Rahul K
@theresearch.bsky.social
I run, ski, and engineer cells and materials; asking how nutrient sensing & signaling work: bit.ly/RK-GoogleScholar
🇪🇪: TalTech| Ex: Tartu Ülikool; 🇸🇪: Karolinska Institutet, Chalmers; 🇯🇵: Kyutech; 🇮🇳: IITD
🇪🇪: TalTech| Ex: Tartu Ülikool; 🇸🇪: Karolinska Institutet, Chalmers; 🇯🇵: Kyutech; 🇮🇳: IITD
Pinned
Rahul K
@theresearch.bsky.social
· Nov 11
I’d like to invite everyone working on engineering living materials to share this starter pack. Please drop me a message or leave a comment if you like to join the #ELMs community. go.bsky.app/RinsDZh
Reposted by Rahul K
🧪Hey Sciencers:
What's the best protein to tag if you want to look at the recycling endosome without disrupting it's function in human cells?
@franbottanelli.bsky.social ?
What's the best protein to tag if you want to look at the recycling endosome without disrupting it's function in human cells?
@franbottanelli.bsky.social ?
November 11, 2025 at 1:59 PM
🧪Hey Sciencers:
What's the best protein to tag if you want to look at the recycling endosome without disrupting it's function in human cells?
@franbottanelli.bsky.social ?
What's the best protein to tag if you want to look at the recycling endosome without disrupting it's function in human cells?
@franbottanelli.bsky.social ?
Reposted by Rahul K
I’m happy to share Hector Soria Carrera and Leonie Kauling’s recent work in Chem by @cellpress.bsky.social!
A 🧵 below:
www.cell.com/chem/fulltex...
A 🧵 below:
www.cell.com/chem/fulltex...
Primitive genotype-phenotype coupling in fuel-dependent synthetic cells with an autocatalyst
A challenge in the de novo synthesis of life is coupling genotype with phenotype.
To achieve this, we use fuel-dependent synthetic cells that host a low-fidelity replicator.
This replicator increases ...
www.cell.com
November 11, 2025 at 8:31 AM
I’m happy to share Hector Soria Carrera and Leonie Kauling’s recent work in Chem by @cellpress.bsky.social!
A 🧵 below:
www.cell.com/chem/fulltex...
A 🧵 below:
www.cell.com/chem/fulltex...
Reposted by Rahul K
Stress granules and protein aggregates reveal intracellular resource competition https://www.biorxiv.org/content/10.1101/2025.11.08.687377v1
November 10, 2025 at 8:30 PM
Stress granules and protein aggregates reveal intracellular resource competition https://www.biorxiv.org/content/10.1101/2025.11.08.687377v1
Reposted by Rahul K
There's a word for learning from evolution's inventions: bioinspiration. Here's my interactive story on the way animals and plants fuel technological creativity. Gift link: nyti.ms/4otNQyl
How Inventors Find Inspiration in Evolution (Gift Article)
Soft batteries and water-walking robots are among the many creations made possible by studying animals and plants.
nyti.ms
November 10, 2025 at 3:37 PM
There's a word for learning from evolution's inventions: bioinspiration. Here's my interactive story on the way animals and plants fuel technological creativity. Gift link: nyti.ms/4otNQyl
Reposted by Rahul K
Intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction https://www.biorxiv.org/content/10.1101/2025.11.10.687620v1
November 10, 2025 at 5:30 PM
Intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction https://www.biorxiv.org/content/10.1101/2025.11.10.687620v1
Reposted by Rahul K
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Rahul K
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Rahul K
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
November 10, 2025 at 2:58 PM
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
Reposted by Rahul K
In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5′‐End Modification During TOR Inhibition.
Saccharomyces cerevisiae produces exonuclease-resistant rRNA molecules upon TOR inhibition. This phenomenon occurs when cells enter the diauxic phase, upon addition of rapamycin to the culture, or wh...
onlinelibrary.wiley.com
November 10, 2025 at 2:10 PM
In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Rahul K
Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation!
Nonmetabolic function of HK2 acting as an RBP and translation regulator.
dx.plos.org/10.1371/jour...
Nonmetabolic function of HK2 acting as an RBP and translation regulator.
dx.plos.org/10.1371/jour...
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation
Hexokinase 2 (HK2) is traditionally known for its metabolic role in glycolysis. This study shows that it also functions as an RNA-binding protein that regulates mRNA translation, particularly of SOX10...
dx.plos.org
November 9, 2025 at 5:15 PM
Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation!
Nonmetabolic function of HK2 acting as an RBP and translation regulator.
dx.plos.org/10.1371/jour...
Nonmetabolic function of HK2 acting as an RBP and translation regulator.
dx.plos.org/10.1371/jour...
Reposted by Rahul K
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 9, 2025 at 12:53 PM
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Reposted by Rahul K
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: vector-stimuli-responsive magnetorheological fibrous materials, mechanophore crosslinkers, humidity responsive origami metamaterials, & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: vector-stimuli-responsive magnetorheological fibrous materials, mechanophore crosslinkers, humidity responsive origami metamaterials, & more 🧪
Vector-stimuli-responsive magnetorheological fibrous materials - Nature
Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.
www.nature.com
November 9, 2025 at 4:45 PM
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: vector-stimuli-responsive magnetorheological fibrous materials, mechanophore crosslinkers, humidity responsive origami metamaterials, & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: vector-stimuli-responsive magnetorheological fibrous materials, mechanophore crosslinkers, humidity responsive origami metamaterials, & more 🧪
Reposted by Rahul K
Congrats to Moritz Schlapansky, who successfully defended his PhD thesis on Friday! You can read his work on "scOUT-seq" profiling of single cell transcriptomes + editing outcomes in millions of cells and living mice at www.biorxiv.org/content/10.1...
November 10, 2025 at 7:56 AM
Congrats to Moritz Schlapansky, who successfully defended his PhD thesis on Friday! You can read his work on "scOUT-seq" profiling of single cell transcriptomes + editing outcomes in millions of cells and living mice at www.biorxiv.org/content/10.1...
Reposted by Rahul K
Microbiologists, take a bit of your time to advise FEMS online!
Learned societies are the backbone of science - let's support them (and let them support us)
Learned societies are the backbone of science - let's support them (and let them support us)
Final 48 Hours!
A huge THANK YOU to everyone who has already completed the FEMS survey. Your input is shaping the future of microbiology.
Have not finished yet? Please take a few more minutes to complete it. Every completed response is vital.
If you haven't started, click here: buff.ly/ZghfWnM
A huge THANK YOU to everyone who has already completed the FEMS survey. Your input is shaping the future of microbiology.
Have not finished yet? Please take a few more minutes to complete it. Every completed response is vital.
If you haven't started, click here: buff.ly/ZghfWnM
November 10, 2025 at 7:41 AM
Microbiologists, take a bit of your time to advise FEMS online!
Learned societies are the backbone of science - let's support them (and let them support us)
Learned societies are the backbone of science - let's support them (and let them support us)
Reposted by Rahul K
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬
join.com/companies/im...
join.com/companies/im...
Botnar Institute of Immune Engineering - BIIE (Zürich): Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants
Botnar Institute of Immune Engineering - BIIE has a job opening for Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants in Zürich (published: 30.10.2025). Apply now or check the ...
join.com
November 9, 2025 at 10:41 PM
1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!
Reposted by Rahul K
Scholars - if you're publishing articles behind a paywall, why not make your work accessible to everyone by also publishing a preprint version?
November 9, 2025 at 10:14 PM
Scholars - if you're publishing articles behind a paywall, why not make your work accessible to everyone by also publishing a preprint version?
Reposted by Rahul K
My books cartoon for this week’s @theguardian.com
November 9, 2025 at 4:04 PM
My books cartoon for this week’s @theguardian.com
Reposted by Rahul K
this looks very interesting with numerous implications for nuclear biology and gene expression.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 9, 2025 at 5:07 PM
this looks very interesting with numerous implications for nuclear biology and gene expression.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Reposted by Rahul K
Cool new bioorthogonal reaction: malononitrile addition to azodicarboxylate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates - Nature Communications
Developing bioorthogonal reactions that enable investigation of biological processes is an important aim in chemical biology. Here, the authors report the malononitrile addition to azodicarboxylate (M...
www.nature.com
November 9, 2025 at 5:14 PM
Cool new bioorthogonal reaction: malononitrile addition to azodicarboxylate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rahul K
The new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...
October 24, 2025 at 8:28 AM
The new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...
Reposted by Rahul K
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 12:55 AM
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
Reposted by Rahul K
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
Reposted by Rahul K
Reposted by Rahul K
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
bit.ly
October 4, 2025 at 2:40 PM
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Reposted by Rahul K
Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels https://www.biorxiv.org/content/10.1101/2025.11.06.687046v1
November 8, 2025 at 3:47 PM
Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels https://www.biorxiv.org/content/10.1101/2025.11.06.687046v1