Ozren Bogdanovic
@obog.bsky.social
Principal Investigator at https://www.cabd.es | Interested in developmental epigenomics | Coordinator of the DANIO-ReCODE MSCA DN | https://danio-recode.eu | @daniorecode.bsky.social | webpage: www.bogdanoviclab.org
Reposted by Ozren Bogdanovic
🐟Meet the DANIO-ReCODE team!🐟
This week:Parth Bhatia and Prof @ferencmueller.bsky.social from @unibirmingham.bsky.social
Parth´s research focuses on the annotation,characterisation and dynamics of cis-regulatory elements (CREs) in telencephalon injury
📢Stay tuned! #DANIO #MSCA @obog.bsky.social
This week:Parth Bhatia and Prof @ferencmueller.bsky.social from @unibirmingham.bsky.social
Parth´s research focuses on the annotation,characterisation and dynamics of cis-regulatory elements (CREs) in telencephalon injury
📢Stay tuned! #DANIO #MSCA @obog.bsky.social
November 11, 2025 at 8:30 AM
🐟Meet the DANIO-ReCODE team!🐟
This week:Parth Bhatia and Prof @ferencmueller.bsky.social from @unibirmingham.bsky.social
Parth´s research focuses on the annotation,characterisation and dynamics of cis-regulatory elements (CREs) in telencephalon injury
📢Stay tuned! #DANIO #MSCA @obog.bsky.social
This week:Parth Bhatia and Prof @ferencmueller.bsky.social from @unibirmingham.bsky.social
Parth´s research focuses on the annotation,characterisation and dynamics of cis-regulatory elements (CREs) in telencephalon injury
📢Stay tuned! #DANIO #MSCA @obog.bsky.social
Reposted by Ozren Bogdanovic
Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin - Nature Structural & Molecular Biology
Yan et al. use cryo-EM to obtain structures that reveal how DNMT3A2 and DNMT3L cooperate to read histone signals and bind chromatin, illustrating a mechanism that controls DNA methylation and shapes e...
www.nature.com
November 4, 2025 at 2:55 PM
Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...
Reposted by Ozren Bogdanovic
#CABDseminars
"Rewriting Cell Identity Through TET2 Chromatin Profiling and DNA Methylation Editing" by José Luis Sardina @jlsardinalab.bsky.social, @carrerasijc.bsky.social
🗓️ November 7th
⏰ 12 pm
📍sala Grado, edificio 25 (biblioteca UPO) ‼️
Hosted by @obog.bsky.social
"Rewriting Cell Identity Through TET2 Chromatin Profiling and DNA Methylation Editing" by José Luis Sardina @jlsardinalab.bsky.social, @carrerasijc.bsky.social
🗓️ November 7th
⏰ 12 pm
📍sala Grado, edificio 25 (biblioteca UPO) ‼️
Hosted by @obog.bsky.social
November 3, 2025 at 2:01 PM
#CABDseminars
"Rewriting Cell Identity Through TET2 Chromatin Profiling and DNA Methylation Editing" by José Luis Sardina @jlsardinalab.bsky.social, @carrerasijc.bsky.social
🗓️ November 7th
⏰ 12 pm
📍sala Grado, edificio 25 (biblioteca UPO) ‼️
Hosted by @obog.bsky.social
"Rewriting Cell Identity Through TET2 Chromatin Profiling and DNA Methylation Editing" by José Luis Sardina @jlsardinalab.bsky.social, @carrerasijc.bsky.social
🗓️ November 7th
⏰ 12 pm
📍sala Grado, edificio 25 (biblioteca UPO) ‼️
Hosted by @obog.bsky.social
Reposted by Ozren Bogdanovic
Part 6: For decades, the zebrafish has helped scientists unlock the mysteries of genetics, development, & disease. But the fish that power most discoveries have spent generations inside lab tanks. This video captures footage of zebrafish in their natural environment in Nepal.
youtu.be/cCZhZpPALqw
youtu.be/cCZhZpPALqw
Zebrafish in the wild
YouTube video by John Rawls
youtu.be
October 28, 2025 at 2:09 PM
Part 6: For decades, the zebrafish has helped scientists unlock the mysteries of genetics, development, & disease. But the fish that power most discoveries have spent generations inside lab tanks. This video captures footage of zebrafish in their natural environment in Nepal.
youtu.be/cCZhZpPALqw
youtu.be/cCZhZpPALqw
Reposted by Ozren Bogdanovic
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 21, 2025 at 11:14 AM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Ozren Bogdanovic
💥 Another fruitful collaboration!
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
October 16, 2025 at 6:10 PM
💥 Another fruitful collaboration!
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis
👇
www.embopress.org/doi/full/10....
We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
Bogdanovic Lab
www.bogdanoviclab.org
October 6, 2025 at 12:34 PM
We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org
Reposted by Ozren Bogdanovic
🐟Meet the DANIO-ReCODE team!🐟
This week: Dario González and Dr Csilla Várnai from @unibirmingham.bsky.social
Dario studies the annotation, characterisation, and conservation of 3D chromatin topology in telencephalon injury
📢Stay tuned!
#DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social
This week: Dario González and Dr Csilla Várnai from @unibirmingham.bsky.social
Dario studies the annotation, characterisation, and conservation of 3D chromatin topology in telencephalon injury
📢Stay tuned!
#DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social
October 6, 2025 at 8:55 AM
🐟Meet the DANIO-ReCODE team!🐟
This week: Dario González and Dr Csilla Várnai from @unibirmingham.bsky.social
Dario studies the annotation, characterisation, and conservation of 3D chromatin topology in telencephalon injury
📢Stay tuned!
#DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social
This week: Dario González and Dr Csilla Várnai from @unibirmingham.bsky.social
Dario studies the annotation, characterisation, and conservation of 3D chromatin topology in telencephalon injury
📢Stay tuned!
#DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social
Reposted by Ozren Bogdanovic
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Reposted by Ozren Bogdanovic
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Reposted by Ozren Bogdanovic
Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk
Non-CG DNA methylation in animal genomes
Nature Genetics - This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a...
rdcu.be
September 11, 2025 at 10:11 AM
Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk
Reposted by Ozren Bogdanovic
Reposted by Ozren Bogdanovic
Many people were essential, I can only tag a handful here! @caseywdunn.bsky.social @stevehaddock.bsky.social @colinjanthony.bsky.social @rebeccarhelm.bsky.social @catmunro.bsky.social @amandine-oceano.bsky.social @scientifikita.bsky.social @guillermodelia.bsky.social & Yale Peabody Museum
June 19, 2025 at 7:51 PM
Many people were essential, I can only tag a handful here! @caseywdunn.bsky.social @stevehaddock.bsky.social @colinjanthony.bsky.social @rebeccarhelm.bsky.social @catmunro.bsky.social @amandine-oceano.bsky.social @scientifikita.bsky.social @guillermodelia.bsky.social & Yale Peabody Museum
Reposted by Ozren Bogdanovic
Excited to share our study on sailing siphonophores, AKA bluebottles or man-o'-war! 🌊 we received hundreds of samples from scientists around the world, part of a huge effort to sequence genomes and test for multiple species 🧬 out today in @currentbiology.bsky.social doi.org/10.1016/j.cu... 🦑🧪📌
June 19, 2025 at 7:51 PM
Excited to share our study on sailing siphonophores, AKA bluebottles or man-o'-war! 🌊 we received hundreds of samples from scientists around the world, part of a huge effort to sequence genomes and test for multiple species 🧬 out today in @currentbiology.bsky.social doi.org/10.1016/j.cu... 🦑🧪📌
Reposted by Ozren Bogdanovic
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
June 6, 2025 at 11:39 AM
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Reposted by Ozren Bogdanovic
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
June 13, 2025 at 4:30 AM
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
Reposted by Ozren Bogdanovic
Sequence-alignment is not the best way to detect conserved cis-regulatory elements?
Tobi Zehnder from Vingron-Lab developed #IPP a synteny based algorithm with @ferencmueller.bsky.social, @borislenhard.bsky.social& @da-bar.bsky.social
We used it to find conserved enhancers with diverged sequences
Tobi Zehnder from Vingron-Lab developed #IPP a synteny based algorithm with @ferencmueller.bsky.social, @borislenhard.bsky.social& @da-bar.bsky.social
We used it to find conserved enhancers with diverged sequences
May 27, 2025 at 12:19 PM
Sequence-alignment is not the best way to detect conserved cis-regulatory elements?
Tobi Zehnder from Vingron-Lab developed #IPP a synteny based algorithm with @ferencmueller.bsky.social, @borislenhard.bsky.social& @da-bar.bsky.social
We used it to find conserved enhancers with diverged sequences
Tobi Zehnder from Vingron-Lab developed #IPP a synteny based algorithm with @ferencmueller.bsky.social, @borislenhard.bsky.social& @da-bar.bsky.social
We used it to find conserved enhancers with diverged sequences
Reposted by Ozren Bogdanovic
I am super excited to announce the first (brief) pre-print purely from my group:
Start right to end right: authentic open reading frame selection matters
www.biorxiv.org/content/10.1...
This marks a return to NMD research for me. NMD detects early stop codons but we need to find the true stop!
Start right to end right: authentic open reading frame selection matters
www.biorxiv.org/content/10.1...
This marks a return to NMD research for me. NMD detects early stop codons but we need to find the true stop!
June 11, 2025 at 10:40 PM
I am super excited to announce the first (brief) pre-print purely from my group:
Start right to end right: authentic open reading frame selection matters
www.biorxiv.org/content/10.1...
This marks a return to NMD research for me. NMD detects early stop codons but we need to find the true stop!
Start right to end right: authentic open reading frame selection matters
www.biorxiv.org/content/10.1...
This marks a return to NMD research for me. NMD detects early stop codons but we need to find the true stop!
Reposted by Ozren Bogdanovic
So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.
www.science.org
June 14, 2025 at 12:47 AM
So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!
Reposted by Ozren Bogdanovic
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
Beetween
app.beetween.com
June 13, 2025 at 1:28 PM
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
new lab preprint 👇
Ever wondered how sperm are formed? Spermatogenesis is a microscopic marathon that starts in the testes and ends with fully functional sperm! Our new preprint bitly.cx/jC4Qg takes a deep dive into zebrafish spermatogenesis, mapping out every fascinating step. 🧵👇 1/7
A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation
Spermatogenesis is the biological process by which male sperm cells (spermatozoa) are produced in the testes. Beyond facilitating the transmission of genetic information, spermatogenesis also provides...
bitly.cx
March 13, 2025 at 12:47 PM
new lab preprint 👇
Reposted by Ozren Bogdanovic
We are offering 15 PhD positions in Decoding Transcriptional Regulation in Regeneration by Advanced Genomics and Computational tools (funded by the DANIO-ReCODE MSCA 2023 Doctoral Network) 🇪🇸 🇭🇷 🇸🇮 🇬🇧 🇩🇪 🇦🇹 Apply now: euraxess.ec.europa.eu/jobs/290548
15 PhD positions in Decoding Transcriptional Regulation in Regeneration by Advanced Genomics and Computational tools (funded by the DANIO-ReCODE MSCA 2023 Doctoral Network)
The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multilayered process of ...
euraxess.ec.europa.eu
November 17, 2024 at 7:46 PM
We are offering 15 PhD positions in Decoding Transcriptional Regulation in Regeneration by Advanced Genomics and Computational tools (funded by the DANIO-ReCODE MSCA 2023 Doctoral Network) 🇪🇸 🇭🇷 🇸🇮 🇬🇧 🇩🇪 🇦🇹 Apply now: euraxess.ec.europa.eu/jobs/290548
Reposted by Ozren Bogdanovic
🚀 Great Opportunity! The Danio ReCode EU consortium is offering **15 PhD positions** across diverse biological fields, from development to computer science! 🌱💻 apply here:
🔗 [https://euraxess.ec.europa.eu/jobs/290548](euraxess.ec.europa.eu/jobs/290548) #zebrafish #positions
November 14, 2024 at 11:12 AM
🚀 Great Opportunity! The Danio ReCode EU consortium is offering **15 PhD positions** across diverse biological fields, from development to computer science! 🌱💻 apply here:
🔗 [https://euraxess.ec.europa.eu/jobs/290548](euraxess.ec.europa.eu/jobs/290548) #zebrafish #positions
Reposted by Ozren Bogdanovic
SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6
The emergence of Sox and POU transcription factors predates the origins of animal stem cells
Nature Communications - The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals...
rdcu.be
November 14, 2024 at 5:15 PM
SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6