Bianca Schrul
@biancaschrul.bsky.social
Professor for Medical Biochemistry at Saarland University, Germany. My lab studies the biogenesis and function of lipid droplets
Pinned
Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism?
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
Reposted by Bianca Schrul
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Bianca Schrul
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
November 14, 2025 at 8:07 PM
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Curious how proteins find their way to #LipidDroplets?
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Navigating lipid droplet proteins – part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning
Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...
portlandpress.com
October 31, 2025 at 9:53 AM
Curious how proteins find their way to #LipidDroplets?
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Curious how proteins find their way to #LipidDroplets?
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins
#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins
#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry
Navigating lipid droplet proteins – part I: ER targeting routes of lipid droplet-destined membrane proteins
Lipid droplets (LDs) are cytosolic lipid storage organelles that derive from the endoplasmic reticulum (ER). Their biogenesis and function are essential for maintaining cellular lipid homeostasis and ...
portlandpress.com
October 31, 2025 at 9:51 AM
Curious how proteins find their way to #LipidDroplets?
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins
#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins
#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry
Reposted by Bianca Schrul
amazing #lipidtime story from Tontonoz lab! Lipid scrambling and cholesterol accessibility IN T-CELLS regulates nutrient uptake in small intestine 🤯🤯
Physiology is so weird!
www.science.org/doi/10.1126/...
Physiology is so weird!
www.science.org/doi/10.1126/...
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption
The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A link...
www.science.org
October 17, 2025 at 6:33 PM
amazing #lipidtime story from Tontonoz lab! Lipid scrambling and cholesterol accessibility IN T-CELLS regulates nutrient uptake in small intestine 🤯🤯
Physiology is so weird!
www.science.org/doi/10.1126/...
Physiology is so weird!
www.science.org/doi/10.1126/...
First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science.
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
August 22, 2025 at 4:35 PM
First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science.
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
Reposted by Bianca Schrul
Upcoming interdisciplinary meeting: Cell Physics 2025
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
June 21, 2025 at 7:25 PM
Upcoming interdisciplinary meeting: Cell Physics 2025
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
May 14, 2025 at 8:57 AM
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Reposted by Bianca Schrul
We are looking for a new colleague in the biology department at Saarland University!
We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.
Please share!
jobs.zeit.de/jobs/w2-prof...
We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.
Please share!
jobs.zeit.de/jobs/w2-prof...
W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) - Universität des Saarlandes
Universität des Saarlandes bietet Stelle als W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) in Saarbrücken - jetzt bewerben!
jobs.zeit.de
April 30, 2025 at 10:49 AM
We are looking for a new colleague in the biology department at Saarland University!
We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.
Please share!
jobs.zeit.de/jobs/w2-prof...
We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.
Please share!
jobs.zeit.de/jobs/w2-prof...
Dear #LipidDroplet friends, we are so much looking forward to the 2nd edition of our #EMBOLipidDroplets Workshop. Join us 21-26 September 2025 at beautiful Costa Brava!
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
March 11, 2025 at 3:17 PM
Dear #LipidDroplet friends, we are so much looking forward to the 2nd edition of our #EMBOLipidDroplets Workshop. Join us 21-26 September 2025 at beautiful Costa Brava!
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
This cannot be reiterated enough.
Ten simple rules for developing good reading habits during graduate school and beyond
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
January 26, 2025 at 12:33 PM
This cannot be reiterated enough.
Reposted by Bianca Schrul
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
www.biorxiv.org
January 11, 2025 at 7:51 PM
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism?
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
January 8, 2025 at 1:47 PM
Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism?
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
Reposted by Bianca Schrul
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
December 13, 2024 at 4:21 PM
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
New grant approved! Hooray! Looking for a #PhDstudent with strong interest in membrane protein reconstitution, physicochemical membrane properties and FRET-based assays. 👉 Which membrane properties drive protein partitioning to #LipidDroplets?
Please share!
#organelles #PhDposition #ScienceJobs
Please share!
#organelles #PhDposition #ScienceJobs
Prof. Dr. Bianca Schrul
www.uni-saarland.de
December 13, 2024 at 11:17 AM
New grant approved! Hooray! Looking for a #PhDstudent with strong interest in membrane protein reconstitution, physicochemical membrane properties and FRET-based assays. 👉 Which membrane properties drive protein partitioning to #LipidDroplets?
Please share!
#organelles #PhDposition #ScienceJobs
Please share!
#organelles #PhDposition #ScienceJobs
Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025, again at beautiful Costa Brava. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles #LipidMetabolism
Lipid Droplets: Cell-Biological Control of Metabolism
Lipid droplets are master regulators of nutrient and energy homeostasis, but their functions go far beyond these classical roles: They are important in cellular differentiation and various stress res…
meetings.embo.org
December 11, 2024 at 12:14 PM
Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025, again at beautiful Costa Brava. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles #LipidMetabolism
Reposted by Bianca Schrul
Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!
November 28, 2024 at 10:02 AM
Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!
Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
November 26, 2024 at 2:51 PM
Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
Attention #LipidDroplet friends. The website for our 2nd edition of the #EMBO Workshop about lipid droplets will be launched soon. Stay tuned for an amazing lineup of speakers and sign up here for automatic notification when we go online: coming-soon.embo.org/w25-16
#Organelles #LipidMetabolism
#Organelles #LipidMetabolism
November 24, 2024 at 1:29 PM
Attention #LipidDroplet friends. The website for our 2nd edition of the #EMBO Workshop about lipid droplets will be launched soon. Stay tuned for an amazing lineup of speakers and sign up here for automatic notification when we go online: coming-soon.embo.org/w25-16
#Organelles #LipidMetabolism
#Organelles #LipidMetabolism
Reposted by Bianca Schrul
The German Society for Biochemistry and Molecular Biology (GBM) founded a new study group on Cellular Organelles. We just had a first exciting ‚Organelles&Friends’ meeting here at the RPTU. If you are GBM member and want to join the group, just enroll on the GBM homepage. @gbmev.bsky.social
November 22, 2024 at 7:19 AM
The German Society for Biochemistry and Molecular Biology (GBM) founded a new study group on Cellular Organelles. We just had a first exciting ‚Organelles&Friends’ meeting here at the RPTU. If you are GBM member and want to join the group, just enroll on the GBM homepage. @gbmev.bsky.social
Reposted by Bianca Schrul
November 16, 2024 at 7:35 PM
Reposted by Bianca Schrul
Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados!
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
November 16, 2024 at 3:53 AM
Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados!
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
Reposted by Bianca Schrul
Made one of these for lipids, will update continuously. Please share and let me know who I've missed
go.bsky.app/A27yZA6
go.bsky.app/A27yZA6
November 13, 2024 at 4:38 PM
Made one of these for lipids, will update continuously. Please share and let me know who I've missed
go.bsky.app/A27yZA6
go.bsky.app/A27yZA6
Reposted by Bianca Schrul
Our group investigates the role of #lipid droplets (green) in killing intracellular pathogens (blue, E coli in human macrophages) when they are searching for nutrients. In our family we have nicknamed them defensive lipid droplets and FATal attraction. Credit @robparton.bsky.social @UQpress
November 13, 2024 at 5:57 PM
Our group investigates the role of #lipid droplets (green) in killing intracellular pathogens (blue, E coli in human macrophages) when they are searching for nutrients. In our family we have nicknamed them defensive lipid droplets and FATal attraction. Credit @robparton.bsky.social @UQpress