Grosshans Lab
@labgrosshans.bsky.social
Studying mechanisms of developmental clocks and timers at the Friedrich Miescher Institute for Biomedical Research, Basel.
Pinned
Grosshans Lab
@labgrosshans.bsky.social
· Oct 10
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
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🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...
February 12, 2026 at 6:47 AM
🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...
Reposted by Grosshans Lab
👩🔬 On February 11, to mark the International Day of Women and Girls in Science, we’re hosting a panel discussion on how scientific progress and gender equality can advance together. The panel brings together voices from academia, industry, and EDI. Join us for this important conversation!
#IDWGS
#IDWGS
February 6, 2026 at 7:08 AM
👩🔬 On February 11, to mark the International Day of Women and Girls in Science, we’re hosting a panel discussion on how scientific progress and gender equality can advance together. The panel brings together voices from academia, industry, and EDI. Join us for this important conversation!
#IDWGS
#IDWGS
Reposted by Grosshans Lab
Now out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...
How a sweet treat can change memories
Memories must be flexible so animals can adapt when the world changes. FMI neuroscientists found that in fruit flies, simply tasting a sugar reward again can weaken all previous associated memories. T...
www.fmi.ch
February 5, 2026 at 10:10 AM
Now out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...
Reposted by Grosshans Lab
Very thankful for this thoughtful dispatch by @shaisrael.bsky.social sky.social and Moshe Parnas about our work. Learning and memory: Forgetting to remember: Current Biology www.cell.com/current-biol...
February 5, 2026 at 1:24 PM
Very thankful for this thoughtful dispatch by @shaisrael.bsky.social sky.social and Moshe Parnas about our work. Learning and memory: Forgetting to remember: Current Biology www.cell.com/current-biol...
Reposted by Grosshans Lab
Our annual brochure “Year in Review” is out now! It highlights the FMI’s key scientific publications, major events, and facts & figures from 2025, a year that marked our 55th anniversary.
www.fmi.ch/news-events/...
www.fmi.ch/news-events/...
FMI Year in Review 2025
Our annual brochure highlighting the FMI’s key scientific publications, major events, and facts & figures from the past year is now available. Discover the highlights of 2025, a year that marked the F...
www.fmi.ch
January 19, 2026 at 2:50 PM
Our annual brochure “Year in Review” is out now! It highlights the FMI’s key scientific publications, major events, and facts & figures from 2025, a year that marked our 55th anniversary.
www.fmi.ch/news-events/...
www.fmi.ch/news-events/...
Congratulations, Fiona!
January 16, 2026 at 6:59 AM
Congratulations, Fiona!
Reposted by Grosshans Lab
Prof. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine!
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...
January 15, 2026 at 10:09 AM
Prof. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine!
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...
RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
January 15, 2026 at 7:48 AM
RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...
December 8, 2025 at 11:47 AM
Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
Reposted by Grosshans Lab
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
November 25, 2025 at 6:18 AM
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
Reposted by Grosshans Lab
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
November 10, 2025 at 2:58 PM
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
Reposted by Grosshans Lab
And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 6, 2025 at 4:35 AM
And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
Reposted by Grosshans Lab
Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
One clock, two functions: from daily rhythms to development
Scientists at the FMI and the University of California-Santa Cruz have found that similar molecular machineries control daily circadian rhythms and developmental timing. Their work in worms shows that...
www.fmi.ch
November 4, 2025 at 8:28 AM
Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
Reposted by Grosshans Lab
Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
October 30, 2025 at 9:17 AM
Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
"[In C. elegans] researchers uncovered key principles of cell death and RNA interference [that] paved the way for new therapies and technologies. These breakthroughs were made not because they were sought by design, but because a few scientists, supported by public grants, followed their curiosity"
October 29, 2025 at 12:02 PM
"[In C. elegans] researchers uncovered key principles of cell death and RNA interference [that] paved the way for new therapies and technologies. These breakthroughs were made not because they were sought by design, but because a few scientists, supported by public grants, followed their curiosity"
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
doi.org
October 29, 2025 at 11:57 AM
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
Flying worms! www.science.org/content/arti... (And I always wondered how worm cuticular alae (= wings) got their name 😉)
Bull’s-eye! Static electricity pulls worm through air to its insect victim
Electrostatic charges may help roundworms infect a wide variety of hosts
www.science.org
October 29, 2025 at 8:08 AM
Flying worms! www.science.org/content/arti... (And I always wondered how worm cuticular alae (= wings) got their name 😉)
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🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Olivia Rissland (Univ. of Colorado School of Medicine, USA)!
📅 27.10. 16:30 – University of Bern, DCBP
📅 28.10. 15:00 – ETH Zurich, Hönggerberg
👉 More info: nccr-rna-and-disease.ch/education/nc...
@unibe.ch @ethz.ch @snf-fns.ch
📅 27.10. 16:30 – University of Bern, DCBP
📅 28.10. 15:00 – ETH Zurich, Hönggerberg
👉 More info: nccr-rna-and-disease.ch/education/nc...
@unibe.ch @ethz.ch @snf-fns.ch
October 24, 2025 at 7:09 AM
🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Olivia Rissland (Univ. of Colorado School of Medicine, USA)!
📅 27.10. 16:30 – University of Bern, DCBP
📅 28.10. 15:00 – ETH Zurich, Hönggerberg
👉 More info: nccr-rna-and-disease.ch/education/nc...
@unibe.ch @ethz.ch @snf-fns.ch
📅 27.10. 16:30 – University of Bern, DCBP
📅 28.10. 15:00 – ETH Zurich, Hönggerberg
👉 More info: nccr-rna-and-disease.ch/education/nc...
@unibe.ch @ethz.ch @snf-fns.ch
Reposted by Grosshans Lab
For what it’s worth, The Wyoming Worm lab has funding for 5 years along with exciting projects with solid foundations. We are is still looking for capable, dedicated, and fun-to-work-with lab members at all career stages. davidfay@uwyo.edu
scholar.google.com/citations?us...
scholar.google.com/citations?us...
October 22, 2025 at 1:28 PM
For what it’s worth, The Wyoming Worm lab has funding for 5 years along with exciting projects with solid foundations. We are is still looking for capable, dedicated, and fun-to-work-with lab members at all career stages. davidfay@uwyo.edu
scholar.google.com/citations?us...
scholar.google.com/citations?us...
Fabulous @katb92.bsky.social was the lead on our side!
bsky.app
October 20, 2025 at 2:22 PM
Fabulous @katb92.bsky.social was the lead on our side!
This invites speculations about the evolution of circadian vs. developmental clocks and the features that make the PER/LIN-42:CK1/KIN-20 module so central to different timing mechanisms – as discussed in the accompanying News & Views article @embojournal.org doi.org/10.1038/s443... . 8/n
Old cogs, new clocks: a conserved protein complex controls developmental and circadian timing | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
doi.org
October 20, 2025 at 1:25 PM
This invites speculations about the evolution of circadian vs. developmental clocks and the features that make the PER/LIN-42:CK1/KIN-20 module so central to different timing mechanisms – as discussed in the accompanying News & Views article @embojournal.org doi.org/10.1038/s443... . 8/n
Intriguingly, this tango also appears to happen in circadian clocks: while CK1 licenses PER for degradation, PER also regulates CK1 activity and its targeting of the CLOCK protein in the nucleus. 7/n
October 20, 2025 at 1:25 PM
Intriguingly, this tango also appears to happen in circadian clocks: while CK1 licenses PER for degradation, PER also regulates CK1 activity and its targeting of the CLOCK protein in the nucleus. 7/n
Indeed, KIN-20 exhibits dynamic localization to the nucleus – dependent on LIN-42 binding. We speculate that this may provide KIN-20 to access to additional substrates. 6/n
October 20, 2025 at 1:25 PM
Indeed, KIN-20 exhibits dynamic localization to the nucleus – dependent on LIN-42 binding. We speculate that this may provide KIN-20 to access to additional substrates. 6/n
Animals lacking CK1/KIN-20 or its enzymatic activity are highly arrhythmic – in fact much more so than animals only lacking the LIN-42_CK1BD. This made us wonder whether the key function of the complex is regulation of KIN-20 by LIN-42, rather than the other way around. 5/n
October 20, 2025 at 1:25 PM
Animals lacking CK1/KIN-20 or its enzymatic activity are highly arrhythmic – in fact much more so than animals only lacking the LIN-42_CK1BD. This made us wonder whether the key function of the complex is regulation of KIN-20 by LIN-42, rather than the other way around. 5/n
LIN-42 co-immunoprecipitates KIN-20 – an orthologue of Casein Kinase 1delta/epsilon that also occurs in a complex with PER in mammals. The LT/SYQ region forms a CK1-binding domain (CK1BD) that also regulates CK1 activity. CK1 phosphorylates LIN-42. 4/n
October 20, 2025 at 1:25 PM
LIN-42 co-immunoprecipitates KIN-20 – an orthologue of Casein Kinase 1delta/epsilon that also occurs in a complex with PER in mammals. The LT/SYQ region forms a CK1-binding domain (CK1BD) that also regulates CK1 activity. CK1 phosphorylates LIN-42. 4/n