Joe Chambers
@joechambers.bsky.social
Researcher at the CIMR, University of Cambridge @MarciniakLab interested in cell biology, especially proteostasis and the ER.
Pinned
Joe Chambers
@joechambers.bsky.social
· Mar 10
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
www.nature.com
Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
Go Lily! Huge congrats - massively deserved!
I'm very honoured to have been chosen for the Alpha-1 Antitrypsin Laurell's Training Award (ALTA), an early-career research fellowship
I would like to thank my supervisors @profmarciniak.bsky.social @joechambers.bsky.social, and my wonderful institute @thecimr.bsky.social for making this possible!
I would like to thank my supervisors @profmarciniak.bsky.social @joechambers.bsky.social, and my wonderful institute @thecimr.bsky.social for making this possible!
October 26, 2025 at 8:44 PM
Go Lily! Huge congrats - massively deserved!
Reposted by Joe Chambers
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Reposted by Joe Chambers
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome
Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...
www.biorxiv.org
October 6, 2025 at 9:50 AM
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Such elegant work, as ever!
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
rdcu.be/ey8iL
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
August 13, 2025 at 4:39 PM
Such elegant work, as ever!
Reposted by Joe Chambers
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
July 30, 2025 at 3:28 PM
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Reposted by Joe Chambers
New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing
Background: Idiopathic pulmonary fibrosis is a fatal lung disease of progressive lung parenchymal scarring caused by the aberrant response of an alveolar epithelium repeatedly exposed to injury. Under...
www.biorxiv.org
July 22, 2025 at 8:01 PM
New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Joe Chambers
Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social !
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001
July 16, 2025 at 6:44 AM
Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social !
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001
Great opportunity!
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 24, 2025 at 8:36 AM
Great opportunity!
Fantastic stuff by Sam and team!
3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.
3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.
Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1
June 11, 2025 at 9:27 AM
Fantastic stuff by Sam and team!
3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.
3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.
Reposted by Joe Chambers
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature
High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...
www.nature.com
April 16, 2025 at 3:16 PM
Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...
Reposted by Joe Chambers
#newPI and time is running.
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
April 22, 2025 at 7:37 PM
#newPI and time is running.
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:
warwick.ac.uk/fac/sci/med/...
Reposted by Joe Chambers
Well done Jessy @jessyzhu-jiayi.bsky.social who gave her #biologists100 flash talk today about her new GCN2 activators
@biologists.bsky.social
@thecimr.bsky.social
@biologists.bsky.social
@thecimr.bsky.social
March 28, 2025 at 5:48 PM
Well done Jessy @jessyzhu-jiayi.bsky.social who gave her #biologists100 flash talk today about her new GCN2 activators
@biologists.bsky.social
@thecimr.bsky.social
@biologists.bsky.social
@thecimr.bsky.social
Fantastic Skytorial!
Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12]
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
www.nature.com
March 27, 2025 at 10:17 PM
Fantastic Skytorial!
Congratulations @lily-wu.bsky.social for winning a poster prize at the @biologists.bsky.social #biologists100 conference! What a superstar!
@thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social
@thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social
March 27, 2025 at 7:17 PM
Congratulations @lily-wu.bsky.social for winning a poster prize at the @biologists.bsky.social #biologists100 conference! What a superstar!
@thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social
@thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social
Great to see this published! Congrats on a really beautiful paper!
😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 25, 2025 at 9:04 PM
Great to see this published! Congrats on a really beautiful paper!
Reposted by Joe Chambers
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
February 23, 2025 at 1:03 PM
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
Reposted by Joe Chambers
The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!
March 20, 2025 at 5:56 PM
The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!
Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
www.nature.com
March 10, 2025 at 10:38 AM
Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.
@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute
Reposted by Joe Chambers
February 13, 2025 at 12:47 AM
Amazing Conference Alert!!
Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins!
Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.
Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins!
Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.
January 30, 2025 at 9:43 AM
Amazing Conference Alert!!
Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins!
Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.
Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins!
Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.
Reposted by Joe Chambers
Great to see this collaborative effort out! Check out our new alveolar organoid model, ripe for studying disease mechanisms including those involving surfactant proteins:
www.embopress.org/doi/full/10....
Front cover image to follow soon!
@eimearrutherford.bsky.social @profmarciniak.bsky.social
www.embopress.org/doi/full/10....
Front cover image to follow soon!
@eimearrutherford.bsky.social @profmarciniak.bsky.social
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease | The EMBO Journal
imageimageDisorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable, mature human fetal-derived alveolar type 2 ...
www.embopress.org
January 15, 2025 at 3:18 PM
Great to see this collaborative effort out! Check out our new alveolar organoid model, ripe for studying disease mechanisms including those involving surfactant proteins:
www.embopress.org/doi/full/10....
Front cover image to follow soon!
@eimearrutherford.bsky.social @profmarciniak.bsky.social
www.embopress.org/doi/full/10....
Front cover image to follow soon!
@eimearrutherford.bsky.social @profmarciniak.bsky.social
Reposted by Joe Chambers
We have a postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬
The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️
For more detail and to apply:
babrahaminstitute.livevacancies.co.uk#/job/details...
The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️
For more detail and to apply:
babrahaminstitute.livevacancies.co.uk#/job/details...
hireful.
babrahaminstitute.livevacancies.co.uk
January 8, 2025 at 4:17 AM
We have a postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬
The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️
For more detail and to apply:
babrahaminstitute.livevacancies.co.uk#/job/details...
The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️
For more detail and to apply:
babrahaminstitute.livevacancies.co.uk#/job/details...
Reposted by Joe Chambers
‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk
Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future
www.exppg.lifesci.cam.ac.uk
January 7, 2025 at 6:50 AM
‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk
Reposted by Joe Chambers
Taking back the ER -
rupress.org/jcb/article/...
rupress.org/jcb/article/...
ER–plasma membrane contact sites deliver ER lipids and proteins for rapid cell surface expansion | Journal of Cell Biology | Rockefeller University Press
rupress.org
December 4, 2024 at 6:31 AM
Taking back the ER -
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Reposted by Joe Chambers
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
November 19, 2024 at 8:22 PM
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳