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PLOS Biology
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A leading life science journal that champions high-impact research across all disciplines—from molecules to ecosystems. We offer innovative formats and collaborative editorial support to ensure your work achieves its full scientific impact.
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We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.

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PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog
Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…
plos.io
Reposted by PLOS Biology
New work from Chengtian Zhao Lab at Ocean University 🐟🇨🇳
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
February 19, 2026 at 5:47 PM
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
February 19, 2026 at 5:30 PM
The #fly community aims to achieve a comprehensive genomic study of the Drosophilidae family. @pankajd.bsky.social @bernardkim.bsky.social @petrovadmitri.bsky.social @darrenobbard.bsky.social present a comparative gene annotation for 301 #Drosophilidae species @plosbiology.org 🧪 plos.io/4c3pyrI
February 19, 2026 at 5:25 PM
#Photoreceptor cells vary in the morphology of the light-absorbing outer segment, but why? This study in #zebrafish shows that the wavelength sensitivity of the expressed #opsin and the intensity of light exposure determine outer segment morphology @plosbiology.org 🧪 plos.io/4aKJi15
February 19, 2026 at 2:00 PM
The #fly community aims to achieve a comprehensive genomic study of the Drosophilidae family. @pankajd.bsky.social @bernardkim.bsky.social @petrovadmitri.bsky.social @darrenobbard.bsky.social present a comparative gene annotation for 301 #Drosophilidae species @plosbiology.org 🧪 plos.io/4c3pyrI
February 19, 2026 at 1:55 PM
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org 🧪 plos.io/4aoOQiX
February 18, 2026 at 5:25 PM
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org 🧪 plos.io/4aoOQiX
February 18, 2026 at 1:55 PM
Reposted by PLOS Biology
🧪 #episky #IDsky This is worth repeating
"Ultimately (in our view), this happens because the currency of scholarship—publication—is becoming increasingly
detached from the notion that publication is meant to add to the sum of human knowledge."
Improvements to methods should lead to more robust evidence and more rapid advances in knowledge. In their Perspective, Marcus Munafò & @mendelrandom.bsky.social look at why this hasn't been the case and what can be done about it #AcademicSky 🧪
Is scientific reform an unwinnable arms race?
Methodological improvements should, in theory, mean more robust evidence and inference, and more rapid advances in knowledge. However, these methods are often subsequently used in the pursuit of…
plos.io
February 18, 2026 at 11:48 AM
Reposted by PLOS Biology
This is happening "because the currency of scholarship—publication—is becoming increasingly detached from the notion that publication is meant to add to the sum of human knowledge. In other words, publication has increasingly become an end in itself."
February 18, 2026 at 10:03 AM
Reposted by PLOS Biology
"Journals are being swamped by manuscripts of increasingly minimal or even negative scholarly value, even as ever more journals are being launched to deal with a tidal wave of research."
February 18, 2026 at 10:02 AM
Reposted by PLOS Biology
Excellent (if somewhat depressing) article by Marcus Munafo and George Davey Smith. It's centered on epidemiology but the lessons apply broadly...
Improvements to methods should lead to more robust evidence and more rapid advances in knowledge. In their Perspective, Marcus Munafò & @mendelrandom.bsky.social look at why this hasn't been the case and what can be done about it #AcademicSky 🧪
Is scientific reform an unwinnable arms race?
Methodological improvements should, in theory, mean more robust evidence and inference, and more rapid advances in knowledge. However, these methods are often subsequently used in the pursuit of…
plos.io
February 18, 2026 at 10:00 AM
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org 🧪 plos.io/4aoOQiX
February 18, 2026 at 9:37 AM
Reposted by PLOS Biology
"the currency of scholarship—publication—is becoming increasingly detached from the notion that publication is meant to add to the sum of human knowledge. "
Improvements to methods should lead to more robust evidence and more rapid advances in knowledge. In their Perspective, Marcus Munafò & @mendelrandom.bsky.social look at why this hasn't been the case and what can be done about it #AcademicSky 🧪
Is scientific reform an unwinnable arms race?
Methodological improvements should, in theory, mean more robust evidence and inference, and more rapid advances in knowledge. However, these methods are often subsequently used in the pursuit of…
plos.io
February 18, 2026 at 8:06 AM
Reposted by PLOS Biology
Recently, there has been increasing discussion about the possible influence of viral infections 🦠 on neurodegeneration 🧠. A “Perspective” in @plosbiology.org by #DZNE scientists provides an overview of this emerging topic.
👉 journals.plos.org/plosbiology/...
Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower dement...
journals.plos.org
February 17, 2026 at 1:49 PM
Reposted by PLOS Biology
"We are seeing readily available data assets, such as... the UK Biobank, NHANES, and many other databases, being weaponized to generate manuscripts with minimal scholarly value and utility"
Improvements to methods should lead to more robust evidence and more rapid advances in knowledge. In their Perspective, Marcus Munafò & @mendelrandom.bsky.social look at why this hasn't been the case and what can be done about it #AcademicSky 🧪
Is scientific reform an unwinnable arms race?
Methodological improvements should, in theory, mean more robust evidence and inference, and more rapid advances in knowledge. However, these methods are often subsequently used in the pursuit of…
plos.io
February 17, 2026 at 12:01 PM
Reposted by PLOS Biology
How the processes of recuperation vitiate apparent methodological advances in medical research, from meta-analysis to Mendelian randomization
Improvements to methods should lead to more robust evidence and more rapid advances in knowledge. In their Perspective, Marcus Munafò & @mendelrandom.bsky.social look at why this hasn't been the case and what can be done about it #AcademicSky 🧪
Is scientific reform an unwinnable arms race?
Methodological improvements should, in theory, mean more robust evidence and inference, and more rapid advances in knowledge. However, these methods are often subsequently used in the pursuit of…
plos.io
February 17, 2026 at 8:26 AM
Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social
Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…
plos.io
February 17, 2026 at 8:55 AM
Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social
Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…
plos.io
February 16, 2026 at 5:35 PM
Differences between M & F are pervasive, but we often focus on #SexDifferences in the mean. @pietropollo.bsky.social @danielwanoble.bsky.social @itchyshin.bsky.social &co present #stats tools that allow comparison of #skewness, #kurtosis & correlations b'n groups @plosbiology.org 🧪 plos.io/4093nJs
February 16, 2026 at 5:30 PM
#Epilepsy is thought to develop via pathological connections involving widespread #brain regions. James Niemeyer explores a @plosbiology.org study showing how these connections are formed, and how this interconnectivity can serve as treatment target 🧪 Paper: plos.io/4cqSfij Primer: plos.io/4aBtqhq
February 16, 2026 at 5:25 PM
Reposted by PLOS Biology
Augmentation of frontoparietal gamma-band phase coupling enhances human altruistic behavior.

journals.plos.org/plosbiology/...
Augmentation of frontoparietal gamma-band phase coupling enhances human altruistic behavior
Prior work from this group showed that some types of altruistic choices were related to the coherence of gamma-band neural oscillations between frontal and parietal brain regions. This study in humans...
journals.plos.org
February 11, 2026 at 9:36 PM
Reposted by PLOS Biology
Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social
Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…
plos.io
February 16, 2026 at 2:05 PM
Differences between M & F are pervasive, but we often focus on #SexDifferences in the mean. @pietropollo.bsky.social @danielwanoble.bsky.social @itchyshin.bsky.social &co present #stats tools that allow comparison of #skewness, #kurtosis & correlations b'n groups @plosbiology.org 🧪 plos.io/4093nJs
February 16, 2026 at 2:00 PM