Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jem
🌐 rupress.org/jem
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The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...
Aroca-Crevillén, @drusqui.bsky.social et al. @isciiisalud.bsky.social show that a #circadian #neutrophil checkpoint protects tissues from exuberant #inflammation and can be activated to protect the host. rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity
#CardiovascularBiology #InnateImmunity
December 26, 2025 at 7:30 PM
Aroca-Crevillén, @drusqui.bsky.social et al. @isciiisalud.bsky.social show that a #circadian #neutrophil checkpoint protects tissues from exuberant #inflammation and can be activated to protect the host. rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity
#CardiovascularBiology #InnateImmunity
New findings from Urs Mörbe, William Agace et al. provide an important framework for understanding gut-associated lymphoid tissue (GALT) diversity and function. rupress.org/jem/article/...
#MucosalImmunology #IBD #Crohns
#MucosalImmunology #IBD #Crohns
December 26, 2025 at 7:10 PM
New findings from Urs Mörbe, William Agace et al. provide an important framework for understanding gut-associated lymphoid tissue (GALT) diversity and function. rupress.org/jem/article/...
#MucosalImmunology #IBD #Crohns
#MucosalImmunology #IBD #Crohns
Xiaoyun Li, Sofie Hedlund Møller, Ping-Chih Ho et al. show that tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor #macrophages 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
December 26, 2025 at 3:15 PM
Xiaoyun Li, Sofie Hedlund Møller, Ping-Chih Ho et al. show that tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor #macrophages 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#TumorImmunology
New study from Yongkang Yang, Gregg Semenza et al. @jhu.edu suggests that targeting ISG20, in combination with #immunotherapy, could be an effective therapeutic strategy for triple-negative #BreastCancer. rupress.org/jem/article/...
#Hypoxia #Metastasis
#Hypoxia #Metastasis
December 26, 2025 at 2:45 PM
New study from Yongkang Yang, Gregg Semenza et al. @jhu.edu suggests that targeting ISG20, in combination with #immunotherapy, could be an effective therapeutic strategy for triple-negative #BreastCancer. rupress.org/jem/article/...
#Hypoxia #Metastasis
#Hypoxia #Metastasis
New work by @ursmoerbe.bsky.social et al. provides an important framework for understanding gut-associated lymphoid tissues (GALT) diversity and function. rupress.org/jem/article/...
🎥 See a short video summary by Mörbe: youtu.be/iIWKSSnwFTg
🎥 See a short video summary by Mörbe: youtu.be/iIWKSSnwFTg
December 25, 2025 at 8:15 PM
New work by @ursmoerbe.bsky.social et al. provides an important framework for understanding gut-associated lymphoid tissues (GALT) diversity and function. rupress.org/jem/article/...
🎥 See a short video summary by Mörbe: youtu.be/iIWKSSnwFTg
🎥 See a short video summary by Mörbe: youtu.be/iIWKSSnwFTg
Bringing Natural killer cells to the clinic: opportunities beyond #cancer. New review from Marjorie Cayatte, Valentin Picant, Marie Vétizou, and Eric Vivier @ciml.bsky.social: rupress.org/jem/article/...
#Autoimmunity #NKCells #Neurodegeneration
#Autoimmunity #NKCells #Neurodegeneration
December 24, 2025 at 7:30 PM
Bringing Natural killer cells to the clinic: opportunities beyond #cancer. New review from Marjorie Cayatte, Valentin Picant, Marie Vétizou, and Eric Vivier @ciml.bsky.social: rupress.org/jem/article/...
#Autoimmunity #NKCells #Neurodegeneration
#Autoimmunity #NKCells #Neurodegeneration
New work by Smyth et al (rupress.org/jem/article/... ) opens a new direction for #Alzheimers research, identifying CSF clearance at arachnoid cuff exits as a potential therapeutic target for modifying disease progression. Insights from Ting Du et al. rupress.org/jem/article/...
December 24, 2025 at 4:10 PM
New work by Smyth et al (rupress.org/jem/article/... ) opens a new direction for #Alzheimers research, identifying CSF clearance at arachnoid cuff exits as a potential therapeutic target for modifying disease progression. Insights from Ting Du et al. rupress.org/jem/article/...
Reposted by Journal of Experimental Medicine
As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk
December 24, 2025 at 3:47 PM
As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk
Tanaka, Maeda, Sakaguchi et al. provide a general model of how altered TCR signaling evokes #autoimmune disease. rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
December 24, 2025 at 3:15 PM
Tanaka, Maeda, Sakaguchi et al. provide a general model of how altered TCR signaling evokes #autoimmune disease. rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. New study from Liling Xu, Facundo D. Batista and colleagues @ragoninstitute.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #Metabolism #Autophagy #Mitophagy
#LymphocyteBiology #Metabolism #Autophagy #Mitophagy
December 24, 2025 at 2:45 PM
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. New study from Liling Xu, Facundo D. Batista and colleagues @ragoninstitute.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #Metabolism #Autophagy #Mitophagy
#LymphocyteBiology #Metabolism #Autophagy #Mitophagy
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
December 23, 2025 at 9:30 PM
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
The ability to specifically engage tumor-reactive T cells for therapeutic benefit is the ultimate goal of cancer #immunotherapy. New review by Mirabile-Brightman and Butterfield discusses advances in the development of personalized neoantigen therapies. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
December 23, 2025 at 8:30 PM
The ability to specifically engage tumor-reactive T cells for therapeutic benefit is the ultimate goal of cancer #immunotherapy. New review by Mirabile-Brightman and Butterfield discusses advances in the development of personalized neoantigen therapies. rupress.org/jem/article/...
#TumorImmunology
#TumorImmunology
Horton, Wenzel et al. @uthealthhouston.bsky.social identify mechanometabolism as a determinant of hematopoietic fate that could inform engineering of hematopoietic stem cells for disease modeling and treatment. rupress.org/jem/article/...
#Metabolism #CardiovascularBiology #Hematopoiesis
#Metabolism #CardiovascularBiology #Hematopoiesis
December 23, 2025 at 7:45 PM
Horton, Wenzel et al. @uthealthhouston.bsky.social identify mechanometabolism as a determinant of hematopoietic fate that could inform engineering of hematopoietic stem cells for disease modeling and treatment. rupress.org/jem/article/...
#Metabolism #CardiovascularBiology #Hematopoiesis
#Metabolism #CardiovascularBiology #Hematopoiesis
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M #malaria #vaccine. From Jonathan McDaniel, William Voss, @profkatieewer.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
December 23, 2025 at 3:15 PM
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M #malaria #vaccine. From Jonathan McDaniel, William Voss, @profkatieewer.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
In this Viewpoint, Shimon Sakaguchi recounts the work which lead to the identification of regulatory T cells. (Part of JEM's 125th Anniversary Historical Testimonials series): rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
December 23, 2025 at 3:15 PM
In this Viewpoint, Shimon Sakaguchi recounts the work which lead to the identification of regulatory T cells. (Part of JEM's 125th Anniversary Historical Testimonials series): rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
New study from the Ye Zheng lab @salkinstitute.bsky.social and colleagues uncovers an essential role of REV-ERB in the regulation of colonic RORγt⁺Foxp3⁺ Treg cell differentiation and function. rupress.org/jem/article/...
#Tolerance #Autoimmunity #LymphocyteBiology
#Tolerance #Autoimmunity #LymphocyteBiology
December 23, 2025 at 2:45 PM
New study from the Ye Zheng lab @salkinstitute.bsky.social and colleagues uncovers an essential role of REV-ERB in the regulation of colonic RORγt⁺Foxp3⁺ Treg cell differentiation and function. rupress.org/jem/article/...
#Tolerance #Autoimmunity #LymphocyteBiology
#Tolerance #Autoimmunity #LymphocyteBiology
Reposted by Journal of Experimental Medicine
Put a perspective piece together on how fever may have driven the evolution of antiviral genes: rupress.org/jem/article/...
Does fever drive the evolution of antiviral genes? | Journal of Experimental Medicine | Rockefeller University Press
Fever is an evolutionary conserved response to pathogens. In this Perspective, Langlois hypothesizes that antiviral genes are selected for their function a
rupress.org
December 15, 2025 at 3:20 PM
Put a perspective piece together on how fever may have driven the evolution of antiviral genes: rupress.org/jem/article/...
Reposted by Journal of Experimental Medicine
Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review, open-access
rupress.org/jem/article/...
rupress.org/jem/article/...
December 20, 2025 at 4:08 PM
Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review, open-access
rupress.org/jem/article/...
rupress.org/jem/article/...
New video summary from Pamela Wenzel (@uthealthhouston.bsky.social) on a new study "Mechanometabolism instructs hematopoietic stem cell specification" (Horton et al. rupress.org/jem/article/...)
youtu.be/T8VHOsA6o40
#Metabolism
youtu.be/T8VHOsA6o40
#Metabolism
Mechanometabolism instructs hematopoietic stem cell specification
Original paper: https://rupress.org/jem/article/223/3/e20250607/278562/Mechanometabolism-instructs-hematopoietic-stem
Video summary by Pamela L. Wenzel (The University of Texas Health Science Center…
youtu.be
December 22, 2025 at 4:30 PM
New video summary from Pamela Wenzel (@uthealthhouston.bsky.social) on a new study "Mechanometabolism instructs hematopoietic stem cell specification" (Horton et al. rupress.org/jem/article/...)
youtu.be/T8VHOsA6o40
#Metabolism
youtu.be/T8VHOsA6o40
#Metabolism
A 2019 study from Sakaguchi and colleagues showed that the tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
December 22, 2025 at 3:15 PM
A 2019 study from Sakaguchi and colleagues showed that the tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
Marjon Wouters, Isabelle Meyts @isabellemeyts.bsky.social and colleagues show that dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#InbornErrorsOfImmunity
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#InbornErrorsOfImmunity
December 22, 2025 at 3:15 PM
Marjon Wouters, Isabelle Meyts @isabellemeyts.bsky.social and colleagues show that dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#InbornErrorsOfImmunity
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#InbornErrorsOfImmunity
Reposted by Journal of Experimental Medicine
#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia.
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS
1. Sera from individuals acutely ill with lobar pneumonia possess the capacity to precipitate in high titre a non-protein somatic fraction derived from pne
rupress.org
December 21, 2025 at 5:40 PM
#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia.
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
Reposted by Journal of Experimental Medicine
Today's #JEMSpotlight @jem.org highlights the work of Michael Gerner & colleagues investigating early Th2 differentiation in lymph nodes after cutaneous allergen administration with quantitative imaging 📸
rupress.org/jem/article/...
rupress.org/jem/article/...
Site-specific regulation of Th2 differentiation within lymph node microenvironments | Journal of Experimental Medicine | Rockefeller University Press
The authors show that early Th2 cell differentiation is driven via prolonged T–DC macro-clustering in lymph nodes and occurs in a skin site-specific manner
rupress.org
December 21, 2025 at 5:51 PM
Today's #JEMSpotlight @jem.org highlights the work of Michael Gerner & colleagues investigating early Th2 differentiation in lymph nodes after cutaneous allergen administration with quantitative imaging 📸
rupress.org/jem/article/...
rupress.org/jem/article/...
Reposted by Journal of Experimental Medicine
Today’s #JEMjc @jem.org highlights the work of Alan Saltiel & colleagues @nature.com reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils preserve energy storage in sympathetically activated adipocytes - Nature
Neutrophil-derived IL-1β has a role in preserving lipid stores during metabolic stress.
www.nature.com
December 21, 2025 at 6:10 PM
Today’s #JEMjc @jem.org highlights the work of Alan Saltiel & colleagues @nature.com reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rhodehouse, Siliciano @jhu.edu and colleagues show that, in a nonhuman primate (NHP) model, natural control can be nearly as effective as antiretroviral therapy in controlling viral replication. rupress.org/jem/article/...
#Virology #LymphocyteBiology #InfectiousDisease #HostDefense
#Virology #LymphocyteBiology #InfectiousDisease #HostDefense
December 19, 2025 at 8:45 PM
Rhodehouse, Siliciano @jhu.edu and colleagues show that, in a nonhuman primate (NHP) model, natural control can be nearly as effective as antiretroviral therapy in controlling viral replication. rupress.org/jem/article/...
#Virology #LymphocyteBiology #InfectiousDisease #HostDefense
#Virology #LymphocyteBiology #InfectiousDisease #HostDefense