Francesca Cesari
@francesari.bsky.social
Chief Biological, Clinical and Social Sciences Editor of Nature
Any views expressed here are my own
Any views expressed here are my own
Two registered clinical trials in Nature report the successful use of the GLP-1 and glucagon receptor co-agonist Mazdutide for type 2 diabetes.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mazdutide versus placebo in Chinese adults with type 2 diabetes - Nature
Nature - Mazdutide versus placebo in Chinese adults with type 2 diabetes
www.nature.com
December 18, 2025 at 11:41 AM
Two registered clinical trials in Nature report the successful use of the GLP-1 and glucagon receptor co-agonist Mazdutide for type 2 diabetes.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A paper in Nature reports the prevalence of Alzheimer’s Disease Neuropathological Changes in a Norwegian population-based cohort, assessed using a blood-based biomarker🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prevalence of Alzheimer’s disease pathology in the community - Nature
The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.
www.nature.com
December 18, 2025 at 11:39 AM
A paper in Nature reports the prevalence of Alzheimer’s Disease Neuropathological Changes in a Norwegian population-based cohort, assessed using a blood-based biomarker🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An article in Nature assesses the effect of Australian protected areas on vegetation in adjacent areas, and finds evidence of a positive spillover effect, that is, increases in a given vegetation type relative to what would be expected from the broader landscape.🧪 www.nature.com/articles/s41...
Protected area management has significant spillover effects on vegetation - Nature
Analysis of effect sizes of vegetation spillovers from protected areas in Australia shows that 71% of over 3,063 analysed protected areas had a positive spillover effect, and that these effects c...
www.nature.com
December 18, 2025 at 11:38 AM
An article in Nature assesses the effect of Australian protected areas on vegetation in adjacent areas, and finds evidence of a positive spillover effect, that is, increases in a given vegetation type relative to what would be expected from the broader landscape.🧪 www.nature.com/articles/s41...
A meta-analysis of 34,000 individuals identifies reproducible associations between gut microbial species and diet and health markers. The associations were used to generate a ranking of species that are either positively and negatively associated with health markers.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut micro-organisms associated with health, nutrition and dietary interventions - Nature
Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the h...
www.nature.com
December 18, 2025 at 11:37 AM
A meta-analysis of 34,000 individuals identifies reproducible associations between gut microbial species and diet and health markers. The associations were used to generate a ranking of species that are either positively and negatively associated with health markers.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ancient DNA analysis at the important archaeological site of Shimao city in northern China provides insights into the social organization and burial practices in a Neolithic community🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ancient DNA from Shimao city records kinship practices in Neolithic China - Nature
Sequencing of 144 ancient genomes from Shimao city and its satellites presents pedigrees among tomb owners spanning up to four generations showing predominantly patrilineal descent structure across Sh...
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December 18, 2025 at 11:34 AM
Ancient DNA analysis at the important archaeological site of Shimao city in northern China provides insights into the social organization and burial practices in a Neolithic community🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A study in Nature finds that 0.37 million tonnes of wild meat are extracted annually in Amazonia.This amount of wild meat can meet nearly half of protein and iron dietary requirements for rural people and a substantial portion of their needs for B vitamins and zinc.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Healthy forests safeguard traditional wild meat food systems in Amazonia - Nature
Data provided by Amazonian peoples are used to estimate the value of wild animals as a source of food, including its spatial distribution and nutritional value, providing information that will be key ...
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December 18, 2025 at 11:31 AM
A study in Nature finds that 0.37 million tonnes of wild meat are extracted annually in Amazonia.This amount of wild meat can meet nearly half of protein and iron dietary requirements for rural people and a substantial portion of their needs for B vitamins and zinc.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How related is economic inequality to mental health? This meta-analysis shows a complex picture in which this relationship is only evident among low-income populations and in contexts of high inflation. 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
No meta-analytical effect of economic inequality on well-being or mental health - Nature
A meta-analysis of 168 studies reveals that economic inequality is not significantly associated with subjective well-being or mental health.
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December 8, 2025 at 1:45 PM
How related is economic inequality to mental health? This meta-analysis shows a complex picture in which this relationship is only evident among low-income populations and in contexts of high inflation. 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How do video glitches impact hiring decisions, trust in a medical provider, and parole decisions? A study published in Nature finds that these glitches negatively impact these decisions by breaking the illusion of face-to-face contact 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Video-call glitches trigger uncanniness and harm consequential life outcomes - Nature
Glitches in video calls can have a negative effect on the judgement of the people involved and correspond to worse outcomes in major areas of life such as job interviews and parole hearings.
www.nature.com
December 8, 2025 at 1:41 PM
How do video glitches impact hiring decisions, trust in a medical provider, and parole decisions? A study published in Nature finds that these glitches negatively impact these decisions by breaking the illusion of face-to-face contact 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Speech sounds like vowels and consonants in native and foreign languages elicit similar neural responses in the superior temporal, but only during native listening does this area encode word boundaries, frequency, and language-specific information.
🧪 www.nature.com/articles/s41...
🧪 www.nature.com/articles/s41...
Shared and language-specific phonological processing in the human temporal lobe - Nature
The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-sp...
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November 21, 2025 at 3:44 PM
Speech sounds like vowels and consonants in native and foreign languages elicit similar neural responses in the superior temporal, but only during native listening does this area encode word boundaries, frequency, and language-specific information.
🧪 www.nature.com/articles/s41...
🧪 www.nature.com/articles/s41...
Marburg virus is a highly virulent/transmissible filovirus with no vaccine/treatments and recent outbreaks in Africa. Scientists have isolated/characterized a highly potent neutralizing monoclonal antibody effective against Marburg and related viruses Dehong and Ravn.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Potent neutralization of Marburg virus by a vaccine-elicited antibody - Nature
Nature - Potent neutralization of Marburg virus by a vaccine-elicited antibody
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November 19, 2025 at 8:39 AM
Marburg virus is a highly virulent/transmissible filovirus with no vaccine/treatments and recent outbreaks in Africa. Scientists have isolated/characterized a highly potent neutralizing monoclonal antibody effective against Marburg and related viruses Dehong and Ravn.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A Nature paper details a new AI model called EchoPrime, which can read and interpret echocardiograms 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Comprehensive echocardiogram evaluation with view primed vision language AI - Nature
Nature - Comprehensive echocardiogram evaluation with view primed vision language AI
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November 19, 2025 at 8:34 AM
A Nature paper details a new AI model called EchoPrime, which can read and interpret echocardiograms 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A study looks at the mortality impacts of unmanaged rainfall and future sea level rise, with disproportionate risk for children, women, and residents of slums in a developing megacity🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
November 19, 2025 at 8:32 AM
A study looks at the mortality impacts of unmanaged rainfall and future sea level rise, with disproportionate risk for children, women, and residents of slums in a developing megacity🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Computer vision, on which many AI applications rely on, is based on non-consensual datasets, compromising fairness and accuracy in AI. Now, an ethically curated, diverse human-image data set, sets a new standard for responsible data curation and trustworthy AI. 🧪 www.nature.com/articles/s41...
Fair human-centric image dataset for ethical AI benchmarking - Nature
The Fair Human-Centric Image Benchmark (FHIBE, pronounced ‘Feebee’)—an image dataset that implements best practices for consent, privacy, compensation, safety, diversity and utility—can be used respon...
www.nature.com
November 12, 2025 at 2:58 PM
Computer vision, on which many AI applications rely on, is based on non-consensual datasets, compromising fairness and accuracy in AI. Now, an ethically curated, diverse human-image data set, sets a new standard for responsible data curation and trustworthy AI. 🧪 www.nature.com/articles/s41...
A paper in Nature reports high-resolution structures of aSyn fibrils 1B and their in vivo seeding product 1BP. They appear remarkably similar, suggesting a high-fidelity conformational replication process to perpetuate MSA-like pathology 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology - Nature
Synthetic fibril strain 1B is a pathogen that is capable of self-replication and inducing glial cytoplasmic inclusions in vivo in mice, and the structural features of 1B may underlie the pathology of ...
www.nature.com
November 12, 2025 at 2:44 PM
A paper in Nature reports high-resolution structures of aSyn fibrils 1B and their in vivo seeding product 1BP. They appear remarkably similar, suggesting a high-fidelity conformational replication process to perpetuate MSA-like pathology 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Snake bites kill/debilitate 1000s of people annually in Sub-Saharan African. A new nanobody cocktail is shown to be highly effective against 17 of the most dangerous African snake species. Unlike other anti-venoms it also protects against venom-induced dermal necrosis🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkha...
www.nature.com
October 30, 2025 at 7:26 AM
Snake bites kill/debilitate 1000s of people annually in Sub-Saharan African. A new nanobody cocktail is shown to be highly effective against 17 of the most dangerous African snake species. Unlike other anti-venoms it also protects against venom-induced dermal necrosis🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new study in published in Nature presents a comprehensive resource of immunological changes occurring during normal aging 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
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October 30, 2025 at 7:20 AM
A new study in published in Nature presents a comprehensive resource of immunological changes occurring during normal aging 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Where do invertebrates without calcium-rich bones or shells store their calcium? In the fruit-fly, at least, it’s the malpighian tubules, where calcium is mobilised by a neuropeptide hormone called Capability. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neuroendocrine control of calcium mobilization in the fruit fly - Nature
The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.
www.nature.com
October 30, 2025 at 7:19 AM
Where do invertebrates without calcium-rich bones or shells store their calcium? In the fruit-fly, at least, it’s the malpighian tubules, where calcium is mobilised by a neuropeptide hormone called Capability. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An article in Nature reports that ecosystem energy flow, through food consumption by wild birds and mammals, has decreased by over one third in sub-Saharan Africa since around 1700 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Energy flows reveal declining ecosystem functions by animals across Africa - Nature
An ecosystem energetics approach, quantifying trophic energy flows across species, offers a unified framework for linking animal biodiversity loss to changes in ecosystem function and Earth system pro...
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October 30, 2025 at 7:17 AM
An article in Nature reports that ecosystem energy flow, through food consumption by wild birds and mammals, has decreased by over one third in sub-Saharan Africa since around 1700 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A short-necked sauropodomorph from a new Triassic locality in Argentina shows sign of the neck extension that characterised its larger, later cousins.🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A long-necked early dinosaur from a newly discovered Upper Triassic basin in the Andes - Nature
Discovery of a nearly complete skeleton of Huayracursor jaguensis, a Carnian dinosaur from the Northern Precordillera Basin in northwestern Argentina provides evidence of increased body size and early...
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October 23, 2025 at 1:18 PM
A short-necked sauropodomorph from a new Triassic locality in Argentina shows sign of the neck extension that characterised its larger, later cousins.🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A vaccine central in A(H5) influenza virus antigenic space confers subtype-wide immunity 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A vaccine central in A(H5) influenza antigenic space confers broad immunity - Nature
A high-resolution antigenic map of influenza A(H5) haemagglutinin (HA) enables the design of immunogenic and antigenically central vaccine HA antigens that elicit antibody responses broadly covering t...
www.nature.com
October 23, 2025 at 1:16 PM
A vaccine central in A(H5) influenza virus antigenic space confers subtype-wide immunity 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A paper in Nature presents MetaGraph, which indexes petabase-scale biological sequences for accurate and efficient searches across vast sequence space 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Efficient and accurate search in petabase-scale sequence repositories - Nature
MetaGraph enables scalable indexing of large sets of DNA, RNA or protein sequences using annotated de Bruijn graphs.
www.nature.com
October 8, 2025 at 4:54 PM
A paper in Nature presents MetaGraph, which indexes petabase-scale biological sequences for accurate and efficient searches across vast sequence space 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧪 Women are represented as younger than men across occupations/social roles in data from Google,Wikipedia,IMDB, Flickr,YouTube and LLMs.The bias is strongest for occupations with high status/earnings.ChatGPT perpetuates this bias when generating and evaluating resumes. www.nature.com/articles/s41...
Age and gender distortion in online media and large language models - Nature
Stereotypes of age-related gender bias are socially distorted, as evidenced by the age gap in the representations of women and men across various media and algorithms, despite no systematic age differences in the workforce.
www.nature.com
October 8, 2025 at 4:53 PM
🧪 Women are represented as younger than men across occupations/social roles in data from Google,Wikipedia,IMDB, Flickr,YouTube and LLMs.The bias is strongest for occupations with high status/earnings.ChatGPT perpetuates this bias when generating and evaluating resumes. www.nature.com/articles/s41...
An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Diverging fish biodiversity trends in cold and warm rivers and streams - Nature
In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.
www.nature.com
September 25, 2025 at 5:22 PM
An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A study in Nature uncovers the mechanism behind a new metabolic class of drug for treatment of neuroblastoma 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
www.nature.com
September 25, 2025 at 5:20 PM
A study in Nature uncovers the mechanism behind a new metabolic class of drug for treatment of neuroblastoma 🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In a Perspective article in Nature the Biodiversity Cell Atlas describes its plans and goals for mapping the tree of life with single-cell genomics technologies🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature
The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species.
www.nature.com
September 25, 2025 at 5:14 PM
In a Perspective article in Nature the Biodiversity Cell Atlas describes its plans and goals for mapping the tree of life with single-cell genomics technologies🧪👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...