Emmanuele Severi
@emmseveri.bsky.social
Research Fellow at Northumbria University: phage, synthetic biology, sialic acid, transport proteins. He/him.
Pinned
VOM-UK Conferences - NU-OMICS
Viruses of Microbes UK (VoM-UK) Conference The Virus of Microbes UK (VoM-UK) Conference is hosted by Microbiome Excellence Peak of Excellence at Northumbria University. This two-day conference takes place annually at the end of January/beginning of February and is a chance for researchers to gather and share their knowledge. The VoM-UK conference is designed to […]
hosting.northumbria.ac.uk
hosting.northumbria.ac.uk/nu-omics/vom...
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
Reposted by Emmanuele Severi
nature.com/articles/s41564-025-02207-0
We found one of these pseudo-lysogenic phages, also for E. coli, named SW1, that is T1-related, provides a benefit to kin that carry it, and depends on cryptic prophage protein YfdM: doi 10.1016/j.celrep.2019.03.070 (Cell Reports 2019).
We found one of these pseudo-lysogenic phages, also for E. coli, named SW1, that is T1-related, provides a benefit to kin that carry it, and depends on cryptic prophage protein YfdM: doi 10.1016/j.celrep.2019.03.070 (Cell Reports 2019).
Persistent virulent phages exist across bacterial isolates - Nature Microbiology
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
nature.com
December 30, 2025 at 8:01 PM
nature.com/articles/s41564-025-02207-0
We found one of these pseudo-lysogenic phages, also for E. coli, named SW1, that is T1-related, provides a benefit to kin that carry it, and depends on cryptic prophage protein YfdM: doi 10.1016/j.celrep.2019.03.070 (Cell Reports 2019).
We found one of these pseudo-lysogenic phages, also for E. coli, named SW1, that is T1-related, provides a benefit to kin that carry it, and depends on cryptic prophage protein YfdM: doi 10.1016/j.celrep.2019.03.070 (Cell Reports 2019).
Reposted by Emmanuele Severi
EMBO Workshop 24 – 27 April 2026 | Taipei, Taiwan
Evolving together: from genomics to biological interactions
meetings.embo.org/event/26-bio...
@chuanku.bsky.social
Evolving together: from genomics to biological interactions
meetings.embo.org/event/26-bio...
@chuanku.bsky.social
December 29, 2025 at 1:31 PM
EMBO Workshop 24 – 27 April 2026 | Taipei, Taiwan
Evolving together: from genomics to biological interactions
meetings.embo.org/event/26-bio...
@chuanku.bsky.social
Evolving together: from genomics to biological interactions
meetings.embo.org/event/26-bio...
@chuanku.bsky.social
Reposted by Emmanuele Severi
Society Event Grant: Eligible members can apply for the to attend the 2026 Annual Conference in Belfast, offering up to £350 for UK attendees and £650 for international participants. Apply by midnight GMT, January 2, 2026.
🔗Link here: microb.io/AC26Grant
#Microbio26 #Microbiology #MiM26
🔗Link here: microb.io/AC26Grant
#Microbio26 #Microbiology #MiM26
Society Events Grant
Funds are available to support eligible members attending the Society Annual Conference or one other Society meeting per year.
microb.io
December 28, 2025 at 1:01 PM
Society Event Grant: Eligible members can apply for the to attend the 2026 Annual Conference in Belfast, offering up to £350 for UK attendees and £650 for international participants. Apply by midnight GMT, January 2, 2026.
🔗Link here: microb.io/AC26Grant
#Microbio26 #Microbiology #MiM26
🔗Link here: microb.io/AC26Grant
#Microbio26 #Microbiology #MiM26
Reposted by Emmanuele Severi
(OK, I know this is not how I'd do it from the start, but I'm not doing it from the start)
Anyone know of a pipeline that uses nanopore reads to call SNPs in a bacterial genome. Kind of like breseq but nanopore (guessing there's way to do this with minmap etc... looking for something benchmarked)
Anyone know of a pipeline that uses nanopore reads to call SNPs in a bacterial genome. Kind of like breseq but nanopore (guessing there's way to do this with minmap etc... looking for something benchmarked)
December 27, 2025 at 10:27 PM
(OK, I know this is not how I'd do it from the start, but I'm not doing it from the start)
Anyone know of a pipeline that uses nanopore reads to call SNPs in a bacterial genome. Kind of like breseq but nanopore (guessing there's way to do this with minmap etc... looking for something benchmarked)
Anyone know of a pipeline that uses nanopore reads to call SNPs in a bacterial genome. Kind of like breseq but nanopore (guessing there's way to do this with minmap etc... looking for something benchmarked)
Reposted by Emmanuele Severi
Interesting new paper on Enterococcus lactis (the species formerly known as Clade B E. faecium)
'The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization'
onlinelibrary.wiley.com/doi/abs/10.1...
'The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization'
onlinelibrary.wiley.com/doi/abs/10.1...
The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization
Enterococcus lactis, a recently established species that was previously classified as Enterococcus faecium clade B. Given its recent taxonomic classification, studies on this bacterium are scarce, an...
onlinelibrary.wiley.com
December 27, 2025 at 11:48 AM
Interesting new paper on Enterococcus lactis (the species formerly known as Clade B E. faecium)
'The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization'
onlinelibrary.wiley.com/doi/abs/10.1...
'The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization'
onlinelibrary.wiley.com/doi/abs/10.1...
#microsky
Always exciting to read about an ABC transporter which uses separate SBPs to capture and transport related yet different substrates. Many such systems are unexplored, but so intriguing.
Transporters matter!!
journals.asm.org/doi/10.1128/...
Always exciting to read about an ABC transporter which uses separate SBPs to capture and transport related yet different substrates. Many such systems are unexplored, but so intriguing.
Transporters matter!!
journals.asm.org/doi/10.1128/...
A highly conserved ABC transporter mediates cello-oligosaccharide uptake in the extremely thermophilic, lignocellulolytic bacterium Anaerocellum bescii (f. Caldicellulosiruptor bescii) | Applied and E...
Anaerocellum bescii is the most thermophilic lignocellulolytic bacterium known and holds potential for
bioprocessing lignocellulosic biomass into renewable fuels. Its diverse ATP-binding
cassette (ABC...
journals.asm.org
December 26, 2025 at 10:20 AM
#microsky
Always exciting to read about an ABC transporter which uses separate SBPs to capture and transport related yet different substrates. Many such systems are unexplored, but so intriguing.
Transporters matter!!
journals.asm.org/doi/10.1128/...
Always exciting to read about an ABC transporter which uses separate SBPs to capture and transport related yet different substrates. Many such systems are unexplored, but so intriguing.
Transporters matter!!
journals.asm.org/doi/10.1128/...
#microsky #phagesky
Metagenomics suggests temperate #phages contribute auxiliary metabolic genes to small genome bacteria
journals.asm.org/doi/10.1128/...
Metagenomics suggests temperate #phages contribute auxiliary metabolic genes to small genome bacteria
journals.asm.org/doi/10.1128/...
Metagenomics reveals potential interactions between Patescibacteriota and their phages in groundwater ecosystems | mSystems
Here, we sought phages that were capable of infecting Patescibacteriota metagenome-assembled
genomes (MAGs), and further explored the diversity and novelty of Patescibacteriota
phages, as well as the ...
journals.asm.org
December 24, 2025 at 12:26 PM
#microsky #phagesky
Metagenomics suggests temperate #phages contribute auxiliary metabolic genes to small genome bacteria
journals.asm.org/doi/10.1128/...
Metagenomics suggests temperate #phages contribute auxiliary metabolic genes to small genome bacteria
journals.asm.org/doi/10.1128/...
#microsky #phagesky
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
High-throughput transposon mutagenesis defines the essential genome of diverse phages
Phages are important drivers of bacterial evolution with therapeutic potential as antimicrobials. However, gaps in our understanding of phages and our inability to rapidly engineer them with new genet...
www.biorxiv.org
December 21, 2025 at 5:01 AM
#microsky #phagesky
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
Reposted by Emmanuele Severi
Evolution of rhizobial siderophore utilization via accessory xeno-siderophore receptors and flexible intake machinery for self-produced siderophores
academic.oup.com/ismej/advanc...
academic.oup.com/ismej/advanc...
Evolution of rhizobial siderophore utilization via accessory xeno-siderophore receptors and flexible intake machinery for self-produced siderophores
Abstract. Bradyrhizobium and Sinorhizobium are dominant soybean microsymbionts in acidic/neutral and alkaline soils, respectively. However, the molecular m
academic.oup.com
December 20, 2025 at 5:40 PM
Evolution of rhizobial siderophore utilization via accessory xeno-siderophore receptors and flexible intake machinery for self-produced siderophores
academic.oup.com/ismej/advanc...
academic.oup.com/ismej/advanc...
Reposted by Emmanuele Severi
replicationists & recombinatics take note 👇
cells deal with transcription-replication collisions (TRCs) much more professionally and efficiently than the best bridge engineers. OK, they've had more time to practice...
thx, zeynep for pointing this out 🙏 #MicroSky
cells deal with transcription-replication collisions (TRCs) much more professionally and efficiently than the best bridge engineers. OK, they've had more time to practice...
thx, zeynep for pointing this out 🙏 #MicroSky
December 17, 2025 at 9:23 AM
replicationists & recombinatics take note 👇
cells deal with transcription-replication collisions (TRCs) much more professionally and efficiently than the best bridge engineers. OK, they've had more time to practice...
thx, zeynep for pointing this out 🙏 #MicroSky
cells deal with transcription-replication collisions (TRCs) much more professionally and efficiently than the best bridge engineers. OK, they've had more time to practice...
thx, zeynep for pointing this out 🙏 #MicroSky
Reposted by Emmanuele Severi
Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - @arccoesb.bsky.social go.nature.com/48Fqxwi
Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - Nature Biotechnology
The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed duri...
go.nature.com
December 15, 2025 at 4:41 PM
Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - @arccoesb.bsky.social go.nature.com/48Fqxwi
Reposted by Emmanuele Severi
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
Viral enzymes degrade to evade
Across all domains of life, immune systems rely on nucleotide-based signaling molecules
to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg,
and colleagues identify ...
www.cell.com
December 11, 2025 at 7:48 AM
Reposted by Emmanuele Severi
Check out the original paper (not by us; we just wrote the "journal club") which describes what they did! Also, in a great bit of timing, the authors just published this cool paper in Nature Communications on how these endosymbioses evolve:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Induced endosymbiosis between a fungus and bacterium reveals a shift from antagonism to commensalism - Nature Communications
Gassler et al. implant a free-living bacterium into fungal cells to study early steps in the establishment of an endosymbiosis. They observe vertical transmission of the bacteria despite initial host ...
www.nature.com
December 9, 2025 at 6:20 PM
Check out the original paper (not by us; we just wrote the "journal club") which describes what they did! Also, in a great bit of timing, the authors just published this cool paper in Nature Communications on how these endosymbioses evolve:
www.nature.com/articles/s41...
www.nature.com/articles/s41...