SinghLab@SNIoE
@singhlab.bsky.social
Regenerative & Stress Biology Lab, Shiv Nadar University, Delhi-NCR, India
Regenerative Plasticity | Zebrafish | In vivo Fluorescent Imaging | Liver Regeneration | Starvation Response | Alcoholic Liver Disease
Regenerative Plasticity | Zebrafish | In vivo Fluorescent Imaging | Liver Regeneration | Starvation Response | Alcoholic Liver Disease
Pinned
SinghLab@SNIoE
@singhlab.bsky.social
· Jun 6
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
As part of the Faculty Development Program at Shiv Nadar University , received these 10 commandments for faculty. This is the best advice I have seen, and certainly hits the nail on the head. Especially about focusing and getting the first study out early on.
July 31, 2025 at 10:59 AM
As part of the Faculty Development Program at Shiv Nadar University , received these 10 commandments for faculty. This is the best advice I have seen, and certainly hits the nail on the head. Especially about focusing and getting the first study out early on.
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
nature.com
June 6, 2025 at 11:39 AM
🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)
Reposted by SinghLab@SNIoE
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
CellTalk HHD | Human Heart Development Research
CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.
www.heartdevelopment.org
May 16, 2025 at 10:10 AM
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
Pleased to have contributed commentary to this recent article by Maria Bolevich for Interesting Engineering, which explores the science of tissue #regeneration and its potential applications in medicine.
Read the full article here: interestingengineering.com/health/body-...
Read the full article here: interestingengineering.com/health/body-...
Why the body's natural regeneration isn't enough to stop chronic disease
From skin renewal to liver repair, the body is rebuilding itself. Scientists are now uncovering why some organs heal and others don’t.
interestingengineering.com
June 2, 2025 at 3:15 AM
Pleased to have contributed commentary to this recent article by Maria Bolevich for Interesting Engineering, which explores the science of tissue #regeneration and its potential applications in medicine.
Read the full article here: interestingengineering.com/health/body-...
Read the full article here: interestingengineering.com/health/body-...
We just posted our new preprint, spearheaded by Garnik Hovhannisyan in collaboration with Esteban Gurzov Lab! biorxiv.org/content/10.1... #zebrafish #liverregeneration #DevBio #LineageTracing
CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages
Regeneration can rely on multiple cellular sources, including stem cells, self-duplicating cells, and transdifferentiating cells. A central question in regenerative biology is how these distinct linea...
biorxiv.org
May 28, 2025 at 3:18 PM
We just posted our new preprint, spearheaded by Garnik Hovhannisyan in collaboration with Esteban Gurzov Lab! biorxiv.org/content/10.1... #zebrafish #liverregeneration #DevBio #LineageTracing
Stunning 3D fluorescent images of the human #tooth and the first cellular/molecular map of tooth #decay! Hoang Thai Ha from Nicolas Baeyens Lab nails it with tissue clearing + imaging.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 16, 2025 at 6:16 PM
Stunning 3D fluorescent images of the human #tooth and the first cellular/molecular map of tooth #decay! Hoang Thai Ha from Nicolas Baeyens Lab nails it with tissue clearing + imaging.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by SinghLab@SNIoE
Interested in understanding how neural-pancreas interplay contributes to blood sugar control? We have an exciting PhD project to study galanin regulation of pancreatic #islet hormone secretion in live #zebrafish
www.exeter.ac.uk/research/ins...
www.exeter.ac.uk/research/ins...
May 14, 2025 at 1:49 PM
Interested in understanding how neural-pancreas interplay contributes to blood sugar control? We have an exciting PhD project to study galanin regulation of pancreatic #islet hormone secretion in live #zebrafish
www.exeter.ac.uk/research/ins...
www.exeter.ac.uk/research/ins...
Liver regeneration after killing part of the liver! In this image, the same liver from same #zebrafish is imaged before (left) and after (right) regeneration. The newly born liver cells are in blue.
Project led by @selifeski.bsky.social
Project led by @selifeski.bsky.social
May 14, 2025 at 6:53 PM
Liver regeneration after killing part of the liver! In this image, the same liver from same #zebrafish is imaged before (left) and after (right) regeneration. The newly born liver cells are in blue.
Project led by @selifeski.bsky.social
Project led by @selifeski.bsky.social
We celebrated a big milestone in our lab: our first #Undergrad intern presented her work at lab meeting! She helped develop two new #liver #injury models, and is on her way to becoming a fantastic scientist. Thanks to PhD student Garnik for mentoring her so well! 👏🧪 #TeamScience
May 3, 2025 at 6:33 AM
We celebrated a big milestone in our lab: our first #Undergrad intern presented her work at lab meeting! She helped develop two new #liver #injury models, and is on her way to becoming a fantastic scientist. Thanks to PhD student Garnik for mentoring her so well! 👏🧪 #TeamScience
Whole mount EdU staining of 5 day old #zebrafish.
April 12, 2025 at 5:34 PM
Whole mount EdU staining of 5 day old #zebrafish.
I'm excited to share that I will join School of Natural Sciences, Shiv Nadar University as an Associate Professor! Looking forward to working with amazing students and being part of a thriving research community.
April 8, 2025 at 7:26 AM
I'm excited to share that I will join School of Natural Sciences, Shiv Nadar University as an Associate Professor! Looking forward to working with amazing students and being part of a thriving research community.
Reposted by SinghLab@SNIoE
Come help us build an inclusive community, for those finterested! Did they mention it’s FREE?!? 🧪
The first IZFS and ZDMS joint webinar promoting global awareness about our varied backgrounds and experiences in science takes place tomorrow, March 6th at 10am EST! Featuring speaker Dr. Rachel Brewster, you will not want to miss this! Register here today: forms.gle/5uWMpdspRhtz...
Joint DEI session IZFS/ZDMS
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March 5, 2025 at 5:35 PM
Come help us build an inclusive community, for those finterested! Did they mention it’s FREE?!? 🧪
Delighted to receive FOXO Transcription Factors edited by Dr. Wolfgang Link! FOXO genes are key in stress response & metabolism. Inés Garteizgogeascoa Suñer details a knock-in #zebrafish foxo1a reporter: pubmed.ncbi.nlm.nih.gov/39565585/ Check out the book for key advances!
March 3, 2025 at 9:16 AM
Delighted to receive FOXO Transcription Factors edited by Dr. Wolfgang Link! FOXO genes are key in stress response & metabolism. Inés Garteizgogeascoa Suñer details a knock-in #zebrafish foxo1a reporter: pubmed.ncbi.nlm.nih.gov/39565585/ Check out the book for key advances!
Had a great time meeting the students at Freedom Employability Academy (FEA:
feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education
feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education
February 12, 2025 at 3:08 PM
Had a great time meeting the students at Freedom Employability Academy (FEA:
feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education
feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education
Reposted by SinghLab@SNIoE
We demonstrate that this biphasic regulation limits the neutrophil-driven acute inflammatory phase, preventing chronic inflammation, fostering a lesion environment with mechano-structural properties conducive to regeneration.
January 27, 2025 at 7:17 PM
We demonstrate that this biphasic regulation limits the neutrophil-driven acute inflammatory phase, preventing chronic inflammation, fostering a lesion environment with mechano-structural properties conducive to regeneration.
Reposted by SinghLab@SNIoE
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
www.biorxiv.org
January 27, 2025 at 7:17 PM
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Reposted by SinghLab@SNIoE
Fantastic collaboration with the labs of Sven Falk, @singhlab.bsky.social, Jochen Guck, @franzelab.bsky.social, Kanwarpal Singh, and Federico Marini. @fau.de @mpi-scienceoflight.bsky.social Johannes Gutenberg University University of Cambridge @iribhm.bsky.social, @mcmasteruniversity.bsky.social
January 27, 2025 at 7:17 PM
Fantastic collaboration with the labs of Sven Falk, @singhlab.bsky.social, Jochen Guck, @franzelab.bsky.social, Kanwarpal Singh, and Federico Marini. @fau.de @mpi-scienceoflight.bsky.social Johannes Gutenberg University University of Cambridge @iribhm.bsky.social, @mcmasteruniversity.bsky.social
Reposted by SinghLab@SNIoE
We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)!
Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!
Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!
December 9, 2024 at 8:48 PM
We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)!
Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!
Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!
Reposted by SinghLab@SNIoE
Our debut here 🥰
Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND)
Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils
Keep following us, spread the word!
Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND)
Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils
Keep following us, spread the word!
November 8, 2024 at 8:46 PM
Our debut here 🥰
Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND)
Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils
Keep following us, spread the word!
Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND)
Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils
Keep following us, spread the word!
Reposted by SinghLab@SNIoE
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
PhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala University
PhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University
www.uu.se
January 14, 2025 at 10:52 AM
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Reposted by SinghLab@SNIoE
Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 10, 2025 at 11:07 AM
Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish
The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...
www.biorxiv.org
January 10, 2025 at 7:57 AM
Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)
Reposted by SinghLab@SNIoE
5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
January 8, 2025 at 12:29 PM
5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
The majority of them (3,088) are enriched at the protein but not RNA level.
The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
What shapes the #immune profile of organs? Study from Ninov Lab #CRTD, led by Nadeem, find that developmental #celldeath define the immune cells of the pancreatic #islet in #zebrafish ! 🎉👏 Read more @embojournal.bsky.social : embopress.org/doi/full/10.... #Diabetes
Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk | The EMBO Journal
imageimageDuring islet development, beta-cell death, rather than proliferation alone, regulates
beta-cell mass and shapes the immune environment. This process triggers immune system
crosstalk, influen...
embopress.org
January 7, 2025 at 9:26 AM
What shapes the #immune profile of organs? Study from Ninov Lab #CRTD, led by Nadeem, find that developmental #celldeath define the immune cells of the pancreatic #islet in #zebrafish ! 🎉👏 Read more @embojournal.bsky.social : embopress.org/doi/full/10.... #Diabetes
Reposted by SinghLab@SNIoE
We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required.
January 6, 2025 at 5:54 PM
We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required.