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Nature Cell Biology
@natcellbio.nature.com
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A journal dedicated to publishing the latest advances across all areas of cell biology. Part of @natureportfolio.nature.com
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Nature Cell Biology @natcellbio.nature.com · 1h
👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...
natcellbio.nature.com
👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...
February 14, 2026 at 1:09 PM
natcellbio.nature.com
☕Bång-Rudenstam et al. report that the acidic #tumor microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent #ferroptosis, thereby providing an adaptive mechanism upon tumor acidosis.
bit.ly/3Mvuvz1
Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis - Nature Cell Biology
Bång-Rudenstam et al. report that the acidic tumour microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent ferroptosis, thereby pr...
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February 13, 2026 at 6:17 PM
natcellbio.nature.com
☕Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.
bit.ly/46MZ3Di
DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology
Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...
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February 13, 2026 at 6:15 PM
natcellbio.nature.com
☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE
ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology
Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.
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February 13, 2026 at 6:13 PM
natcellbio.nature.com
☕ @zyt0329.bsky.social et al develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH.
👉https://rdcu.be/e3TPL
bit.ly/4auh4aD
DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology
Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...
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February 13, 2026 at 6:07 PM
natcellbio.nature.com
☕Thendral et al. describe a mitophagic programme that removes deleterious mtDNA during the oocyte-to-zygote transition in C. elegans, promoting #mitochondria health and offspring survival. Loss of this #mitophagy leads to mutant mtDNA accumulation.
👉https://rdcu.be/e3tpJ
bit.ly/4aqi7Zk
Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance - Nature Cell Biology
Thendral et al. describe a mitophagic programme that removes deleterious mtDNA during the oocyte-to-zygote transition in Caenorhabditis elegans, promoting mitochondrial health and offspring survival. ...
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February 11, 2026 at 12:41 PM
natcellbio.nature.com
☕Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumulation at stalled forks followed by replication protein A exhaustion and cell death.
bit.ly/4rBKhYe
RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress - Nature Cell Biology
Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumu...
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February 11, 2026 at 12:39 PM
natcellbio.nature.com
☕Wang, Chu, Chen, Wei et al discover a subset of tumour-associated #macrophages expressing SLC2A1 whose spatial proximity to CD8+ T cells drives resistance to anti-PD-L1 treatment in non-small-cell #LungCancer.
bit.ly/4tCcNLd
SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer - Nature Cell Biology
Wang, Chu, Chen, Wei and colleagues discover a subset of tumour-associated macrophages expressing SLC2A1 whose spatial proximity to CD8+ T cells drives resistance to anti-PD-L1 treatment in non-small-...
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February 11, 2026 at 12:37 PM
natcellbio.nature.com
☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social
bit.ly/4asbwO3
p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology
Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...
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February 11, 2026 at 12:33 PM
Reposted by Nature Cell Biology
keisukeito-lab.bsky.social
Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
rdcu.be/e3smG
February 11, 2026 at 11:43 AM
natcellbio.nature.com
☕Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages #histology images and enhances the resolution of spatial #transcriptomics, thus enabling the dissection of complex tissue structures.
bit.ly/4chkfoD
The interpretable multimodal dimension reduction framework SpaHDmap enhances resolution in spatial transcriptomics - Nature Cell Biology
Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages histology images and enhances the resolution of spatial transcriptomics, thus...
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February 8, 2026 at 3:12 PM
natcellbio.nature.com
☕Li, Cui, Yang, Lu, Jiang, Zhang et al identify a lactate transport mechanism from tumor-associated #macrophages that regulates DNA repair and immune cell infiltration, which could be targeted to enhance #immunotherapy efficacy in #glioblastoma models.
👉https://rdcu.be/e2WxT
bit.ly/3MwtOph
Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma - Nature Cell Biology
Li, Cui, Yang, Lu, Jiang, Zhang and colleagues identify a lactate transport mechanism from tumour-associated macrophages that regulates DNA repair and immune cell infiltration, which could be targeted...
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February 8, 2026 at 3:09 PM
natcellbio.nature.com
☕Scourzic et al. showed that germinal centre #Bcells display an enhanced ability to #reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher #plasticity level and is T follicular helper cell-dependent.
👉https://rdcu.be/e2Wxm
bit.ly/4aDyDWY
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response - Nature Cell Biology
Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity ...
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February 8, 2026 at 3:04 PM
natcellbio.nature.com
☕ @karsten-rippe.bsky.social & co analyse #chromatin accessibility to identify sites that open simultaneously in response to TNF. They discover 2 distinct types of co-accessible regulatory module for controlling the induction of #proinflammatory gene expression.
👉https://rdcu.be/e2WwS
bit.ly/3MiB4oH
Two distinct chromatin modules regulate proinflammatory gene expression - Nature Cell Biology
Seufert et al. analyse chromatin accessibility to identify sites that open simultaneously in response to TNF. They discover two distinct types of co-accessible regulatory module for controlling the in...
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February 8, 2026 at 3:01 PM
natcellbio.nature.com
☕ @allanaschooley.bsky.social @jobdekker.bsky.social & co find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
bit.ly/4r6uO2D
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology
Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
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February 8, 2026 at 2:58 PM
natcellbio.nature.com
☕Smith and Bartel show that #mRNA recruitment to #StressGranules imparts resistance to the integrated stress response translational shutdown.
bit.ly/45WSNbP
The G3BP stress-granule proteins reinforce the integrated stress response translation programme - Nature Cell Biology
Smith and Bartel show that mRNA recruitment to stress granules imparts resistance to the integrated stress response translational shutdown.
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February 8, 2026 at 2:53 PM
natcellbio.nature.com
☕Using #pancreatic #organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.
bit.ly/4qozmjG
Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids - Nature Cell Biology
Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.
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February 8, 2026 at 2:51 PM
Reposted by Nature Cell Biology
slefkopoulos.bsky.social
🥂Congratulations to @nmoris.bsky.social & co for their study in our journal generating human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
bit.ly/3LoaXw2
Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology
Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumb...
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January 18, 2026 at 1:09 PM
natcellbio.nature.com
Join Springer Nature editors and the protocols.io team for an exciting event as part of #LoveMethods26!
🔮Gain insight on methods publishing at our Methods Mythbusting on Jan 22. Our editor Sabrya Carim will be there!
👉FREE registration & more details:
www.protocols.io/blog/join-pr...
Bring structure to your research - protocols.io
A secure platform for developing and sharing reproducible methods.
protocols.io
January 16, 2026 at 2:40 PM
natcellbio.nature.com
🎆 Happy new year and our first 2026 issue is out!
Cover: #epiblast development

👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!

www.nature.com/ncb/volumes/...
January 16, 2026 at 8:18 AM
natcellbio.nature.com
☕Borsa et al. show that asymmetric #Tcell division after activation requires #autophagy to promote #mitochondria turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.
bit.ly/458ODgL
Client Challenge
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January 13, 2026 at 5:59 PM
Reposted by Nature Cell Biology
slefkopoulos.bsky.social
🥂 Happy 2026 all! I 'm looking forward to working with as many of you as possible this year! I 'll be back in the office on Monday, so feel free to shoot emails for meetings and papers you might wanna discuss for @natcellbio.nature.com ! Let's see where #CellBiology takes us this year :D
January 3, 2026 at 10:59 AM
Reposted by Nature Cell Biology
slefkopoulos.bsky.social
🥂Congratulations to @grazianomartello.bsky.social & co: they optimize an in vitro human #epiblast model, which they use to show that early #TGFβ family inhibition prevents epithelial identity, while it is dispensable after epithelium formation.
👉https://rdcu.be/eVPMa

www.nature.com/articles/s41...
A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development - Nature Cell Biology
The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is dispensable after epithelium formation. ...
www.nature.com
January 4, 2026 at 5:05 PM
natcellbio.nature.com
☕ @nmoris.bsky.social & co generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
bit.ly/3LoaXw2
Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology
Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumb...
bit.ly
January 2, 2026 at 3:59 PM
natcellbio.nature.com
☕The authors show that increased #Xist RNA levels can induce de novo silencing of genes that normally escape #Xinactivation. SPEN depletion prevents the silencing of escape genes upon Xist RNA overexpression in neural progenitors. @agneseloda.bsky.social @heardlab.bsky.social
bit.ly/3YUnzhw
Escape from X inactivation is directly modulated by Xist noncoding RNA - Nature Cell Biology
The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape genes upon Xist RNA overexpre...
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January 2, 2026 at 3:56 PM