Filipa Simões
@simoesfilipa.bsky.social
Development and Regeneration of the Heart | Cardio-Immuno Genomics | Group Leader University of Oxford IDRM-DPAG | playing with zebrafish & cardiac organoids | academic mama of 2 children & 1 dog | curiosity led
Pinned
Immune-mediated cardiac development and regeneration
The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving fie…
www.sciencedirect.com
Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...
Reposted by Filipa Simões
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
November 20, 2025 at 6:11 PM
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
Reposted by Filipa Simões
A remarkable scientist, innovator, and role model--well worth a read. 🧪
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...
Q & A
Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms
employed during early animal embryogenesis to specify cell fate, development, and
differentiation at Harvard Univ...
www.cell.com
November 20, 2025 at 12:04 PM
A remarkable scientist, innovator, and role model--well worth a read. 🧪
Reposted by Filipa Simões
I am very excited to be organizing a session for postdocs (with focus on those in the job market). Be on the lookout for info and registration! 🐟🧪
November 19, 2025 at 7:12 PM
I am very excited to be organizing a session for postdocs (with focus on those in the job market). Be on the lookout for info and registration! 🐟🧪
Reposted by Filipa Simões
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
shorturl.at
November 18, 2025 at 12:48 PM
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
Reposted by Filipa Simões
Folks, it is finally out! Our paper on T2T assemblies of the zebrafish genome is on BioRxiv:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 17, 2025 at 11:22 PM
Folks, it is finally out! Our paper on T2T assemblies of the zebrafish genome is on BioRxiv:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Filipa Simões
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 15, 2025 at 8:15 AM
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Reposted by Filipa Simões
The importance of getting away from your screen and talking to other people: The Sense of Community (with thanks to @andrewmaynard.net for stimulating this post) occamstypewriter.org/athenedonald...
The Importance of Community | Athene Donald's Blog
occamstypewriter.org
November 16, 2025 at 10:19 AM
The importance of getting away from your screen and talking to other people: The Sense of Community (with thanks to @andrewmaynard.net for stimulating this post) occamstypewriter.org/athenedonald...
Reposted by Filipa Simões
I came to this country as a child refugee. No English, no certainty, no idea what my life could become. Britain gave me refuge.
Not on a timer, not with conditions attached, but with a chance to grow roots.
A thread 🧵 1/8
www.bbc.co.uk/news/article...
Not on a timer, not with conditions attached, but with a chance to grow roots.
A thread 🧵 1/8
www.bbc.co.uk/news/article...
UK set to limit refugees to temporary stays
Shabana Mahmood is expected to say the era of permanent protection for refugees is over, in major changes to the UK's asylum and immigration system.
www.bbc.co.uk
November 15, 2025 at 10:29 AM
I came to this country as a child refugee. No English, no certainty, no idea what my life could become. Britain gave me refuge.
Not on a timer, not with conditions attached, but with a chance to grow roots.
A thread 🧵 1/8
www.bbc.co.uk/news/article...
Not on a timer, not with conditions attached, but with a chance to grow roots.
A thread 🧵 1/8
www.bbc.co.uk/news/article...
Reposted by Filipa Simões
Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration
November 11, 2025 at 2:28 AM
Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration
Reposted by Filipa Simões
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
November 7, 2025 at 4:43 PM
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
Reposted by Filipa Simões
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Reposted by Filipa Simões
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
September 22, 2025 at 11:24 AM
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Reposted by Filipa Simões
Last week I had the pleasure of hosting Dr Marianne Bronner for our CReM seminar series. Through this series, we’re committed to giving our mentees and trainees exposure to 🤯 science from those pushing the boundaries in their field, and extraordinary mentors , and Marianne checks every single box.
November 13, 2025 at 10:43 PM
Last week I had the pleasure of hosting Dr Marianne Bronner for our CReM seminar series. Through this series, we’re committed to giving our mentees and trainees exposure to 🤯 science from those pushing the boundaries in their field, and extraordinary mentors , and Marianne checks every single box.
Reposted by Filipa Simões
Sara Cox completes marathon challenge and raises over £7m for Children in Need
Sara Cox completes marathon challenge and raises over £7m for Children in Need
Radio 2 DJ covered 135 miles in five days carrying a Pudsey Bear backpack from Kielder Forest to Pudsey, Leeds
The BBC presenter Sara Cox has completed her arduous challenge to cover 135 miles in five days, which has raised more than £7m for the Children in Need charity.
The 50-year-old, who presents Radio 2’s Teatime show on weekdays, crossed the finish line for her great northern marathon challenge at about 3.30pm on Friday after covering the equivalent of five marathons in five days, where she was greeted by a performance from former Spice Girl Melanie C. Continue reading...
www.theguardian.com
November 14, 2025 at 7:00 PM
Sara Cox completes marathon challenge and raises over £7m for Children in Need
I’ve been quite in awe (and inspired!) by Sara’s grit and determination- running the equivalent of 5 marathons in 5 days #powerwoman💥 if you can, consider donating for BBC Children in Need: www.bbcchildreninneed.co.uk/shows/sara-c...
November 14, 2025 at 9:57 AM
I’ve been quite in awe (and inspired!) by Sara’s grit and determination- running the equivalent of 5 marathons in 5 days #powerwoman💥 if you can, consider donating for BBC Children in Need: www.bbcchildreninneed.co.uk/shows/sara-c...
Reposted by Filipa Simões
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
November 13, 2025 at 8:49 PM
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
Reposted by Filipa Simões
Check out our latest episode with Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social!
Learn about her research on neural regeneration in the neonatal mouse #cerebellum. 🧠
Learn about her research on neural regeneration in the neonatal mouse #cerebellum. 🧠
November 12, 2025 at 1:57 AM
Check out our latest episode with Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social!
Learn about her research on neural regeneration in the neonatal mouse #cerebellum. 🧠
Learn about her research on neural regeneration in the neonatal mouse #cerebellum. 🧠
Reposted by Filipa Simões
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
November 13, 2025 at 5:20 PM
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
Reposted by Filipa Simões
This Christmas, we’re teaming up with the Department of Paediatrics to support #Sleigh2Give and bring festive cheer to children in hospitals and families across Oxfordshire. 🎁✨
Donate brand new, unwrapped gifts by 12 Dec to help make the holidays a little brighter.
Donate brand new, unwrapped gifts by 12 Dec to help make the holidays a little brighter.
November 13, 2025 at 5:35 PM
This Christmas, we’re teaming up with the Department of Paediatrics to support #Sleigh2Give and bring festive cheer to children in hospitals and families across Oxfordshire. 🎁✨
Donate brand new, unwrapped gifts by 12 Dec to help make the holidays a little brighter.
Donate brand new, unwrapped gifts by 12 Dec to help make the holidays a little brighter.
Reposted by Filipa Simões
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 3:56 PM
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Reposted by Filipa Simões
International scientists constitute the engine of much of the most exciting US science. My friend Sonali Majumdar has written precisely the kind of guide that international scientists crave in order succeed as resilient and brilliant scientists. Check it out! @sonali-m-19.bsky.social
November 13, 2025 at 2:18 AM
International scientists constitute the engine of much of the most exciting US science. My friend Sonali Majumdar has written precisely the kind of guide that international scientists crave in order succeed as resilient and brilliant scientists. Check it out! @sonali-m-19.bsky.social
Reposted by Filipa Simões
Check out this month's handpicked preprints in developmantal & stem cell biology on the Node
thenode.biologists.com/prelighters-...
thenode.biologists.com/prelighters-...
thenode.biologists.com
November 13, 2025 at 8:18 AM
Check out this month's handpicked preprints in developmantal & stem cell biology on the Node
thenode.biologists.com/prelighters-...
thenode.biologists.com/prelighters-...
Reposted by Filipa Simões
NEWS: Oxford scientists capture genome’s structure in unprecedented detail
@rdm.ox.ac.uk scientists have achieved the most detailed view yet of how DNA folds and functions inside living cells, using a new technique called MCC ultra .
@rdm.ox.ac.uk scientists have achieved the most detailed view yet of how DNA folds and functions inside living cells, using a new technique called MCC ultra .
Oxford scientists capture genome’s structure in unprecedented detail
Radcliff Department of Medicine scientists have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control when and how genes are switched on.
www.medsci.ox.ac.uk
November 13, 2025 at 11:00 AM
NEWS: Oxford scientists capture genome’s structure in unprecedented detail
@rdm.ox.ac.uk scientists have achieved the most detailed view yet of how DNA folds and functions inside living cells, using a new technique called MCC ultra .
@rdm.ox.ac.uk scientists have achieved the most detailed view yet of how DNA folds and functions inside living cells, using a new technique called MCC ultra .
Reposted by Filipa Simões
We have a new lab photo. Busy times in the Delas Lab!
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
November 12, 2025 at 2:04 PM
We have a new lab photo. Busy times in the Delas Lab!
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
Last month Maria and Shaun joined us to start their PhDs.
Learn more about our research and our team: delaslab.com
We will be recruiting another postdoc next year so have a look through our recent work and get in touch if you are interested.
