Vijay G. Sankaran
@bloodgenes.bsky.social
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist
bloodgenes.org
bloodgenes.org
Really excited for this session at #ASH25 💻🧠🩸!! Please come and join us on Saturday, December 6th, at 4 pm!
#ASH25 is your front-row seat to the future of #hematology Experience the breakthroughs changing the field with Dr. Vijay G. Sankaran as experts explore how #AI is driving new possibilities in research & the care of patients.
🔗 https://ow.ly/7Ev850XpIzU
#ASHinaFlash
🔗 https://ow.ly/7Ev850XpIzU
#ASHinaFlash
November 11, 2025 at 1:25 AM
Really excited for this session at #ASH25 💻🧠🩸!! Please come and join us on Saturday, December 6th, at 4 pm!
Reposted by Vijay G. Sankaran
Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 5, 2025 at 10:45 PM
Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great to see these fantastic studies defining thymic stromal cells that could enable regeneration of T cells from @ScaddenLab (mesenchymal) and from @dudakov-lab.bsky.social, @DrMvandenBrink, and colleagues (epithelial):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 4, 2025 at 1:52 PM
Great to see these fantastic studies defining thymic stromal cells that could enable regeneration of T cells from @ScaddenLab (mesenchymal) and from @dudakov-lab.bsky.social, @DrMvandenBrink, and colleagues (epithelial):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Really fortunate to have had the privilege to work with Parmesh Thakoordial! Congratulations, Parmesh!!!
www.albany.edu/news-center/...
www.albany.edu/news-center/...
Junior Earns Obama-Chesky Scholarship for Public Service
UAlbany Junior Parmesh Thakoordial was recently named a recipient of the Obama-Chesky Scholarship for Public Service, a prestigious national program created by former President Barack Obama, Michelle ...
www.albany.edu
October 30, 2025 at 12:50 PM
Really fortunate to have had the privilege to work with Parmesh Thakoordial! Congratulations, Parmesh!!!
www.albany.edu/news-center/...
www.albany.edu/news-center/...
Reposted by Vijay G. Sankaran
What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
www.nature.com
October 29, 2025 at 4:10 PM
What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
New findings from Xiaohui Zhang, Bo Huang et al. not only elucidate the molecular mechanism of JAK2V617F essential #thrombocythemia but also provide a potential strategy for its treatment. rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
October 29, 2025 at 2:45 PM
New findings from Xiaohui Zhang, Bo Huang et al. not only elucidate the molecular mechanism of JAK2V617F essential #thrombocythemia but also provide a potential strategy for its treatment. rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Terrific work from @kyleferchen.bsky.social, @nathansalomonis.bsky.social, @leegrimeslab.bsky.social, and colleagues that advances our understanding of hematopoiesis by integrating multiple single-cell data types in @natimmunol.nature.com: rdcu.be/eL8oO
October 29, 2025 at 1:25 PM
Terrific work from @kyleferchen.bsky.social, @nathansalomonis.bsky.social, @leegrimeslab.bsky.social, and colleagues that advances our understanding of hematopoiesis by integrating multiple single-cell data types in @natimmunol.nature.com: rdcu.be/eL8oO
If you are stuck in an airport, it is made so much better by having friendly hematologists around!🩸
October 25, 2025 at 12:56 AM
If you are stuck in an airport, it is made so much better by having friendly hematologists around!🩸
Reposted by Vijay G. Sankaran
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 5:22 PM
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Reposted by Vijay G. Sankaran
We are pleased to announce Dr. Wendy Chung of Harvard Medical School as the 2026 APS & SPR Mary Ellen Avery Neonatal Award Recipient! The award will be presented at the PAS 2026 Meeting. Congratulations, Dr. Chung!
Read More: https://ow.ly/kOb850Xbagg
Read More: https://ow.ly/kOb850Xbagg
October 14, 2025 at 4:02 PM
We are pleased to announce Dr. Wendy Chung of Harvard Medical School as the 2026 APS & SPR Mary Ellen Avery Neonatal Award Recipient! The award will be presented at the PAS 2026 Meeting. Congratulations, Dr. Chung!
Read More: https://ow.ly/kOb850Xbagg
Read More: https://ow.ly/kOb850Xbagg
Fortunate to work and 🎳 with this amazing team!!!
October 9, 2025 at 9:27 PM
Fortunate to work and 🎳 with this amazing team!!!
Reposted by Vijay G. Sankaran
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
We are proud to announce that U.S. News & World Report has recognized Dana-Farber/Boston Children's (@bostonchildrens.bsky.social) Cancer and Blood Disorders Center as the #3 pediatric cancer program in the nation in its 2025-26 Best Children's Hospitals report.
Learn more: bit.ly/4o7ApUc
Learn more: bit.ly/4o7ApUc
October 7, 2025 at 5:10 PM
We are proud to announce that U.S. News & World Report has recognized Dana-Farber/Boston Children's (@bostonchildrens.bsky.social) Cancer and Blood Disorders Center as the #3 pediatric cancer program in the nation in its 2025-26 Best Children's Hospitals report.
Learn more: bit.ly/4o7ApUc
Learn more: bit.ly/4o7ApUc
Reposted by Vijay G. Sankaran
Breaking News: The Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for their work on immune systems.
Nobel Prize in Physiology or Medicine Is Awarded for Work in Peripheral Immune Tolerance
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi were awarded the prize on Monday.
nyti.ms
October 6, 2025 at 9:44 AM
Breaking News: The Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for their work on immune systems.
Reposted by Vijay G. Sankaran
Abstracts & scholarship apps for #KSHemato26 are due Oct 29—but @beaudinlab.bsky.social explains why you should submit early! 🎥 youtu.be/FcO6D87EC_Q
Join us Feb 23–26, 2026 in Keystone, CO 👉 keysym.us/KSHemato26
@bloodgenes.bsky.social #hematopoiesis #bonemarrow #hematopoieticstemcells
Join us Feb 23–26, 2026 in Keystone, CO 👉 keysym.us/KSHemato26
@bloodgenes.bsky.social #hematopoiesis #bonemarrow #hematopoieticstemcells
KSQA: Dr. Anna Beaudin (Hematopoiesis)
YouTube video by KeystoneSymposia
youtu.be
September 25, 2025 at 4:36 PM
Abstracts & scholarship apps for #KSHemato26 are due Oct 29—but @beaudinlab.bsky.social explains why you should submit early! 🎥 youtu.be/FcO6D87EC_Q
Join us Feb 23–26, 2026 in Keystone, CO 👉 keysym.us/KSHemato26
@bloodgenes.bsky.social #hematopoiesis #bonemarrow #hematopoieticstemcells
Join us Feb 23–26, 2026 in Keystone, CO 👉 keysym.us/KSHemato26
@bloodgenes.bsky.social #hematopoiesis #bonemarrow #hematopoieticstemcells
Reposted by Vijay G. Sankaran
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
September 22, 2025 at 8:41 PM
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Reposted by Vijay G. Sankaran
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
September 22, 2025 at 5:29 AM
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
Such an important article on the challenges facing our ability to develop 🧬 gene therapies for genetic 🩸 disorders:
www.nytimes.com/2025/09/22/h...
www.nytimes.com/2025/09/22/h...
These Patients Got the Cure. Then It Went Away.
www.nytimes.com
September 22, 2025 at 4:32 PM
Such an important article on the challenges facing our ability to develop 🧬 gene therapies for genetic 🩸 disorders:
www.nytimes.com/2025/09/22/h...
www.nytimes.com/2025/09/22/h...
Reposted by Vijay G. Sankaran
Today is World Marrow Donor Day! We hope you will join us today in thanking the selfless individuals who register and donate stem cells to save the lives of patients in need. #WMDD25 #PedsHemeOnc #PHODocs #hematology
September 20, 2025 at 5:02 PM
Today is World Marrow Donor Day! We hope you will join us today in thanking the selfless individuals who register and donate stem cells to save the lives of patients in need. #WMDD25 #PedsHemeOnc #PHODocs #hematology
Reposted by Vijay G. Sankaran
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!!
www.nytimes.com/2025/09/11/h...
www.nytimes.com/2025/09/11/h...
Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers
www.nytimes.com
September 11, 2025 at 6:00 PM
Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!!
www.nytimes.com/2025/09/11/h...
www.nytimes.com/2025/09/11/h...
Reposted by Vijay G. Sankaran
Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1...
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
September 8, 2025 at 5:13 PM
Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1...
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!