Avezov lab
@avezovlab.bsky.social
Exploring brain cell biology, organelle dynamics & proteostasis.
📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
Pinned
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
Reposted by Avezov lab
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...
www.science.org
February 20, 2026 at 11:06 AM
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Reposted by Avezov lab
Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable
🙏
🙏
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
February 14, 2026 at 1:40 PM
Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable
🙏
🙏
Reposted by Avezov lab
Thanks Edward, any time :)
February 14, 2026 at 2:20 PM
Thanks Edward, any time :)
Reposted by Avezov lab
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 14, 2026 at 1:37 PM
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thanks Jonny for the generous creative effort, bottomless appetite to pushing the concept deeper. 🙏
Congrats Pierre and Edward!
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 16, 2026 at 6:06 PM
Thanks Jonny for the generous creative effort, bottomless appetite to pushing the concept deeper. 🙏
Reposted by Avezov lab
Congrats Pierre and Edward!
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 14, 2026 at 6:43 PM
Congrats Pierre and Edward!
Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable
🙏
🙏
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
February 14, 2026 at 1:40 PM
Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable
🙏
🙏
Reposted by Avezov lab
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
February 13, 2026 at 5:14 PM
Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 14, 2026 at 1:37 PM
🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Avezov lab
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
February 13, 2026 at 4:04 PM
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
Reposted by Avezov lab
☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE
bit.ly/40dNHEE
ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology
Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.
bit.ly
February 13, 2026 at 6:13 PM
☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE
bit.ly/40dNHEE
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
February 13, 2026 at 4:04 PM
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
Reposted by Avezov lab
Good Morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...
bims-proteo 2026-02-01 papers
biomed.news
February 1, 2026 at 8:31 AM
Good Morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...
Reposted by Avezov lab
Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
www.science.org
January 30, 2026 at 12:34 PM
Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
Check this out
TuroID attached to inactive Cas to identify transcription regulators 👇
www.nature.com/articles/s41...
TuroID attached to inactive Cas to identify transcription regulators 👇
www.nature.com/articles/s41...
A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins - Nature Plants
The authors developed a CRISPR-based proximity labelling system to profile DNA-binding proteins in plants, especially the transcription factors of target genes, as exemplified by studies on the regula...
www.nature.com
January 27, 2026 at 8:14 AM
Check this out
TuroID attached to inactive Cas to identify transcription regulators 👇
www.nature.com/articles/s41...
TuroID attached to inactive Cas to identify transcription regulators 👇
www.nature.com/articles/s41...
Reposted by Avezov lab
Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct.
Abstract submission/Registration by 31 May/15 Jun
https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪
Abstract submission/Registration by 31 May/15 Jun
https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪
January 19, 2026 at 6:45 AM
Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct.
Abstract submission/Registration by 31 May/15 Jun
https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪
Abstract submission/Registration by 31 May/15 Jun
https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪
Reposted by Avezov lab
Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 2, 2026 at 6:18 PM
Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Avezov lab
mSumireF a Monomeric Violet Fluorescent Protein:
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
January 8, 2026 at 6:15 PM
mSumireF a Monomeric Violet Fluorescent Protein:
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Avezov lab
A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓
December 30, 2025 at 6:05 PM
A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓
A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓
December 30, 2025 at 6:05 PM
A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓
Reposted by Avezov lab
A glittery, festive #FluorescenceFriday today, spent playing with some fun samples 🪩🕺
December 12, 2025 at 3:32 PM
A glittery, festive #FluorescenceFriday today, spent playing with some fun samples 🪩🕺
Reposted by Avezov lab
Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇
December 1, 2025 at 8:45 AM
Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇
Reposted by Avezov lab
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...
December 1, 2025 at 11:36 AM
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...
Reposted by Avezov lab
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery
Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...
nature.com
November 4, 2025 at 4:12 PM
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Reposted by Avezov lab
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv