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ryanlab.bsky.social
RyanLab_TCD
@ryanlab.bsky.social
1.1K followers 1.1K following 190 posts
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
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ryanlab.bsky.social
RyanLab_TCD @ryanlab.bsky.social · Aug 4
It was a pleasure to write this News & Views piece with Eloïse marques on the latest work from the lab of Jing Fan @natmetabolism.nature.com ⬇️⬇️

News & Views:
Macrophages say NO to nucleotide synthesis and salvage instead
nature.com/articles/s42...

Article:
nature.com/articles/s42...
Macrophages say NO to nucleotide synthesis and salvage instead - Nature Metabolism
Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a pre...
nature.com
Reposted by RyanLab_TCD
frezzalab.bsky.social
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
Reposted by RyanLab_TCD
cvasilescu.bsky.social
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 9, 2025 at 12:53 PM
Reposted by RyanLab_TCD
davidfinlaytcd.bsky.social
Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation!

Nonmetabolic function of HK2 acting as an RBP and translation regulator.

dx.plos.org/10.1371/jour...
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation
Hexokinase 2 (HK2) is traditionally known for its metabolic role in glycolysis. This study shows that it also functions as an RNA-binding protein that regulates mRNA translation, particularly of SOX10...
dx.plos.org
November 9, 2025 at 5:15 PM
ryanlab.bsky.social
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
November 10, 2025 at 9:23 AM
ryanlab.bsky.social
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria

www.cell.com/molecular-ce...
November 6, 2025 at 5:02 PM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
www.science.org
November 4, 2025 at 10:35 PM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
November 3, 2025 at 11:18 PM
Reposted by RyanLab_TCD
mito-oncogene.bsky.social
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?

rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Reposted by RyanLab_TCD
frezzalab.bsky.social
Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.
November 4, 2025 at 8:01 AM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Cell membrane stress upon viral infection induces expression and stabilization of host SMPDL3B, which, in turn, degrades cGAMP to suppress cGAS-STING signaling and promote viral replication @cp-immunity.bsky.social
www.cell.com/immunity/ful...
November 2, 2025 at 10:44 PM
ryanlab.bsky.social
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
November 3, 2025 at 4:27 PM
ryanlab.bsky.social
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
www.nature.com/articles/s41...
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity - Nature Immunology
Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subse...
www.nature.com
November 3, 2025 at 8:35 AM
ryanlab.bsky.social
An atlas of mitochondrial ATP synthase activity across the lifespan #mitochondria
www.sciencedirect.com/science/arti...
An atlas of mitochondrial ATP synthase activity across the lifespan
Mitochondrial dysfunction and declining energy production are hallmarks of aging, yet we lack a comprehensive systems-level view of ATP synthase (Comp…
www.sciencedirect.com
November 3, 2025 at 8:13 AM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans @jem.org @au.dk
rupress.org/jem/article-...
October 30, 2025 at 12:27 AM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice
www.science.org/doi/10.1126/... @roystrowdmd.bsky.social @wakeforestmed.bsky.social @weillcornell.bsky.social

Great to see @labwaggoner.bsky.social alum Taylor Brooks contributing
October 30, 2025 at 12:15 AM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
SARM1 senses dsDNA to promote NAD+ degradation and cell death @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
October 28, 2025 at 2:39 AM
ryanlab.bsky.social
📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
October 28, 2025 at 9:41 AM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Mitochondrial and lysosomal signaling orchestrates Treg cell metabolic states and functional fitness @sciimmunology.bsky.social @stjuderesearch.bsky.social
www.science.org/doi/10.1126/...
October 24, 2025 at 7:10 PM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Fundamental role of spatial positioning of Mycobacterium tuberculosis in mycobacterial survival in macrophages @natcomms.nature.com @ashwanikumar.bsky.social
www.nature.com/articles/s41...
October 24, 2025 at 1:10 AM
Reposted by RyanLab_TCD
immunoeditor.bsky.social
Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.
www.science.org
October 24, 2025 at 5:26 PM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
October 24, 2025 at 7:09 PM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
Not turbo cancer but turbo cancer-immunotherapy!
Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
October 22, 2025 at 6:51 PM
ryanlab.bsky.social
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Lots of excellent work inside incl.

Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
October 20, 2025 at 12:27 PM
Reposted by RyanLab_TCD
labwaggoner.bsky.social
@cellcellpress.bsky.social spotlight
Caspase-8 loss stings the skin: STING drives necroptosis and interferonopathy
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41...
October 17, 2025 at 4:41 PM
Reposted by RyanLab_TCD
robklose.bsky.social
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM