Elias Spiliotis
@septinlab.bsky.social
Professor of Cell Biology (University of Virginia), Research Scientist. Science, music, sports and politics. Opinions are my own and not of my lab or university.
Pinned
a woman in a suit and tie has the words wait what written on her face
ALT: a woman in a suit and tie has the words wait what written on her face
media.tenor.com
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Elias Spiliotis
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:03 PM
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
“For instance, in 2013, Nathan Wolfe, then a virologist at Stanford University in California, proposed that Epstein fund a sexual-behaviour study of undergraduate students to test “our horny virus hypothesis” — that certain vaginal and penile microorganisms might drive increased sexual activity.”
February 8, 2026 at 12:08 PM
“For instance, in 2013, Nathan Wolfe, then a virologist at Stanford University in California, proposed that Epstein fund a sexual-behaviour study of undergraduate students to test “our horny virus hypothesis” — that certain vaginal and penile microorganisms might drive increased sexual activity.”
My laboratory (www.spiliotislab.org) at University of Virginia is hiring a new Lab Specialist.
Looking for candidates with experience in cell & molecular biology, biochemistry, and/or lab management.
Join us in scenic Charlottesville, Virginia!
jobs.virginia.edu/us/en/job/R0...
Looking for candidates with experience in cell & molecular biology, biochemistry, and/or lab management.
Join us in scenic Charlottesville, Virginia!
jobs.virginia.edu/us/en/job/R0...
Lab Research Professional 2 UVA Spiliotis Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Lab Research Professional 2 UVA Spiliotis Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia
jobs.virginia.edu
February 3, 2026 at 11:41 PM
My laboratory (www.spiliotislab.org) at University of Virginia is hiring a new Lab Specialist.
Looking for candidates with experience in cell & molecular biology, biochemistry, and/or lab management.
Join us in scenic Charlottesville, Virginia!
jobs.virginia.edu/us/en/job/R0...
Looking for candidates with experience in cell & molecular biology, biochemistry, and/or lab management.
Join us in scenic Charlottesville, Virginia!
jobs.virginia.edu/us/en/job/R0...
😮
🎧 listen this is heartbreaking 💔
@coldfishstix on TikTok for the whole track
@coldfishstix on TikTok for the whole track
January 31, 2026 at 3:23 PM
😮
Reposted by Elias Spiliotis
Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM
January 29, 2026 at 9:53 PM
Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM
Reposted by Elias Spiliotis
👇New biosketch requirement update.
“After evaluating the number and types of recent technical inquiries we received to both the SciENcv and eRA Service Desks, we recognize the difficulties these issues have had on the community’s ability to comply with the original timeline of January 25, 2026.”
👇
“After evaluating the number and types of recent technical inquiries we received to both the SciENcv and eRA Service Desks, we recognize the difficulties these issues have had on the community’s ability to comply with the original timeline of January 25, 2026.”
👇
"NIH will provide a warning when the Common Forms are not used but will not withdraw applications that don’t comply with the use of the Common Forms. We expect the leniency to be in place through May 2026"
grants.nih.gov/faqs#/common...
grants.nih.gov/faqs#/common...
Frequently Asked Questions (FAQs) | Grants & Funding
grants.nih.gov
January 29, 2026 at 10:08 PM
👇New biosketch requirement update.
“After evaluating the number and types of recent technical inquiries we received to both the SciENcv and eRA Service Desks, we recognize the difficulties these issues have had on the community’s ability to comply with the original timeline of January 25, 2026.”
👇
“After evaluating the number and types of recent technical inquiries we received to both the SciENcv and eRA Service Desks, we recognize the difficulties these issues have had on the community’s ability to comply with the original timeline of January 25, 2026.”
👇
Reposted by Elias Spiliotis
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
January 28, 2026 at 5:02 PM
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Keep on rockin in the free world...
Neil Young Trashes Amazon, Gives His Complete Musical Catalog to Greenland for Free - Rolling Stone
January 27, 2026 at 2:15 PM
Keep on rockin in the free world...
29,998 more to go... in the US
"As many as 30,000 people could have been killed in the streets of Iran on Jan. 8 and 9 alone, two senior officials of the country’s Ministry of Health told TIME—indicating a dramatic surge in the death toll."
time.com/7357635/more...
time.com/7357635/more...
Iran Protest Death Toll Could Top 30,000: Local Officials
According to two senior officials of the country’s Ministry of Health who spoke with TIME.
time.com
January 25, 2026 at 6:03 PM
29,998 more to go... in the US
Reposted by Elias Spiliotis
Trump agent killing a man by shooting him in the back.
Left hand on the ground trying not to hit the pavement; right hand still holding a cell phone. ICE person standing with a one handed grip pointing his gun right at the man’s head.
There is nothing about this that we should accept. We all must reject this. This is our government, & they want this
There is nothing about this that we should accept. We all must reject this. This is our government, & they want this
January 25, 2026 at 3:28 PM
Trump agent killing a man by shooting him in the back.
Reposted by Elias Spiliotis
Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress www.biorxiv.org/content/10.6...
Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress
Invasively migrating cells thread their nucleus through confined interstitial spaces. How cells protect the nucleus from intracellular forces is poorly understood. Here, we show that the septin cytoskeleton buffers the actomyosin forces that power nuclear movement. Septin filaments comprising SEPT9, a septin amplified in breast cancer, align with perinuclear actomyosin cables which exhibit higher tensile stress during 3D confined migration through narrower pores. SEPT9 depletion amplifies actin stress during confined migration and after myosin II hyper-activation in non-migrating cells causing actin and nuclear envelope ruptures. Following confined migration, DNA breaks, nuclear blebs, micronuclei and cell death increase in SEPT9-depleted cells, phenotypes rescued by the oncogenic SEPT9 isoform 1. Clinicogenomic data reveal that SEPT9 amplification associates with lower genomic alteration in aggressive breast tumors and higher patient mortality. We propose that septins are a mechanoprotective element of the cytoskeleton, and SEPT9 amplification enhances tumor cell survival by preventing nuclear damage. ### Competing Interest Statement The authors have no competing interests. National Institute of General Medical Sciences, https://ror.org/04q48ey07, 2 R35GM136337-07 National Institute on Aging, https://ror.org/049v75w11, 4 R01AG068908-03
www.biorxiv.org
January 23, 2026 at 4:07 PM
Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress www.biorxiv.org/content/10.6...
Reposted by Elias Spiliotis
But don’t take just our word for it, check out the companion paper from the @septinlab.bsky.social lab: doi.org/10.64898/202...
If you want more details be sure to read the paper in full!: doi.org/10.64898/202...
If you want more details be sure to read the paper in full!: doi.org/10.64898/202...
doi.org
January 23, 2026 at 5:45 PM
But don’t take just our word for it, check out the companion paper from the @septinlab.bsky.social lab: doi.org/10.64898/202...
If you want more details be sure to read the paper in full!: doi.org/10.64898/202...
If you want more details be sure to read the paper in full!: doi.org/10.64898/202...
Reposted by Elias Spiliotis
So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread:
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
January 23, 2026 at 5:45 PM
So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread:
doi.org/10.64898/202...
doi.org/10.64898/202...
America under the terror of… snow!
January 23, 2026 at 5:55 AM
America under the terror of… snow!
Reposted by Elias Spiliotis
Emma Burns, Anastasia Amoiroglou, Gregory Rogers, Nasser Rusan and colleagues develop an expansion microscopy protocol for Drosophila cultured cells and tissues, which they use to dissect centriole biology.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
January 22, 2026 at 12:09 PM
Emma Burns, Anastasia Amoiroglou, Gregory Rogers, Nasser Rusan and colleagues develop an expansion microscopy protocol for Drosophila cultured cells and tissues, which they use to dissect centriole biology.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
a woman in a suit and tie has the words wait what written on her face
ALT: a woman in a suit and tie has the words wait what written on her face
media.tenor.com
January 21, 2026 at 9:18 PM
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Elias Spiliotis
Mapping the ultrastructural topology of septin cage entrapment
PhD studentship with @carolynmoores1.bsky.social
Direct link here: www.lshtm.ac.uk/study/fees-a...
PhD studentship with @carolynmoores1.bsky.social
Direct link here: www.lshtm.ac.uk/study/fees-a...
2026-27 Bloomsbury Colleges PhD Studentships | LSHTM
The Bloomsbury Colleges group was set up in 2004 and consists of five institutions: Birkbeck, London School of Hygiene & Tropical Medicine (LSHTM), the Royal Veterinary College (RVC), the School of
www.lshtm.ac.uk
January 20, 2026 at 1:47 PM
Mapping the ultrastructural topology of septin cage entrapment
PhD studentship with @carolynmoores1.bsky.social
Direct link here: www.lshtm.ac.uk/study/fees-a...
PhD studentship with @carolynmoores1.bsky.social
Direct link here: www.lshtm.ac.uk/study/fees-a...
Sleater-Kinney - Jumpers [OFFICIAL VIDEO]
YouTube video by Sub Pop
www.youtube.com
January 20, 2026 at 2:56 PM
Reposted by Elias Spiliotis
In our last week's #journalclub, we looked at how the dynein light chain LC8 stablises the disordered domain of KANK1, transforming it into a rigid, hinged rod that can span the cortex–microtubule gap and recruit kinesin-4 to cortical microtubule plus ends.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 20, 2026 at 10:49 AM
In our last week's #journalclub, we looked at how the dynein light chain LC8 stablises the disordered domain of KANK1, transforming it into a rigid, hinged rod that can span the cortex–microtubule gap and recruit kinesin-4 to cortical microtubule plus ends.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Meme of the year!
Too soon?!?
Too soon?!?
January 19, 2026 at 5:16 AM
Meme of the year!
Too soon?!?
Too soon?!?
Reposted by Elias Spiliotis
A beautiful, informative and perceptive review of neuronal ER, and how its form relates to its function. Nice work from @marijnkuijpers.bsky.social and colleagues. #ER_Literature
The diverse forms and roles of the neuronal endoplasmic reticulum - Nature Reviews Neuroscience
The dynamic and versatile architecture of the neuronal endoplasmic reticulum (ER) enables it to support a wide range of functions. In this Review, Carvalhais, Kole and Kuijpers describe the mechanisms...
www.nature.com
January 18, 2026 at 10:06 AM
A beautiful, informative and perceptive review of neuronal ER, and how its form relates to its function. Nice work from @marijnkuijpers.bsky.social and colleagues. #ER_Literature