Hellerschmied Lab
@hellerschmiedlab.bsky.social
Biochemistry and cell biology lab @unidue-zmb.bsky.social
Excited about secretory pathway and #Golgi #proteostasis mechanisms
funded by AvHStiftung, part of @crc1430.bsky.social
(tweets by PI)
Excited about secretory pathway and #Golgi #proteostasis mechanisms
funded by AvHStiftung, part of @crc1430.bsky.social
(tweets by PI)
Pinned
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
Reposted by Hellerschmied Lab
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Junior Group Leader Positions | Research Institute of Molecular Pathology
www.imp.ac.at
November 10, 2025 at 10:49 AM
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Reposted by Hellerschmied Lab
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Reposted by Hellerschmied Lab
Today we celebrate the birthday of not one, but two amazing women in science! 🤗🎉Marie Skłodowska-Curie (1867), who discovered #radium & #polonium & pioneered #radioactivity, & Lise Meitner (1878), whose brilliance uncovered the physics behind #nuclearfission. Happy birthday, trailblazers! ✨
November 7, 2025 at 1:10 PM
Today we celebrate the birthday of not one, but two amazing women in science! 🤗🎉Marie Skłodowska-Curie (1867), who discovered #radium & #polonium & pioneered #radioactivity, & Lise Meitner (1878), whose brilliance uncovered the physics behind #nuclearfission. Happy birthday, trailblazers! ✨
Reposted by Hellerschmied Lab
Nov 7th is the birthday of both Lise Meitner & Marie Curie. Of the 13 chemical elements named directly after real people (not mythological figures) only two are named after women: meitnerium and curium (the latter of which is named in honour of both Marie & her husband) #chemsky 🧪
November 7, 2025 at 9:49 PM
Nov 7th is the birthday of both Lise Meitner & Marie Curie. Of the 13 chemical elements named directly after real people (not mythological figures) only two are named after women: meitnerium and curium (the latter of which is named in honour of both Marie & her husband) #chemsky 🧪
Reposted by Hellerschmied Lab
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 5, 2025 at 10:59 AM
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
Reposted by Hellerschmied Lab
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
November 6, 2025 at 4:20 PM
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
Reposted by Hellerschmied Lab
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation www.biorxiv.org/content/10.1...
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation
Misfolded or unassembled membrane proteins in the endoplasmic reticulum (ER) are polyubiquitinated, translocated into the cytosol, and degraded by the proteasome, a poorly understood process that is c...
www.biorxiv.org
November 3, 2025 at 3:35 PM
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation www.biorxiv.org/content/10.1...
Reposted by Hellerschmied Lab
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Hellerschmied Lab
ICYMI: New Online! Decoding ubiquitin signals inside cells
Decoding ubiquitin signals inside cells
Nature Reviews Molecular Cell Biology, Published online: 31 October 2025; doi:10.1038/s41580-025-00919-zIn this Tools of the Trade article, Kiss (Schulman lab) discusses the development of UbiREAD, a method that delivers in vitro-ubiquitinated protein reporters into cells to systematically assess how different ubiquitin chain configurations affect protein stability and degradation.
bit.ly
November 3, 2025 at 5:06 PM
ICYMI: New Online! Decoding ubiquitin signals inside cells
Reposted by Hellerschmied Lab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Hellerschmied Lab
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
October 27, 2025 at 7:00 AM
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
Reposted by Hellerschmied Lab
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Reposted by Hellerschmied Lab
📣 #OpenCall: SNSF Starting Grants 2026
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
October 6, 2025 at 8:01 AM
📣 #OpenCall: SNSF Starting Grants 2026
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
Reposted by Hellerschmied Lab
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Hellerschmied Lab
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Reposted by Hellerschmied Lab
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
October 9, 2025 at 6:42 AM
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Reposted by Hellerschmied Lab
🏆 #LabOlympics 2025 at the ZMB are over — congratulations to the 'Ehrmännchen'! 🎉
They didn’t just take home the trophy, but also the honor of hosting the 2026 edition!
A big thanks to @hellerschmiedlab.bsky.social, @icce-unidue.bsky.social and all other participants for their amazing team spirit!
They didn’t just take home the trophy, but also the honor of hosting the 2026 edition!
A big thanks to @hellerschmiedlab.bsky.social, @icce-unidue.bsky.social and all other participants for their amazing team spirit!
October 9, 2025 at 9:13 AM
🏆 #LabOlympics 2025 at the ZMB are over — congratulations to the 'Ehrmännchen'! 🎉
They didn’t just take home the trophy, but also the honor of hosting the 2026 edition!
A big thanks to @hellerschmiedlab.bsky.social, @icce-unidue.bsky.social and all other participants for their amazing team spirit!
They didn’t just take home the trophy, but also the honor of hosting the 2026 edition!
A big thanks to @hellerschmiedlab.bsky.social, @icce-unidue.bsky.social and all other participants for their amazing team spirit!
Reposted by Hellerschmied Lab
Explore emerging research with field leaders @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26 www.keystonesymposia.org/conferences/...
Autophagy: Mechanisms to Therapy | Keystone Symposia
Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!
keysym.us
October 9, 2025 at 4:52 AM
Explore emerging research with field leaders @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26 www.keystonesymposia.org/conferences/...
Reposted by Hellerschmied Lab
A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...
Application – EMBL International PhD Programme
www.embl.org
October 9, 2025 at 4:51 AM
A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...
Reposted by Hellerschmied Lab
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 5:50 AM
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hellerschmied Lab
🧬Ubiquitin Precursor: A Key to Healthy Aging?
Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA
Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA
A quiet ally: a ubiquitin precursor promotes stress resistance and longevity
In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and...
uni.koeln
October 2, 2025 at 2:43 PM
🧬Ubiquitin Precursor: A Key to Healthy Aging?
Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA
Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA
Reposted by Hellerschmied Lab
Preprint alert! 🚨
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...
CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub
The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...
www.biorxiv.org
October 6, 2025 at 2:19 PM
Preprint alert! 🚨
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...
Reposted by Hellerschmied Lab
The Sacca' lab investigates the behavior of molecular motors within engineered DNA origami nano-compartments to understanding of how nanoscale confinements influence biochemical processes and energy conversion. Interested? Then apply to @imprs-lm.bsky.social
#IMPRS #PhDposition #Syntheticbiology
#IMPRS #PhDposition #Syntheticbiology
September 22, 2025 at 3:26 PM
The Sacca' lab investigates the behavior of molecular motors within engineered DNA origami nano-compartments to understanding of how nanoscale confinements influence biochemical processes and energy conversion. Interested? Then apply to @imprs-lm.bsky.social
#IMPRS #PhDposition #Syntheticbiology
#IMPRS #PhDposition #Syntheticbiology
Reposted by Hellerschmied Lab
Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.
September 3, 2025 at 8:53 AM
Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.
Reposted by Hellerschmied Lab
If you would like to contribute to uncover the mechanisms by which proteolytic enzymes in the ubiquitin system operate and exploit these insights for novel therapeutic approaches, then apply to the Gersch lab @maltegersch.bsky.social #IMPRS-LM.
#IMPRS #PhDposition #PhDprogram #ChemicalBiology
#IMPRS #PhDposition #PhDprogram #ChemicalBiology
September 26, 2025 at 4:12 PM
If you would like to contribute to uncover the mechanisms by which proteolytic enzymes in the ubiquitin system operate and exploit these insights for novel therapeutic approaches, then apply to the Gersch lab @maltegersch.bsky.social #IMPRS-LM.
#IMPRS #PhDposition #PhDprogram #ChemicalBiology
#IMPRS #PhDposition #PhDprogram #ChemicalBiology