Nature Structural & Molecular Biology, Published online: 14 November 2025; doi:10.1038/s41594-025-01713-3Inspired by the advance in protein structure prediction, CryoAtom builds protein models directly from cryogenic electron microscopy maps, producing more complete models, reducing the resolution requirement and accelerating modeling.

Nature Structural & Molecular Biology, Published online: 13 November 2025; doi:10.1038/s41594-025-01727-xParticipation in peer review is essential training for all scientists. We are now offering all Nature Structural & Molecular Biology reviewers the opportunity to invite an early career researcher to formally co-review manuscripts with them.

Nature Structural & Molecular Biology, Published online: 14 November 2025; doi:10.1038/s41594-025-01713-3Inspired by the advance in protein structure prediction, CryoAtom builds protein models directly from cryogenic electron microscopy maps, producing more complete models, reducing the resolution requirement and accelerating modeling.

Nature Structural & Molecular Biology, Published online: 12 November 2025; doi:10.1038/s41594-025-01711-5Zhou et al. report cryo-electron microscopy structures of human SLC37A4 in four states, elucidating conformational transitions during glucose-6-phosphate/phosphate transport and S-4048 inhibition. This study links structural mechanisms to glycogen storage disease type Ib pathology, offering therapeutic insights.

Nature Structural & Molecular Biology, Published online: 12 November 2025; doi:10.1038/s41594-025-01712-4Lai and Xu et al. used cryo-electron microscopy and functional analyses to elucidate the glucose-6-phosphate uniport mechanism of human solute carrier family 37 member 2 and its structural dynamics, offering insights into glucose metabolism and related disorders.

Nature Structural & Molecular Biology, Published online: 13 November 2025; doi:10.1038/s41594-025-01727-xParticipation in peer review is essential training for all scientists. We are now offering all Nature Structural & Molecular Biology reviewers the opportunity to invite an early career researcher to formally co-review manuscripts with them.

Nature Structural & Molecular Biology, Published online: 11 November 2025; doi:10.1038/s41594-025-01719-xAlphaSync synchronizes AlphaFold Protein Structure Database predictions with UniProt sequences, providing up-to-date protein structures with residue-level annotations for humans, model organisms and pathogens through an accessible web interface and application programming interface.

Nature Structural & Molecular Biology, Published online: 12 November 2025; doi:10.1038/s41594-025-01711-5Zhou et al. report cryo-electron microscopy structures of human SLC37A4 in four states, elucidating conformational transitions during glucose-6-phosphate/phosphate transport and S-4048 inhibition. This study links structural mechanisms to glycogen storage disease type Ib pathology, offering therapeutic insights.

Nature Structural & Molecular Biology, Published online: 12 November 2025; doi:10.1038/s41594-025-01712-4Lai and Xu et al. used cryo-electron microscopy and functional analyses to elucidate the glucose-6-phosphate uniport mechanism of human solute carrier family 37 member 2 and its structural dynamics, offering insights into glucose metabolism and related disorders.

Nature Structural & Molecular Biology, Published online: 10 November 2025; doi:10.1038/s41594-025-01710-6He, Teng and Yang et al. report how metformin, the widely used antidiabetic drug, inhibit its target, the respiratory complex I, through a distinct state-dependent, inhibitor trapping mechanism, thus providing the molecular basis for its superior clinical tolerance.

Nature Structural & Molecular Biology, Published online: 11 November 2025; doi:10.1038/s41594-025-01719-xAlphaSync synchronizes AlphaFold Protein Structure Database predictions with UniProt sequences, providing up-to-date protein structures with residue-level annotations for humans, model organisms and pathogens through an accessible web interface and application programming interface.

Nature Structural & Molecular Biology, Published online: 10 November 2025; doi:10.1038/s41594-025-01710-6He, Teng and Yang et al. report how metformin, the widely used antidiabetic drug, inhibit its target, the respiratory complex I, through a distinct state-dependent, inhibitor trapping mechanism, thus providing the molecular basis for its superior clinical tolerance.

Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and...

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01709-zmTORC1 promotes cell growth by sensing nutrients and driving anabolic processes. When nutrients are scarce, GATOR1 turns off growth signals. Our study describes how KICSTOR links GATOR1 to lysosomes to enable its function, a finding that may help us to understand certain neurological disorders.

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01695-2The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation.

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01693-4Teng and Zeng et al. use cryo-electron microscopy to show that the crescent scaffold of KICSTOR anchors GATOR1 to lysosomes and disruption of the interaction causes mTORC1 hyperactivation and TFE3 mislocalization. KICSTOR enables nutrient-dependent mTORC1 regulation by binding anionic lipids for lysosomal targeting.

Nature Structural & Molecular Biology, Published online: 05 November 2025; doi:10.1038/s41594-025-01699-yLi et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and bacteria.

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01709-zmTORC1 promotes cell growth by sensing nutrients and driving anabolic processes. When nutrients are scarce, GATOR1 turns off growth signals. Our study describes how KICSTOR links GATOR1 to lysosomes to enable its function, a finding that may help us to understand certain neurological disorders.

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01695-2The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation.

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01693-4Teng and Zeng et al. use cryo-electron microscopy to show that the crescent scaffold of KICSTOR anchors GATOR1 to lysosomes and disruption of the interaction causes mTORC1 hyperactivation and TFE3 mislocalization. KICSTOR enables nutrient-dependent mTORC1 regulation by binding anionic lipids for lysosomal targeting.

Nature Structural & Molecular Biology, Published online: 05 November 2025; doi:10.1038/s41594-025-01699-yLi et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and bacteria.

Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01671-wMalagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger microRNAs, revealing a strand-switch mechanism in tumorigenesis.

Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01697-0The authors here show that the TRIM21–OTUD6A axis controls AKT activity through K27-linked ubiquitination, which is further regulated by S6K1-mediated phosphorylation, introducing a putative therapeutic strategy against AKT-driven cancers.

Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01701-7Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are globally upregulated and active. Thus, this setting induces both loss and gain of miRNA function.

Nature Structural & Molecular Biology, Published online: 03 November 2025; doi:10.1038/s41594-025-01683-6The Japan Autophagy Consortium (JAPC) was established to support collaborative autophagy research and advance public understanding. By bridging basic research, product development and public engagement, the JAPC aims to create a sustainable foundation for autophagy-related innovation in both academic and commercial sectors.