Teresa Rayon
@trayon.bsky.social
Developmental biologist. EvoDevo & comparative stem cell dynamics 🐭⌛️👤⏳. Group Leader @BabrahamInst.
@SEBiolDev board member
@SEBiolDev board member
Pinned
Teresa Rayon
@trayon.bsky.social
· Sep 28
This meant that degradative machineries may be in charge:
✔️ differential abundance & stability of proteasomal particles
✔️ higher proteasomal activity in 🐭 compared to 👤 embryonic spinal cord
✔️ differential abundance & stability of proteasomal particles
✔️ higher proteasomal activity in 🐭 compared to 👤 embryonic spinal cord
Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.
Congrats to Giulia and co 🍾🥂
Congrats to Giulia and co 🍾🥂
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
November 11, 2025 at 7:36 AM
Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.
Congrats to Giulia and co 🍾🥂
Congrats to Giulia and co 🍾🥂
Reposted by Teresa Rayon
Brillante entrevista a Darío Lupiáñez, ganador del #JLGS2024. Inspiración y visión de un destacado integrante de nuestra sociedad. ¡Orgullo SEBD! @sebioldev.bsky.social Muy recomendable! No os la perdáis!
To celebrate the most recently attributed José Luis Gomez Skarmeta prize #JLGS2024 we interviewed the prize winner @dariloops.bsky.social @cabd-upo-csic.bsky.social on his research and his thoughts on #DevBio youtu.be/eldKr4MIrIU?...
Premio José Luis Gómez Skarmeta a la excelencia científica 2024 a Dario Lupiáñez García
YouTube video by Sociedad Española de Biología del Desarrollo
youtu.be
November 3, 2025 at 4:00 PM
Brillante entrevista a Darío Lupiáñez, ganador del #JLGS2024. Inspiración y visión de un destacado integrante de nuestra sociedad. ¡Orgullo SEBD! @sebioldev.bsky.social Muy recomendable! No os la perdáis!
Reposted by Teresa Rayon
🤝¿Sabías que @elmundotoday.com ha iniciado una colaboración con el #CSIC?
Con este texto arrancaba (vía @csicdivulga.bsky.social) 👇
https://t.co/6SxyWUCAe5
Con este texto arrancaba (vía @csicdivulga.bsky.social) 👇
https://t.co/6SxyWUCAe5
October 25, 2025 at 11:01 AM
🤝¿Sabías que @elmundotoday.com ha iniciado una colaboración con el #CSIC?
Con este texto arrancaba (vía @csicdivulga.bsky.social) 👇
https://t.co/6SxyWUCAe5
Con este texto arrancaba (vía @csicdivulga.bsky.social) 👇
https://t.co/6SxyWUCAe5
Reposted by Teresa Rayon
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
October 17, 2025 at 3:31 PM
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
Reposted by Teresa Rayon
And here is a layperson video summary of parts of our recent paper👇
🎥 FMI scientists discovered that thousands of C. elegans genes switch on and off in rhythmic patterns controlled by chromatin, revealing how gene timing shapes development & offering clues to human biological clocks. @labgrosshans.bsky.social www.youtube.com/watch?v=Dibw...
DNA rhythms orchestrate gene activity across development
YouTube video by The Friedrich Miescher Institute for Biomedical Research
www.youtube.com
October 15, 2025 at 10:39 AM
And here is a layperson video summary of parts of our recent paper👇
October 12, 2025 at 9:25 AM
Reposted by Teresa Rayon
We can identify genetic associations with disease, but the hard part is figuring out what effects the variants at those loci actually do, including how penetrant they are. This is hard. But one phrase in this piece struck me in particular... /1
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Penetrance and variant consequences—Two sides of the same coin?
To get more out of genome sequences, the effects of variants need to be quantified
www.science.org
October 2, 2025 at 9:21 PM
We can identify genetic associations with disease, but the hard part is figuring out what effects the variants at those loci actually do, including how penetrant they are. This is hard. But one phrase in this piece struck me in particular... /1
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social
🔥 now including in vivo 🐭&👤 embryo data
www.biorxiv.org/content/10.1...
🔥 now including in vivo 🐭&👤 embryo data
www.biorxiv.org/content/10.1...
September 28, 2025 at 10:05 AM
We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social
🔥 now including in vivo 🐭&👤 embryo data
www.biorxiv.org/content/10.1...
🔥 now including in vivo 🐭&👤 embryo data
www.biorxiv.org/content/10.1...
Reposted by Teresa Rayon
Today we celebrate the life and legacy of Bob Edwards, pioneer of IVF, welcoming over 200 visitors for a two part event to mark what would have been his 100th birthday! Read more at www.cam.ac.uk/research/new...
Cambridge marks centenary of IVF pioneer Sir Robert Edwards’ birth
Celebrations at the University of Cambridge honour the life, work and legacy of Sir Robert Edwards, whose work revolutionised fertility treatment through the
www.cam.ac.uk
September 26, 2025 at 8:59 AM
Today we celebrate the life and legacy of Bob Edwards, pioneer of IVF, welcoming over 200 visitors for a two part event to mark what would have been his 100th birthday! Read more at www.cam.ac.uk/research/new...
Reposted by Teresa Rayon
Excited for the #CSHAmeeting on Human Development - From Embryos to Stem Cell Models in Suzhou, China? Our Editor, Peter Rugg-Gunn, is attending and has curated a collection of review-type and Research Articles on this topic: journals.biologists.com/dev/collecti...
September 18, 2025 at 3:48 PM
Excited for the #CSHAmeeting on Human Development - From Embryos to Stem Cell Models in Suzhou, China? Our Editor, Peter Rugg-Gunn, is attending and has curated a collection of review-type and Research Articles on this topic: journals.biologists.com/dev/collecti...
Reposted by Teresa Rayon
On the train back now from the 2nd ever #EMBODevMet, where I got to see many familiar faces, meet new people, and hear about lots of great and inspiring work combining two of my top scientific interests (development & metabolism) in so many different systems! 🤓🤩
✨ That's a wrap on #EMBODevMet after four inspiring days of cutting-edge science, new ideas, and reconnections.
👏 A huge thanks to all participants, speakers, and organisers who made this event so special.
We can't wait to welcome you back to another EMBL event 👉 embl.org/events
👏 A huge thanks to all participants, speakers, and organisers who made this event so special.
We can't wait to welcome you back to another EMBL event 👉 embl.org/events
September 12, 2025 at 1:46 PM
On the train back now from the 2nd ever #EMBODevMet, where I got to see many familiar faces, meet new people, and hear about lots of great and inspiring work combining two of my top scientific interests (development & metabolism) in so many different systems! 🤓🤩
Reposted by Teresa Rayon
Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing - Nature Cell Biology
Xu et al. perform a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling biv...
www.nature.com
September 3, 2025 at 6:14 AM
Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congrats to authors on this preprint!🦈 brains, what’s not to like?
*Deep conservation in brain basal progenitors. Cool!
*Deep conservation in brain basal progenitors. Cool!
Short answer: YES! We identified a mitotic cell state in sharks that matches mouse basal progenitors both transcriptomically and anatomically. While we found key similarities, some differences hint at unique evolutionary paths in sharks and mammals. For a deeper dive, check out the full paper!
September 3, 2025 at 7:32 AM
Congrats to authors on this preprint!🦈 brains, what’s not to like?
*Deep conservation in brain basal progenitors. Cool!
*Deep conservation in brain basal progenitors. Cool!
Reposted by Teresa Rayon
Super excited that our latest work is out!
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 27, 2025 at 10:52 AM
Super excited that our latest work is out!
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
We use optogenetics to dynamically control and study the formation of morphogen gradients.
If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.
Reposted by Teresa Rayon
Read more about @sermenchero.bsky.social 's work in this PNAS Journal Club. #opossums!
In #opossums and other #marsupials, #GeneExpression follows familiar rules, but at an unusual pace. In PNAS Journal Club: www.pnas.org/post/journal...
#DevelopmentalBiology #evolution #embryo #transcriptome
#DevelopmentalBiology #evolution #embryo #transcriptome
August 21, 2025 at 7:30 PM
Read more about @sermenchero.bsky.social 's work in this PNAS Journal Club. #opossums!
Why would anyone want to be a scientist? 👩🔬
Very much enjoyed this piece. Of course there may be other reasons, but these resonate well with me.
A reminder for all of us that I find rarely mentioned: “Great work becomes part of the background”
Very much enjoyed this piece. Of course there may be other reasons, but these resonate well with me.
A reminder for all of us that I find rarely mentioned: “Great work becomes part of the background”
"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com
August 17, 2025 at 12:29 PM
Why would anyone want to be a scientist? 👩🔬
Very much enjoyed this piece. Of course there may be other reasons, but these resonate well with me.
A reminder for all of us that I find rarely mentioned: “Great work becomes part of the background”
Very much enjoyed this piece. Of course there may be other reasons, but these resonate well with me.
A reminder for all of us that I find rarely mentioned: “Great work becomes part of the background”
Reposted by Teresa Rayon
“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.”
Great paper and very important finding - many congrats Axel & team! 👏👏
Great paper and very important finding - many congrats Axel & team! 👏👏
August 8, 2025 at 8:51 PM
“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.”
Great paper and very important finding - many congrats Axel & team! 👏👏
Great paper and very important finding - many congrats Axel & team! 👏👏
Reposted by Teresa Rayon
Hi bsky!
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
August 7, 2025 at 3:01 PM
Hi bsky!
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
Reposted by Teresa Rayon
In preprints: setting the tempo of development
@gabbov.bsky.social and @mdiazcuadros.bsky.social highlight two preprints that describe how developmental timing is set by cell-intrinsic mechanisms.
journals.biologists.com/dev/article/...
@gabbov.bsky.social and @mdiazcuadros.bsky.social highlight two preprints that describe how developmental timing is set by cell-intrinsic mechanisms.
journals.biologists.com/dev/article/...
July 25, 2025 at 2:11 PM
In preprints: setting the tempo of development
@gabbov.bsky.social and @mdiazcuadros.bsky.social highlight two preprints that describe how developmental timing is set by cell-intrinsic mechanisms.
journals.biologists.com/dev/article/...
@gabbov.bsky.social and @mdiazcuadros.bsky.social highlight two preprints that describe how developmental timing is set by cell-intrinsic mechanisms.
journals.biologists.com/dev/article/...
🔥🔥🔥🔥🔥🔥
Worth a read if interested in developmental timing & heterochronies.
What a beautiful work in an unusual model organism. Congrats Sergio et al!!!!
Worth a read if interested in developmental timing & heterochronies.
What a beautiful work in an unusual model organism. Congrats Sergio et al!!!!
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show
rapid progression of transcriptional programs in specific tissues relative to morphological
landmarks. This shift in...
www.cell.com
July 25, 2025 at 12:36 PM
🔥🔥🔥🔥🔥🔥
Worth a read if interested in developmental timing & heterochronies.
What a beautiful work in an unusual model organism. Congrats Sergio et al!!!!
Worth a read if interested in developmental timing & heterochronies.
What a beautiful work in an unusual model organism. Congrats Sergio et al!!!!
Found this unbelievably accurate “integrated stem
cell model” by JA Thomson in 1996 of marmoset ESCs 🐒
pubmed.ncbi.nlm.nih.gov/8828827/
The simplest protocol one can think of built quite remarkable structures !?!?
cell model” by JA Thomson in 1996 of marmoset ESCs 🐒
pubmed.ncbi.nlm.nih.gov/8828827/
The simplest protocol one can think of built quite remarkable structures !?!?
July 24, 2025 at 7:31 PM
Found this unbelievably accurate “integrated stem
cell model” by JA Thomson in 1996 of marmoset ESCs 🐒
pubmed.ncbi.nlm.nih.gov/8828827/
The simplest protocol one can think of built quite remarkable structures !?!?
cell model” by JA Thomson in 1996 of marmoset ESCs 🐒
pubmed.ncbi.nlm.nih.gov/8828827/
The simplest protocol one can think of built quite remarkable structures !?!?
Reposted by Teresa Rayon
Happy #MicroscopyMonday! This video, captured by Berta in the @trayon.bsky.social lab in collaboration with our Imaging facility, shows a mouse embryo dividing. This video allows researchers to visualise the events that happen before implantation at an early stage of development.
July 21, 2025 at 3:44 PM
Happy #MicroscopyMonday! This video, captured by Berta in the @trayon.bsky.social lab in collaboration with our Imaging facility, shows a mouse embryo dividing. This video allows researchers to visualise the events that happen before implantation at an early stage of development.
Really excited to visit the Karolinska Institute:
dev brains & spinal cord!!
dev brains & spinal cord!!
July 19, 2025 at 9:04 AM
Really excited to visit the Karolinska Institute:
dev brains & spinal cord!!
dev brains & spinal cord!!
Tight control
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
July 18, 2025 at 7:19 PM
Tight control
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
of Notch1 intracellular domain (NICD) stability to tune devel-
opmental timing in the context of human somitogenesis.
Original paper: genesdev.cshlp.org/content/gene...
Reposted by Teresa Rayon
🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open.
www.symposia.org.uk/courses/stem...
www.symposia.org.uk/courses/stem...
July 8, 2025 at 11:01 AM
🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open.
www.symposia.org.uk/courses/stem...
www.symposia.org.uk/courses/stem...