RyanLab_TCD
@ryanlab.bsky.social
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
Pinned
RyanLab_TCD
@ryanlab.bsky.social
· Nov 20
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social
February 9, 2026 at 7:39 PM
Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social
Reposted by RyanLab_TCD
#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature
Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...
doi.org
February 1, 2026 at 3:52 PM
#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by RyanLab_TCD
****2-NBDG does not measure glucose uptake****
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Single Cell Glucose Uptake Assays: A Cautionary Tale
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...
pmc.ncbi.nlm.nih.gov
January 30, 2026 at 1:57 AM
****2-NBDG does not measure glucose uptake****
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by RyanLab_TCD
A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
January 26, 2026 at 8:09 PM
A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
Reposted by RyanLab_TCD
YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
January 26, 2026 at 7:29 PM
YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
Reposted by RyanLab_TCD
Immunometabolism researchers are meeting in Newcastle on 16-17 April!
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
January 15, 2026 at 11:00 AM
Immunometabolism researchers are meeting in Newcastle on 16-17 April!
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
Looking forward to speaking at this #UKimmunomet26 conference in Newcastle. Make sure to check it out! @britsocimm.bsky.social
www.immunology.org/events/fuell...
www.immunology.org/events/fuell...
Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology
www.immunology.org
January 26, 2026 at 5:40 PM
Looking forward to speaking at this #UKimmunomet26 conference in Newcastle. Make sure to check it out! @britsocimm.bsky.social
www.immunology.org/events/fuell...
www.immunology.org/events/fuell...
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com
biomed.news/bims-imicid/...
Interesting finding:
Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com
January 26, 2026 at 2:10 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com
biomed.news/bims-imicid/...
Interesting finding:
Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com
Reposted by RyanLab_TCD
Why does mitochondrial disease still take ~8 years to diagnose?
This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier.
Recognition — not testing — is the bottleneck.
doi.org/10.1002/jmd2...
This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier.
Recognition — not testing — is the bottleneck.
doi.org/10.1002/jmd2...
January 24, 2026 at 3:06 PM
Why does mitochondrial disease still take ~8 years to diagnose?
This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier.
Recognition — not testing — is the bottleneck.
doi.org/10.1002/jmd2...
This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier.
Recognition — not testing — is the bottleneck.
doi.org/10.1002/jmd2...
Reposted by RyanLab_TCD
#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
doi.org
January 24, 2026 at 3:46 PM
#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
The transition from monocyte to tissue-resident macrophage requires DHPS 🧪 #immunometabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The transition from monocyte to tissue-resident macrophage requires DHPS - Nature
In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.
www.nature.com
January 22, 2026 at 12:25 AM
The transition from monocyte to tissue-resident macrophage requires DHPS 🧪 #immunometabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
💡 #ListerFellow @tjryan.bsky.social et al. reveal how microglia immune cells help organise memory engrams during early development. A clue to the mechanisms regulating "infantile amnesia" and why we forget our baby days? @ryanlab.bsky.social
👉 PLOS Biology journals.plos.org/plosbiology/...
👉 PLOS Biology journals.plos.org/plosbiology/...
Microglial activity during postnatal development is required for infantile amnesia in mice
Infantile amnesia limits recall of early-life memories, but its cellular basis is unclear. This study reveals that transient microglial activity during postnatal development regulates infant memory pe...
journals.plos.org
January 21, 2026 at 10:32 AM
💡 #ListerFellow @tjryan.bsky.social et al. reveal how microglia immune cells help organise memory engrams during early development. A clue to the mechanisms regulating "infantile amnesia" and why we forget our baby days? @ryanlab.bsky.social
👉 PLOS Biology journals.plos.org/plosbiology/...
👉 PLOS Biology journals.plos.org/plosbiology/...
Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome #mitochondria
rdcu.be/eZXXC
rdcu.be/eZXXC
Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome
Nature Communications - Mitochondrial respiration involves super-complexes whose assembly pathway is debated. Here, authors reveal structural intermediates showing that complex IV matures last,...
rdcu.be
January 21, 2026 at 1:10 AM
Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome #mitochondria
rdcu.be/eZXXC
rdcu.be/eZXXC
Reposted by RyanLab_TCD
Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
January 20, 2026 at 11:47 PM
Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke
www.researchsquare.com/article/rs-8...
www.researchsquare.com/article/rs-8...
Reposted by RyanLab_TCD
#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!
Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature
Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease t...
doi.org
January 19, 2026 at 4:21 PM
#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!
Reposted by RyanLab_TCD
⚠️ We are hiring a Postdoctoral Research Associate ⚠️
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍
#CambridgeUniversity #PostdoctoralResearch #JobOpportunity
For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍
#CambridgeUniversity #PostdoctoralResearch #JobOpportunity
For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced
www.cam.ac.uk
January 19, 2026 at 9:08 AM
⚠️ We are hiring a Postdoctoral Research Associate ⚠️
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍
#CambridgeUniversity #PostdoctoralResearch #JobOpportunity
For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍
#CambridgeUniversity #PostdoctoralResearch #JobOpportunity
For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...
Reposted by RyanLab_TCD
Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism
Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...
www.nature.com
January 18, 2026 at 12:36 PM
Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
January 18, 2026 at 12:13 PM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
Reposted by RyanLab_TCD
Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 17, 2026 at 5:44 AM
Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by RyanLab_TCD
Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
January 16, 2026 at 3:41 AM
Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
Reposted by RyanLab_TCD
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
www.nature.com
January 16, 2026 at 7:46 AM
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 13, 2026 at 4:25 PM
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
January 12, 2026 at 9:28 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
Reposted by RyanLab_TCD
Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
January 11, 2026 at 6:37 AM
Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
Reposted by RyanLab_TCD
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger
academic.oup.com
January 11, 2026 at 3:58 PM
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...