Avezov lab
@avezovlab.bsky.social
Exploring brain cell biology, organelle dynamics & proteostasis.
📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
Pinned
Avezov lab
@avezovlab.bsky.social
· Nov 26
🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field.
See you there! **Please RT** 🥳
t.co/6eq3cyGlVZ
Reposted by Avezov lab
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery
Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...
nature.com
November 4, 2025 at 4:12 PM
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Reposted by Avezov lab
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
Reposted by Avezov lab
Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
September 29, 2025 at 6:12 PM
Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio
Reposted by Avezov lab
Researchers led by Prof Jernej Ule (@ulelab.bsky.social)
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡
The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡
The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...
Better together: researchers discover how cells keep groups of proteins in check
Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...
www.crick.ac.uk
September 29, 2025 at 4:20 PM
Researchers led by Prof Jernej Ule (@ulelab.bsky.social)
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡
The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡
The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...
Reposted by Avezov lab
Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
www.biorxiv.org
July 28, 2025 at 10:46 AM
Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
Reposted by Avezov lab
and the reverse is also true ... factors believed to exert their functions inside playing roles outside ....
July 28, 2025 at 2:38 PM
and the reverse is also true ... factors believed to exert their functions inside playing roles outside ....
Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
www.biorxiv.org
July 28, 2025 at 10:46 AM
Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...
and MANF before www.nature.com/articles/s41...
Reposted by Avezov lab
This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
🗣️: 4 #preprints from
@qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
🗣️: 4 #preprints from
@qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
bims-proteo 2025-07-20 papers
biomed.news
July 20, 2025 at 5:08 AM
This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
🗣️: 4 #preprints from
@qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
🗣️: 4 #preprints from
@qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Avezov lab
#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org 🧪 plos.io/4lv6gxu
July 11, 2025 at 1:27 PM
#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org 🧪 plos.io/4lv6gxu
Check this out 👇fly sleep and organelle
morphology changes www.nature.com/articles/s41...
morphology changes www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
July 16, 2025 at 7:53 PM
Check this out 👇fly sleep and organelle
morphology changes www.nature.com/articles/s41...
morphology changes www.nature.com/articles/s41...
Reposted by Avezov lab
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox www.science.org/doi/10.1126/...
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
www.science.org
July 11, 2025 at 10:50 AM
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox www.science.org/doi/10.1126/...
Reposted by Avezov lab
. @whiteheadinstitute.bsky.social researchers developed Perturb-Multimodal, a powerful new approach that simultaneously measures how genetic changes affect both #GeneExpression and cell structure in intact liver tissue.
📰: bit.ly/440TrVi
📝 @cellpress.bsky.social: bit.ly/3TEs2ST
📰: bit.ly/440TrVi
📝 @cellpress.bsky.social: bit.ly/3TEs2ST
June 25, 2025 at 8:08 PM
. @whiteheadinstitute.bsky.social researchers developed Perturb-Multimodal, a powerful new approach that simultaneously measures how genetic changes affect both #GeneExpression and cell structure in intact liver tissue.
📰: bit.ly/440TrVi
📝 @cellpress.bsky.social: bit.ly/3TEs2ST
📰: bit.ly/440TrVi
📝 @cellpress.bsky.social: bit.ly/3TEs2ST
Reposted by Avezov lab
Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells.
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
Researchers identify lost genetic messages as a target for treating dementia
Researchers at the Francis Crick Institute and UCL have shown that genetic messages are misplaced in nerve cells in a model of Alzheimer’s disease and frontotemporal dementia.
www.crick.ac.uk
June 25, 2025 at 3:12 PM
Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells.
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
Reposted by Avezov lab
🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
June 18, 2025 at 5:07 PM
🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)
Where we explore how the physical properties of living systems can help cells process spatial information.
Reposted by Avezov lab
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
June 6, 2025 at 1:46 PM
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
Reposted by Avezov lab
Researchers led by @clairedurrant1.bsky.social have used living human brain tissue to show for the first time how a toxic protein in Alzheimer’s can damage synapses👏
The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa
The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa
April 30, 2025 at 4:08 PM
Researchers led by @clairedurrant1.bsky.social have used living human brain tissue to show for the first time how a toxic protein in Alzheimer’s can damage synapses👏
The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa
The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa
Reposted by Avezov lab
Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!
🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
April 25, 2025 at 10:25 AM
Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!
Reposted by Avezov lab
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
April 24, 2025 at 1:19 PM
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
This is one to watch 🔬Congratulations!
#newPI and time is running.
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
April 23, 2025 at 8:02 AM
This is one to watch 🔬Congratulations!
Reposted by Avezov lab
Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience
Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...
www.nature.com
April 1, 2025 at 4:06 PM
Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!
Reposted by Avezov lab
I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway
Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...
rdcu.be
March 25, 2025 at 12:37 PM
I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Reposted by Avezov lab
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 24, 2025 at 3:02 PM
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
