Elias Spiliotis
@septinlab.bsky.social
Professor of Cell Biology (University of Virginia), Research Scientist. Science, music, sports and politics. Opinions are my own and not of my lab or university.
Reposted by Elias Spiliotis
One of my science heroes, Joan Brugge, talks about how science funding cuts are slowing their work on breast cancer prevention--share this widely
www.facebook.com/60minutes/vi...
www.facebook.com/60minutes/vi...
439K views · 15K reactions | Harvard researcher Joan Brugge says her work has the potential to prevent breast cancer, but she was notified last spring that her federal funding was terminated. “It was ...
Harvard researcher Joan Brugge says her work has the potential to prevent breast cancer, but she was notified last spring that her federal funding was terminated. “It was just like a gut punch. My...
www.facebook.com
November 10, 2025 at 11:12 AM
One of my science heroes, Joan Brugge, talks about how science funding cuts are slowing their work on breast cancer prevention--share this widely
www.facebook.com/60minutes/vi...
www.facebook.com/60minutes/vi...
Bradknam style!
The new meme for all exciting neuronal cell bio results.
Use in a sentence: My axon extension movies are so sick, I am hopping around the lab Bradknam style.
The new meme for all exciting neuronal cell bio results.
Use in a sentence: My axon extension movies are so sick, I am hopping around the lab Bradknam style.
November 9, 2025 at 10:23 AM
Bradknam style!
The new meme for all exciting neuronal cell bio results.
Use in a sentence: My axon extension movies are so sick, I am hopping around the lab Bradknam style.
The new meme for all exciting neuronal cell bio results.
Use in a sentence: My axon extension movies are so sick, I am hopping around the lab Bradknam style.
6 am ice cream breakfast in Doha, Qatar? Why not!?!
November 9, 2025 at 3:05 AM
6 am ice cream breakfast in Doha, Qatar? Why not!?!
I didn’t expect to run into Gritty in Pune India 😳
November 8, 2025 at 7:27 AM
I didn’t expect to run into Gritty in Pune India 😳
Reposted by Elias Spiliotis
In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:45 PM
In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
In Pune, India for EMBO Cytoskeleton.
Didnt have sitar performance and Filament cocktail bar in my bingo card but… hey!
Come think of it every conference should feature a music performance by a local act and a bar called filament or tubule!
Didnt have sitar performance and Filament cocktail bar in my bingo card but… hey!
Come think of it every conference should feature a music performance by a local act and a bar called filament or tubule!
November 4, 2025 at 6:12 PM
In Pune, India for EMBO Cytoskeleton.
Didnt have sitar performance and Filament cocktail bar in my bingo card but… hey!
Come think of it every conference should feature a music performance by a local act and a bar called filament or tubule!
Didnt have sitar performance and Filament cocktail bar in my bingo card but… hey!
Come think of it every conference should feature a music performance by a local act and a bar called filament or tubule!
UVA Cell Biology got talent!
Happy Halloween 🎃
Happy Halloween 🎃
October 31, 2025 at 2:16 PM
UVA Cell Biology got talent!
Happy Halloween 🎃
Happy Halloween 🎃
Happy Halloween y’all… from the victors of the Creepiest award of the 2025 Spooktacular Carving Contest
October 31, 2025 at 2:12 PM
Happy Halloween y’all… from the victors of the Creepiest award of the 2025 Spooktacular Carving Contest
Reposted by Elias Spiliotis
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵
www.anthropic.com/news/claude-...
www.anthropic.com/news/claude-...
Claude for Life Sciences
Discover how Claude accelerates life sciences research with new scientific connectors, skills, and improved performance for drug discovery and clinical work.
www.anthropic.com
October 20, 2025 at 5:27 PM
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵
www.anthropic.com/news/claude-...
www.anthropic.com/news/claude-...
Do not fold, do not sign
October 17, 2025 at 8:11 PM
Do not fold, do not sign
Ooo-la-la!
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Structure and Function of the Cytoskeleton
The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …
meetings.embo.org
October 7, 2025 at 11:16 PM
Ooo-la-la!
Reposted by Elias Spiliotis
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
October 2, 2025 at 5:11 PM
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
Exciting news!
Submissions are now open for the first @ascbiology.bsky.social #MBOC Spercial Issue on #Septins
Submission deadline: April 30, 2026
RT and spread the word at #CellBio2025
www.molbiolcell.org/cell-biology...
Submissions are now open for the first @ascbiology.bsky.social #MBOC Spercial Issue on #Septins
Submission deadline: April 30, 2026
RT and spread the word at #CellBio2025
www.molbiolcell.org/cell-biology...
October 1, 2025 at 8:43 PM
Exciting news!
Submissions are now open for the first @ascbiology.bsky.social #MBOC Spercial Issue on #Septins
Submission deadline: April 30, 2026
RT and spread the word at #CellBio2025
www.molbiolcell.org/cell-biology...
Submissions are now open for the first @ascbiology.bsky.social #MBOC Spercial Issue on #Septins
Submission deadline: April 30, 2026
RT and spread the word at #CellBio2025
www.molbiolcell.org/cell-biology...
NYTimes biopic and chronicle on Stephen Starr who can be credited for the start of Philly's culinary scene.
Good source of restaurant names for your Philly ASCB lab dinners.
www.nytimes.com/2025/09/30/d...
Good source of restaurant names for your Philly ASCB lab dinners.
www.nytimes.com/2025/09/30/d...
The $400 Million Restaurant Man
www.nytimes.com
October 1, 2025 at 2:05 PM
NYTimes biopic and chronicle on Stephen Starr who can be credited for the start of Philly's culinary scene.
Good source of restaurant names for your Philly ASCB lab dinners.
www.nytimes.com/2025/09/30/d...
Good source of restaurant names for your Philly ASCB lab dinners.
www.nytimes.com/2025/09/30/d...
Reposted by Elias Spiliotis
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 29, 2025 at 7:09 PM
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
👏
The fiscal year ends tomorrow.
Here are results from NIH Reporter downloaded an hour ago.
The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.
1/3
Here are results from NIH Reporter downloaded an hour ago.
The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.
1/3
September 29, 2025 at 11:24 PM
👏
Kudos to NYTImes for running this!
Misfit rock'n'roll drummers for 500...
www.nytimes.com/2025/09/28/a...
Misfit rock'n'roll drummers for 500...
www.nytimes.com/2025/09/28/a...
Viv Prince, Rock’s Original Madman Drummer, Is Dead at 84
www.nytimes.com
September 29, 2025 at 10:02 AM
Kudos to NYTImes for running this!
Misfit rock'n'roll drummers for 500...
www.nytimes.com/2025/09/28/a...
Misfit rock'n'roll drummers for 500...
www.nytimes.com/2025/09/28/a...
Reposted by Elias Spiliotis
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 8:48 AM
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 24, 2025 at 12:28 PM
Reposted by Elias Spiliotis
Write your program officer and grants management official TODAY and thank them! It takes 30 seconds and its really appreciated. The only reason they're remotely this close is because those folks are working 60 hour weeks under immense pressure
Here are data on the percentage of FY2024 appropriation committed to date in FY2025. Most ICs are well on track, but four ICs (NIMHD, NINR, NHLBI, NHGRI) still appear to be under 80%.
Note that values >100% reflect either a higher appropriation for FY25 or an increased % devoted to grants.
Note that values >100% reflect either a higher appropriation for FY25 or an increased % devoted to grants.
September 23, 2025 at 11:11 PM
Write your program officer and grants management official TODAY and thank them! It takes 30 seconds and its really appreciated. The only reason they're remotely this close is because those folks are working 60 hour weeks under immense pressure
September 24, 2025 at 12:20 PM
I think I have spent all my R35's annual budget on Sigma's GOLDEN 25% off sale...
a man is sitting on a boat taking a picture of the water with an ethereum logo in the background .
ALT: a man is sitting on a boat taking a picture of the water with an ethereum logo in the background .
media.tenor.com
September 23, 2025 at 7:29 PM
I think I have spent all my R35's annual budget on Sigma's GOLDEN 25% off sale...
Reposted by Elias Spiliotis
we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social
September 22, 2025 at 11:00 AM
we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social
Reposted by Elias Spiliotis
Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.
September 21, 2025 at 12:52 PM
Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.
Put it in the Louvre!
8. EAGLES BLOCK THE FIELD GOAL [AGAIN] TO WIN THE GAME!
JORDAN DAVIS!
JORDAN DAVIS!
September 21, 2025 at 11:59 PM
Put it in the Louvre!