Avezov lab
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avezovlab.bsky.social
Avezov lab
@avezovlab.bsky.social
Exploring brain cell biology, organelle dynamics & proteostasis.
📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
Pinned
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris
Reposted by Avezov lab
Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable

🙏
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
February 14, 2026 at 1:40 PM
Reposted by Avezov lab
Thanks Edward, any time :)
February 14, 2026 at 2:20 PM
Reposted by Avezov lab
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...
February 14, 2026 at 1:37 PM
Thanks Jonny for the generous creative effort, bottomless appetite to pushing the concept deeper. 🙏
Congrats Pierre and Edward!
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...
February 16, 2026 at 6:06 PM
Reposted by Avezov lab
Congrats Pierre and Edward!
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...
February 14, 2026 at 6:43 PM
Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable

🙏
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
February 14, 2026 at 1:40 PM
Reposted by Avezov lab
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
February 13, 2026 at 5:14 PM
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...
February 14, 2026 at 1:37 PM
Reposted by Avezov lab
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris
February 13, 2026 at 4:04 PM
Reposted by Avezov lab
☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE
ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology
Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.
bit.ly
February 13, 2026 at 6:13 PM
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris
February 13, 2026 at 4:04 PM
Reposted by Avezov lab
Good Morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...
bims-proteo 2026-02-01 papers
biomed.news
February 1, 2026 at 8:31 AM
Reposted by Avezov lab
Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
www.science.org
January 30, 2026 at 12:34 PM
Check this out
TuroID attached to inactive Cas to identify transcription regulators 👇
www.nature.com/articles/s41...
A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins - Nature Plants
The authors developed a CRISPR-based proximity labelling system to profile DNA-binding proteins in plants, especially the transcription factors of target genes, as exemplified by studies on the regula...
www.nature.com
January 27, 2026 at 8:14 AM
Reposted by Avezov lab
Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct.

Abstract submission/Registration by 31 May/15 Jun

https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪
January 19, 2026 at 6:45 AM
Reposted by Avezov lab
Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution.

www.biorxiv.org/content/10.6...
January 2, 2026 at 6:18 PM
Reposted by Avezov lab
mSumireF a Monomeric Violet Fluorescent Protein:
pubs.acs.org/doi/full/10....
January 8, 2026 at 6:15 PM
Reposted by Avezov lab
A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓
December 30, 2025 at 6:05 PM
A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓
December 30, 2025 at 6:05 PM
Reposted by Avezov lab
A glittery, festive #FluorescenceFriday today, spent playing with some fun samples 🪩🕺
December 12, 2025 at 3:32 PM
Reposted by Avezov lab
Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇
December 1, 2025 at 8:45 AM
Reposted by Avezov lab
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...
December 1, 2025 at 11:36 AM
Reposted by Avezov lab
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH

This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery
Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...
nature.com
November 4, 2025 at 4:12 PM
Reposted by Avezov lab
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM