Allegra Angeloni
@angeloniallegra.bsky.social
Postdoc @ Garvan Institute | Epigenetics, development, evolution
Reposted by Allegra Angeloni
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
November 19, 2025 at 9:48 AM
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
Reposted by Allegra Angeloni
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
www.biorxiv.org
November 12, 2025 at 2:57 AM
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
Reposted by Allegra Angeloni
We are excited to announce the first Eastern ☀️VGZT session for this season!✨🎉
📅Tomorrow, November 12th
⏰ 9:00 UTC / 9:00 GMT / 10:00 CET / 14:30 IST / 18:00 JST / 20:00 AEDT
Our speakers are:
👉Sameer Thukral (on X: @SameerThukral6)
👉Axel Newton (on X: @AxelHNewton)
See you on tomorrow☕️👋
📅Tomorrow, November 12th
⏰ 9:00 UTC / 9:00 GMT / 10:00 CET / 14:30 IST / 18:00 JST / 20:00 AEDT
Our speakers are:
👉Sameer Thukral (on X: @SameerThukral6)
👉Axel Newton (on X: @AxelHNewton)
See you on tomorrow☕️👋
November 11, 2025 at 12:47 PM
We are excited to announce the first Eastern ☀️VGZT session for this season!✨🎉
📅Tomorrow, November 12th
⏰ 9:00 UTC / 9:00 GMT / 10:00 CET / 14:30 IST / 18:00 JST / 20:00 AEDT
Our speakers are:
👉Sameer Thukral (on X: @SameerThukral6)
👉Axel Newton (on X: @AxelHNewton)
See you on tomorrow☕️👋
📅Tomorrow, November 12th
⏰ 9:00 UTC / 9:00 GMT / 10:00 CET / 14:30 IST / 18:00 JST / 20:00 AEDT
Our speakers are:
👉Sameer Thukral (on X: @SameerThukral6)
👉Axel Newton (on X: @AxelHNewton)
See you on tomorrow☕️👋
Reposted by Allegra Angeloni
2025 ANZSCDB NSW Branch Symposium happening this Wednesday, 5 November at the Garvan Institute, Sydney!
Full program: www.anzscdb.org/new-south-wa...
🙏 A big thank you to our Major Sponsor: @biologists.bsky.social
And to all our generous sponsors for supporting this event!
Full program: www.anzscdb.org/new-south-wa...
🙏 A big thank you to our Major Sponsor: @biologists.bsky.social
And to all our generous sponsors for supporting this event!
November 3, 2025 at 3:39 AM
2025 ANZSCDB NSW Branch Symposium happening this Wednesday, 5 November at the Garvan Institute, Sydney!
Full program: www.anzscdb.org/new-south-wa...
🙏 A big thank you to our Major Sponsor: @biologists.bsky.social
And to all our generous sponsors for supporting this event!
Full program: www.anzscdb.org/new-south-wa...
🙏 A big thank you to our Major Sponsor: @biologists.bsky.social
And to all our generous sponsors for supporting this event!
Reposted by Allegra Angeloni
Reposted by Allegra Angeloni
We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
Bogdanovic Lab
www.bogdanoviclab.org
October 6, 2025 at 12:34 PM
We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
Reposted by Allegra Angeloni
Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
VGZT Season 7 - Nomination
Virtual Gastrulation Zoom Talks (VGZT) is an opportunity to share your science with an engaged, international audience of developmental biologists. Running from October 2025 to July 2026, this online ...
www.tinyurl.com
October 6, 2025 at 8:12 AM
Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
Reposted by Allegra Angeloni
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 1, 2025 at 6:08 PM
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Allegra Angeloni
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
September 25, 2025 at 2:17 PM
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
September 19, 2025 at 7:29 AM
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
Reposted by Allegra Angeloni
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
September 17, 2025 at 5:26 PM
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
Reposted by Allegra Angeloni
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Reposted by Allegra Angeloni
www.nature.com/articles/s41...
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Removal of promoter CpG methylation by epigenome editing reverses HBG silencing - Nature Communications
DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening...
www.nature.com
September 14, 2025 at 1:30 AM
www.nature.com/articles/s41...
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
Reposted by Allegra Angeloni
Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk
Non-CG DNA methylation in animal genomes
Nature Genetics - This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a...
rdcu.be
September 11, 2025 at 10:11 AM
Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk
Reposted by Allegra Angeloni
In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
September 2, 2025 at 3:54 PM
In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...
Reposted by Allegra Angeloni
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
Biochemistry; Cell biology; Developmental biology; Computational bioinformatics
www.cell.com
September 2, 2025 at 9:44 PM
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"!
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost.
www.cell.com/iscience/ful...
Reposted by Allegra Angeloni
You link #phenotype 🦜 to #genotype 🧬 with #comparative #genomics 💻?
This #review is for you 📜: authors.elsevier.com/sd/article/S...
We review new #methods, remaining #challenges and #future directions and highlight recent key studies.
Thanks @hillermich.bsky.social!
Please share! 🙂
This #review is for you 📜: authors.elsevier.com/sd/article/S...
We review new #methods, remaining #challenges and #future directions and highlight recent key studies.
Thanks @hillermich.bsky.social!
Please share! 🙂
July 24, 2025 at 8:00 AM
You link #phenotype 🦜 to #genotype 🧬 with #comparative #genomics 💻?
This #review is for you 📜: authors.elsevier.com/sd/article/S...
We review new #methods, remaining #challenges and #future directions and highlight recent key studies.
Thanks @hillermich.bsky.social!
Please share! 🙂
This #review is for you 📜: authors.elsevier.com/sd/article/S...
We review new #methods, remaining #challenges and #future directions and highlight recent key studies.
Thanks @hillermich.bsky.social!
Please share! 🙂
Reposted by Allegra Angeloni
ANZSCDB is pleased to launch our Zoom seminar series!
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
August 21, 2025 at 12:10 AM
ANZSCDB is pleased to launch our Zoom seminar series!
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White.
Please register and attend to ensure the success and long-term sustainability of this initiative.
Reposted by Allegra Angeloni
🎉 Another exciting contribution from our lab this summer!
🧬 Nearly complete, gapless genome of the sex-changing central bearded dragon (Pogona vitticeps) shed new light on the mystery of reptile sex determination.
Proud to be part of this collaborative effort!
academic.oup.com/gigascience/...
🧬 Nearly complete, gapless genome of the sex-changing central bearded dragon (Pogona vitticeps) shed new light on the mystery of reptile sex determination.
Proud to be part of this collaborative effort!
academic.oup.com/gigascience/...
A near telomere-to-telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps
AbstractBackground. The central bearded dragon (Pogona vitticeps) is widely distributed in central eastern Australia and adapts readily to captivity. Among
academic.oup.com
August 19, 2025 at 11:21 PM
🎉 Another exciting contribution from our lab this summer!
🧬 Nearly complete, gapless genome of the sex-changing central bearded dragon (Pogona vitticeps) shed new light on the mystery of reptile sex determination.
Proud to be part of this collaborative effort!
academic.oup.com/gigascience/...
🧬 Nearly complete, gapless genome of the sex-changing central bearded dragon (Pogona vitticeps) shed new light on the mystery of reptile sex determination.
Proud to be part of this collaborative effort!
academic.oup.com/gigascience/...
Reposted by Allegra Angeloni
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
August 18, 2025 at 12:23 PM
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
Reposted by Allegra Angeloni
Delighted to share the peer-reviewed version of our study led by @tomlewin.bsky.social now out in Genome Biology @bmc.springernature.com! We analyzed 64 chromosome-level genomes across 15 animal phyla and found that extensive genome rearrangements are the norm in bilaterians.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Conservation of bilaterian genome structure is the exception, not the rule - Genome Biology
Species from diverse animal lineages have conserved groups of orthologous genes together on the same chromosome for over half a billion years since the last common ancestor of bilaterians. Although no...
doi.org
August 18, 2025 at 9:39 AM
Delighted to share the peer-reviewed version of our study led by @tomlewin.bsky.social now out in Genome Biology @bmc.springernature.com! We analyzed 64 chromosome-level genomes across 15 animal phyla and found that extensive genome rearrangements are the norm in bilaterians.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Reposted by Allegra Angeloni
Our featured article:
Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob
Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob
Epigenome dynamics in early mammalian embryogenesis - Nature Reviews Genetics
Upon fertilization and during early mammalian development, major changes in cellular plasticity occur. This is accompanied by large-scale epigenome remodelling, as has been recently highlighted by the...
go.nature.com
August 18, 2025 at 9:27 AM
Our featured article:
Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob
Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob
Reposted by Allegra Angeloni
🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
bit.ly
August 14, 2025 at 8:42 PM
🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
rdcu.be/eAKzp
bit.ly/4fyZ9Sg