Razvan Borza
@rborza.bsky.social
PhD Candidate at Netherlands Cancer Institute〡Structural Biology〡Experimental–Computational Integration〡
Curious about AI-Integrated Biology and Synthetic Biology 🔬〡
Bioillustration using Blender🧬〡
🇪🇸 🇳🇱
https://beacons.ai/rborza
Curious about AI-Integrated Biology and Synthetic Biology 🔬〡
Bioillustration using Blender🧬〡
🇪🇸 🇳🇱
https://beacons.ai/rborza
Reposted by Razvan Borza
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
July 15, 2025 at 10:50 PM
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
Reposted by Razvan Borza
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
July 4, 2025 at 11:00 AM
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Reposted by Razvan Borza
I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
SRBD1, a highly conserved gene required for chromosome individualization
SRBD1, a highly conserved gene required for chromosome individualization
Raaijmakers et al. study S1 domain containing protein 1 (SRBD1), a previously uncharacterized essential protein. The loss of SRBD1 results in a complete failure in anaphase chromosome segregation due to defects established in prophase. The phenotype…
dlvr.it
September 28, 2025 at 8:43 PM
I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
Reposted by Razvan Borza
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
July 8, 2025 at 11:18 AM
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
Reposted by Razvan Borza
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
July 9, 2025 at 10:43 PM
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
Reposted by Razvan Borza
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression pubmed.ncbi.nlm.nih.gov/40608935/ #cryoem
July 4, 2025 at 5:24 PM
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression pubmed.ncbi.nlm.nih.gov/40608935/ #cryoem
Reposted by Razvan Borza
Zincore: an unconventional coregulator complex that interacts with the DNA binding domain of #zincfinger transcription factors & stabilizes them on their genomic consensus motifs ➡️ www.science.org/doi/10.1126/... #generegulation #transcriptionfactor #transcription
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
July 4, 2025 at 6:03 AM
Zincore: an unconventional coregulator complex that interacts with the DNA binding domain of #zincfinger transcription factors & stabilizes them on their genomic consensus motifs ➡️ www.science.org/doi/10.1126/... #generegulation #transcriptionfactor #transcription
Reposted by Razvan Borza
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression @science.org @thijnbrummel.bsky.social #Perrakis #Sebastian @daaninthelab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 3, 2025 at 8:20 PM
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression @science.org @thijnbrummel.bsky.social #Perrakis #Sebastian @daaninthelab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
⚠️Don't forget! You have FREE alternatives!
🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov
📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.
🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov
📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.
September 29, 2025 at 10:27 PM
⚠️Don't forget! You have FREE alternatives!
🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov
📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.
🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov
📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.
I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
SRBD1, a highly conserved gene required for chromosome individualization
SRBD1, a highly conserved gene required for chromosome individualization
Raaijmakers et al. study S1 domain containing protein 1 (SRBD1), a previously uncharacterized essential protein. The loss of SRBD1 results in a complete failure in anaphase chromosome segregation due to defects established in prophase. The phenotype…
dlvr.it
September 28, 2025 at 8:43 PM
I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
Its similarity to Spt6/SUPT6H continues to intrigue me 🤔
Reposted by Razvan Borza
📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
January 23, 2025 at 10:09 PM
📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️
www.cell.com/trends/cell-...
Reposted by Razvan Borza
🚨 New strategy against colorectal cancer!
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis
Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells
www.nature.com
July 15, 2025 at 9:39 AM
🚨 New strategy against colorectal cancer!
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪
➡️Read more: www.nature.com/articles/s41...
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
July 15, 2025 at 10:50 PM
👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.
❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁
Read it: www.jbc.org/article/S002...
Reposted by Razvan Borza
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
April 15, 2025 at 11:24 PM
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
July 9, 2025 at 10:43 PM
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
July 8, 2025 at 11:18 AM
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
Reposted by Razvan Borza
🚀 Excited about our pre-print:
AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions
Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go!
🔁Try it and share your thoughts!
📜 Article: www.biorxiv.org/content/10.1...
AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions
Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go!
🔁Try it and share your thoughts!
📜 Article: www.biorxiv.org/content/10.1...
October 28, 2024 at 7:03 PM
🚀 Excited about our pre-print:
AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions
Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go!
🔁Try it and share your thoughts!
📜 Article: www.biorxiv.org/content/10.1...
AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions
Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go!
🔁Try it and share your thoughts!
📜 Article: www.biorxiv.org/content/10.1...
Reposted by Razvan Borza
📢 Make your work FASTER and EASIER!
Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts.
➡️ Let AlphaBridge help you accelerate your workflow!
❤️ Share and try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts.
➡️ Let AlphaBridge help you accelerate your workflow!
❤️ Share and try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
December 3, 2024 at 11:15 PM
📢 Make your work FASTER and EASIER!
Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts.
➡️ Let AlphaBridge help you accelerate your workflow!
❤️ Share and try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts.
➡️ Let AlphaBridge help you accelerate your workflow!
❤️ Share and try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
Reposted by Razvan Borza
AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔
➡️ AlphaBridge will identify the most confident interactions, making your analysis easier!
🌐Try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
➡️ AlphaBridge will identify the most confident interactions, making your analysis easier!
🌐Try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
November 5, 2024 at 12:18 AM
AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔
➡️ AlphaBridge will identify the most confident interactions, making your analysis easier!
🌐Try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
➡️ AlphaBridge will identify the most confident interactions, making your analysis easier!
🌐Try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...
Reposted by Razvan Borza
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
July 8, 2025 at 1:11 AM
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
April 15, 2025 at 11:24 PM
🚨New Article Out!!
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒
🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance
♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...
Reposted by Razvan Borza
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
November 17, 2024 at 6:48 PM
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...