Alison Forrester
@aforrester.bsky.social
A fan of ER and derivatives thereof, I’m a microscopic cell biologist.
PI at University of Namur in Belgium
PI at University of Namur in Belgium
Pinned
Alison Forrester
@aforrester.bsky.social
· Feb 23
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
I'm very happy to have been involved in this roadmap. Thank you all for the fantastic discussions, I hope that it initiates many more!
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 9:30 AM
I'm very happy to have been involved in this roadmap. Thank you all for the fantastic discussions, I hope that it initiates many more!
Dear all, I have coined a phrase:
To A.Iron
Definition: To polish text using AI
@academic-chatter.bsky.social
To A.Iron
Definition: To polish text using AI
@academic-chatter.bsky.social
June 18, 2025 at 11:01 AM
Dear all, I have coined a phrase:
To A.Iron
Definition: To polish text using AI
@academic-chatter.bsky.social
To A.Iron
Definition: To polish text using AI
@academic-chatter.bsky.social
Reposted by Alison Forrester
📄Shoutout to our 2019 Research Center awardees at Yale (@pdc-lab.bsky.social, @shawnferguson.bsky.social) for their new publication on the bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage - Nature Cell Biology
Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal damage.
www.nature.com
April 22, 2025 at 3:36 PM
📄Shoutout to our 2019 Research Center awardees at Yale (@pdc-lab.bsky.social, @shawnferguson.bsky.social) for their new publication on the bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alison Forrester
For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you. podcasts.apple.com/us/podcast/n...
April 22, 2025 at 3:03 PM
For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you. podcasts.apple.com/us/podcast/n...
Reposted by Alison Forrester
Congrats to the Johannes lab! 👏 E MacDonald, @aforrester.bsky.social @cessvala.bsky.social E Dransart, A Akhil Shp, L Leconte, V Chambon, D Ghosh, A Pinet, D Bhatia, B Lombard, D Loew, MShafaq-Zadah, @christianwunder.bsky.social
@institutcurie.bsky.social
pubmed.ncbi.nlm.nih.gov/39984654/
@institutcurie.bsky.social
pubmed.ncbi.nlm.nih.gov/39984654/
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis - PubMed
Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynam...
pubmed.ncbi.nlm.nih.gov
April 22, 2025 at 4:07 PM
Congrats to the Johannes lab! 👏 E MacDonald, @aforrester.bsky.social @cessvala.bsky.social E Dransart, A Akhil Shp, L Leconte, V Chambon, D Ghosh, A Pinet, D Bhatia, B Lombard, D Loew, MShafaq-Zadah, @christianwunder.bsky.social
@institutcurie.bsky.social
pubmed.ncbi.nlm.nih.gov/39984654/
@institutcurie.bsky.social
pubmed.ncbi.nlm.nih.gov/39984654/
Reposted by Alison Forrester
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
Postdoctoral Researcher
Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...
elxw.fa.em3.oraclecloud.com
March 20, 2025 at 9:22 AM
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!
March 20, 2025 at 5:56 PM
The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!
Reposted by Alison Forrester
A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.
rdcu.be/ecb2B
Interesting section on unanswered questions.
rdcu.be/ecb2B
The pathways of secretory cargo export at the endoplasmic reticulum
Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...
rdcu.be
March 4, 2025 at 10:00 PM
A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.
rdcu.be/ecb2B
Interesting section on unanswered questions.
rdcu.be/ecb2B
Reposted by Alison Forrester
Reposted by Alison Forrester
Lab manager position open. Does the idea of helping a busy structural cell biology and biochemistry-based drug discovery lab stave off chaos appeal to you? Apply now at tinyurl.com/4dsvpwbw
An error has occurred.
tinyurl.com
February 24, 2025 at 8:46 PM
Lab manager position open. Does the idea of helping a busy structural cell biology and biochemistry-based drug discovery lab stave off chaos appeal to you? Apply now at tinyurl.com/4dsvpwbw
Reposted by Alison Forrester
Just a week left to apply for this postdoc position in my lab in Oxford.
I'm happy to announce a postdoctoral position is available in my lab. We have lots of great data to analyze with respect to transposons & epigenetics and cool biological questions to answer.
Please reskeet and share.
Please reskeet and share.
Joining | The Mosher Lab
www.mosherlab.com
February 21, 2025 at 9:32 AM
Just a week left to apply for this postdoc position in my lab in Oxford.
Reposted by Alison Forrester
... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...
Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate
Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...
www.biorxiv.org
February 22, 2025 at 10:31 PM
... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
February 23, 2025 at 1:03 PM
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
Reposted by Alison Forrester
I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies.
doi.org/10.1111/boc....
doi.org/10.1111/boc....
Flotillins in membrane trafficking and physiopathology
Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...
doi.org
January 29, 2025 at 11:21 AM
I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies.
doi.org/10.1111/boc....
doi.org/10.1111/boc....
Going Green at the Department of Biology and Faculty of Medicine at the University of Namur! We've worked on it for a year, now it's time to go big 😁💚🔬 The initiative seems to be making some waves and it's great to see som much enthusiasm! @fsilvestrelab.bsky.social #sustainability #GreenLab
February 19, 2025 at 11:10 AM
Going Green at the Department of Biology and Faculty of Medicine at the University of Namur! We've worked on it for a year, now it's time to go big 😁💚🔬 The initiative seems to be making some waves and it's great to see som much enthusiasm! @fsilvestrelab.bsky.social #sustainability #GreenLab
Reposted by Alison Forrester
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
February 10, 2025 at 8:21 AM
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Reposted by Alison Forrester
Inscriptions for the 27th annual meeting of the Club Exo-Endo are opened. Please register on exoendo.org !!
February 6, 2025 at 8:33 PM
Inscriptions for the 27th annual meeting of the Club Exo-Endo are opened. Please register on exoendo.org !!
Reposted by Alison Forrester
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
www.nature.com
February 6, 2025 at 10:59 PM
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alison Forrester
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 31, 2025 at 10:28 AM
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alison Forrester
Our plasmids for editing are now on @addgene.bsky.social! www.addgene.org/Francesca_Bo... I promise you a detailed protocol on how to use them is coming very very soon! Currently proofreading :)
Addgene: Francesca Bottanelli Lab Materials
www.addgene.org
February 3, 2025 at 12:53 PM
Our plasmids for editing are now on @addgene.bsky.social! www.addgene.org/Francesca_Bo... I promise you a detailed protocol on how to use them is coming very very soon! Currently proofreading :)
Reposted by Alison Forrester
Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4
February 6, 2025 at 7:51 PM
Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4
Reposted by Alison Forrester
We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !
Club Exo Endo - Exocytose Endocytose
Le Club Exocytose-Endocytose est une association à but non lucratif, sans financement ni cotisation. Il rassemble près de 340 chercheurs, enseignants ou étudiants travaillant dans des domaines variés ...
exoendo.org
February 6, 2025 at 8:26 PM
We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !
Reposted by Alison Forrester
The #MembraneTrafficking seminar series is back this Thursday, and we are very happy to start the 2025 season with two talks by early career scientists: Adam Krahn from the Glick Lab at University of Chicago and @jkefauver.bsky.social at CINN-CSIC, Spain.
MEMBRANE TRAFFICKING | Membrane Trafficking
felixcampelo.wixsite.com
January 27, 2025 at 5:57 PM
The #MembraneTrafficking seminar series is back this Thursday, and we are very happy to start the 2025 season with two talks by early career scientists: Adam Krahn from the Glick Lab at University of Chicago and @jkefauver.bsky.social at CINN-CSIC, Spain.
Reposted by Alison Forrester
Just wrapped up an incredible meeting in Innsbruck with an amazing group of membrane traffickERs. The intimate, congenial setting fostered open, positive discussions and constructive critiques—intense and inspiring. Huge thanks to Hesso @hessofarhan.bsky.social for organising!
January 21, 2025 at 8:03 AM
Just wrapped up an incredible meeting in Innsbruck with an amazing group of membrane traffickERs. The intimate, congenial setting fostered open, positive discussions and constructive critiques—intense and inspiring. Huge thanks to Hesso @hessofarhan.bsky.social for organising!
It’s been a gEReat few days with a wondERful group! A million thanks to @hessofarhan.bsky.social for organising it. I’m already excited about the next one! #It’snotanERGIC…isitanERGIC?
January 21, 2025 at 12:18 AM
It’s been a gEReat few days with a wondERful group! A million thanks to @hessofarhan.bsky.social for organising it. I’m already excited about the next one! #It’snotanERGIC…isitanERGIC?