In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and...

The population of older Americans is expanding rapidly and is expected to double by 2060. While people are living longer than ever, many are also living with chronic health problems that impact their ...

Background: Frailty syndrome in older adults represents a significant public health concern, characterized by a reduction in physiological reserves and an increased susceptibility to stressors. This can result in adverse health outcomes, including falls, hospitalization, disability and mortality. The early identification and management of frailty are essential for improving quality of life and reducing healthcare costs. Conventional assessment techniques, including dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and muscle ultrasonography (US), are efficacious but frequently constrained in primary care settings by financial and accessibility limitations. Objective: To analyse the differences in anthropometric characteristics, physical function, nutritional status, cognitive status, and body composition among older adults identified as frail, pre-frail, or robust in primary care services using the PowerFrail mobile application. Furthermore, the study assesses the predictive capacity of body composition variables (whole-body phase angle (WBPhA) via BIA, US-measured rectus femoris muscle thickness, and DXA-derived lean mass) in identifying frailty and evaluates their feasibility for implementation in primary care. Methods: A descriptive cross-sectional study was conducted with 94 older adult participants aged between 70 and 80 years, recruited through the Andalusian Health System in Spain. Frailty status was classified using the PowerFrail App, which integrates muscle power assessment and provides personalized physical activity recommendations. Body composition was measured using WBPhA (BIA), muscle US, and DXA. Statistical analyses included one-way ANOVA for group comparisons, logistic regression to investigate associations, and receiver operating characteristic (ROC) curve analysis to evaluate the predictive accuracy of the body composition measures. Results: Participants were categorized into frail (28), pre-frail (33), and robust (33) groups. All body composition measures exhibited high specificity in detecting frailty, with varying sensitivity. Unadjusted US showed highest specificity but low sensitivity (10.7%). WBPhA and right leg lean mass (LeanM RL) demonstrated significant predictive capabilities, especially when adjusted for age and sex, with area under the curve (AUC) values ranging from 0.678 to 0.762. The adjusted LeanM RL model showed a good balance between sensitivity (35.7%) and specificity (93.9%, p=0.045), indicating its potential as a reliable frailty predictor. These findings are consistent with previous research emphasizing the importance of muscle mass and cellular health in frailty assessment. Conclusions: Body composition variables, particularly WBPhA, LeanM RL and US are effective predictors of frailty in older adults. The PowerFrail mobile application, combined with advanced body composition analysis, offers a practical and non-invasive method for early frailty detection in primary care settings. Integrating such technological tools can enhance the early identification and management of frailty, thereby improving health outcomes in the aging population.

Aging | doi:10.18632/aging.206090. Xiaohui Hao, Weiwei Zhao, Xianyu Zhang, Xiurong Lu, Cong Wang, Zhilin Zhang

Older adults reflect less on their personality traits than younger adults, and people with lower emotional stability or extraversion tend to reflect more on these traits, according to new findings published...

Aging | doi:10.18632/aging.206253. Emma S. Gargus, Rhea Sharma, Rebecca Gu, Camille Mulcahy, Brian W. Johnson, Jing Song, Jungwha Lee, Mary Zelinski, Francesca E. Duncan