Jonny Nixon-Abell
@abelljonny.bsky.social
Group Leader @TheCIMR. Organelle Interactions and dynamics in neurons. Wellcome CDA Fellow. prev: @NIH, @UCL, @HHMIJanelia. 🧠+🔬 (AbellJonny on X)
https://www.cimr.cam.ac.uk/staff/dr-jonathon-nixon-abell
https://www.cimr.cam.ac.uk/staff/dr-jonathon-nixon-abell
Pinned
Jonny Nixon-Abell
@abelljonny.bsky.social
· Dec 28
‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏
December 29, 2025 at 6:21 AM
‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏
December 28, 2025 at 7:28 AM
‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏
Massive congrats Alex and the lab!!!
December 9, 2025 at 9:12 AM
Massive congrats Alex and the lab!!!
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome
Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...
www.biorxiv.org
October 6, 2025 at 9:50 AM
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
😍😍😍. Congrats folks.!!
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 16, 2025 at 6:36 AM
😍😍😍. Congrats folks.!!
Reposted by Jonny Nixon-Abell
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Congrats Miranda!!!
August 27, 2025 at 8:27 PM
Congrats Miranda!!!
Reposted by Jonny Nixon-Abell
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
Reposted by Jonny Nixon-Abell
The german research foundation DFG will fund the new graduate school for
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
Förderentscheidung für 18 neue #Graduiertenkollegs, darunter 4 internationale Verbünde mit Partnern in den USA, Italien, Kanada und Frankreich. Themen reichen von klimaneutralem Stahl bis zur Erforschung von Infektionserkrankungen . ➡️ www.dfg.de/de/service/p...
June 16, 2025 at 8:37 AM
The german research foundation DFG will fund the new graduate school for
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
www.nature.com
April 26, 2025 at 6:05 AM
Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jonny Nixon-Abell
Do you see any underlying driver/correlator for these numbers?
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
March 24, 2025 at 9:56 PM
Do you see any underlying driver/correlator for these numbers?
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Reposted by Jonny Nixon-Abell
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 23, 2025 at 9:25 AM
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 24, 2025 at 3:02 PM
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
Great interview with the always inspiring JLS - absolutely shaped so much about mine and so many others careers…
Interview with Jennifer Lippincott-Schwartz
ABSTRACT. Jennifer Lippincott-Schwartz is a Senior Group Leader and Head of 4D Cellular Physiology at Howard Hughes Medical Institute's (HHMI) Janelia Research Campus. Throughout her career, Jennifer ...
journals.biologists.com
March 22, 2025 at 5:51 AM
Great interview with the always inspiring JLS - absolutely shaped so much about mine and so many others careers…
Yep. Even with the starter packs ‘active’ 🤷
March 12, 2025 at 3:45 PM
Yep. Even with the starter packs ‘active’ 🤷
I have not - it’s another useful suggestion I should try. Thanks!
March 12, 2025 at 8:14 AM
I have not - it’s another useful suggestion I should try. Thanks!
Then where are the less established folks haha?!? But yes your point about US is surely a factor.
March 12, 2025 at 7:56 AM
Then where are the less established folks haha?!? But yes your point about US is surely a factor.
Plenty of good starter packs…even so, I find I encounter far fewer papers that are relevant for my interests here…maybe this trick from @flodebarre.bsky.social will help though!
March 12, 2025 at 7:54 AM
Plenty of good starter packs…even so, I find I encounter far fewer papers that are relevant for my interests here…maybe this trick from @flodebarre.bsky.social will help though!
Reposted by Jonny Nixon-Abell
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
March 10, 2025 at 6:14 PM
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
I had not seen this but this is great!! Thanks for the suggestion. Only downside is that it’s only papers from followers right. Although still a big improvement from my current feeds!
March 12, 2025 at 7:30 AM
I had not seen this but this is great!! Thanks for the suggestion. Only downside is that it’s only papers from followers right. Although still a big improvement from my current feeds!
This is true on ‘discover’ and even the ‘following’ feeds. Any suggestions on how to help with this?!
March 12, 2025 at 7:19 AM
This is true on ‘discover’ and even the ‘following’ feeds. Any suggestions on how to help with this?!
I have to say…unlike the Twitter heyday (and even still X now), I just don’t get good science content on Bluesky. In particular, I can’t find people posting new cell biology/microscopy/neurobiology papers at anywhere near the same frequency. My feed on Twitter used to be 90%+ of this content…
March 12, 2025 at 7:19 AM
I have to say…unlike the Twitter heyday (and even still X now), I just don’t get good science content on Bluesky. In particular, I can’t find people posting new cell biology/microscopy/neurobiology papers at anywhere near the same frequency. My feed on Twitter used to be 90%+ of this content…