Stylianos Lefkopoulos (he/him)
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slefkopoulos.bsky.social
Stylianos Lefkopoulos (he/him)
@slefkopoulos.bsky.social
Senior Editor at @natcellbio.nature.com: #stemcells & development #disease #preclinical & #clinical studies | proud scientist | 🏳️‍🌈 non-binary, antisexist & liberal | 🍫 📚 🐶 🧑‍🍳 |📍Berlin | views are his own | call him Stelios
Pinned
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
3rd: conclusion/impact/implications
1 sentence is often enough; sometimes 2 are necessary. Provide a short, concise conclusion - what is the punchline? Do you have sth *important* to comment on regarding implications? Could be therapeutic implications or a finding that changes a dogma. Be specific.
2nd: the findings
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
1st: 1-2 (max) sentences - intro
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
December 30, 2025 at 10:50 AM
2nd: the findings
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
1st: 1-2 (max) sentences - intro
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
December 30, 2025 at 10:49 AM
1st: 1-2 (max) sentences - intro
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
December 30, 2025 at 10:48 AM
🧑‍🎄I 'm far from what they call a religious person and yet I find so much joy in celebrating Christmas. I love the lights, the decorations, the family and friends gatherings. Friends, authors, reviewers, colleagues, and wonderful readers - happy holidays everyone! See you next year 🥂
December 24, 2025 at 11:07 AM
Reposted by Stylianos Lefkopoulos (he/him)
☕Minetti, Omrani et al. report that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3N38jfy
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis - Nature Cell Biology
Minetti, Omrani et al. report that delayed intestinal regeneration results from protein homeostasis stress and can be improved by modulation of the polyamine pathway dynamics.
bit.ly
December 16, 2025 at 10:13 PM
Reposted by Stylianos Lefkopoulos (he/him)
🍰Interested in reading more about the study? Here is the News & Views article written by @cterminiphd.bsky.social:
👉https://rdcu.be/eUZBi
bit.ly/4q7ozKQ
Blocking ferroptosis to expand human HSCs - Nature Cell Biology
Haematopoietic stem cells (HSCs) are used in a variety of cellular therapies, but our ability to support these cells ex vivo remains technically challenging. A new study discovers that inhibiting ferr...
bit.ly
December 16, 2025 at 10:05 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕Sankaran (@bloodgenes.bsky.social) & co augment the ex vivo expansion potential of human #hematopoietic #StemCells (HSCs) by inhibiting #ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo repopulation capacity.
bit.ly/4pEAzU9
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology
della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...
bit.ly
December 16, 2025 at 10:05 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕The composition of #ExtracellularVesicles (EVs) is central to their function, yet the field lacks systematic characterization. Here Rai et al. perform #proteomic and #lipidomic analyses of circulating human #plasma EVs and create a web tool for data exploration.
bit.ly/3N7xm0Y
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma - Nature Cell Biology
The composition of extracellular vesicles (EVs) is central to their function, yet the field lacks systematic characterization. Here Rai et al. perform proteomic and lipidomic analyses of circulating h...
bit.ly
December 17, 2025 at 8:51 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕The authors optimize an in vitro human #epiblast model, which they utilize to show that early #TGFβ family inhibition prevents epithelial identity, while it is dispensable after epithelium formation. @grazianomartello.bsky.social
👉https://rdcu.be/eVPMa
bit.ly/4pNo2xL
A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development - Nature Cell Biology
The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is dispensable after epithelium formation. ...
bit.ly
December 22, 2025 at 11:31 AM
Reposted by Stylianos Lefkopoulos (he/him)
🚨 New paper out!
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD
A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development
Nature Cell Biology - The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is...
rdcu.be
December 11, 2025 at 1:32 PM
Reposted by Stylianos Lefkopoulos (he/him)
December 19, 2025 at 7:22 PM
Reposted by Stylianos Lefkopoulos (he/him)
Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology
Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
www.nature.com
December 16, 2025 at 10:04 AM
🥂Congrats to Ori, Neri & co for their new Open Access study in our journal @natcellbio.nature.com showing that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3YhxZHC
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis - Nature Cell Biology
Minetti, Omrani et al. report that delayed intestinal regeneration results from protein homeostasis stress and can be improved by modulation of the polyamine pathway dynamics.
bit.ly
December 7, 2025 at 10:32 AM
This month I complete 4 years as an editor at @natcellbio.nature.com. It’s hard to express how grateful I am for the things I ‘ve learnt, the incredible projects I ‘ve had the honor to be a part of, the wonderful people I ‘ve met in my journey so far and the very inspiring interactions I ‘ve had.
December 5, 2025 at 2:27 AM
Reposted by Stylianos Lefkopoulos (he/him)
‼️The Importance of #DiversityEquityInclusion to science by @needhibhalla.bsky.social @joann-trejo.bsky.social @marymunson4.bsky.social in @natcellbio.nature.com:
“diversity in the scientific workforce increases creativity and success in tackling challenging problems.”
Link for free: rdcu.be/eSPGH
Scaling back DEI programmes and the loss of scientific talent - Nature Cell Biology
Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases creativity and success in tackl...
www.nature.com
December 2, 2025 at 7:24 PM
Reposted by Stylianos Lefkopoulos (he/him)
What can researchers do if they suspect that their manuscripts have been peer reviewed using AI?

go.nature.com/49Lk3Nk
Major AI conference flooded with peer-reviews written fully by AI
Nature - Controversy has erupted after 21% of manuscript reviews for an international AI conference were found to be generated by artificial intelligence.
go.nature.com
November 29, 2025 at 11:46 AM
🥂Congratulations to @bloodgenes.bsky.social & co for their new study in our journal enhancing the ex vivo expansion and in vivo reconstitution potential of human #hematopoietic #StemCells by inhibiting #ferroptosis . Where? @natcellbio.nature.com ofc!

www.nature.com/articles/s41...
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology
della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...
www.nature.com
November 22, 2025 at 12:27 AM
A great journey’s come to an end and I can 100% say this is the most impressive project I had the honor to be a part of in my 4 years as an editor. A huge thank you to all organizers, speakers, participants and my wonderful colleagues, @nandemokaizen.bsky.social Hannah Walters and Veronique Gebala!
November 21, 2025 at 3:48 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation - Nature Cell Biology
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
bit.ly
November 15, 2025 at 8:17 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕Wu & co introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST), a graph contrastive learning-based method for #spatial #transcriptomics analysis that detects low-variance structures.
bit.ly/4p5IklA
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets - Nature Cell Biology
Wu, Zhang and colleagues introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST), a graph contrastive learning-based method for spatial transcriptomics analysis that detects low-variance st...
bit.ly
November 15, 2025 at 8:08 PM
Reposted by Stylianos Lefkopoulos (he/him)
👋Our November issue's out!
Cover: Electrostatic forces in condensates

👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
November 14, 2025 at 8:07 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕Mohri et al. show that, in response to genotoxic stress, #melanocyte #StemCells undergo #senescence - associated differentiation, causing their depletion and protecting them against melanomagenesis. This process is suppressed by #carcinogens.
👉https://rdcu.be/eOAMp
bit.ly/4oNMu16
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma - Nature Cell Biology
Mohri et al. show that, in response to genotoxic stress, melanocyte stem cells undergo senescence-associated differentiation, causing their depletion and protecting them against melanomagenesis. This ...
bit.ly
November 6, 2025 at 1:41 PM
Reposted by Stylianos Lefkopoulos (he/him)
☕Li, He, Liu et al characterize the dynamic bivalent #chromatin landscape during mouse peri- #implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.
👉https://rdcu.be/eOgUb
bit.ly/4nBjnNC
Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis - Nature Cell Biology
Li, He, Liu and colleagues characterize the dynamic bivalent chromatin landscape during mouse peri-implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently main...
bit.ly
November 4, 2025 at 6:32 PM
Apologies, but manuscripts will have to wait this evening - little fellows are to be prioritized 🤗
Happy Halloween! 🎃
October 31, 2025 at 1:44 PM
2nd: the findings
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers
Tip 1: Follow a tight structure
There’s not only one way, but there certainly is a “safe” and always successful recipe. Your abstract consists of 3 parts:
1st: 1-2 (max!) sentences - intro;
2nd: the longest - the findings;
3rd: 1 sentence (2 could work, but often unnecessary) - wrap it up.
Tbc
Not the submission process, not reviewer #2, not the editor. Writing the abstract of the paper is often a far greater challenge. And there’s one simple reason for that: most people have a hard time figuring out what’s important for the reader. I ‘ll be sharing tips in next posts - stay tuned!
October 25, 2025 at 9:17 PM