Hesso Farhan
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hessofarhan.bsky.social
Hesso Farhan
@hessofarhan.bsky.social
470 followers 410 following 19 posts
Professor at the Medical University of Innsbruck, Austria. Interested in Endoplasmic Reticulum, Mechanobiology, Proteostasis, Organelles, Cell migration, Pseudoenzymes
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Reposted by Hesso Farhan
jcb.org
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...

#ER_literature #Migration #Organelles
November 6, 2025 at 5:00 PM
Reposted by Hesso Farhan
jcb.org
What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/...
#ER_literature
October 31, 2025 at 5:15 PM
Reposted by Hesso Farhan
ericchevet.bsky.social
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy | Science Translational Medicine www.science.org/doi/10.1126/...
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy
Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.
www.science.org
October 30, 2025 at 12:35 PM
Reposted by Hesso Farhan
nature.com
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com/4hj9NNV
Economics Nobel prize won by researchers who showed how science boosts growth
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com
October 13, 2025 at 8:37 PM
Reposted by Hesso Farhan
fwf-at.bsky.social
Bei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft.
@fwf-at.bsky.social @oeaw.bsky.social

Bessere Ideen 👉
www.diepresse.com/20152064/bei...
Bei Grundlagenforschung kürzen? Keine gute Idee!
Kein Geist, kein Sinn. Österreich braucht keine männliche MINT-Monokultur, sondern eine starke und vielfältige Wissenschaft.
www.diepresse.com
September 30, 2025 at 1:26 PM
Reposted by Hesso Farhan
lisaheinke.bsky.social
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
September 30, 2025 at 7:35 AM
hessofarhan.bsky.social
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
September 30, 2025 at 7:36 AM
hessofarhan.bsky.social
The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs.
rdcu.be/eHw46
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control
Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...
rdcu.be
September 22, 2025 at 8:49 AM
hessofarhan.bsky.social
Beautiful work which supports a role for the ER in mechanobiology.
August 25, 2025 at 3:47 PM
Reposted by Hesso Farhan
nature.com
Nature research paper: Quantitative imaging of lipid transport in mammalian cells

go.nature.com/4mmSygd
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
go.nature.com
August 21, 2025 at 12:58 PM
hessofarhan.bsky.social
New paper by the Reggiori and Ungermann Labs showing using a yeast model that contact sites between the phagophore and ERES are important for phagophore elongation.
rdcu.be/ezUeZ
Establishment of the phagophore–ERES membrane contact site initiates phagophore elongation
Nature Structural & Molecular Biology - Gómez-Sánchez et al. show that generation of phagophore–endoplasmic reticulum exit sites (ERES) membrane contact sites, mediated by Atg2...
rdcu.be
August 8, 2025 at 2:23 PM
hessofarhan.bsky.social
Great preprint showing that COPII vesicles do exist in vicinity of ERES. Very interesting.
August 4, 2025 at 2:39 PM
Reposted by Hesso Farhan
molinarilab-er.bsky.social
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux
Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...
rdcu.be
August 4, 2025 at 11:41 AM
Reposted by Hesso Farhan
hellerschmiedlab.bsky.social
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
July 15, 2025 at 6:06 AM
hessofarhan.bsky.social
Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...
The endoplasmic reticulum proteostasis network and bone disease
Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...
www.cell.com
July 11, 2025 at 9:22 AM
hessofarhan.bsky.social
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
rdcu.be
July 9, 2025 at 5:55 PM
Reposted by Hesso Farhan
cellclub.bsky.social
External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics | Science Advances www.science.org/doi/10.1126/...
External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics
Plasma membrane–endoplasmic reticulum physical tethering is a mechanotransduction pathway.
www.science.org
June 26, 2025 at 1:16 PM
Reposted by Hesso Farhan
agostinislab.bsky.social
🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
doi.org
June 13, 2025 at 10:31 AM
hessofarhan.bsky.social
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass: Developmental Cell www.cell.com/developmenta...
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass
Song et al. demonstrate that an ER tubulovesicular structure (ER tubular body [ER-TB]), shaped by the tubular ER-phagy receptors ATL3 and RTN3L, plays an important role in stress-induced Golgi bypass ...
www.cell.com
June 12, 2025 at 6:41 AM
Reposted by Hesso Farhan
cahirokane.bsky.social
ER needs ATP for processes like protein quality control, but can't make its own. Here, how ATP is imported into the ER lumen and exchanged for ADP.
May 24, 2025 at 4:56 AM
hessofarhan.bsky.social
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage
Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused in part by macroautophagy and i...
www.cell.com
May 15, 2025 at 9:04 PM
hessofarhan.bsky.social
Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...
Genetically encoded reporters of actin filament organization in living cells and tissues
Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...
www.cell.com
May 2, 2025 at 11:41 AM
hessofarhan.bsky.social
Excited to present our unpublished data tomorrow on how Mechanosesing at the Endoplasmic Reticulum regulates Proteostasis. #Organelles #Mechanobiology
April 23, 2025 at 11:36 AM
Reposted by Hesso Farhan
jcb.org
Kunyou Park, Victor Hsu, Seung-Yeol Park and colleagues find that a critical lipid is delivered through membrane contact to support the fission of COPI vesicles. rupress.org/jcb/article/...

#Golgi #ER_literature #Trafficking
April 11, 2025 at 4:34 PM
Reposted by Hesso Farhan
plosbiology.org
How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp
A) Diagram of the RUSH system. The Halo-tagged cargo is retained in the ER by the binding of the Streptavidin binding peptide (SBP) to Streptavidin (StrepA), which is fused to the ER retention signal, KDEL. The cargo is synchronously released upon the addition of biotin, which outcompetes SBP for binding to Streptavidin.B) Diagram of the tagged cargo constructs used in this study. C) Steady state expression of UAS-SBP-Halo-Cadherin99c (magenta) under the control of traffic jam-Gal4, showing its localization to the apical microvilli. Phalloidin staining of F-actin (green) labels the apical microvilli in the follicle cells and the oocyte. Scale bar 10 µm. D) Steady state expression of UAS-SBP-SNAP-Ndg (magenta) under the control of traffic jam-Gal4, showing its localization to the basement membrane. Actin is shown in green. Scale bar 10 µm. E) En face view of SBP-SNAP-Ndg in the basement membrane. Scale bar 10 µm. F) Time course of SBP-Halo-Cadherin99C trafficking in fixed samples. G) 25 min after release from the ER, Cad99c (green) localizes to subapical puncta that are labeled by Rab11 (magenta). Scale bar 10 µm. In all figures with a cross-section of the follicle cells, apical is toward the top of the image and basal toward the bottom.
April 14, 2025 at 11:58 AM