Stylianos Lefkopoulos (he/him)
@slefkopoulos.bsky.social
Senior Editor at @natcellbio.nature.com: #stemcells & development #disease #preclinical & #clinical studies | proud scientist | 🏳️🌈 non-binary, antisexist & liberal | 🍫 📚 🐶 🧑🍳 |📍Berlin | views are his own | call him Stelios
Pinned
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
Reposted by Stylianos Lefkopoulos (he/him)
☕Mohri et al. show that, in response to genotoxic stress, #melanocyte #StemCells undergo #senescence - associated differentiation, causing their depletion and protecting them against melanomagenesis. This process is suppressed by #carcinogens.
👉https://rdcu.be/eOAMp
bit.ly/4oNMu16
👉https://rdcu.be/eOAMp
bit.ly/4oNMu16
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma - Nature Cell Biology
Mohri et al. show that, in response to genotoxic stress, melanocyte stem cells undergo senescence-associated differentiation, causing their depletion and protecting them against melanomagenesis. This ...
bit.ly
November 6, 2025 at 1:41 PM
☕Mohri et al. show that, in response to genotoxic stress, #melanocyte #StemCells undergo #senescence - associated differentiation, causing their depletion and protecting them against melanomagenesis. This process is suppressed by #carcinogens.
👉https://rdcu.be/eOAMp
bit.ly/4oNMu16
👉https://rdcu.be/eOAMp
bit.ly/4oNMu16
Reposted by Stylianos Lefkopoulos (he/him)
☕Li, He, Liu et al characterize the dynamic bivalent #chromatin landscape during mouse peri- #implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.
👉https://rdcu.be/eOgUb
bit.ly/4nBjnNC
👉https://rdcu.be/eOgUb
bit.ly/4nBjnNC
Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis - Nature Cell Biology
Li, He, Liu and colleagues characterize the dynamic bivalent chromatin landscape during mouse peri-implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently main...
bit.ly
November 4, 2025 at 6:32 PM
☕Li, He, Liu et al characterize the dynamic bivalent #chromatin landscape during mouse peri- #implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.
👉https://rdcu.be/eOgUb
bit.ly/4nBjnNC
👉https://rdcu.be/eOgUb
bit.ly/4nBjnNC
Apologies, but manuscripts will have to wait this evening - little fellows are to be prioritized 🤗
Happy Halloween! 🎃
Happy Halloween! 🎃
October 31, 2025 at 1:44 PM
Apologies, but manuscripts will have to wait this evening - little fellows are to be prioritized 🤗
Happy Halloween! 🎃
Happy Halloween! 🎃
2nd: the findings
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
October 25, 2025 at 9:17 PM
2nd: the findings
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
Reposted by Stylianos Lefkopoulos (he/him)
A vaccine central in A(H5) influenza virus antigenic space confers subtype-wide immunity 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A vaccine central in A(H5) influenza antigenic space confers broad immunity - Nature
A high-resolution antigenic map of influenza A(H5) haemagglutinin (HA) enables the design of immunogenic and antigenically central vaccine HA antigens that elicit antibody responses broadly covering t...
www.nature.com
October 23, 2025 at 1:16 PM
A vaccine central in A(H5) influenza virus antigenic space confers subtype-wide immunity 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Stylianos Lefkopoulos (he/him)
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
Scaling back DEI programmes and the loss of scientific talent
Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...
www.nature.com
October 23, 2025 at 4:36 PM
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
1st: 1-2 (max) sentences - intro
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
October 17, 2025 at 8:59 PM
1st: 1-2 (max) sentences - intro
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
Reposted by Stylianos Lefkopoulos (he/him)
🎃Our October issue's out!
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
October 17, 2025 at 10:25 AM
🎃Our October issue's out!
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
October 16, 2025 at 8:34 PM
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
Is it ok to use AI in scientific publishing?
There’s a lot of confusion around this topic. The impact of progress depends on how one chooses to make use of it, and my personal opinion is that such tools can be useful, but there should be clear limits. Briefly, for Nature journals:
(1/5)
There’s a lot of confusion around this topic. The impact of progress depends on how one chooses to make use of it, and my personal opinion is that such tools can be useful, but there should be clear limits. Briefly, for Nature journals:
(1/5)
October 16, 2025 at 12:54 PM
Is it ok to use AI in scientific publishing?
There’s a lot of confusion around this topic. The impact of progress depends on how one chooses to make use of it, and my personal opinion is that such tools can be useful, but there should be clear limits. Briefly, for Nature journals:
(1/5)
There’s a lot of confusion around this topic. The impact of progress depends on how one chooses to make use of it, and my personal opinion is that such tools can be useful, but there should be clear limits. Briefly, for Nature journals:
(1/5)
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
October 14, 2025 at 9:13 PM
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
Reposted by Stylianos Lefkopoulos (he/him)
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 8, 2025 at 3:51 PM
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Reposted by Stylianos Lefkopoulos (he/him)
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Reposted by Stylianos Lefkopoulos (he/him)
We, editors, don't "count votes", and yes, we may make decisions that differ from your recommendation. And that doesn't mean we "are wrong".
October 7, 2025 at 11:31 AM
We, editors, don't "count votes", and yes, we may make decisions that differ from your recommendation. And that doesn't mean we "are wrong".
“The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance".” #nobelprize #immunology
October 6, 2025 at 11:49 AM
“The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance".” #nobelprize #immunology
Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
bit.ly
October 4, 2025 at 2:42 PM
Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!
I’m always incredibly excited to go through the monthly physical copy (yes, even though I do know its content).
@natcellbio.nature.com
@natcellbio.nature.com
October 2, 2025 at 9:32 AM
I’m always incredibly excited to go through the monthly physical copy (yes, even though I do know its content).
@natcellbio.nature.com
@natcellbio.nature.com
Reposted by Stylianos Lefkopoulos (he/him)
Sept 2025 marks 4 years after I joined @natcellbio.nature.com & 7.5+ years since starting editorial at @natcomms.nature.com !
To mark this occasion, I’ll highlight 5 pieces that I’ve had the privilege to help shepherd to publication. (a thread for today/tomorrow)
Bonus Pic of me as a baby editor .
To mark this occasion, I’ll highlight 5 pieces that I’ve had the privilege to help shepherd to publication. (a thread for today/tomorrow)
Bonus Pic of me as a baby editor .
September 29, 2025 at 8:13 PM
Sept 2025 marks 4 years after I joined @natcellbio.nature.com & 7.5+ years since starting editorial at @natcomms.nature.com !
To mark this occasion, I’ll highlight 5 pieces that I’ve had the privilege to help shepherd to publication. (a thread for today/tomorrow)
Bonus Pic of me as a baby editor .
To mark this occasion, I’ll highlight 5 pieces that I’ve had the privilege to help shepherd to publication. (a thread for today/tomorrow)
Bonus Pic of me as a baby editor .
Reposted by Stylianos Lefkopoulos (he/him)
An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Diverging fish biodiversity trends in cold and warm rivers and streams - Nature
In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.
www.nature.com
September 25, 2025 at 5:22 PM
An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Although we ‘re colleagues, I still haven’t met @ritastrack.bsky.social, and yet I feel like I know her, through her strong presence on social media, the great work she’s published, and numerous researchers I ‘ve met and who always had sth great to say about her. All the best for your new role!
"It is a big loss for Nature Methods and its audience. I think your role there in the past decade has transformed and re-defined the imaging related landscape for the entire community." 😭 These notes make me sentimental, but they also show me that doing this job well matters. #editorgoals
September 25, 2025 at 7:09 AM
Although we ‘re colleagues, I still haven’t met @ritastrack.bsky.social, and yet I feel like I know her, through her strong presence on social media, the great work she’s published, and numerous researchers I ‘ve met and who always had sth great to say about her. All the best for your new role!
In the 26-year history of our journal @natcellbio.nature.com this has never happened before, but the time has come: Nature Cell Biology is now open to considering #ClinicalTrials . I’m curious to hear what people in the field are up to - please reach out to me!
#CellTherapy #stemcells #genetherapy
#CellTherapy #stemcells #genetherapy
September 24, 2025 at 7:11 PM
In the 26-year history of our journal @natcellbio.nature.com this has never happened before, but the time has come: Nature Cell Biology is now open to considering #ClinicalTrials . I’m curious to hear what people in the field are up to - please reach out to me!
#CellTherapy #stemcells #genetherapy
#CellTherapy #stemcells #genetherapy
Ever since I switched to a vegetarian diet, I ‘ve been trying to find new recipes and familiarize myself with a different cooking philosophy. Believe me: #vegetarian & #vegan recipes can be INCREDIBLE! And this is absolutely one of them: cauliflower steak served with roasted potatoes and hummus.
September 20, 2025 at 4:07 PM
Ever since I switched to a vegetarian diet, I ‘ve been trying to find new recipes and familiarize myself with a different cooking philosophy. Believe me: #vegetarian & #vegan recipes can be INCREDIBLE! And this is absolutely one of them: cauliflower steak served with roasted potatoes and hummus.
Every single time I see this “he or she”, a glimpse of hope dies inside me.
September 20, 2025 at 11:38 AM
Every single time I see this “he or she”, a glimpse of hope dies inside me.
Reposted by Stylianos Lefkopoulos (he/him)
EpiSci - 🧬 - 🧪 -
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate
www.nature.com/articles/s41...
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate
www.nature.com/articles/s41...
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate - Nature Cell Biology
Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate.
www.nature.com
September 18, 2025 at 7:46 AM
EpiSci - 🧬 - 🧪 -
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate
www.nature.com/articles/s41...
A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate
www.nature.com/articles/s41...