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Nature Cell Biology
@natcellbio.nature.com
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A journal dedicated to publishing the latest advances across all areas of cell biology. Part of @natureportfolio.nature.com
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Nature Cell Biology @natcellbio.nature.com · 7d
👋Our November issue's out!
Cover: Electrostatic forces in condensates

👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
natcellbio.nature.com
☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
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November 16, 2025 at 8:38 AM
natcellbio.nature.com
☕Liu et al. present TemporalVAE, a method for integrating single-cell time course data. The model proposes a workflow to determine the biological timing of samples and its temporally sensitive genes, enabling single-cell developmental stage inference.
👉https://rdcu.be/eP9HH
bit.ly/49VARB8
TemporalVAE: atlas-assisted temporal mapping of time-series single-cell transcriptomes during embryogenesis - Nature Cell Biology
Liu et al. present TemporalVAE, a method for integrating single-cell time course data. The model proposes a workflow to determine the biological timing of samples and its temporally sensitive genes, e...
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November 16, 2025 at 8:34 AM
natcellbio.nature.com
☕Xu, Kong, Li, Pisignano et al provide a map of pseudouridine sites in human noncoding RNA. Using a systematic knockout approach, they associate each pseudouridine site with the activity of a specific pseudouridine synthase.
bit.ly/48hM65C
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases - Nature Cell Biology
Xu, Kong, Li, Pisignano and colleagues provide a map of pseudouridine sites in human noncoding RNA. Using a systematic knockout approach, they associate each pseudouridine site with the activity of a ...
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November 16, 2025 at 8:32 AM
natcellbio.nature.com
☕ @katerinakraft.bsky.social @sedonamurphy.bsky.social @mattjones.bsky.social et al. identify extrachromosomal DNA(ecDNA)-interacting elements (EIEs) enriched for #TransposableElements in #ColorectalCancer. EIE 14 integrated within ecDNA acts as an enhancer to promote cancer fitness.
bit.ly/49iFC7C
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
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November 16, 2025 at 8:29 AM
natcellbio.nature.com
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
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November 16, 2025 at 8:23 AM
natcellbio.nature.com
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation - Nature Cell Biology
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
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November 15, 2025 at 8:17 PM
natcellbio.nature.com
☕Khawaja et al. show sex-specific differences in neuronal-activity regulation by #chaperone - mediated autophagy. Loss of chaperone-mediated #autophagy leads to defective #neuronal physiology and increased seizure susceptibility.
👉https://rdcu.be/eP69w
bit.ly/4pctKJ2
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome - Nature Cell Biology
Khawaja et al. show sex-specific differences in neuronal-activity regulation by chaperone-mediated autophagy and that loss of chaperone-mediated autophagy leads to defective neuronal physiology and in...
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November 15, 2025 at 8:15 PM
natcellbio.nature.com
☕Nguyen, Collier et al. find a #mitochondria – #lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate #pyroptosis.
bit.ly/4oF4Fqb
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death - Nature Cell Biology
Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent ...
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November 15, 2025 at 8:09 PM
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☕Wu & co introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST), a graph contrastive learning-based method for #spatial #transcriptomics analysis that detects low-variance structures.
bit.ly/4p5IklA
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets - Nature Cell Biology
Wu, Zhang and colleagues introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST), a graph contrastive learning-based method for spatial transcriptomics analysis that detects low-variance st...
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November 15, 2025 at 8:08 PM
natcellbio.nature.com
☕Endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate #cholesterol synthesis, sequestering SCAP when #EndoplasmicReticulum cholesterol is high but dissociating upon low cholesterol levels, allowing SCAP to activate cholesterol synthesis.
👉https://rdcu.be/eP67g
bit.ly/43suDVy
Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity - Nature Cell Biology
The authors show that the endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate cholesterol biosynthesis, sequestering SCAP when endoplasmic reticulum cholesterol is high but di...
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November 15, 2025 at 8:04 PM
natcellbio.nature.com
👋Our November issue's out!
Cover: Electrostatic forces in condensates

👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
November 14, 2025 at 8:07 PM
natcellbio.nature.com
☕Mohri et al. show that, in response to genotoxic stress, #melanocyte #StemCells undergo #senescence - associated differentiation, causing their depletion and protecting them against melanomagenesis. This process is suppressed by #carcinogens.
👉https://rdcu.be/eOAMp
bit.ly/4oNMu16
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma - Nature Cell Biology
Mohri et al. show that, in response to genotoxic stress, melanocyte stem cells undergo senescence-associated differentiation, causing their depletion and protecting them against melanomagenesis. This ...
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November 6, 2025 at 1:41 PM
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☕The authors integrate single-cell #transcriptomic data with prior gene graphs to produce a biologically meaningful cell state manifold that can predict driver genes for #genetic perturbations and differentiation events across diverse cell types.
bit.ly/4nIarpI
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold - Nature Cell Biology
The authors integrate single-cell transcriptomic data with prior gene graphs to produce a biologically meaningful cell state manifold that can predict driver genes for genetic perturbations and differ...
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November 6, 2025 at 1:37 PM
natcellbio.nature.com
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling - Nature Cell Biology
Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and...
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November 4, 2025 at 6:35 PM
natcellbio.nature.com
☕Li, He, Liu et al characterize the dynamic bivalent #chromatin landscape during mouse peri- #implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.
👉https://rdcu.be/eOgUb
bit.ly/4nBjnNC
Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis - Nature Cell Biology
Li, He, Liu and colleagues characterize the dynamic bivalent chromatin landscape during mouse peri-implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently main...
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November 4, 2025 at 6:32 PM
natcellbio.nature.com
☕Zhang et al. delineate the heterogeneity of core regulatory circuitry in #glioblastoma and identify HOXB3 condensation as a vulnerability that may be targeted with a therapeutic peptide in mouse models.
👉https://rdcu.be/eOgQQ
bit.ly/3XdeSxW
Defining heterogeneity in core regulatory circuitry reveals HOXB3 condensation as a potential target in glioblastoma - Nature Cell Biology
Zhang et al. delineate the heterogeneity of core regulatory circuitry in glioblastoma and identify HOXB3 condensation as a vulnerability that may be targeted with a therapeutic peptide in mouse models...
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November 4, 2025 at 6:28 PM
natcellbio.nature.com
☕Li, Burgos-Bravo et al. report that NDF #PhaseSeparation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome disassembly while preserving #chromatin integrity by retaining histones.
bit.ly/3JwVetO
Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin - Nature Cell Biology
Li, Burgos-Bravo and colleagues report that NDF phase separation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome di...
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November 4, 2025 at 6:22 PM
Reposted by Nature Cell Biology
djdavid.bsky.social
Thrilled to be en route to the @dgz.bsky.social #DGZ50 International Meeting as I'm there Mon-Wed!

Looking forward to chatting all things Cell Biology & anything else you'd like. Will be representing @natcellbio.nature.com (as Senior Editor) + npj Biological Physics & Mechanics (Advisory Editor)
October 27, 2025 at 8:12 AM
natcellbio.nature.com
🎃Our October issue's out!
Cover: mechanoresponsive #microtubules

👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
October 17, 2025 at 10:25 AM
natcellbio.nature.com
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
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October 4, 2025 at 2:40 PM
natcellbio.nature.com
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology
Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
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October 4, 2025 at 2:32 PM
natcellbio.nature.com
💫NEW: Here the authors show that LC3-associated #phagocytosis is initiated by various receptors, which enrich #phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for #phagosome maturation.
bit.ly/4qckc2b
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis - Nature Cell Biology
Here the authors show that LC3-associated phagocytosis is initiated by various receptors, which enrich phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for phagosome maturation.
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October 4, 2025 at 2:26 PM
natcellbio.nature.com
💫NEW: Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control #GeneExpression and human #StemCell fate.
👉https://rdcu.be/eJqGP
bit.ly/4gYgJjm
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate - Nature Cell Biology
Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate.
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October 4, 2025 at 2:24 PM
natcellbio.nature.com
☕Pan, David, Chevrier & co show that the microbial #metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows #tumor growth, decreases the translation of ribosomal proteins and is cleaved by IRE1 on the ER #ribosome.
👉https://rdcu.be/eJqFc
bit.ly/46BPXtJ
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control - Nature Cell Biology
Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth, decreases the translation of ribosomal proteins and is cleaved by IRE1 on the ER ribosome.
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October 4, 2025 at 2:21 PM
natcellbio.nature.com
☕Zheng et al. identify a role for CD160 in regulating CD8+ T cell exhaustion and cytotoxicity through the AKT–NF-κB pathway. The transfer of CD160+CD8+ T cells overcomes resistance to anti-PD-1 treatment in #ColorectalCancer models. #immunotherapy
👉https://rdcu.be/eJqEA
bit.ly/46Qiv1r
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer - Nature Cell Biology
Zheng et al. identify a role for CD160 in regulating CD8+ T cell exhaustion and cytotoxicity through the AKT–NF-κB pathway. The transfer of CD160+CD8+ T cells overcomes resistance to anti-PD-1 treatment in colorectal cancer models.
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October 4, 2025 at 2:16 PM