Eric Chevet
@ericchevet.bsky.social
ER_literature, endoplasmic reticulum, proteostasis, secretory pathway, cancer research and more
PI @inserm
https://oss-clcc.univ-rennes.fr/
PI @inserm
https://oss-clcc.univ-rennes.fr/
Reposted by Eric Chevet
This review summarizes the #Ubiquitination & #Deubiquitination mechanisms, exploring their signaling crosstalk and multilayered regulatory functions in health & disease, while highlighting the clinical potential of their therapeutic targeting.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
December 28, 2025 at 2:30 AM
This review summarizes the #Ubiquitination & #Deubiquitination mechanisms, exploring their signaling crosstalk and multilayered regulatory functions in health & disease, while highlighting the clinical potential of their therapeutic targeting.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Reposted by Eric Chevet
Good morning all! Here is the last weekly issue of the year in #cancermetabolism and #mitochondrialbiology to accompany your readings! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
bims-camemi 2025-12-28 papers
biomed.news
December 28, 2025 at 6:56 AM
Good morning all! Here is the last weekly issue of the year in #cancermetabolism and #mitochondrialbiology to accompany your readings! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
ER-associated single-capped vaults are surprising and really cool!🤩 Some even contain ribosomes. Vault function is still mysterious but a role in protein quality control seems plausible.
Also great to see Dicty in the #TeamTomo spotlight! #ProtistsOnSky @kgeissler.bsky.social @becklab.bsky.social 🧪
Also great to see Dicty in the #TeamTomo spotlight! #ProtistsOnSky @kgeissler.bsky.social @becklab.bsky.social 🧪
December 28, 2025 at 8:34 PM
Reposted by Eric Chevet
ER-associated single-capped vaults are surprising and really cool!🤩 Some even contain ribosomes. Vault function is still mysterious but a role in protein quality control seems plausible.
Also great to see Dicty in the #TeamTomo spotlight! #ProtistsOnSky @kgeissler.bsky.social @becklab.bsky.social 🧪
Also great to see Dicty in the #TeamTomo spotlight! #ProtistsOnSky @kgeissler.bsky.social @becklab.bsky.social 🧪
December 28, 2025 at 12:54 PM
ER-associated single-capped vaults are surprising and really cool!🤩 Some even contain ribosomes. Vault function is still mysterious but a role in protein quality control seems plausible.
Also great to see Dicty in the #TeamTomo spotlight! #ProtistsOnSky @kgeissler.bsky.social @becklab.bsky.social 🧪
Also great to see Dicty in the #TeamTomo spotlight! #ProtistsOnSky @kgeissler.bsky.social @becklab.bsky.social 🧪
Reposted by Eric Chevet
‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏
December 28, 2025 at 7:28 AM
‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏
Reposted by Eric Chevet
Molecular glue degraders don't just block proteins; they reprogram cellular recognition logic to eliminate "undruggable" targets entirely.
Clues for Glues review by @zkozicka.bsky.social
doi.org/10.1042/EBC2...
Clues for Glues review by @zkozicka.bsky.social
doi.org/10.1042/EBC2...
December 28, 2025 at 3:20 PM
Molecular glue degraders don't just block proteins; they reprogram cellular recognition logic to eliminate "undruggable" targets entirely.
Clues for Glues review by @zkozicka.bsky.social
doi.org/10.1042/EBC2...
Clues for Glues review by @zkozicka.bsky.social
doi.org/10.1042/EBC2...
Reposted by Eric Chevet
In the decades after becoming a megastar, the French actress Brigitte Bardot, who has died at 91, became as known for her politics as she once had been for her acting career.
From Sex Appeal to the Far Right, Brigitte Bardot Symbolized a Changing France
In the decades after becoming a megastar, the French actress became as known for her politics as she once had been for her acting career.
nyti.ms
December 28, 2025 at 3:40 PM
In the decades after becoming a megastar, the French actress Brigitte Bardot, who has died at 91, became as known for her politics as she once had been for her acting career.
5′ UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins
5′ UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins
Han et al. demonstrate that binding of eIF3 to distinct sites in mRNA 5′ UTRs mediates chaperone recruitment to translating 80S ribosomes. This recruitment is essential for the correct folding of nascent ER membrane proteins, indicating that instructions for ER membrane protein folding are hardwired in the genome.
dlvr.it
December 28, 2025 at 8:15 PM
Reposted by Eric Chevet
The final set of #autophagy and #mTOR papers published this year and preselected by @biomednews.bsky.social engine. Enjoy!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
a merry christmas card with a christmas tree
ALT: a merry christmas card with a christmas tree
media.tenor.com
December 28, 2025 at 9:45 AM
The final set of #autophagy and #mTOR papers published this year and preselected by @biomednews.bsky.social engine. Enjoy!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
This week's selection of articles and #preprints on #proteostasisi thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Multi-scale classification decodes the complexity of the human E3 ligome www.nature.com/articles/s41...
Highlight: Multi-scale classification decodes the complexity of the human E3 ligome www.nature.com/articles/s41...
bims-proteo 2025-12-28 papers
biomed.news
December 28, 2025 at 11:24 AM
This week's selection of articles and #preprints on #proteostasisi thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Multi-scale classification decodes the complexity of the human E3 ligome www.nature.com/articles/s41...
Highlight: Multi-scale classification decodes the complexity of the human E3 ligome www.nature.com/articles/s41...
Reposted by Eric Chevet
If you want to map the spatial composition of a tissue or organ, 3D mapping is not an option.
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
December 24, 2025 at 10:32 AM
If you want to map the spatial composition of a tissue or organ, 3D mapping is not an option.
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
Reposted by Eric Chevet
The Trump admin sanctions several European officials today after Elon Musk was fined for several violations of their Digital Services Act.
December 23, 2025 at 8:56 PM
The Trump admin sanctions several European officials today after Elon Musk was fined for several violations of their Digital Services Act.
Reposted by Eric Chevet
Entering the USA no more… sorry for all American scientists and friends…
The Trump admin sanctions several European officials today after Elon Musk was fined for several violations of their Digital Services Act.
December 24, 2025 at 6:38 AM
Entering the USA no more… sorry for all American scientists and friends…
Reposted by Eric Chevet
Announcing the #China-#France Joint #Conference on #Neurodegeneration and #Secretion, to be held on March 10-13, 2026, in #Shenzhen.
Inserm #ShenzhenBayLaboratory #ambassadedefranceenchine #institutfrançais
lnkd.in/eygqBe8H
lnkd.in/ee88be-F
lnkd.in/e__7WYTJ
Inserm #ShenzhenBayLaboratory #ambassadedefranceenchine #institutfrançais
lnkd.in/eygqBe8H
lnkd.in/ee88be-F
lnkd.in/e__7WYTJ
December 17, 2025 at 6:39 PM
Announcing the #China-#France Joint #Conference on #Neurodegeneration and #Secretion, to be held on March 10-13, 2026, in #Shenzhen.
Inserm #ShenzhenBayLaboratory #ambassadedefranceenchine #institutfrançais
lnkd.in/eygqBe8H
lnkd.in/ee88be-F
lnkd.in/e__7WYTJ
Inserm #ShenzhenBayLaboratory #ambassadedefranceenchine #institutfrançais
lnkd.in/eygqBe8H
lnkd.in/ee88be-F
lnkd.in/e__7WYTJ
Reposted by Eric Chevet
Why should public or charitable funds support journals that refuse to meet basic standards of how they review papers and use publication fees?
11/11
11/11
December 24, 2025 at 12:12 AM
Why should public or charitable funds support journals that refuse to meet basic standards of how they review papers and use publication fees?
11/11
11/11
Reposted by Eric Chevet
Once a journal meets disclosure requirements, then scientists, not funders, should decide where to publish.
Transparency sets the floor.
Scientific judgment stays with researchers.
10/11
Transparency sets the floor.
Scientific judgment stays with researchers.
10/11
December 24, 2025 at 12:12 AM
Once a journal meets disclosure requirements, then scientists, not funders, should decide where to publish.
Transparency sets the floor.
Scientific judgment stays with researchers.
10/11
Transparency sets the floor.
Scientific judgment stays with researchers.
10/11
Reposted by Eric Chevet
These requirements reduce information asymmetries, increase accountability, and let scientists make informed publishing choices.
Funders should use their leverage to force transparency, not to rank or judge journals.
9/11
Funders should use their leverage to force transparency, not to rank or judge journals.
9/11
December 24, 2025 at 12:12 AM
These requirements reduce information asymmetries, increase accountability, and let scientists make informed publishing choices.
Funders should use their leverage to force transparency, not to rank or judge journals.
9/11
Funders should use their leverage to force transparency, not to rank or judge journals.
9/11
Reposted by Eric Chevet
Example:
Publishing in Biology (MDPI) costs ~$3,400
for profit, 17.5 day turnaround, doesn't pay reviewers
Biology Open @biologists.bsky.social costs $2,500
nonprofit, ≤7 working day turnaround, pays reviewers, uses explicit rubrics and QC checks.
5/11
journals.biologists.com/bio/pages/fa...
Publishing in Biology (MDPI) costs ~$3,400
for profit, 17.5 day turnaround, doesn't pay reviewers
Biology Open @biologists.bsky.social costs $2,500
nonprofit, ≤7 working day turnaround, pays reviewers, uses explicit rubrics and QC checks.
5/11
journals.biologists.com/bio/pages/fa...
Biology Open | The Company of Biologists
Biology Open | The Company of Biologists
Fast & Fair peer review
A new initiative offering high-quality peer review within 7 working days of submission
Biology Open (BiO) has embar...
journals.biologists.com
December 24, 2025 at 12:12 AM
Example:
Publishing in Biology (MDPI) costs ~$3,400
for profit, 17.5 day turnaround, doesn't pay reviewers
Biology Open @biologists.bsky.social costs $2,500
nonprofit, ≤7 working day turnaround, pays reviewers, uses explicit rubrics and QC checks.
5/11
journals.biologists.com/bio/pages/fa...
Publishing in Biology (MDPI) costs ~$3,400
for profit, 17.5 day turnaround, doesn't pay reviewers
Biology Open @biologists.bsky.social costs $2,500
nonprofit, ≤7 working day turnaround, pays reviewers, uses explicit rubrics and QC checks.
5/11
journals.biologists.com/bio/pages/fa...
Reposted by Eric Chevet
Some funders are taking small steps.
@hhmi-science.bsky.social requires preprints on servers like @openrxiv.bsky.social
Others restrict use of grant funds for APCs. But these policies don't address journal quality and peer-review rigor.
3/11
@hhmi-science.bsky.social requires preprints on servers like @openrxiv.bsky.social
Others restrict use of grant funds for APCs. But these policies don't address journal quality and peer-review rigor.
3/11
December 24, 2025 at 12:12 AM
Some funders are taking small steps.
@hhmi-science.bsky.social requires preprints on servers like @openrxiv.bsky.social
Others restrict use of grant funds for APCs. But these policies don't address journal quality and peer-review rigor.
3/11
@hhmi-science.bsky.social requires preprints on servers like @openrxiv.bsky.social
Others restrict use of grant funds for APCs. But these policies don't address journal quality and peer-review rigor.
3/11
Reposted by Eric Chevet
Responsible use of tax dollars or charitable funds means ensuring research is published in journals that meet clear standards for rigor and transparency.
This is not about prestige.
It’s about quality and accountability.
2/11
This is not about prestige.
It’s about quality and accountability.
2/11
December 24, 2025 at 12:12 AM
Responsible use of tax dollars or charitable funds means ensuring research is published in journals that meet clear standards for rigor and transparency.
This is not about prestige.
It’s about quality and accountability.
2/11
This is not about prestige.
It’s about quality and accountability.
2/11
Reposted by Eric Chevet
Should funders mandate where grantees can publish?
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
December 24, 2025 at 12:12 AM
Should funders mandate where grantees can publish?
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Reposted by Eric Chevet
L'Europe doit rester solide face à ces connards, parce que c'est typiquement les move de bâtards comme Musk qui vont vouloir s'en débarrasser et tous les droitos de merde. Le truc hilarant c'est l'ED française ou autre qui ne comprend pas que les US leur chie dessus pareil en ce moment.
December 24, 2025 at 8:11 AM
L'Europe doit rester solide face à ces connards, parce que c'est typiquement les move de bâtards comme Musk qui vont vouloir s'en débarrasser et tous les droitos de merde. Le truc hilarant c'est l'ED française ou autre qui ne comprend pas que les US leur chie dessus pareil en ce moment.
Reposted by Eric Chevet
Trump et son gouvernement vont donc lutter contre les gens qui luttent contre la haine.
C'est un beau résumé de ces gros nazis.
C'est un beau résumé de ces gros nazis.
Le régime de Trump frappe de sanctions personnelles :
- Les juges qui agissent contre les crimes internationaux
- Les responsables d'ONG luttant contre la haine (!)
- Un ex-commissaire européen en raison d'un choix démocratique souverain.
Ce régime est ennemi mortel de la démocratie libérale.
- Les juges qui agissent contre les crimes internationaux
- Les responsables d'ONG luttant contre la haine (!)
- Un ex-commissaire européen en raison d'un choix démocratique souverain.
Ce régime est ennemi mortel de la démocratie libérale.
December 24, 2025 at 7:59 AM
Trump et son gouvernement vont donc lutter contre les gens qui luttent contre la haine.
C'est un beau résumé de ces gros nazis.
C'est un beau résumé de ces gros nazis.
Reposted by Eric Chevet
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
The Center is a wonderful collaboration with scientists extraordinaire @taijamakinenlab.bsky.social Kari Vaahtomeri and Cecilia Sahlgren.
We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
I am delighted to introduce our new Centre of Excellence in Immune-Endothelial Interfaces (IMMENs) funded by the Research Council of Finland.
www.helsinki.fi/en/researchg...
I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
www.helsinki.fi/en/researchg...
I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
December 21, 2025 at 8:58 AM
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
Reposted by Eric Chevet
This is exactly why people claiming "it came up with a new set of experiments/ideas/concepts" are carrying water for the weasels trying to put genAI on everything. This is how we get science defunded. This is how your colleagues lose their jobs 🧪
Suppose you ask #AI for improvements to your writing.
The #LLM was trained on, but doesn’t mention, Smith’s work.
You adopt the suggestions containing Smith’s ideas.
You don’t even realize YOU’VE PLAGIARIZED because you’ve never read or heard of Smith.
The #LLM was trained on, but doesn’t mention, Smith’s work.
You adopt the suggestions containing Smith’s ideas.
You don’t even realize YOU’VE PLAGIARIZED because you’ve never read or heard of Smith.
LLM use in scholarly writing poses a provenance problem
Nature Machine Intelligence - LLM use in scholarly writing poses a provenance problem
doi.org
December 23, 2025 at 2:55 PM
This is exactly why people claiming "it came up with a new set of experiments/ideas/concepts" are carrying water for the weasels trying to put genAI on everything. This is how we get science defunded. This is how your colleagues lose their jobs 🧪