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Phage papers
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Phage-induced protection against lethal bacterial reinfection.

DOI: 10.1073/pnas.2423286122

https://pubmed.ncbi.nlm.nih.gov/40445752/
Phage-induced protection against lethal bacterial reinfection - PubMed
Bacteriophages, or phages, are viruses that target and infect bacteria. Due to a worldwide rise in antimicrobial resistance (AMR), phages have been proposed as a promising alternative to antibiotics for the treatment of resistant bacterial infections. Up to this point in history, phage use in precli …
pubmed.ncbi.nlm.nih.gov
November 10, 2025 at 3:33 PM
phagepapers.bsky.social
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection.

DOI: 10.1098/rstb.2024.0474

https://pubmed.ncbi.nlm.nih.gov/40904102/
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection - PubMed
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance. <i>Pseudomonas aeruginosa</i> can evolve resistance against its phage DMS<i>3vir</i> either by surf …
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 7:32 PM
phagepapers.bsky.social
Innovative Approaches to Combat Antimicrobial Resistance: A Review of Emerging Therapies and Technologies.

DOI: 10.1007/s12602-025-10676-2

https://pubmed.ncbi.nlm.nih.gov/41026406/
Innovative Approaches to Combat Antimicrobial Resistance: A Review of Emerging Therapies and Technologies - PubMed
The threat of antimicrobial resistance (AMR) presents a challenge in infectious diseases, leading to higher illness and deaths worldwide. No new antibiotic has been introduced, leaving healthcare systems vulnerable to resistant pathogens. Researchers are exploring innovative approaches to overcome t …
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 7:32 AM
phagepapers.bsky.social
PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis.

DOI: 10.1186/s12917-025-04975-7

https://pubmed.ncbi.nlm.nih.gov/40993698/
PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis - PubMed
Our findings establish SMphage-derived lysins as a conserved, therapeutically valuable class of antimicrobials with inherent broad-spectrum potential across diverse streptococcal pathogens. Building on the previously demonstrated in vivo efficacy of PlySK1249 against S. dysgalactiae and S. agalactia …
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 3:31 AM
phagepapers.bsky.social
Domain Interactions in a Chimeric Dual-domain Lysin Lead to Broad Bactericidal Activity.

DOI: 10.1016/j.jmb.2025.169373

https://pubmed.ncbi.nlm.nih.gov/40769489/
Domain Interactions in a Chimeric Dual-domain Lysin Lead to Broad Bactericidal Activity - PubMed
Phage-derived lysins represent a novel, non-traditional therapeutic agent against multidrug-resistant bacteria. However, engineering lysins with broad host range remain poorly addressed. Previously, we reported that the chimeric lysin ClyR, which harbors the CHAP catalytic domain of PlyC lysin (PlyC …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 11:31 PM
phagepapers.bsky.social
A novel lysin Ply691 exhibits potent bactericidal activity against Streptococcus suis.

DOI: 10.3389/fvets.2025.1653748

https://pubmed.ncbi.nlm.nih.gov/40989952/
A novel lysin Ply691 exhibits potent bactericidal activity against Streptococcus suis - PubMed
Ply691 exhibits broad-spectrum lytic activity against <i>S. suis</i> with unique structural advantages. It demonstrates robust efficacy <i>in vivo</i> without inducing resistance, showing significant therapeutic potential for streptococcal infections.
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 7:31 PM
phagepapers.bsky.social
A novel phage lysin Lys19 can serve as potential biocontrol agent against Clostridium perfringens and Streptococcus suis.

DOI: 10.1016/j.ijfoodmicro.2025.111475

https://pubmed.ncbi.nlm.nih.gov/41066954/
A novel phage lysin Lys19 can serve as potential biocontrol agent against Clostridium perfringens and Streptococcus suis - PubMed
Food contamination with Clostridium perfringens (C. perfringens) and Streptococcus suis (S. suis) may lead to severe foodborne illnesses in humans, and new effective strategies are needed to limit foodborne microbial contamination. In this study, a novel C. perfringens phage, XBG01, was isolated, an …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 3:31 PM
phagepapers.bsky.social
Isolation, whole-genome analysis, and anti-biofilm activity of carbapenem-resistant Enterobacteriaceae phage KP-BW9 and its lysin Lys-BW9.

DOI: 10.1016/j.micpath.2025.107960

https://pubmed.ncbi.nlm.nih.gov/40769225/
Isolation, whole-genome analysis, and anti-biofilm activity of carbapenem-resistant Enterobacteriaceae phage KP-BW9 and its lysin Lys-BW9 - PubMed
Carbapenem-resistant Enterobacteriaceae (CRE) have been classified as "urgent priority pathogens" due to their high drug resistance and wide spread. Among them, carbapenem-resistant Escherichia coli (CREco) and carbapenem-resistant Klebsiella pneumoniae (CRKP) are the main types. Phages are naturall …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 11:31 AM
phagepapers.bsky.social
Isolation and molecular characterization of bacteriophages isolated from lake water and their application in foods against Bacillus cereus.

DOI: 10.1186/s13104-025-07436-4

https://pubmed.ncbi.nlm.nih.gov/40890878/
Isolation and molecular characterization of bacteriophages isolated from lake water and their application in foods against Bacillus cereus - PubMed
Bacteriophages were isolated by using Bacillus cereus (B. cereus) as reference host. We found bacteriophage BC-VP titers (1.16 ± 0.18 × 10<sup>9</sup> PFU/mL) and BC-AJ (1.72 ± 0.19 × 10<sup>8</sup> PFU/mL). Both bacteriophages were polyvalent, targeting not only B. cereus, but also lysing enteropat …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 7:30 AM
phagepapers.bsky.social
Next-generation antimicrobials: A review of phage lysins as precision weapons against drug-resistant pathogens.

DOI: 10.1080/21505594.2025.2562634

https://pubmed.ncbi.nlm.nih.gov/40970331/
Next-generation antimicrobials: A review of phage lysins as precision weapons against drug-resistant pathogens - PubMed
The escalating misuse of antibiotics has precipitated a dramatic rise in bacterial drug resistance, rendering conventional therapies increasingly ineffective. In this post-antibiotic era, phage lysins have emerged as a novel class of antimicrobial agents, attracting significant attention for their p …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 3:30 AM
phagepapers.bsky.social
Biochemical characterization and X-ray structural and mutagenic analyses of the putative autolysin CdCwlT33800 catalytic domain from Clostridioides difficile.

DOI: 10.1128/aem.01216-25

https://pubmed.ncbi.nlm.nih.gov/40956107/
Biochemical characterization and X-ray structural and mutagenic analyses of the putative autolysin CdCwlT33800 catalytic domain from Clostridioides difficile - PubMed
<span><i>Clostridioides difficile</i> is a major pathogen of pseudomembranous colitis, and new antimicrobial agents are needed for its treatment. Autolysins are peptidoglycan-degrading enzymes that generally reorganize the cell wall during cell division but kill bacteria by bacteriolysis when applied from</span> …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 11:30 PM
phagepapers.bsky.social
Endolysin of Aeromonas bacteriophage 3: a novel Ca(2+)-activated peptidoglycan hydrolase giving insight into the regulation of phage lysis in Gram-negative bacteria.

DOI: 10.1016/j.ijbiomac.2025.146934

https://pubmed.ncbi.nlm.nih.gov/40825433/
Endolysin of Aeromonas bacteriophage 3: a novel Ca2+-activated peptidoglycan hydrolase giving insight into the regulation of phage lysis in Gram-negative bacteria - PubMed
A search for bacteriophage proteins with an EF-like calcium-binding loop, first discovered in the phage T5 endolysin (EndoT5), revealed a group of 71 peptidases of the M15_C subfamily. All the sequences found belonged to the phages infecting Gram-negative bacteria (Escherichia, Salmonella, Klebsiell …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 7:30 PM
phagepapers.bsky.social
ICTV Virus Taxonomy Profile: Plasmaviridae.

DOI: 10.1099/jgv.0.001060

https://pubmed.ncbi.nlm.nih.gov/29611799/
ICTV Virus Taxonomy Profile: Plasmaviridae - PubMed
The family Plasmaviridae includes bacterial viruses with slightly pleomorphic, enveloped virions with a diameter of 50-125 nm. Virions contain infectious, circular, supercoiled dsDNA molecule(s) of approximately 12 kbp. Plasmaviruses infect Acholeplasma species, wall-less bacteria of the class Molli …
pubmed.ncbi.nlm.nih.gov
August 10, 2025 at 5:56 PM
phagepapers.bsky.social
Characterization of novel Erwinia amylovora-specific phiEaSP1 phage and its application as phage cocktail for managing fire blight in apples.

DOI: 10.1016/j.micres.2025.128087

https://pubmed.ncbi.nlm.nih.gov/39892321/
Characterization of novel Erwinia amylovora-specific phiEaSP1 phage and its application as phage cocktail for managing fire blight in apples - PubMed
Erwinia amylovora (Ea) is a devastating bacterial pathogen that causes fire blight disease in Rosaceae family plants, including apples and pears. The use of bacteriophages is an alternative strategy to antibiotics for managing bacterial pathogens. In this study, the Ea-specific virulent phiEaSP1 pha …
pubmed.ncbi.nlm.nih.gov
August 8, 2025 at 1:54 AM
phagepapers.bsky.social
The activity of indigo carmine against bacteriophages: an edible antiphage agent.

DOI: 10.1007/s00253-025-13414-4

https://pubmed.ncbi.nlm.nih.gov/39862274/
The activity of indigo carmine against bacteriophages: an edible antiphage agent - PubMed
Bacteriophage infections in bacterial cultures pose a significant challenge to industrial bioprocesses, necessitating the development of innovative antiphage solutions. This study explores the antiphage potential of indigo carmine (IC), a common FDA-approved food additive. IC demonstrated selective …
pubmed.ncbi.nlm.nih.gov
August 7, 2025 at 9:54 PM
phagepapers.bsky.social
Bridging phage production models and practical applications to control antibiotic-resistant bacteria.

DOI: 10.1016/j.micres.2025.128230

https://pubmed.ncbi.nlm.nih.gov/40424684/
Bridging phage production models and practical applications to control antibiotic-resistant bacteria - PubMed
The emergence of multidrug-resistant (MDR) bacteria represents a significant global health threat, demanding urgent development of alternative treatment strategies. Bacteriophages (phages) have gained attention as promising alternatives to antibiotics due to their specificity, abundance, and minimal …
pubmed.ncbi.nlm.nih.gov
August 7, 2025 at 1:53 PM
phagepapers.bsky.social
Optimization of the large-scale production for Erwinia amylovora bacteriophages.

DOI: 10.1186/s12934-024-02607-7

https://pubmed.ncbi.nlm.nih.gov/39710718/
Optimization of the large-scale production for Erwinia amylovora bacteriophages - PubMed
We demonstrated the successful optimization and scale-up of E. amylovora phage production, emphasizing the potential for industrial bioprocessing with the reduced use of host cells and phage seeds. Overall, by refining key production parameters, we established a robust and scalable method for enhanc …
pubmed.ncbi.nlm.nih.gov
August 6, 2025 at 9:52 PM
phagepapers.bsky.social
Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coli.

DOI: 10.1007/s10123-024-00508-8

https://pubmed.ncbi.nlm.nih.gov/38517580/
Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coli - PubMed
Phage therapy has recently been revitalized in the West with many successful applications against multi-drug-resistant bacterial infections. However, the lack of geographically diverse bacteriophage (phage) genomes has constrained our understanding of phage diversity and its genetics underpinning ho …
pubmed.ncbi.nlm.nih.gov
August 5, 2025 at 1:52 AM
phagepapers.bsky.social
Deciphering Bacterial and Archaeal Transcriptional Dark Matter and Its Architectural Complexity.

DOI: 10.1101/2024.04.02.587803

https://pubmed.ncbi.nlm.nih.gov/38617363/
Deciphering Bacterial and Archaeal Transcriptional Dark Matter and Its Architectural Complexity - PubMed
Transcripts are potential therapeutic targets, yet bacterial transcripts remain biological dark matter with uncharacterized biodiversity. We developed and applied an algorithm to predict transcripts for Escherichia coli K12 and E2348/69 strains (Bacteria:gamma-Proteobacteria) with newly generated ON …
pubmed.ncbi.nlm.nih.gov
August 4, 2025 at 9:52 PM
phagepapers.bsky.social
Whole genome sequences of eight Erwinia amylovora phages isolated from South Korea.

DOI: 10.1128/mra.01062-24

https://pubmed.ncbi.nlm.nih.gov/39999472/
Whole genome sequences of eight Erwinia amylovora phages isolated from South Korea - PubMed
The gram-negative <i>Enterobacteriaceae Erwinia amylovora</i> is the causative agent of fire blight. Herein, we announce the full genome sequencing and annotation of eight <i>E. amylovora</i> bacteriophages from apple and pear orchards in South Korea, which have remarkable similarity to <i>Erwinia</i> …
pubmed.ncbi.nlm.nih.gov
August 4, 2025 at 5:52 PM
phagepapers.bsky.social
Factors Affecting Phage-Bacteria Coevolution Dynamics.

DOI: 10.3390/v17020235

https://pubmed.ncbi.nlm.nih.gov/40006990/
Factors Affecting Phage-Bacteria Coevolution Dynamics - PubMed
Bacteriophages (phages) have coevolved with their bacterial hosts for billions of years. With the rise of antibiotic resistance, the significance of using phages in therapy is increasing. Investigating the dynamics of phage evolution can provide valuable insights for pre-adapting phages to more chal …
pubmed.ncbi.nlm.nih.gov
July 30, 2025 at 1:52 AM
phagepapers.bsky.social
Factors Affecting Phage-Bacteria Coevolution Dynamics.

DOI: 10.3390/v17020235

https://pubmed.ncbi.nlm.nih.gov/40006990/
Factors Affecting Phage-Bacteria Coevolution Dynamics - PubMed
Bacteriophages (phages) have coevolved with their bacterial hosts for billions of years. With the rise of antibiotic resistance, the significance of using phages in therapy is increasing. Investigating the dynamics of phage evolution can provide valuable insights for pre-adapting phages to more chal …
pubmed.ncbi.nlm.nih.gov
July 25, 2025 at 9:52 PM
phagepapers.bsky.social
In silico and in vitro comparative analysis of 79 Acinetobacter baumannii clinical isolates.

DOI: 10.1128/spectrum.02849-24

https://pubmed.ncbi.nlm.nih.gov/40377313/
In silico and in vitro comparative analysis of 79 Acinetobacter baumannii clinical isolates - PubMed
<span><i>Acinetobacter baumannii</i> is a significant nosocomial bacterial pathogen that poses a substantial infection risk due to its high resistance to antibiotics and ability to survive in hospital environments. In this study, we performed comprehensive <i>in silico</i> and <i>in vitro</i> analyses on</span> …
pubmed.ncbi.nlm.nih.gov
July 25, 2025 at 1:52 PM
phagepapers.bsky.social
Factors Affecting Phage-Bacteria Coevolution Dynamics.

DOI: 10.3390/v17020235

https://pubmed.ncbi.nlm.nih.gov/40006990/
Factors Affecting Phage-Bacteria Coevolution Dynamics - PubMed
Bacteriophages (phages) have coevolved with their bacterial hosts for billions of years. With the rise of antibiotic resistance, the significance of using phages in therapy is increasing. Investigating the dynamics of phage evolution can provide valuable insights for pre-adapting phages to more chal …
pubmed.ncbi.nlm.nih.gov
July 25, 2025 at 9:52 AM
phagepapers.bsky.social
The activity of indigo carmine against bacteriophages: an edible antiphage agent.

DOI: 10.1007/s00253-025-13414-4

https://pubmed.ncbi.nlm.nih.gov/39862274/
The activity of indigo carmine against bacteriophages: an edible antiphage agent - PubMed
Bacteriophage infections in bacterial cultures pose a significant challenge to industrial bioprocesses, necessitating the development of innovative antiphage solutions. This study explores the antiphage potential of indigo carmine (IC), a common FDA-approved food additive. IC demonstrated selective …
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 5:52 AM