Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jem
🌐 rupress.org/jem
Pinned
Journal of Experimental Medicine
@jem.org
· Dec 17
The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...
Reposted by Journal of Experimental Medicine
Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
Ostendorf et al. show that activation of liver-X-receptors preconditions T cells to render them more receptive to adopting effector states upon activation.
doi.org
February 10, 2026 at 3:39 PM
Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.
Nasal #vaccination aims to generate protection from pathogens. Liu, Stoler-Barak, and @zivshulman.bsky.social demonstrate that B cells in the nasal lymph nodes depend on BCR affinity and CCR6 for positioning in the NALT subepithelial dome and class switching to IgA. rupress.org/jem/article/...
February 10, 2026 at 5:45 PM
Nasal #vaccination aims to generate protection from pathogens. Liu, Stoler-Barak, and @zivshulman.bsky.social demonstrate that B cells in the nasal lymph nodes depend on BCR affinity and CCR6 for positioning in the NALT subepithelial dome and class switching to IgA. rupress.org/jem/article/...
@ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
February 10, 2026 at 5:04 PM
@ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
A recent JEM study from Aroca-Crevillén, @drusqui.bsky.social et al. (rupress.org/jem/article/... ) may provide a novel clue into the connection between neutrophils and the severity of daytime heart attacks. More in @jama.com: jamanetwork.com/journals/jama/fullarticle/2844961
Why Are Daytime Heart Attacks Worse?
This Medical News article discusses a new study that may reveal why myocardial infarctions tend to be less severe at night and how modulating the circadian rhythms of an immune cell may be a key to…
jamanetwork.com
February 9, 2026 at 3:30 PM
A recent JEM study from Aroca-Crevillén, @drusqui.bsky.social et al. (rupress.org/jem/article/... ) may provide a novel clue into the connection between neutrophils and the severity of daytime heart attacks. More in @jama.com: jamanetwork.com/journals/jama/fullarticle/2844961
Birui Pan, Chen Dong et al. identify Zbtb32 as a key promoter of terminally exhausted CD8⁺ T cell differentiation, enhancing cell cytotoxicity and anti-tumor function. This study valuable insights for cancer #immunotherapy. rupress.org/jem/article/...
February 6, 2026 at 5:00 PM
Birui Pan, Chen Dong et al. identify Zbtb32 as a key promoter of terminally exhausted CD8⁺ T cell differentiation, enhancing cell cytotoxicity and anti-tumor function. This study valuable insights for cancer #immunotherapy. rupress.org/jem/article/...
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. New study from Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth @yaleschoolofmed.bsky.social, Uthaman Gowthaman @umasschan.bsky.social and colleagues: rupress.org/jem/article/...
#LymphocyteBiology
#LymphocyteBiology
February 4, 2026 at 7:02 PM
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. New study from Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth @yaleschoolofmed.bsky.social, Uthaman Gowthaman @umasschan.bsky.social and colleagues: rupress.org/jem/article/...
#LymphocyteBiology
#LymphocyteBiology
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers, say Yuliang Wang, Xinyi Yang, Yunli Wang, Xiaoming Wang, Jingjing Chen (Nanjing Medical University) and colleagues: rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics #Metabolism
#LymphocyteBiology #Epigenetics #Metabolism
February 4, 2026 at 4:05 PM
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers, say Yuliang Wang, Xinyi Yang, Yunli Wang, Xiaoming Wang, Jingjing Chen (Nanjing Medical University) and colleagues: rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics #Metabolism
#LymphocyteBiology #Epigenetics #Metabolism
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. New study from Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues @impvienna.bsky.social: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
February 4, 2026 at 2:15 PM
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. New study from Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues @impvienna.bsky.social: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
JEM’s February issue is here! rupress.org/jem/issue/22...
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
February 2, 2026 at 3:02 PM
JEM’s February issue is here! rupress.org/jem/issue/22...
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
Reposted by Journal of Experimental Medicine
Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!
@lesly-calderon.bsky.social, Busslinger et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...
January 29, 2026 at 10:28 AM
Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!
Siniscalco, Fisher, Lu, Eisenbarth, Gowthaman et al. reveal that DOCK8 and STAT3 cooperate in CD4⁺ T cells to restrain Tfh13 differentiation and prevent food-specific IgE. rupress.org/jem/article/...
#LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics
#LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics
January 28, 2026 at 8:15 PM
Siniscalco, Fisher, Lu, Eisenbarth, Gowthaman et al. reveal that DOCK8 and STAT3 cooperate in CD4⁺ T cells to restrain Tfh13 differentiation and prevent food-specific IgE. rupress.org/jem/article/...
#LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics
#LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics
Yuliang Wang, Xinyi Yang, Jingjing Chen et al. demonstrate CD205 is upregulated in pre-plasma cells. The H3K27 demethylase Kdm6b, not Kdm6a, allows prePCs to become bona fide PCs by removing H3K27me3 marks at the Irf4 locus. rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics #Metabolism
#LymphocyteBiology #Epigenetics #Metabolism
January 28, 2026 at 5:30 PM
Yuliang Wang, Xinyi Yang, Jingjing Chen et al. demonstrate CD205 is upregulated in pre-plasma cells. The H3K27 demethylase Kdm6b, not Kdm6a, allows prePCs to become bona fide PCs by removing H3K27me3 marks at the Irf4 locus. rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics #Metabolism
#LymphocyteBiology #Epigenetics #Metabolism
@lesly-calderon.bsky.social, Busslinger et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...
January 28, 2026 at 5:00 PM
@lesly-calderon.bsky.social, Busslinger et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...
Explore new #Immunology papers incl. antitumor T cell responses, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, #myeloid cells ontogeny & the impacts of #circadian checkpoints on their function, and local B cell alterations in #neuroinflammation. 👉 rupress.org/jem/collecti...
January 28, 2026 at 3:15 PM
Explore new #Immunology papers incl. antitumor T cell responses, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, #myeloid cells ontogeny & the impacts of #circadian checkpoints on their function, and local B cell alterations in #neuroinflammation. 👉 rupress.org/jem/collecti...
@jengommerman.bsky.social lab reveals that dynamic changes in the brain, leptomeninges, & dural B cells are associated w/ age-dependent disease severity in an animal model of progressive #MultipleSclerosis rupress.org/jem/article/...
📘 #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 27, 2026 at 4:15 PM
@jengommerman.bsky.social lab reveals that dynamic changes in the brain, leptomeninges, & dural B cells are associated w/ age-dependent disease severity in an animal model of progressive #MultipleSclerosis rupress.org/jem/article/...
📘 #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
MHC one–two punch knocks out #cancer. Amir Ghorbani and Jonathan Yewdell @niaidnews.bsky.social discuss new study by Zhang, Chamoto and colleagues @ccii-kyoto.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
January 27, 2026 at 2:30 PM
MHC one–two punch knocks out #cancer. Amir Ghorbani and Jonathan Yewdell @niaidnews.bsky.social discuss new study by Zhang, Chamoto and colleagues @ccii-kyoto.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#TumorImmunology #Immunotherapy
#TumorImmunology #Immunotherapy
Oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. From Masaya Arai, Ryoji Kawakami, Shimon Sakaguchi and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 26, 2026 at 6:15 PM
Oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. From Masaya Arai, Ryoji Kawakami, Shimon Sakaguchi and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
SLC7A8 is essential for metabolic fitness and function of Th2 cells. From Santosh Panda, Marco Colonna and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 26, 2026 at 4:15 PM
SLC7A8 is essential for metabolic fitness and function of Th2 cells. From Santosh Panda, Marco Colonna and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance, say Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 25, 2026 at 6:15 PM
XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance, say Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 25, 2026 at 4:15 PM
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
Fibroblast diversity within human gut-associated lymphoid tissues. From Urs Mörbe (@ursmoerbe.bsky.social), William Agace and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 24, 2026 at 6:15 PM
Fibroblast diversity within human gut-associated lymphoid tissues. From Urs Mörbe (@ursmoerbe.bsky.social), William Agace and colleagues: rupress.org/jem/article/...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
Aroca-Crevillén, @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 24, 2026 at 4:15 PM
Aroca-Crevillén, @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood. From LeBlanc, Sobel, @mikerobe.bsky.social and colleagues: rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 23, 2026 at 6:15 PM
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood. From LeBlanc, Sobel, @mikerobe.bsky.social and colleagues: rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
Cunzhen Li et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 23, 2026 at 4:15 PM
Cunzhen Li et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
#Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @imgprague.bsky.social: rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
January 22, 2026 at 4:15 PM
#Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @imgprague.bsky.social: rupress.org/jem/article/...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...
📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...