Journal of Experimental Medicine
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jem.org
Journal of Experimental Medicine
@jem.org
4.4K followers 570 following 680 posts
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
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jem.org
Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...

#InnateImmunity #inflammation
@hhmi.org
November 10, 2025 at 5:01 PM
jem.org
Explore the latest discoveries in #cancer #immunology and #immunotherapy published in JEM. This collection covers a broad range of topics, including T cell biology, immune checkpoint inhibitor therapies, and signaling pathways involved in antitumor immunity. 👉 rupress.org/jem/collecti...

#SITC25
November 10, 2025 at 4:02 PM
jem.org
Xiaofei Yu and colleagues uncover MCRS1 as a new activator of major histocompatibility complex (MHC) class I, which elicits anti-tumor immunity and enhances anti-PD-1 therapy. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...

#SITC25
November 8, 2025 at 6:15 PM
jem.org
Wen et al. review how YTHDF proteins regulate tumor responses to #radiotherapy by modulating DNA repair & the immune microenvironment, and discuss their potential as therapeutic targets. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 8, 2025 at 3:15 PM
jem.org
Arja Ray, @maxkrummel.bsky.social et al. show that targeting CD206⁺ #macrophages disrupts the establishment of a key antitumor immune axis. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...

#SITC25
November 7, 2025 at 6:15 PM
jem.org
Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/...

🎥 See a short video summary: youtu.be/AKSuTne83jQ

#Ribosomes
November 7, 2025 at 5:02 PM
jem.org
Explore recent studies on antiviral defense programs in human placenta, responses elicited after microbial sensing, noninflammatory #neurodegeneration, tumor-derived signals controlling #cancer progression, links between #arthritis and #obesity, and more 👉 rupress.org/jem/collecti...
#Cytokines
November 7, 2025 at 4:15 PM
jem.org
@kepauken.bsky.social, Sharpe et al. show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...

📘 #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 7, 2025 at 3:15 PM
jem.org
Villavicencio Gonzalez and Zoghbi review emerging insights into how proteins with an expanded #polyglutamine tract disrupt distinct cellular functions, and examine a multitude of discoveries that are inspiring and reshaping novel therapeutic strategies. rupress.org/jem/article/...

#Neuroscience
November 6, 2025 at 8:15 PM
jem.org
Xbp1 controls the reparative function of intestinal ILC2s during #colitis, say Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Shiyang Li and colleagues (Shandong University): rupress.org/jem/article/...

#MucosalImmunology
November 6, 2025 at 8:03 PM
jem.org
Ferry, Goldrath et al. show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 6, 2025 at 6:15 PM
jem.org
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy. The SPI1–YTHDF2–Notch signaling–MHC-I axis orchestrates the antigen cross-presentation function of dendritic cells. rupress.org/jem/article/...
November 6, 2025 at 5:00 PM
jem.org
We are pleased to introduce Natalie Cain as the Executive Editor of the journal! Natalie will guide the collaborative editorial process at JEM. Follow her at 🦋 @nataliecain.bsky.social
Learn more about Natalie 👉 rupress.org/jem/pages/je...
November 6, 2025 at 4:02 PM
jem.org
Deng Pan lab report that an in vivo #CRISPR-Cas9 screen reveals that inactivation of Calreticulin (CALR) potentiates CD8⁺ T cell-mediated anti-tumor immunity and overcomes tumor immune evasion. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 6, 2025 at 3:15 PM
jem.org
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms, say Cameron Bissett, Teresa Lambe and colleagues @ovg.ox.ac.uk: rupress.org/jem/article/...

#InfectiousDisease #HostDefense #MucosalImmunology #SARSCoV2 #COVID19
November 6, 2025 at 2:45 PM
jem.org
Vobořil, Hogquist @cfi-umn.bsky.social and colleagues reveal the #thymus as a niche for diverse, developmentally distinct #myeloid cells and elucidate their specific requirements for development and maturation. rupress.org/jem/article/...

#Hematopoiesis #Tolerance #LymphocyteBiology
November 5, 2025 at 8:30 PM
jem.org
Chehyun Nam et al. uncover MLL3 mutations as early events driving UASCC development, highlighting their role in tumor evolution and immune modulation. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 5, 2025 at 6:15 PM
jem.org
Esther Obeng is an attending physician and associate professor at Emory University, where she leads a research group focused on myelodysplastic syndromes (MDS). We spoke with Esther about her career, how her patients inform her research, and more: rupress.org/jem/article/...

#WomenInSTEM
November 5, 2025 at 5:00 PM
jem.org
✍️💻 Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME Activity is now available 👉 mskcc.cloud-cme.com/course/cours...
November 5, 2025 at 4:15 PM
jem.org
Xing et al. develop an approach which potently enhanced the proliferation, metabolic fitness & immunological activities of CAR-T cells, & subsequently enhanced the OV/CAR-T synergetic cytotoxicity. rupress.org/jem/article/...

📘 #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 5, 2025 at 3:15 PM
jem.org
Herpesvirus CNS infections in genetically heterozygous - transcriptionally homozygous IRF7 deficiency. New study from Marvin Werner, Trine Mogensen and colleagues @au.dk: rupress.org/jem/article/...

#HumanDiseaseGenetics #Immunodeficiency #InfectiousDisease #HostDefense #InbornErrorsOfImmunity
November 5, 2025 at 3:15 PM
jem.org
Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the JEM Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...
November 4, 2025 at 10:04 PM
jem.org
Yingying Qu et al. show that MYO1F in #neutrophils is required for the response to immune checkpoint blockade therapy. rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 4, 2025 at 6:15 PM
jem.org
New study from Bauer, Halin et al. @ethz.ch reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/...

#Lymphatics
November 4, 2025 at 5:00 PM
jem.org
Yan Xu et al. show that tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity: rupress.org/jem/article/...

📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 4, 2025 at 4:15 PM