@PoratShliomLab
@poratshliomlab.bsky.social
Cell Biologist and microscopist. My lab
@NCIResearchCtr focuses on mitochondria, metabolism, and liver cancer. Views are my own #cellbiology #microscopy
@NCIResearchCtr focuses on mitochondria, metabolism, and liver cancer. Views are my own #cellbiology #microscopy
Pinned
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
Milestones is an annual publication covering the exciting research performed at the National Cancer Institute, NIH. This year, my group is honored to be included!
It's truly a privilege to work with @poratshliomlab.bsky.social at NIH/NCI on understanding metabolic multi-tasking at the tissue level, in the liver and in the kidney.
Congrats to the entire lab for the highlight (on p.20) as well as the stunning cover image! 🎉
ccr.cancer.gov/news/milesto...
Congrats to the entire lab for the highlight (on p.20) as well as the stunning cover image! 🎉
ccr.cancer.gov/news/milesto...
CCR Milestones - 2025 | Center for Cancer Research
Every year, CCR makes remarkable contributions to the understanding, detection, treatment and prevention of cancer. This digital-only issue of our annual publication, Milestones, features 13 of our to...
ccr.cancer.gov
May 9, 2025 at 5:25 PM
Milestones is an annual publication covering the exciting research performed at the National Cancer Institute, NIH. This year, my group is honored to be included!
Reposted by @PoratShliomLab
We also host a microscopy database on FocalPlane, which you can use for searching for collaborators, reviewers and speakers.
We'd like to invite all members of the community to join and use the Network.
focalplane.biologists.com/network/
We'd like to invite all members of the community to join and use the Network.
focalplane.biologists.com/network/
April 14, 2025 at 9:36 AM
We also host a microscopy database on FocalPlane, which you can use for searching for collaborators, reviewers and speakers.
We'd like to invite all members of the community to join and use the Network.
focalplane.biologists.com/network/
We'd like to invite all members of the community to join and use the Network.
focalplane.biologists.com/network/
Reposted by @PoratShliomLab
Single cell spatial proteomics maps human liver zonation patterns and their vulnerability to fibrosis https://www.biorxiv.org/content/10.1101/2025.04.13.648568v1
April 14, 2025 at 5:16 AM
Single cell spatial proteomics maps human liver zonation patterns and their vulnerability to fibrosis https://www.biorxiv.org/content/10.1101/2025.04.13.648568v1
Reposted by @PoratShliomLab
Preprint alert ‼️
Excited to share our work investigating liver zonation in human health and disease with our advanced single-cell Deep Visual Peoteomics framework!
Excited to share our work investigating liver zonation in human health and disease with our advanced single-cell Deep Visual Peoteomics framework!
Introducing our single-cell DVP framework combining strategic cell selection with protein gradient mapping algorithms. Analyzing hepatocyte proteomes across 18 human livers, revealing cross-species differences, and mapping disruptions in liver fibrosis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 14, 2025 at 12:34 PM
Preprint alert ‼️
Excited to share our work investigating liver zonation in human health and disease with our advanced single-cell Deep Visual Peoteomics framework!
Excited to share our work investigating liver zonation in human health and disease with our advanced single-cell Deep Visual Peoteomics framework!
Is liver zonation conserved from mice to humans? And how does fibrosis affect zonation in patients? Now, these questions are answered using scDVP. Some collaborations are meant to be! @carolineweiss.bsky.social@frosenberger.bsky.social @mannlab.bsky.social@mlsb-borgwardt.bsky.social
Introducing our single-cell DVP framework combining strategic cell selection with protein gradient mapping algorithms. Analyzing hepatocyte proteomes across 18 human livers, revealing cross-species differences, and mapping disruptions in liver fibrosis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 14, 2025 at 2:35 PM
Is liver zonation conserved from mice to humans? And how does fibrosis affect zonation in patients? Now, these questions are answered using scDVP. Some collaborations are meant to be! @carolineweiss.bsky.social@frosenberger.bsky.social @mannlab.bsky.social@mlsb-borgwardt.bsky.social
Reposted by @PoratShliomLab
Check out this preprint from collaborator Lance Johnson @johnsonlab.bsky.social and team characterizing the APOE3 vs E4 #LipidDroplet -ome! Some interesting Easter eggs in there 🐇🥚😉
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
December 21, 2024 at 5:12 PM
Check out this preprint from collaborator Lance Johnson @johnsonlab.bsky.social and team characterizing the APOE3 vs E4 #LipidDroplet -ome! Some interesting Easter eggs in there 🐇🥚😉
Reposted by @PoratShliomLab
Very cool!
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
December 13, 2024 at 10:56 PM
Very cool!
Reposted by @PoratShliomLab
Beautiful work - I love the analysis of organelle rearrangement in response to changes in lipid flux.
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
December 13, 2024 at 6:57 AM
Beautiful work - I love the analysis of organelle rearrangement in response to changes in lipid flux.
Reposted by @PoratShliomLab
Wow!! Amazing preprint from the Porat-Shliom lab showing how organelle signatures vary across space and diet in the liver. This paper has it all: gorgeous microscopy, lipid droplets, mitochondria, and one of my favorite proteins, PLIN5 🤩
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
December 12, 2024 at 11:24 PM
Wow!! Amazing preprint from the Porat-Shliom lab showing how organelle signatures vary across space and diet in the liver. This paper has it all: gorgeous microscopy, lipid droplets, mitochondria, and one of my favorite proteins, PLIN5 🤩
Reposted by @PoratShliomLab
Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis. https://www.biorxiv.org/content/10.1101/2024.12.10.627730v1
December 12, 2024 at 3:31 PM
Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis. https://www.biorxiv.org/content/10.1101/2024.12.10.627730v1
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
December 12, 2024 at 5:11 PM
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
Reposted by @PoratShliomLab
Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025, again at beautiful Costa Brava. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles #LipidMetabolism
Lipid Droplets: Cell-Biological Control of Metabolism
Lipid droplets are master regulators of nutrient and energy homeostasis, but their functions go far beyond these classical roles: They are important in cellular differentiation and various stress res…
meetings.embo.org
December 11, 2024 at 12:14 PM
Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025, again at beautiful Costa Brava. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles #LipidMetabolism
Our annual lab-giving celebration! I am grateful to have such an energetic and positive team!
Happy holiday season from the Porat-Shliom lab🎄🕎
@kbarrows.bsky.social @ivyxiong.bsky.social
Happy holiday season from the Porat-Shliom lab🎄🕎
@kbarrows.bsky.social @ivyxiong.bsky.social
December 11, 2024 at 7:26 PM
Our annual lab-giving celebration! I am grateful to have such an energetic and positive team!
Happy holiday season from the Porat-Shliom lab🎄🕎
@kbarrows.bsky.social @ivyxiong.bsky.social
Happy holiday season from the Porat-Shliom lab🎄🕎
@kbarrows.bsky.social @ivyxiong.bsky.social
Reposted by @PoratShliomLab
Super happy to have Cohen Lab PhD student Ian Windham's paper about #APOE trafficking to #LipidDroplets featured in this exciting collection!!
Our annual collection highlights twelve of the most outstanding papers that showcase the exceptional range and quality of research published by JCB. We are delighted to serve as an independent venue for the awe-inspiring world of cell biology! https://buff.ly/3OO7Nj8
#CellBio2024
#CellBio2024
December 11, 2024 at 3:54 PM
Super happy to have Cohen Lab PhD student Ian Windham's paper about #APOE trafficking to #LipidDroplets featured in this exciting collection!!
Reposted by @PoratShliomLab
Cohen lab will be well represented at #CellBio2024! If you love #Organelles, #MembraneContactSites, and/or #Neurons and #Astrocytes, please come say hello!
December 11, 2024 at 3:51 PM
Cohen lab will be well represented at #CellBio2024! If you love #Organelles, #MembraneContactSites, and/or #Neurons and #Astrocytes, please come say hello!
Reposted by @PoratShliomLab
Stunning free #science vector art for your next poster, paper or talk 🤩
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
December 10, 2024 at 7:52 AM
Stunning free #science vector art for your next poster, paper or talk 🤩
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
Reposted by @PoratShliomLab
Ok, I made a starter pack for membrane trafficking and organelles (broadly defined). Feel free to self-nominate! go.bsky.app/RbtJjt7
November 11, 2024 at 5:03 PM
Ok, I made a starter pack for membrane trafficking and organelles (broadly defined). Feel free to self-nominate! go.bsky.app/RbtJjt7
Reposted by @PoratShliomLab
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 6, 2024 at 8:52 PM
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Reposted by @PoratShliomLab
Another #MicroscopyMonday for the books. This one has an intestinal organoid Andy Warhol style.
December 9, 2024 at 8:26 PM
Another #MicroscopyMonday for the books. This one has an intestinal organoid Andy Warhol style.
Reposted by @PoratShliomLab
I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.
December 4, 2024 at 7:05 PM
I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.
Reposted by @PoratShliomLab
I’m so excited to organize the #Lysosomes Subgroup at @ASCBiology 2024 meeting on Sunday, Dec. 15 at 3:15pm, Room 33B.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
December 5, 2024 at 12:14 AM
I’m so excited to organize the #Lysosomes Subgroup at @ASCBiology 2024 meeting on Sunday, Dec. 15 at 3:15pm, Room 33B.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
December 9, 2024 at 10:12 PM
Cells within organs are exposed to nutrient gradients, resulting in functional zonation. Beautiful work
x.com/BernaSozen_/st…
x.com/BernaSozen_/st…
December 9, 2024 at 10:12 PM
Cells within organs are exposed to nutrient gradients, resulting in functional zonation. Beautiful work
x.com/BernaSozen_/st…
x.com/BernaSozen_/st…
I was pleased to present our work @umncbs, and interact with exceptional graduate students and faculty. Thank you @dgmashek, for the invitation
December 9, 2024 at 10:12 PM
I was pleased to present our work @umncbs, and interact with exceptional graduate students and faculty. Thank you @dgmashek, for the invitation