Sergio Menchero
@sermenchero.bsky.social
Postdoc at @crick.ac.uk | HFSP fellow | DevBio, epigenetics, marsupial, evo-devo | Previous Manzanares lab | #embryo2017 | (he/him)
Pinned
Sergio Menchero
@sermenchero.bsky.social
· Jul 24
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show
rapid progression of transcriptional programs in specific tissues relative to morphological
landmarks. This shift in...
www.cell.com
Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
Reposted by Sergio Menchero
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Reposted by Sergio Menchero
Want to image cells protecting the embryo during early development? We're hiring! 1 Postdoc, 1 PhD student, and 1 Research Technician. Come to Barcelona! www.embryobioimaging.com
December 9, 2025 at 5:44 PM
Want to image cells protecting the embryo during early development? We're hiring! 1 Postdoc, 1 PhD student, and 1 Research Technician. Come to Barcelona! www.embryobioimaging.com
Reposted by Sergio Menchero
🔔 Please share 🔔 I have two open developmental biology/genetics/evo-devo PhD project vacancies for October 2026 start.
1 = 🐚 🐌 🔬(embryos!!)
⏱️📆 DEADLINE 15th DEC 📆⏱️ (competition)
sleightlab.com/vacancies/
2 = 🦪 🐌 🧬
⏱️📆 DEADLINE 14th JAN 📆⏱️(fully funded)
sleightlab.com/phd-vacancy-2/
1 = 🐚 🐌 🔬(embryos!!)
⏱️📆 DEADLINE 15th DEC 📆⏱️ (competition)
sleightlab.com/vacancies/
2 = 🦪 🐌 🧬
⏱️📆 DEADLINE 14th JAN 📆⏱️(fully funded)
sleightlab.com/phd-vacancy-2/
December 1, 2025 at 6:55 PM
🔔 Please share 🔔 I have two open developmental biology/genetics/evo-devo PhD project vacancies for October 2026 start.
1 = 🐚 🐌 🔬(embryos!!)
⏱️📆 DEADLINE 15th DEC 📆⏱️ (competition)
sleightlab.com/vacancies/
2 = 🦪 🐌 🧬
⏱️📆 DEADLINE 14th JAN 📆⏱️(fully funded)
sleightlab.com/phd-vacancy-2/
1 = 🐚 🐌 🔬(embryos!!)
⏱️📆 DEADLINE 15th DEC 📆⏱️ (competition)
sleightlab.com/vacancies/
2 = 🦪 🐌 🧬
⏱️📆 DEADLINE 14th JAN 📆⏱️(fully funded)
sleightlab.com/phd-vacancy-2/
The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk
December 2, 2025 at 11:06 AM
The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk
Reposted by Sergio Menchero
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
November 27, 2025 at 2:18 PM
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
Reposted by Sergio Menchero
We are recruiting PhD students!
Two days left to apply for the LSI studentships - deadline Nov 26
www.exeter.ac.uk/research/ins...
and a few more for the SWBio studentships - deadline Dec 3
www.swbio.ac.uk/programme/pr...
Please repost or forward to prospective students that might be interested!
Two days left to apply for the LSI studentships - deadline Nov 26
www.exeter.ac.uk/research/ins...
and a few more for the SWBio studentships - deadline Dec 3
www.swbio.ac.uk/programme/pr...
Please repost or forward to prospective students that might be interested!
LSI PhD programme | Living Systems Institute | University of Exeter
www.exeter.ac.uk
November 24, 2025 at 3:19 PM
We are recruiting PhD students!
Two days left to apply for the LSI studentships - deadline Nov 26
www.exeter.ac.uk/research/ins...
and a few more for the SWBio studentships - deadline Dec 3
www.swbio.ac.uk/programme/pr...
Please repost or forward to prospective students that might be interested!
Two days left to apply for the LSI studentships - deadline Nov 26
www.exeter.ac.uk/research/ins...
and a few more for the SWBio studentships - deadline Dec 3
www.swbio.ac.uk/programme/pr...
Please repost or forward to prospective students that might be interested!
Reposted by Sergio Menchero
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
November 23, 2025 at 1:51 AM
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Reposted by Sergio Menchero
Our lab is actively looking for posdocs and there is NOW an Open Call for Postdoc contracts (3 years) here: www.aei.gob.es/en/announcem...
www.aei.gob.es
November 7, 2025 at 3:24 PM
Our lab is actively looking for posdocs and there is NOW an Open Call for Postdoc contracts (3 years) here: www.aei.gob.es/en/announcem...
Reposted by Sergio Menchero
And the paper is finally out! Thank you to the reviewers for improving the content, and to everyone who contributed along the way. A very nice way of finishing the transition from Melbourne to Cambridge.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb - Nature Communications
Qu, Razmara et al. show that Gli1+ fetal cells give rise to long-lived cartilage progenitors in the long bones. While normally dormant until postnatally, they expand upon (and compensate for) growth p...
www.nature.com
November 19, 2025 at 9:59 PM
And the paper is finally out! Thank you to the reviewers for improving the content, and to everyone who contributed along the way. A very nice way of finishing the transition from Melbourne to Cambridge.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sergio Menchero
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Sergio Menchero
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
November 17, 2025 at 11:39 AM
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Reposted by Sergio Menchero
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Beautiful work confirming that DNA demethylation dynamics are different between eutherians and marsupials during early development 🦘 We knew about opossums but it's also true in dunnarts!
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
www.biorxiv.org
November 12, 2025 at 6:20 PM
Beautiful work confirming that DNA demethylation dynamics are different between eutherians and marsupials during early development 🦘 We knew about opossums but it's also true in dunnarts!
Reposted by Sergio Menchero
OFERTA DE EMPLEO (por favor difundir):
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
November 6, 2025 at 5:24 PM
OFERTA DE EMPLEO (por favor difundir):
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
Reposted by Sergio Menchero
🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
October 30, 2025 at 5:50 PM
🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
Reposted by Sergio Menchero
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Sergio Menchero
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by Sergio Menchero
Help us to promote this DevBiol course (in Spanish)
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo
Registro "Biología del Desarrollo Sintética: Diseñando la Vida"
Curso Electivo de Verano, dirigido a estudiantes de pregrado
Programa: Link
Fechas: 5 al 15 de Enero de 2026
Lugar: Santiago de Chile, clases presenciales (Campus Manuel Montt, U. Mayor)
Para estudian...
forms.gle
October 26, 2025 at 2:16 PM
Help us to promote this DevBiol course (in Spanish)
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo
Reposted by Sergio Menchero
Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...
A human induced pluripotent stem cell toolbox for studying sex chromosome effects
Sex chromosomes shape male (XY)-female (XX) differences in development and disease. These differences can be modeled in vitro by comparing XY and XX h…
www.sciencedirect.com
October 23, 2025 at 11:06 AM
Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...
Reposted by Sergio Menchero
Come join the #LondonEvoDevo network half day meeting, hosted at @ucl.ac.uk on Friday November 7th, 2025. Submit your abstract by Oct 27th (or your interest in joining) here: forms.gle/TRbdrCkQTcY2.... Friendly vibes and free registration. More info here: londonevodevo.co.uk.
LondonEvoDevo
meeting's website
londonevodevo.co.uk
October 20, 2025 at 1:42 PM
Come join the #LondonEvoDevo network half day meeting, hosted at @ucl.ac.uk on Friday November 7th, 2025. Submit your abstract by Oct 27th (or your interest in joining) here: forms.gle/TRbdrCkQTcY2.... Friendly vibes and free registration. More info here: londonevodevo.co.uk.
Reposted by Sergio Menchero
Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available
go.nature.com/479Sni6
go.nature.com/479Sni6
Is academic research becoming too competitive? Nature examines the data
Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.
go.nature.com
October 17, 2025 at 10:12 AM
Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available
go.nature.com/479Sni6
go.nature.com/479Sni6
Reposted by Sergio Menchero
My lab will be recruiting a PhD student this year. Have a look and apply if it sounds interesting!
adroverlab.com/open-call-fo...
adroverlab.com/open-call-fo...
Open call for a PhD student - Cancer Macroenvironment Lab
Investigating the role of neutrophils in tumour progression, microenvironment dynamics and metastatic spread Application deadline: 5th of November, 2025 Project background and description Our laborato...
adroverlab.com
October 16, 2025 at 8:05 AM
My lab will be recruiting a PhD student this year. Have a look and apply if it sounds interesting!
adroverlab.com/open-call-fo...
adroverlab.com/open-call-fo...
Reposted by Sergio Menchero
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by Sergio Menchero
We are recruiting PhD students! If you are interested in evolutionary neuroscience, consider applying: www.crick.ac.uk/careers-stud...
Prieto Godino Lab | Cellular and molecular bases of neural circuit and behavioural evolution
www.crick.ac.uk
October 8, 2025 at 8:51 PM
We are recruiting PhD students! If you are interested in evolutionary neuroscience, consider applying: www.crick.ac.uk/careers-stud...
Reposted by Sergio Menchero
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...
Elosegui-Artola Lab | Mechanical regulation of tissue dynamics by the extracellular matrix in development and cancer
www.crick.ac.uk
October 9, 2025 at 7:28 AM
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...