Christophe 🔬 L
@christlet.bsky.social
NeuroCyto lab 🤹🏻 Institute of NeuroPhysiopathology at CNRS & Aix-Marseille Université 🧠 Neuronal cell biology 🦠 Super-resolution microscopy 🔬 Come for science 👨🏻🔬 Stay for some cooking, sneakers and bike adventures 🥘 👟🚴
Pinned
Christophe 🔬 L
@christlet.bsky.social
· Sep 17
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
Sunday night hobby is preparing a 12-person meal for 4. Tonight is sausage rice casserole (apple for scale) cooking.nytimes.com/recipes/7635...
January 4, 2026 at 7:35 PM
Sunday night hobby is preparing a 12-person meal for 4. Tonight is sausage rice casserole (apple for scale) cooking.nytimes.com/recipes/7635...
An exhibit at the Marseille History museum: Pétanque!
1970s photographs from Hans Silvester
1970s photographs from Hans Silvester
January 4, 2026 at 5:26 PM
An exhibit at the Marseille History museum: Pétanque!
1970s photographs from Hans Silvester
1970s photographs from Hans Silvester
The feeling of dread upon reading the news is overwhelming. As a child of the 1980s I could never have imagined I'd live to see the collapse of our civilization
January 3, 2026 at 6:53 PM
The feeling of dread upon reading the news is overwhelming. As a child of the 1980s I could never have imagined I'd live to see the collapse of our civilization
2026 off to a strong start I see
a man wearing sunglasses is making a funny face while holding a key .
ALT: a man wearing sunglasses is making a funny face while holding a key .
media.tenor.com
January 3, 2026 at 10:25 AM
2026 off to a strong start I see
What's next, being gaslighted by your toaster for burning the toasts? How can journalists report this shit arstechnica.com/ai/2026/01/n...
No, Grok can’t really “apologize” for posting non-consensual sexual images
Letting the unreliable Grok be its own "spokesperson" lets xAI off the hook.
arstechnica.com
January 3, 2026 at 7:32 AM
What's next, being gaslighted by your toaster for burning the toasts? How can journalists report this shit arstechnica.com/ai/2026/01/n...
The safest way to have astrocytes for the next 3 cultures is:
- to have the PI do the media change,
- to let them starve for three days.
We'll know the answer next week...
- to have the PI do the media change,
- to let them starve for three days.
We'll know the answer next week...
January 2, 2026 at 5:15 PM
The safest way to have astrocytes for the next 3 cultures is:
- to have the PI do the media change,
- to let them starve for three days.
We'll know the answer next week...
- to have the PI do the media change,
- to let them starve for three days.
We'll know the answer next week...
Reposted by Christophe 🔬 L
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
January 2, 2026 at 4:00 PM
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
This energy in 2026
January 2, 2026 at 4:01 PM
This energy in 2026
RIP Francis Hallé, botanist extraordinaire and trees' best friend. Hear him talk about how trees are fascinating here (in French): www.radiofrance.fr/francecultur...
Éloge de l'arbre : épisode 4/5 du podcast Francis Hallé, penser les arbres
AUDIO • Francis Hallé, penser les arbres, épisode 4/5 : Éloge de l'arbre. Une série inédite proposée par France Culture. Écoutez À voix nue, et découvrez nos podcasts en ligne.
www.radiofrance.fr
January 2, 2026 at 12:38 PM
RIP Francis Hallé, botanist extraordinaire and trees' best friend. Hear him talk about how trees are fascinating here (in French): www.radiofrance.fr/francecultur...
A thorough review of deep-learning approaches (I prefer that to "AI") for enhancing super-resolution microscopy by @orangeroad2017.bsky.social, Yang Zhang and colleagues in @natmethods.nature.com: doi.org/10.1038/s415...
AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging - Nature Methods
This Review provides a comprehensive discussion of how methods in machine learning and computer vision have been used to improve super-resolution microscopy to gain insights into subcellular biology.
doi.org
January 1, 2026 at 6:41 PM
A thorough review of deep-learning approaches (I prefer that to "AI") for enhancing super-resolution microscopy by @orangeroad2017.bsky.social, Yang Zhang and colleagues in @natmethods.nature.com: doi.org/10.1038/s415...
First ride of 2026
January 1, 2026 at 4:41 PM
First ride of 2026
Happy new year from France y'all ❤️
December 31, 2025 at 11:08 PM
Happy new year from France y'all ❤️
Reposted by Christophe 🔬 L
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...
www.nature.com
December 31, 2025 at 5:53 PM
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Reposted by Christophe 🔬 L
Full pdf @cp-iscience.bsky.social collab w/ @christlet.bsky.social www.cell.com/action/showP...
I may go down ya'll but this was the best thing I wrote:
DECLARATION OF GENERATIVE AI AND AI-ASSISTED TECHNOLOGIES IN THE WRITING PROCESS
"No AI/AI-assisted tools were used in the writing process"
I may go down ya'll but this was the best thing I wrote:
DECLARATION OF GENERATIVE AI AND AI-ASSISTED TECHNOLOGIES IN THE WRITING PROCESS
"No AI/AI-assisted tools were used in the writing process"
December 31, 2025 at 5:40 PM
Full pdf @cp-iscience.bsky.social collab w/ @christlet.bsky.social www.cell.com/action/showP...
I may go down ya'll but this was the best thing I wrote:
DECLARATION OF GENERATIVE AI AND AI-ASSISTED TECHNOLOGIES IN THE WRITING PROCESS
"No AI/AI-assisted tools were used in the writing process"
I may go down ya'll but this was the best thing I wrote:
DECLARATION OF GENERATIVE AI AND AI-ASSISTED TECHNOLOGIES IN THE WRITING PROCESS
"No AI/AI-assisted tools were used in the writing process"
IMO knowing when to drop (even temporarily) a project is the hardest thing to navigate as a PI. It depends on so many variables, a lot of them unrelated to the actual science. The call is by definition made with incomplete information - deciding when high risk, high gain is just too risky
before I started my lab, I asked several senior PIs what their one piece of advice would be and PI pointedly said: “Know when to drop a project.” And that advice has been invaluable in my lab. There are always other projects to follow up on, dropping one isn’t a failure in and of itself.
Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
December 30, 2025 at 8:03 PM
IMO knowing when to drop (even temporarily) a project is the hardest thing to navigate as a PI. It depends on so many variables, a lot of them unrelated to the actual science. The call is by definition made with incomplete information - deciding when high risk, high gain is just too risky
Reposted by Christophe 🔬 L
⏰ Voting closes TOMORROW, December 31! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 30, 2025 at 3:15 PM
⏰ Voting closes TOMORROW, December 31! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Have your say in celebrating the beauty of science 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
Santa brought me... a cutting board worthy of the knife!
December 29, 2025 at 7:05 PM
Santa brought me... a cutting board worthy of the knife!
Reposted by Christophe 🔬 L
Last couple of days to vote for your favourite 'Featured image' from 2025 ❤️🔬!
focalplane.biologists.com/2025/12/19/v...
focalplane.biologists.com/2025/12/19/v...
December 29, 2025 at 11:23 AM
Last couple of days to vote for your favourite 'Featured image' from 2025 ❤️🔬!
focalplane.biologists.com/2025/12/19/v...
focalplane.biologists.com/2025/12/19/v...
@lemonde.fr with the receipts www.lemonde.fr/en/obituarie...
December 28, 2025 at 7:24 PM
@lemonde.fr with the receipts www.lemonde.fr/en/obituarie...
For anyone French under 50, Brigitte Bardot was a former actress that would periodically appear in the news for another ragingly racist comment 🤷♂️
December 28, 2025 at 4:33 PM
For anyone French under 50, Brigitte Bardot was a former actress that would periodically appear in the news for another ragingly racist comment 🤷♂️
"Flops" exhibit @artsetmetiers.bsky.social. Giant darts, Juicero and more in one of my preferred museums in Paris
December 27, 2025 at 8:08 PM
"Flops" exhibit @artsetmetiers.bsky.social. Giant darts, Juicero and more in one of my preferred museums in Paris
Beautiful exhibits @quaibranly.bsky.social on Chinese dragons and Amazonia
December 26, 2025 at 3:10 PM
Beautiful exhibits @quaibranly.bsky.social on Chinese dragons and Amazonia
It's that time of the year
December 26, 2025 at 7:40 AM
It's that time of the year
Reposted by Christophe 🔬 L
Pope Leo said in a Christmas Eve sermon that the story of Jesus being born in a stable because there was no room at an inn should remind Christians that refusing to help the poor and strangers today is tantamount to rejecting God himself. For @reuters.com
Pope Leo, on Christmas Eve, says denying help to poor is rejecting God
Pope Leo said in a Christmas Eve sermon on Wednesday that the story of Jesus being born in a stable because there was no room at an inn should remind Christians that refusing to help the poor and stra...
www.reuters.com
December 24, 2025 at 9:56 PM
Pope Leo said in a Christmas Eve sermon that the story of Jesus being born in a stable because there was no room at an inn should remind Christians that refusing to help the poor and strangers today is tantamount to rejecting God himself. For @reuters.com
Christmas dinner is khoresh bademjan, with the real limoo amani deal from a badass iranian grocery 🐑🍋🟩🎄
December 24, 2025 at 4:38 PM
Christmas dinner is khoresh bademjan, with the real limoo amani deal from a badass iranian grocery 🐑🍋🟩🎄