Christian Frezza
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frezzalab.bsky.social
Christian Frezza
@frezzalab.bsky.social
4.4K followers 1.9K following 810 posts
I post papers on #cancermetabolism and #mitochondrialbiology. I also post about academia, metal music, and mindfulness.

https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
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frezzalab.bsky.social
Christian Frezza @frezzalab.bsky.social · Nov 13

This is an old post, but I would like to propose it again as I am new here.

This is a topic I am very passionate about. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic.
The mindful scientist network.febs.org/posts/the-mi... #FEBSnet
The mindful scientist
A more mindful approach to science can help scientists to handle negative and positive emotions better.
network.febs.org
frezzalab.bsky.social
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
Reposted by Christian Frezza
gzaffagnini.bsky.social
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:

pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima

and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social

Read the full issue here: biomed.news/bims-cebooc/...

#cebooc
@biomednews.bsky.social
November 9, 2025 at 9:24 AM
frezzalab.bsky.social
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:

biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
frezzalab.bsky.social
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...

Great work from @rjdlab.bsky.social !!
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 7:35 AM
frezzalab.bsky.social
www.linkedin.com/redir/redire...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.linkedin.com
November 6, 2025 at 6:37 PM
frezzalab.bsky.social
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of mitochondrial ribosomes in response to metabolic state. This structural “gear-switching” mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 6:37 PM
frezzalab.bsky.social
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of mitochondrial ribosomes in response to metabolic state. This structural “gear-switching” mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 4:57 PM
frezzalab.bsky.social
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.

journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 6, 2025 at 10:42 AM
frezzalab.bsky.social
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 5:04 PM
frezzalab.bsky.social
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 5, 2025 at 5:03 PM
frezzalab.bsky.social
Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.

network.febs.org/posts/thinki...
Thinking like a Scientist: The Limits of Genome Editing and Omics
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
network.febs.org
November 4, 2025 at 11:21 AM
frezzalab.bsky.social
Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.
November 4, 2025 at 8:01 AM
frezzalab.bsky.social
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:

biomed.news/bims-camemi/...

@biomednews.bsky.social #keepreading

"Coming back to where you started is not the same as never leaving."-Terry Pratchett
November 2, 2025 at 5:49 AM
frezzalab.bsky.social
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment url: academic.oup.com/jimmunol/art...
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment
Abstract. Cellular immunotherapy has revolutionized the treatment of hematologic malignancies yet has had limited success in the solid tumor microenvironme
academic.oup.com
November 1, 2025 at 2:39 PM
frezzalab.bsky.social
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts: Cell Reports www.cell.com/cell-reports...
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts
Chen et al. describe how TMX2, a thioredoxin-related transmembrane protein, moderates oxidative conditions at the endoplasmic reticulum-mitochondria contact site (ERMCS). This allows TMX2 to limit mit...
www.cell.com
November 1, 2025 at 9:25 AM
frezzalab.bsky.social
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://

www.sciencedirect.com/science/article/abs/pii/S1097276525008196

Congratulations @bensahralab.bsky.social !!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 29, 2025 at 5:23 AM
frezzalab.bsky.social
Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"Inside us there is something that has no name, that something is what we are."-José Saramago
October 26, 2025 at 6:25 AM
frezzalab.bsky.social
open.spotify.com/track/7IoK6j...

Oldie but goldie.
Passenger
open.spotify.com
October 25, 2025 at 1:21 PM
Reposted by Christian Frezza
kampmann.bsky.social
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.

Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.

Alzforum
www.alzforum.org/news/researc...

Preprint
www.biorxiv.org/content/10.1...
October 22, 2025 at 6:28 PM
frezzalab.bsky.social
www.sciencedirect.com/science/arti...

Organellar pH as an emerging vulnerability to exploit in cancer

Congrats to @cosimocommisso.bsky.social
Organellar pH as an emerging vulnerability to exploit in cancer
Cancer cells undergo metabolic reprogramming to sustain their energy demands, and favor glycolysis despite the presence of functional mitochondria. Th…
www.sciencedirect.com
October 24, 2025 at 4:48 AM
Reposted by Christian Frezza
barbmarte.bsky.social
new out in Nature www.nature.com/articles/d41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com
October 21, 2025 at 7:22 AM
frezzalab.bsky.social
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation: Trends in Pharmacological Sciences www.cell.com/trends/pharm...
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation
Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...
www.cell.com
October 21, 2025 at 6:49 AM
Reposted by Christian Frezza
nature.com
We asked 3,785 PhD students across 107 countries about their experiences. Where do you think the happiest doctoral candidates were?

go.nature.com/3Wzz2lL
Are these the happiest PhD students in the world?
Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?
go.nature.com
October 20, 2025 at 3:05 PM
Reposted by Christian Frezza
zimmer-bensch.bsky.social
What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation
Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...
www.biorxiv.org
October 20, 2025 at 9:09 AM
frezzalab.bsky.social
Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚

"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
October 19, 2025 at 5:35 AM