging in the central nervous syste...
www.biorxiv.org
October 12, 2025 at 4:24 PM
The latest version of our collaboration with Katalin Torok and her lab is up. We report some new glutamate sensors. Great work from Sara Bertelli in Berlin and the whole team in London (Holly & Oanh particularly).
www.biorxiv.org/content/10.1...
1/6
1/6
Reposted by Fran Bottanelli
Can we move forward to 2027?
Pride Rainbow GIF
ALT: Pride Rainbow GIF
media.tenor.com
January 3, 2026 at 9:00 PM
Can we move forward to 2027?
Looks like a great start into 2026!
elmo from sesame street is standing in front of a wall of fire .
ALT: elmo from sesame street is standing in front of a wall of fire .
media.tenor.com
January 3, 2026 at 8:59 PM
Looks like a great start into 2026!
Reposted by Fran Bottanelli
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
At the helm of JCS – Editors-in-Chief past, present… and future
The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...
doi.org
December 22, 2025 at 10:33 AM
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
Pressing “submit” before the Christmas holidays
December 24, 2025 at 8:38 AM
Pressing “submit” before the Christmas holidays
Reposted by Fran Bottanelli
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
The Center is a wonderful collaboration with scientists extraordinaire @taijamakinenlab.bsky.social Kari Vaahtomeri and Cecilia Sahlgren.
We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
I am delighted to introduce our new Centre of Excellence in Immune-Endothelial Interfaces (IMMENs) funded by the Research Council of Finland.
www.helsinki.fi/en/researchg...
I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
www.helsinki.fi/en/researchg...
I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
December 21, 2025 at 8:58 AM
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
Reposted by Fran Bottanelli
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
December 22, 2025 at 2:57 PM
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
Reposted by Fran Bottanelli
Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM
December 18, 2025 at 9:56 AM
Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM
How your request of proof corrections by Dec 31st find me #PIlife Whether you celebrate or not have a relaxing time or a wonderful Christmas! See you hopefully in a better 2026
a picture of a child on a slide with the words off work like
ALT: a picture of a child on a slide with the words off work like
media.tenor.com
December 23, 2025 at 8:26 PM
How your request of proof corrections by Dec 31st find me #PIlife Whether you celebrate or not have a relaxing time or a wonderful Christmas! See you hopefully in a better 2026
Since I have been giving metabolism classes I cannot stop thinking about how messed up is my NADH/NAD+ balance in this moment #scienceholidays
December 19, 2025 at 9:05 PM
Since I have been giving metabolism classes I cannot stop thinking about how messed up is my NADH/NAD+ balance in this moment #scienceholidays
Reposted by Fran Bottanelli
If you're wondering if your manuscript could be suitable for our special issue but are unsure, don't hesitate to reach out 👍
In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
December 18, 2025 at 8:26 PM
If you're wondering if your manuscript could be suitable for our special issue but are unsure, don't hesitate to reach out 👍
Giving a lecture on the last day before the holidays #PIlife
a robot stands in the middle of a desert with his hands on his hips
ALT: a robot stands in the middle of a desert with his hands on his hips
media.tenor.com
December 18, 2025 at 7:17 PM
Giving a lecture on the last day before the holidays #PIlife
Reposted by Fran Bottanelli
In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
December 18, 2025 at 2:47 PM
In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
Reposted by Fran Bottanelli
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
December 18, 2025 at 2:42 PM
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Reposted by Fran Bottanelli
I had a great day yesterday at UK Membrane Traffic in London. Too many highlights to mention. There's so much exciting work in this field! This year there was a poster session which was a great addition to get more people involved in the meeting. Thanks to Chris Stefan & Jez Carlton for organising.
December 16, 2025 at 6:39 AM
I had a great day yesterday at UK Membrane Traffic in London. Too many highlights to mention. There's so much exciting work in this field! This year there was a poster session which was a great addition to get more people involved in the meeting. Thanks to Chris Stefan & Jez Carlton for organising.
Reposted by Fran Bottanelli
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
www.biorxiv.org
December 16, 2025 at 6:35 AM
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Reposted by Fran Bottanelli
@natcellbio.nature.com - Finally out! Skin cells mechanically protect their genome from UV by positioning melanin above nucleus. Keratin filaments & microtubules drive the process. Led by Silvia Benito-Martinez & @laurasalavessa.bsky.social @membramics-lab.bsky.social www.nature.com/articles/s41...
Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection - Nature Cell Biology
Benito-Martínez, Salavessa and colleagues show that keratin intermediate filaments and microtubules control the three-dimensional perinuclear position of melanin-containing organelles, shielding the D...
www.nature.com
December 15, 2025 at 6:17 PM
@natcellbio.nature.com - Finally out! Skin cells mechanically protect their genome from UV by positioning melanin above nucleus. Keratin filaments & microtubules drive the process. Led by Silvia Benito-Martinez & @laurasalavessa.bsky.social @membramics-lab.bsky.social www.nature.com/articles/s41...
Dear Santa could you please do half of the things on my to do list? Thanks.
a woman in a santa hat is pushing a red shopping cart in a store .
ALT: a woman in a santa hat is pushing a red shopping cart in a store .
media.tenor.com
December 15, 2025 at 8:48 AM
Dear Santa could you please do half of the things on my to do list? Thanks.
Reposted by Fran Bottanelli
Rivero-Ríos, Sutton, Weisman and colleagues show that PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. rupress.org/jcb/article/...
📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025
📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025
December 9, 2025 at 6:15 PM
Rivero-Ríos, Sutton, Weisman and colleagues show that PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. rupress.org/jcb/article/...
📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025
📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025
Thank you @cancelluio.bsky.social @annesimonsen.bsky.social lab for the wonderful two days of BEACH domain proteins and BEACH parties! It’s always nice to be back in Oslo. I even manage to walk to the roof of the famous opera house this time!
December 10, 2025 at 1:14 PM
Thank you @cancelluio.bsky.social @annesimonsen.bsky.social lab for the wonderful two days of BEACH domain proteins and BEACH parties! It’s always nice to be back in Oslo. I even manage to walk to the roof of the famous opera house this time!
Reviews requests mid December
December 7, 2025 at 7:18 PM
Reviews requests mid December
Reposted by Fran Bottanelli
Missed #FluorescenceFriday, but let's go for #GlowingSaturday!
freshly out of the prep JF549 derivative for a colleague
freshly out of the prep JF549 derivative for a colleague
December 6, 2025 at 9:43 AM
Missed #FluorescenceFriday, but let's go for #GlowingSaturday!
freshly out of the prep JF549 derivative for a colleague
freshly out of the prep JF549 derivative for a colleague
MUST TRY NOW!
Preprint drop! 🚨 Rhobin-tag your proteins and watch Saci glow at high temps! 🔥 Bright, photostable, live-cell imaging made possible with JF dyes. Huge thanks to @samjlord.bsky.social @acharlesorszag.bsky.social @mullinslab.bsky.social and Bo Huang lab at UCSF.😊
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy
De novo protein design has emerged as a powerful strategy with the promise to create new tools. The practical performance of designed fluorophore binders, however, has remained far from meeting fluore...
www.biorxiv.org
December 4, 2025 at 9:14 PM
MUST TRY NOW!
Reposted by Fran Bottanelli
We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social
Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway | Journal of Cell Biology | Rockefeller University Press
The study reveals that newly synthesized integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance ce
doi.org
December 4, 2025 at 7:59 AM
We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social
Reposted by Fran Bottanelli
Historic day! 🌾
The #EU agrees on new rules for genomic techniques, paving the way for crops that better resist climate change and pests, deliver higher yields, and need fewer fertilisers & pesticides. A big step towards a more sustainable food system.
www.europarl.europa.eu/news/en/pres...
The #EU agrees on new rules for genomic techniques, paving the way for crops that better resist climate change and pests, deliver higher yields, and need fewer fertilisers & pesticides. A big step towards a more sustainable food system.
www.europarl.europa.eu/news/en/pres...
New genomic techniques: deal to support the green transition in farming | News | European Parliament
The new rules will make the EU food system more secure and sustainable, with climate- and pest-resistant plants that give higher yields and require fewer fertilisers and pesticides.
www.europarl.europa.eu
December 4, 2025 at 6:41 AM
Historic day! 🌾
The #EU agrees on new rules for genomic techniques, paving the way for crops that better resist climate change and pests, deliver higher yields, and need fewer fertilisers & pesticides. A big step towards a more sustainable food system.
www.europarl.europa.eu/news/en/pres...
The #EU agrees on new rules for genomic techniques, paving the way for crops that better resist climate change and pests, deliver higher yields, and need fewer fertilisers & pesticides. A big step towards a more sustainable food system.
www.europarl.europa.eu/news/en/pres...