Juan S. Bonifacino
@juanbonifacino.bsky.social
Cell biologist at NIH researching mechanisms of protein and organelle transport, and related diseases. Special interest in neurons and neurodevelopmental disorders. Passionate about science, nature, travel, and music. Views are my own.
Reposted by Juan S. Bonifacino
This paper was a tour de force and would not be possible without he help of so many collaborators like @juanbonifacino.bsky.social and many more. Thank you!!!
October 24, 2025 at 10:32 PM
This paper was a tour de force and would not be possible without he help of so many collaborators like @juanbonifacino.bsky.social and many more. Thank you!!!
Reposted by Juan S. Bonifacino
Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago
October 24, 2025 at 10:32 PM
Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago
Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...
EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects
Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling
academic.oup.com
October 8, 2025 at 3:33 PM
Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...
Big thanks to Amelia Glazier and @jcellsci.bsky.social for including me in ‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science journals.biologists.com/jcs/article/... Happy to be in such great company!
‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
journals.biologists.com
September 21, 2025 at 4:35 PM
Big thanks to Amelia Glazier and @jcellsci.bsky.social for including me in ‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science journals.biologists.com/jcs/article/... Happy to be in such great company!
Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn
Meet the authors: Raffaella De Pace, Chad Williamson, and Juan Bonifacino http://dlvr.it/TN9cVw
September 21, 2025 at 4:26 PM
Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn
Reposted by Juan S. Bonifacino
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn
September 19, 2025 at 5:31 PM
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn
Reposted by Juan S. Bonifacino
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Excited to share our new review with @depaceraffa.bsky.social, @saikat2025.bsky.social, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...
August 26, 2025 at 3:30 PM
Excited to share our new review with @depaceraffa.bsky.social, @saikat2025.bsky.social, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
CHIP protects lysosomes from CLN4 mutant-induced membrane damage
Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...
rdcu.be
August 25, 2025 at 1:23 PM
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...
August 24, 2025 at 2:37 PM
New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
August 21, 2025 at 6:03 PM
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
Reposted by Juan S. Bonifacino
me, every work week battling with the cloud.
July 21, 2025 at 1:54 PM
me, every work week battling with the cloud.
Reposted by Juan S. Bonifacino
🚨 If you haven’t seen it yet…
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
November 23, 2024 at 11:30 PM
🚨 If you haven’t seen it yet…
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
Nice to meet @manorlaboratory.bsky.social in Canada and learn of his work on label-free imaging!
June 29, 2025 at 10:18 PM
Nice to meet @manorlaboratory.bsky.social in Canada and learn of his work on label-free imaging!
Happy to have made a minor contribution to this exciting study by Tasha Morrison, John O’Shea, and colleagues highlighting the key role of glycosphingolipid metabolism in natural killer and CD8⁺ T cell biology. authors.elsevier.com/c/1l0F9_278y...
April 29, 2025 at 3:19 PM
Happy to have made a minor contribution to this exciting study by Tasha Morrison, John O’Shea, and colleagues highlighting the key role of glycosphingolipid metabolism in natural killer and CD8⁺ T cell biology. authors.elsevier.com/c/1l0F9_278y...
Reposted by Juan S. Bonifacino
Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks !
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n
April 8, 2025 at 11:47 AM
Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks !
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n
Reposted by Juan S. Bonifacino
Job ad is here! Check it out :)
April 16, 2025 at 6:09 PM
Job ad is here! Check it out :)
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!
April 13, 2025 at 4:37 PM
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!
Reposted by Juan S. Bonifacino
just published onlinelibrary.wiley.com/doi/full/10....
Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation
Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following ac...
onlinelibrary.wiley.com
March 19, 2025 at 9:11 AM
just published onlinelibrary.wiley.com/doi/full/10....
Reposted by Juan S. Bonifacino
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
February 27, 2025 at 3:54 PM
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
Reposted by Juan S. Bonifacino
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
December 12, 2024 at 3:19 PM
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
RIP my fellow "porteña" Olivia Hussey. "Born on April 17, 1951, in Buenos Aires, Olivia lived a life full of passion, love, and dedication to the arts, spirituality, and kindness towards animals."
www.cnn.com/2024/12/27/e...
www.cnn.com/2024/12/27/e...
‘Romeo And Juliet’ star Olivia Hussey Eisley dies at 73 | CNN
Olivia Hussey Eisley, star of the 1968 film “Romeo and Juliet” and the slasher classic “Black Christmas,” has died, according to a post on her Instagram page. She was 73.
www.cnn.com
December 28, 2024 at 3:39 PM
RIP my fellow "porteña" Olivia Hussey. "Born on April 17, 1951, in Buenos Aires, Olivia lived a life full of passion, love, and dedication to the arts, spirituality, and kindness towards animals."
www.cnn.com/2024/12/27/e...
www.cnn.com/2024/12/27/e...
Reposted by Juan S. Bonifacino
What are the chances I'd be in Buenos Aires just when @juanbonifacino.bsky.social is enjoying a couple of days off in his hometown? Couldn't dream of a better guide!
December 10, 2024 at 10:04 PM
What are the chances I'd be in Buenos Aires just when @juanbonifacino.bsky.social is enjoying a couple of days off in his hometown? Couldn't dream of a better guide!
“Behind the Paper” commentary on our recent publication demonstrating regulation of Golgi PI4P and downstream processes by a SYS1–ARFRP1–ARL5–ARMH3–PI4KB axis go.nature.com/4fKotEg
A SYS1–ARFRP1–ARL5–ARMH3–PI4KB axis regulates PI4P synthesis at the trans-Golgi network
go.nature.com
December 3, 2024 at 1:29 AM
“Behind the Paper” commentary on our recent publication demonstrating regulation of Golgi PI4P and downstream processes by a SYS1–ARFRP1–ARL5–ARMH3–PI4KB axis go.nature.com/4fKotEg
Fantastic lecture by Svante Pääbo on archaic genomics, shedding light on human evolution and the genetic basis of diseases www.youtube.com/watch?v=tt4I... 🦴🧬
Archaic Genomics—Svante Pääbo Lecture at the ASU Institute of Human Origins
YouTube video by ASU Institute of Human Origins
www.youtube.com
December 2, 2024 at 1:05 AM
Fantastic lecture by Svante Pääbo on archaic genomics, shedding light on human evolution and the genetic basis of diseases www.youtube.com/watch?v=tt4I... 🦴🧬