RyanLab_TCD
@ryanlab.bsky.social
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
Pinned
RyanLab_TCD
@ryanlab.bsky.social
· Nov 20
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling @insight.jci.org @cuanschutz.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
December 24, 2025 at 5:31 AM
Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling @insight.jci.org @cuanschutz.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Reposted by RyanLab_TCD
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19 @insight.jci.org @hopkinsmedicine.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
December 24, 2025 at 5:30 AM
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19 @insight.jci.org @hopkinsmedicine.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
🎄Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
December 23, 2025 at 1:00 PM
🎄Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
Reposted by RyanLab_TCD
link.springer.com/article/10.1...
The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells - The EMBO Journal
Oxidative stress is a major driver of cardiovascular disease; however, the fast changes in cellular metabolism caused by short-lived reactive oxygen species (ROS) remain ill-defined. Here, we characte...
link.springer.com
December 18, 2025 at 8:57 AM
link.springer.com/article/10.1...
The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
Reposted by RyanLab_TCD
Natural daylight during office hours improves glucose control and whole-body substrate metabolism @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
December 18, 2025 at 6:23 PM
Natural daylight during office hours improves glucose control and whole-body substrate metabolism @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by RyanLab_TCD
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons @natneuro.nature.com @massgeneralbrigham.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 17, 2025 at 5:55 PM
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons @natneuro.nature.com @massgeneralbrigham.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
December 16, 2025 at 12:11 PM
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research
Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...
doi.org
December 15, 2025 at 11:07 AM
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Reposted by RyanLab_TCD
We are very excited about the array of future applications for this technology, including diving deeper into the mechanisms of inflammation and accelerating the development of next-gen myeloid cell therapies. Check out the preprint here: www.biorxiv.org/content/10.6...
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells
Primary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we present a viru...
www.biorxiv.org
December 15, 2025 at 2:02 PM
We are very excited about the array of future applications for this technology, including diving deeper into the mechanisms of inflammation and accelerating the development of next-gen myeloid cell therapies. Check out the preprint here: www.biorxiv.org/content/10.6...
Reposted by RyanLab_TCD
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
www.biorxiv.org
December 16, 2025 at 6:35 AM
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Reposted by RyanLab_TCD
🔎 What are the consequences of hypermetabolism in human motor neurons?
Our new study from the @htyynismaa.bsky.social lab is out!
Using human iPSC-derived motor neurons, we show that increased energy demand drives key metabolic trade-offs.
🔗 www.nature.com/articles/s42...
Our new study from the @htyynismaa.bsky.social lab is out!
Using human iPSC-derived motor neurons, we show that increased energy demand drives key metabolic trade-offs.
🔗 www.nature.com/articles/s42...
Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency - Communications Biology
Hypermetabolism results in the redistribution of acetyl-CoA usage, reduced histone acetylation, and potential vulnerabilities of motor neurons via altered maintenance of acetylcholine
www.nature.com
December 15, 2025 at 12:43 PM
🔎 What are the consequences of hypermetabolism in human motor neurons?
Our new study from the @htyynismaa.bsky.social lab is out!
Using human iPSC-derived motor neurons, we show that increased energy demand drives key metabolic trade-offs.
🔗 www.nature.com/articles/s42...
Our new study from the @htyynismaa.bsky.social lab is out!
Using human iPSC-derived motor neurons, we show that increased energy demand drives key metabolic trade-offs.
🔗 www.nature.com/articles/s42...
Reposted by RyanLab_TCD
Reposted by RyanLab_TCD
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase | Science Advances www.science.org/doi/full/10....
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase
One bacterial enzyme LplA or LplJ rescues multiple lethal genetic defects in mitochondrial diseases.
www.science.org
December 14, 2025 at 6:39 PM
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase | Science Advances www.science.org/doi/full/10....
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
December 14, 2025 at 12:09 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
Reposted by RyanLab_TCD
Our latest now published in @natcomms.nature.com, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα.
We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D!
www.nature.com/articles/s41...
We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D!
www.nature.com/articles/s41...
www.nature.com
December 12, 2025 at 4:33 PM
Our latest now published in @natcomms.nature.com, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα.
We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D!
www.nature.com/articles/s41...
We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D!
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
Double stranded RNA sensing is silenced during early embryonic development @natcomms.nature.com @edinburghup.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 11, 2025 at 4:26 PM
Double stranded RNA sensing is silenced during early embryonic development @natcomms.nature.com @edinburghup.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
Fasting induces glucocorticoid receptor signaling that reduces AP-1 activity in ERα-positive breast cancers, acting as adjuvant to enhance endocrine therapy activity @nature.com @zwartlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 11, 2025 at 1:38 AM
Fasting induces glucocorticoid receptor signaling that reduces AP-1 activity in ERα-positive breast cancers, acting as adjuvant to enhance endocrine therapy activity @nature.com @zwartlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer.
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
December 11, 2025 at 11:05 PM
I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer.
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
Reposted by RyanLab_TCD
A direct role for a mitochondrial targeting sequence in signalling stress
A direct role for a mitochondrial targeting sequence in signalling stress - Nature
Cells can sense mitochondrial damage through signalling via an unimported mitochondrial targeting sequence.
www.nature.com
December 11, 2025 at 2:35 AM
A direct role for a mitochondrial targeting sequence in signalling stress
Reposted by RyanLab_TCD
Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...
Spatial and morphological organization of mitochondria in neurons across a connectome
Neuronal function depends on mitochondria, but little is known about their organization across neurons. Using an electron microscopy Drosophila connectome, we uncovered quantitative rules governing th...
www.science.org
December 11, 2025 at 7:26 PM
Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...
Reposted by RyanLab_TCD
Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade.
podcasts.apple.com/us/podcast/n...
podcasts.apple.com/us/podcast/n...
December 11, 2025 at 7:51 PM
Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade.
podcasts.apple.com/us/podcast/n...
podcasts.apple.com/us/podcast/n...
Reposted by RyanLab_TCD
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org
www.embo.org/people/revie...
www.embo.org/people/revie...
Review Commons: rethinking peer review – Features – EMBO
A conversation with Thomas Lemberger, lead of the Review Commons initiative and Head of Open Science Implementation at EMBO.
www.embo.org
December 11, 2025 at 8:52 AM
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org
www.embo.org/people/revie...
www.embo.org/people/revie...
Reposted by RyanLab_TCD
#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses - Nature Metabolism
Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.
www.nature.com
December 10, 2025 at 8:31 PM
#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!
Reposted by RyanLab_TCD
