My Philedelphia marker has been low for a while but this is the first test where my Chronic Myeloid Leukemia has been undetectable.
I still have to continue with medication for a while, but if it stays this way for the next couple tests, I'm cured.
I still have to continue with medication for a while, but if it stays this way for the next couple tests, I'm cured.
November 5, 2025 at 9:59 PM
My Philedelphia marker has been low for a while but this is the first test where my Chronic Myeloid Leukemia has been undetectable.
I still have to continue with medication for a while, but if it stays this way for the next couple tests, I'm cured.
I still have to continue with medication for a while, but if it stays this way for the next couple tests, I'm cured.
What is observed is an increase in myeloid immune cells (macrophages, monocytes, neutrophils) and a decre<se in lymphpoid cells (B and T cells). This trend is in both sexes but more visible in women (more subjects, hence statistically different). This is suggestive, together
3/10
3/10
November 10, 2025 at 3:17 PM
What is observed is an increase in myeloid immune cells (macrophages, monocytes, neutrophils) and a decre<se in lymphpoid cells (B and T cells). This trend is in both sexes but more visible in women (more subjects, hence statistically different). This is suggestive, together
3/10
3/10
From Germany:
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
November 6, 2025 at 1:54 AM
From Germany:
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome
www.nature.com/articles/s41...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome @nature.com @gitlinlabmsk.bsky.social
@mskcancercenter.bsky.social
www.nature.com/articles/s41...
@mskcancercenter.bsky.social
www.nature.com/articles/s41...
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome - Nature
Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
www.nature.com
November 3, 2025 at 11:14 PM
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome @nature.com @gitlinlabmsk.bsky.social
@mskcancercenter.bsky.social
www.nature.com/articles/s41...
@mskcancercenter.bsky.social
www.nature.com/articles/s41...
👇
The cells they've developed for MS are like travelers hiking through the central nervous system and toting packs of supplies. The hikers are myeloid-derived suppressor cells, immune cells that find and suppress inflammation.
The cells they've developed for MS are like travelers hiking through the central nervous system and toting packs of supplies. The hikers are myeloid-derived suppressor cells, immune cells that find and suppress inflammation.
November 7, 2025 at 7:03 PM
👇
The cells they've developed for MS are like travelers hiking through the central nervous system and toting packs of supplies. The hikers are myeloid-derived suppressor cells, immune cells that find and suppress inflammation.
The cells they've developed for MS are like travelers hiking through the central nervous system and toting packs of supplies. The hikers are myeloid-derived suppressor cells, immune cells that find and suppress inflammation.
my good friend jess needs some help with the ongoing complications from graft-vs-host disease, after her bone marrow transplant for acute myeloid leukemia
she is a cool kid who enjoys soccer and books and f1 and lots of other cool things
if you're able, her gfm is here: gofund.me/7acdc94a3
she is a cool kid who enjoys soccer and books and f1 and lots of other cool things
if you're able, her gfm is here: gofund.me/7acdc94a3
Donate to Help Jess Donovan with medical expense due to GVHD Diagnosis, organized by Becca Morton
Thank you for your generous support of Jess Donovan and her f… Becca Morton needs your support for Help Jess Donovan with medical expense due to GVHD Diagnosis
gofund.me
November 3, 2025 at 6:44 PM
my good friend jess needs some help with the ongoing complications from graft-vs-host disease, after her bone marrow transplant for acute myeloid leukemia
she is a cool kid who enjoys soccer and books and f1 and lots of other cool things
if you're able, her gfm is here: gofund.me/7acdc94a3
she is a cool kid who enjoys soccer and books and f1 and lots of other cool things
if you're able, her gfm is here: gofund.me/7acdc94a3
Excited for two great speakers at Friday Afternoon Seminars!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
November 7, 2025 at 9:48 PM
Excited for two great speakers at Friday Afternoon Seminars!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
November 6, 2025 at 2:04 PM
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma @cp-immunity.bsky.social @vanallenlab.bsky.social @danafarber.bsky.social
@harvardmed.bsky.social @broadinstitute.org
www.cell.com/immunity/ful...
@harvardmed.bsky.social @broadinstitute.org
www.cell.com/immunity/ful...
November 2, 2025 at 10:50 PM
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma @cp-immunity.bsky.social @vanallenlab.bsky.social @danafarber.bsky.social
@harvardmed.bsky.social @broadinstitute.org
www.cell.com/immunity/ful...
@harvardmed.bsky.social @broadinstitute.org
www.cell.com/immunity/ful...
We ask the following question:
How did these animals acquire acute myeloid leukemia? Did humans cause this to test new treatments? How many millions of humans and “animals” have been discarded in your species’ futile attempt to alter your common destiny?
How did these animals acquire acute myeloid leukemia? Did humans cause this to test new treatments? How many millions of humans and “animals” have been discarded in your species’ futile attempt to alter your common destiny?
November 5, 2025 at 2:17 PM
We ask the following question:
How did these animals acquire acute myeloid leukemia? Did humans cause this to test new treatments? How many millions of humans and “animals” have been discarded in your species’ futile attempt to alter your common destiny?
How did these animals acquire acute myeloid leukemia? Did humans cause this to test new treatments? How many millions of humans and “animals” have been discarded in your species’ futile attempt to alter your common destiny?
@paralkarlab.bsky.social
Hello, since you are a hematology/oncology influencer, could you re-post my thing about the Myeloid Workshop being on despite ASH not getting it up on the website? Thank you!
Hello, since you are a hematology/oncology influencer, could you re-post my thing about the Myeloid Workshop being on despite ASH not getting it up on the website? Thank you!
November 4, 2025 at 11:43 PM
@paralkarlab.bsky.social
Hello, since you are a hematology/oncology influencer, could you re-post my thing about the Myeloid Workshop being on despite ASH not getting it up on the website? Thank you!
Hello, since you are a hematology/oncology influencer, could you re-post my thing about the Myeloid Workshop being on despite ASH not getting it up on the website? Thank you!
Online now: Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma
Bi et al. describe cell-type-specific transcriptional signatures of interferon (IFN) signaling in renal cell carcinoma (RCC) tumors and examine effects on immunotherapy outcomes. They find that myeloid IFNγ signaling, but not tumor IFNγ signaling, predicts poor outcomes in clinical trial cohorts, pointing to myeloid cells as mediators of IFN-driven immunotherapy resistance in RCC.
dlvr.it
November 1, 2025 at 7:56 PM
Online now: Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma
2️⃣ The Smart Move 🎯
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
November 2, 2025 at 7:53 PM
2️⃣ The Smart Move 🎯
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
Not to be missed! Our next #globalimmuno talk, today Wednesday, October 29th at 9am PST, noon EST, 4pm GMT by Dr. Maria Casanova.
Title: “Tracing Myeloid Cell Diversification from Development to Cancer”
ZOOM LINK: us06web.zoom.us/webinar/regi...
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...
Title: “Tracing Myeloid Cell Diversification from Development to Cancer”
ZOOM LINK: us06web.zoom.us/webinar/regi...
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...
Welcome! You are invited to join a webinar: GLOBAL IMMUNOTALKS: Virtual immunology seminar series . After registering, you will receive a confirmation email about joining the webinar.
Subscribe to our YouTube channel to stay updated and participate in the discussions: https://www.youtube.com/c/GLOBALIMMUNOTALKS
We now offer:
✅ Live streaming on YouTube (in addition to Zoom)
✅ Asyn...
us06web.zoom.us
October 29, 2025 at 10:49 AM
Not to be missed! Our next #globalimmuno talk, today Wednesday, October 29th at 9am PST, noon EST, 4pm GMT by Dr. Maria Casanova.
Title: “Tracing Myeloid Cell Diversification from Development to Cancer”
ZOOM LINK: us06web.zoom.us/webinar/regi...
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...
Title: “Tracing Myeloid Cell Diversification from Development to Cancer”
ZOOM LINK: us06web.zoom.us/webinar/regi...
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...
mRNA vaccines caused transient spikes of IFN-α, IFN-γ, and CXCL10 in humans, with up-regulation of PD-L1 on myeloid cells and activation of NK and T cells within 24 h post-vaccination.
October 25, 2025 at 1:42 PM
mRNA vaccines caused transient spikes of IFN-α, IFN-γ, and CXCL10 in humans, with up-regulation of PD-L1 on myeloid cells and activation of NK and T cells within 24 h post-vaccination.
Are these mice lying? Well, we can't really graft tumors onto humans and give them these treatments to compare what happens for ethical reasons, but we can do the next best thing—we can see whether the pattern of the immune response to mRNA vaccines is similar between mice and humans. They are!
October 25, 2025 at 5:53 PM
Are these mice lying? Well, we can't really graft tumors onto humans and give them these treatments to compare what happens for ethical reasons, but we can do the next best thing—we can see whether the pattern of the immune response to mRNA vaccines is similar between mice and humans. They are!
BH3 mimetics, including venetoclax, are reshaping acute myeloid leukemia treatment by targeting pro-survival proteins and enabling more personalized, effective therapies for diverse patient groups. doi.org/g97sg8
Novel drug combinations pave the way for personalized leukemia therapies
Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have published a review on BH3 mimetics—a new class of drugs that are reshaping the treatment landscape for acute myeloid leukemia (AML), one of the most aggressive and treatment-resistant blood cancers.
medicalxpress.com
October 23, 2025 at 3:43 PM
BH3 mimetics, including venetoclax, are reshaping acute myeloid leukemia treatment by targeting pro-survival proteins and enabling more personalized, effective therapies for diverse patient groups. doi.org/g97sg8
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells @jem.org
rupress.org/jem/article-...
rupress.org/jem/article-...
October 23, 2025 at 5:20 PM
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells @jem.org
rupress.org/jem/article-...
rupress.org/jem/article-...
An oncogenotype-immunophenotype paradigm governing the myeloid landscape in genetically engineered mouse models of prostate cancer https://www.biorxiv.org/content/10.1101/2025.10.21.683668v1
October 22, 2025 at 6:48 PM
An oncogenotype-immunophenotype paradigm governing the myeloid landscape in genetically engineered mouse models of prostate cancer https://www.biorxiv.org/content/10.1101/2025.10.21.683668v1
🛡️ Scientists demonstrated that the adipogenically differentiated MSCs enhance the survival and chemoresistance of acute myeloid leukemia cells by modulating metabolic and signaling pathways.
👉 https://bit.ly/3We8bvg
👉 https://bit.ly/3We8bvg
October 21, 2025 at 11:15 PM
🛡️ Scientists demonstrated that the adipogenically differentiated MSCs enhance the survival and chemoresistance of acute myeloid leukemia cells by modulating metabolic and signaling pathways.
👉 https://bit.ly/3We8bvg
👉 https://bit.ly/3We8bvg
From the US:
Mechanisms of sex differences in acute and long COVID sequelae in mice
www.biorxiv.org/content/10.1...
Screenshot from latest Science for ME weekly update
#LongCovid #Covid
Mechanisms of sex differences in acute and long COVID sequelae in mice
www.biorxiv.org/content/10.1...
Screenshot from latest Science for ME weekly update
#LongCovid #Covid
October 21, 2025 at 1:01 AM
From the US:
Mechanisms of sex differences in acute and long COVID sequelae in mice
www.biorxiv.org/content/10.1...
Screenshot from latest Science for ME weekly update
#LongCovid #Covid
Mechanisms of sex differences in acute and long COVID sequelae in mice
www.biorxiv.org/content/10.1...
Screenshot from latest Science for ME weekly update
#LongCovid #Covid
5) There was, however, a difference in inflammatory immune response as measured in the lungs and spleen during and after infection. Females had more cytokines, such as TNF-α, IL-6, IL-1β, CCL2, CCL3, and CCL4, which are involved in the activation and recruitment of myeloid cells.
October 20, 2025 at 8:14 AM
5) There was, however, a difference in inflammatory immune response as measured in the lungs and spleen during and after infection. Females had more cytokines, such as TNF-α, IL-6, IL-1β, CCL2, CCL3, and CCL4, which are involved in the activation and recruitment of myeloid cells.
3) Ideally, you want a radioactive tracer that is highly specific to a certain cell type or process so that you know exactly what the signal means.
In this ME/CFS study, they used the popular TSPO tracer, which binds to microglia, astrocytes, myeloid cells, etc.
In this ME/CFS study, they used the popular TSPO tracer, which binds to microglia, astrocytes, myeloid cells, etc.
October 19, 2025 at 7:35 AM
3) Ideally, you want a radioactive tracer that is highly specific to a certain cell type or process so that you know exactly what the signal means.
In this ME/CFS study, they used the popular TSPO tracer, which binds to microglia, astrocytes, myeloid cells, etc.
In this ME/CFS study, they used the popular TSPO tracer, which binds to microglia, astrocytes, myeloid cells, etc.
Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis | Science Advances www.science.org/doi/10.1126/... 🧪
Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis
Nanoparticle-armed MDSCs restore CNS immune homeostasis, unlocking a path for targeted MS and autoimmune therapies.
www.science.org
October 17, 2025 at 7:41 PM
Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis | Science Advances www.science.org/doi/10.1126/... 🧪
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
October 15, 2025 at 2:53 PM
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...