Jonny Nixon-Abell
@abelljonny.bsky.social
Group Leader @TheCIMR. Organelle Interactions and dynamics in neurons. Wellcome CDA Fellow. prev: @NIH, @UCL, @HHMIJanelia. 🧠+🔬 (AbellJonny on X)
https://www.cimr.cam.ac.uk/staff/dr-jonathon-nixon-abell
https://www.cimr.cam.ac.uk/staff/dr-jonathon-nixon-abell
Pinned
First Microscopy Post on here 🥳🥳!! Single molecule protein dynamics at ER-Mito contact sites😬...here we are looking at Individual VAPB molecules, an important contact site tethering molecule. From our recent paper www.nature.com/articles/s41...
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome
Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...
www.biorxiv.org
October 6, 2025 at 9:50 AM
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
😍😍😍. Congrats folks.!!
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 16, 2025 at 6:36 AM
😍😍😍. Congrats folks.!!
Reposted by Jonny Nixon-Abell
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Reposted by Jonny Nixon-Abell
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
Reposted by Jonny Nixon-Abell
The german research foundation DFG will fund the new graduate school for
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
Förderentscheidung für 18 neue #Graduiertenkollegs, darunter 4 internationale Verbünde mit Partnern in den USA, Italien, Kanada und Frankreich. Themen reichen von klimaneutralem Stahl bis zur Erforschung von Infektionserkrankungen . ➡️ www.dfg.de/de/service/p...
June 16, 2025 at 8:37 AM
The german research foundation DFG will fund the new graduate school for
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
"Biomolecular Condensates: from physics to biological function" here in Dresden
This new graduate school is part of 18 new graduate schools funded by the DFG in germany!
Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
www.nature.com
April 26, 2025 at 6:05 AM
Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jonny Nixon-Abell
Do you see any underlying driver/correlator for these numbers?
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
March 24, 2025 at 9:56 PM
Do you see any underlying driver/correlator for these numbers?
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Reposted by Jonny Nixon-Abell
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 23, 2025 at 9:25 AM
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 24, 2025 at 3:02 PM
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
Great interview with the always inspiring JLS - absolutely shaped so much about mine and so many others careers…
Interview with Jennifer Lippincott-Schwartz
ABSTRACT. Jennifer Lippincott-Schwartz is a Senior Group Leader and Head of 4D Cellular Physiology at Howard Hughes Medical Institute's (HHMI) Janelia Research Campus. Throughout her career, Jennifer ...
journals.biologists.com
March 22, 2025 at 5:51 AM
Great interview with the always inspiring JLS - absolutely shaped so much about mine and so many others careers…
Reposted by Jonny Nixon-Abell
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
March 10, 2025 at 6:14 PM
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
I have to say…unlike the Twitter heyday (and even still X now), I just don’t get good science content on Bluesky. In particular, I can’t find people posting new cell biology/microscopy/neurobiology papers at anywhere near the same frequency. My feed on Twitter used to be 90%+ of this content…
March 12, 2025 at 7:19 AM
I have to say…unlike the Twitter heyday (and even still X now), I just don’t get good science content on Bluesky. In particular, I can’t find people posting new cell biology/microscopy/neurobiology papers at anywhere near the same frequency. My feed on Twitter used to be 90%+ of this content…
Such a cool story! Congrats guys…
Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
www.nature.com
March 10, 2025 at 11:13 AM
Such a cool story! Congrats guys…
Reposted by Jonny Nixon-Abell
We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country.
This Friday, where will you be?
standupforscience2025.org
This Friday, where will you be?
standupforscience2025.org
March 2, 2025 at 4:27 PM
We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country.
This Friday, where will you be?
standupforscience2025.org
This Friday, where will you be?
standupforscience2025.org
This is such a great programme and a big thanks to Venkat Pisupati who has done all the heavy listing from our group to make this possible.
We're having a great half term week with a fantastic group of young scientists who've given up their school holiday to experience life as a research scientist. Run with @mrc-mbu.bsky.social and St Catharine's College, www.cimr.cam.ac.uk/inspiring-sc... aims to widen participation in STEM & medicine
February 20, 2025 at 12:54 PM
This is such a great programme and a big thanks to Venkat Pisupati who has done all the heavy listing from our group to make this possible.
Reposted by Jonny Nixon-Abell
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 12, 2025 at 11:41 AM
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jonny Nixon-Abell
So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).
February 12, 2025 at 2:39 PM
So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).
Reposted by Jonny Nixon-Abell
Hello! Although we are still in the other place, this will become our main social media feed. We're part of the University of Cambridge Clinical School
Cell biology, molecular mechanisms of human disease
Cell biology, molecular mechanisms of human disease
January 16, 2025 at 10:50 AM
Hello! Although we are still in the other place, this will become our main social media feed. We're part of the University of Cambridge Clinical School
Cell biology, molecular mechanisms of human disease
Cell biology, molecular mechanisms of human disease
Reposted by Jonny Nixon-Abell
Our first preprint list for 2025 is focussed on research using microscopy tools to answer questions in biology. As always, please let us know if there are other preprints that you’d like to see on our list.
focalplane.biologists.com/2025/01/10/m...
focalplane.biologists.com/2025/01/10/m...
Microscopy preprints - applications in biology - FocalPlane
Microscopy preprints - applications in biology - News
focalplane.biologists.com
January 10, 2025 at 3:02 PM
Our first preprint list for 2025 is focussed on research using microscopy tools to answer questions in biology. As always, please let us know if there are other preprints that you’d like to see on our list.
focalplane.biologists.com/2025/01/10/m...
focalplane.biologists.com/2025/01/10/m...
Reposted by Jonny Nixon-Abell
Fantastic work by my Biohub colleague Manu Leonetti and his amazing team published in #Cell! 🧪
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
Organelle proteomics defines the cellular landscape of protein localization and highlights the role of subcellular remodeling in driving responses to perturbations such as viral infections.
www.cell.com
January 7, 2025 at 10:18 AM
Fantastic work by my Biohub colleague Manu Leonetti and his amazing team published in #Cell! 🧪
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
Human cell #proteomics subcellular landscape and its dynamic remodeling using #organelle IP.
Paper here www.cell.com/cell/fulltex...
Explore the date organelles.czbiohub.org
Congratulations to the team
😮💨😮💨😮💨 nothing beats isotropy 🤷
Incredible new work from Yongdeng Zhang demonstrating live 4Pi SIM--and in two colors! www.nature.com/articles/s41...
Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM - Nature Methods
The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic p...
www.nature.com
December 24, 2024 at 2:21 PM
😮💨😮💨😮💨 nothing beats isotropy 🤷
🎉 If you’re at #cellbio24 then make sure to join us tomorrow for a bloody great lineup of talks on the ER! Anddddd if you’re heading to the MBL party tonight then come and find me for some painkillers 😅…
December 18, 2024 at 2:14 AM
🎉 If you’re at #cellbio24 then make sure to join us tomorrow for a bloody great lineup of talks on the ER! Anddddd if you’re heading to the MBL party tonight then come and find me for some painkillers 😅…
Reposted by Jonny Nixon-Abell
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
December 13, 2024 at 2:12 PM
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Very cool!
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
December 13, 2024 at 10:56 PM
Very cool!
Yo yo yo….. #Cellbio2024 friends. Landing today in San Diego and leave evening of 18th. Shoot me a WhatsApp or email if you want to catch up 😊😊. Looking forward to seeing you!!
December 13, 2024 at 5:56 PM
Yo yo yo….. #Cellbio2024 friends. Landing today in San Diego and leave evening of 18th. Shoot me a WhatsApp or email if you want to catch up 😊😊. Looking forward to seeing you!!